Brett C. Sheppard, M.D., FACS

  • Professor of Surgery, Division of Gastrointestinal and General Surgery, School of Medicine
  • William E. Colson Chair of Pancreatic Disease Research, Surgery, School of Medicine
  • Vice Chair for Quality and Clinical Operations, Surgery, School of Medicine
  • Member, Hernia & Abdominal Wall Center (HAWC), School of Medicine

Biography

I am a surgeon who specializes in pancreatic cancer and gastrointestinal surgery. I have advanced training in surgical oncology (cancer care).

As a fourth-year medical student, I met a patient who was preparing for pancreatic cancer surgery. He was very frightened because at that time, the surgery was risky and pancreatic cancer survival rates were not high. I became committed to reducing the risks of pancreatic surgery, finding ways to detect pancreatic cancer earlier, and improving pancreatic cancer treatment.

My relationship with patients and their families, and the challenges they face, give me the foundation to keep working. The biggest thanks I can receive is to watch patients enjoy their lives anew.

Outside of surgery, I am a trail runner, hiker and winter sports enthusiast. I would join a book club if it met between 10 p.m. and midnight.

Education and training

  • Degrees

    • M.D., 1984, University of Health Sciences, The Chicago Medical School

  • Residency

    • General Surgery, Oregon Health & Science University, Portland, OR, 1984-87, 1989-91

  • Fellowship

    • Surgical Oncology, National Institutes of Health/National Cancer Institute, Bethesda, MD, 1987-89

  • Certifications

    • American Board of Surgery, 1992, recertification, 2010

Memberships and associations:

  • Alliance for Clinical Trials in Oncology
  • American Association of Endocrine Surgeons
  • American College of Gastroenterology
  • American College of Surgeons
  • American College of Surgeons Oncology Group (ACOSOG)
  • American Gastroenterological Association (AGA)
  • Americas Hepato Pancreato Biliary Association (AHPBA)
  • American Pancreas Association (APA)
  • American Surgical Association (ASA)
  • MIS Fellowship Council
  • North Pacific Surgical Association
  • Pacific Coast Surgical Association
  • Society of American Gastrointestinal Endoscopic Surgeons (SAGES)
  • Society for Surgery of the Alimentary Tract (SSAT)
  • Society of Surgical Oncology (SSO)
  • Southwest Oncology Group (SWOG)
  • Surgical Outcomes Club (SOC)
  • Western Surgical Association
  • The Mackenzie Alumni Society
  • Multnomah County Medical Society
  • Portland Surgical Society
  • Oregon Medical Association
  • Oregon Chapter-American College of Surgeons
  • Association of Academic Endocrine Surgeons
  • The Pacific Coast Surgical Association
  • The North Pacific Surgical Association
  • The Society for Surgery of the Alimentary tract

Areas of interest

  • Pancreatic Cancer
  • Chronic Pancreatitis

Additional information

Publications

Elsevier pure profile

Publications

  • Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay

    Science translational medicine
    1. Jose L. Montoya Mira
    2. Arnaud Quentel
    3. Ranish K. Patel
    4. Dove Keith
    5. Megan Sousa
    6. Jessica Minnier
    7. Benjamin R. Kingston
    8. Larry David
    9. Sadik C. Esener
    10. Rosalie C. Sears
    11. Charles Lopez
    12. Brett C. Sheppard
    13. Utkan Demirci
    14. Melissa Wong
    15. Jared Fischer

  • Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer

    Nature Cancer
    1. Jason M. Link
    2. Jennifer R. Eng
    3. Carl Pelz
    4. Kevin MacPherson-Hawthorne
    5. Patrick J. Worth
    6. Shamaline Sivagnanam
    7. Dove J. Keith
    8. Sydney Owen
    9. Ellen M. Langer
    10. Alison Grossblatt-Wait
    11. Gustavo Salgado-Garza
    12. Allison L. Creason
    13. Sara Protzek
    14. Julian Egger
    15. Hannah Holly
    16. Michael B. Heskett
    17. Koei Chin
    18. Nell Kirchberger
    19. Konjit Betre
    20. Elmar Bucher
    21. David Kilburn
    22. Zhi Hu
    23. Michael W. Munks
    24. Isabel A. English
    25. Motoyuki Tsuda
    26. Jeremy Goecks
    27. Emek Demir
    28. Andrew C. Adey
    29. Adel Kardosh
    30. Charles D. Lopez
    31. Brett C. Sheppard
    32. Alex Guimaraes
    33. Brian Brinkerhoff
    34. Terry K. Morgan
    35. Gordon B. Mills
    36. Lisa M. Coussens
    37. Jonathan R. Brody
    38. Rosalie C. Sears

  • Protocol to purify and culture human pancreatic cancer cells from patient-derived xenografts

    STAR Protocols
    1. Julien Tessier
    2. Dmytro Grygoryev
    3. Marilynn Chow-Castro
    4. Taelor Ekstrom
    5. Elise Manalo
    6. Seung Won Lee
    7. Mark Berry
    8. Jason M. Link
    9. Dove Keith
    10. Brittany L. Allen-Petersen
    11. Brett Sheppard
    12. Terry Morgan
    13. Rosalie C. Sears
    14. Jungsun Kim

  • CASPER

    Future Oncology
    1. Charles D. Lopez
    2. Adel Kardosh
    3. Emerson Y. Chen
    4. Guillaume Pegna
    5. Alexander Guimaraes
    6. Bryan Foster
    7. Brian Brinkerhoff
    8. Shaun M. Goodyear
    9. Jeong Youn Lim
    10. Erin Taber
    11. Brindha Rajagopalan
    12. Exodus Edmerson
    13. Johnson Vo
    14. Katherine Nelson
    15. Anna Jackson
    16. Tasha Gingerich
    17. Anne Fahlman
    18. Christopher Lessenich
    19. Francesca Fennell
    20. Diane Ventura
    21. Preeyam Roy
    22. Dove Keith
    23. Brett Sheppard
    24. Jonathan R. Brody
    25. Gordon B. Mills
    26. Ze'ev A. Ronai
    27. Rosalie C. Sears

  • Circulating Neoplastic-Immune Hybrid Cells Are Biomarkers of Occult Metastasis and Treatment Response in Pancreatic Cancer

    Cancers
    1. Ranish K. Patel
    2. Michael Parappilly
    3. Hannah C. Farley
    4. Emile J. Latour
    5. Lei G. Wang
    6. Ashvin M. Nair
    7. Ethan S. Lu
    8. Zachary Sims
    9. Byung Park
    10. Katherine Nelson
    11. Skye C. Mayo
    12. Gordon B. Mills
    13. Brett C. Sheppard
    14. Young Hwan Chang
    15. Summer L. Gibbs
    16. Adel Kardosh
    17. Charles D. Lopez
    18. Melissa H. Wong

  • Minimally invasive umbilical hernia repair is safe for patients with liver dysfunction

    Surgery (United States)
    1. Gustavo Salgado-Garza
    2. Ranish K. Patel
    3. Erin W. Gilbert
    4. Brett C. Sheppard
    5. Patrick J. Worth

  • Rapid metastatic recurrence after pancreatic cancer resection

    HPB
    1. Ranish K. Patel
    2. Gustavo Salgado-Garza
    3. Thomas L. Sutton
    4. Jackie L. Phipps
    5. Pavlos Papavasiliou
    6. Jon M. Gerry
    7. Alicia J. Johnson
    8. Flavio G. Rocha
    9. Brett C. Sheppard
    10. Patrick J. Worth

  • Referral and treatment patterns in pancreatic acinar cell carcinoma

    American journal of surgery
    1. Ranish K. Patel
    2. Michael Parappilly
    3. Thomas L. Sutton
    4. Shay Behrens
    5. Issac R. Schwantes
    6. Alicia J. Johnson
    7. Rodney F. Pommier
    8. Brett C. Sheppard

  • Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

    Journal of Visualized Experiments
    1. Amani Alshaikh
    2. Dmytro Grygoryev
    3. Dove Keith
    4. Brett Sheppard
    5. Rosalie C. Sears
    6. Jungsun Kim
    7. Abdenour Soufi

  • Sendai virus is robust and consistent in delivering genes into human pancreatic cancer cells

    Heliyon
    1. Dmytro Grygoryev
    2. Taelor Ekstrom
    3. Elise Manalo
    4. Jason M. Link
    5. Amani Alshaikh
    6. Dove Keith
    7. Brittany L. Allen-Petersen
    8. Brett Sheppard
    9. Terry Morgan
    10. Abdenour Soufi
    11. Rosalie C. Sears
    12. Jungsun Kim

  • Care at high-volume centers is associated with improved outcomes for patients with pancreatic neuroendocrine tumors

    Journal of surgical oncology
    1. Ranish K. Patel
    2. Thomas L. Sutton
    3. Issac R. Schwantes
    4. Shay Behrens
    5. Rodney F. Pommier
    6. Flavio G. Rocha
    7. Brett C. Sheppard

  • Development of a blood-based extracellular vesicle classifier for detection of early-stage pancreatic ductal adenocarcinoma

    Communications Medicine
    1. Juan Pablo Hinestrosa
    2. Rosalie C. Sears
    3. Harmeet Dhani
    4. Jean M. Lewis
    5. Gregor Schroeder
    6. Heath I. Balcer
    7. Dove Keith
    8. Brett C. Sheppard
    9. Razelle Kurzrock
    10. Paul R. Billings

  • High-volume centers are associated with higher receipt of combined therapy in stage III pancreatic cancer

    American journal of surgery
    1. Shay Behrens
    2. Kristin Potter
    3. Ranish K. Patel
    4. Issac R. Schwantes
    5. Thomas L. Sutton
    6. Alicia J. Johnson
    7. Rodney F. Pommier
    8. Brett C. Sheppard

  • Micelle-Formulated Juglone Effectively Targets Pancreatic Cancer and Remodels the Tumor Microenvironment

    Pharmaceutics
    1. Vidhi M. Shah
    2. Syed Rizvi
    3. Alexander Smith
    4. Motoyuki Tsuda
    5. Madeline Krieger
    6. Carl Pelz
    7. Kevin MacPherson
    8. Jenny Eng
    9. Koei Chin
    10. Michael W. Munks
    11. Colin J. Daniel
    12. Adel Al-Fatease
    13. Galip Gürkan Yardimci
    14. Ellen M. Langer
    15. Jonathan R. Brody
    16. Brett C. Sheppard
    17. Adam W.G. Alani
    18. Rosalie C. Sears

  • Neoadjuvant therapy does not impact the biliary microbiome in patients with pancreatic cancer

    Journal of surgical oncology
    1. Shay Behrens
    2. Thomas L. Sutton
    3. Ranish Patel
    4. Issac R. Schwantes
    5. Jack O'Grady
    6. Alicia Johnson
    7. Aaron Grossberg
    8. Charles Lopez
    9. Erin Gilbert
    10. Skye Mayo
    11. Brett C. Sheppard

  • Phase 2 study of preoperative chemotherapy with nab-paclitaxel and gemcitabine followed by chemoradiation for borderline resectable or node-positive pancreatic ductal adenocarcinoma

    Cancer medicine
    1. Emerson Y. Chen
    2. Adel Kardosh
    3. Nima Nabavizadeh
    4. Bryan Foster
    5. Skye C. Mayo
    6. Kevin G. Billingsley
    7. Erin W. Gilbert
    8. Christian Lanciault
    9. Aaron Grossberg
    10. Kenneth G. Bensch
    11. Erin Maynard
    12. Eric C. Anderson
    13. Brett C. Sheppard
    14. Charles R. Thomas
    15. Charles D. Lopez
    16. Gina M. Vaccaro

  • Socioeconomic and Geographic Disparities in the Referral and Treatment of Pancreatic Cancer at High-Volume Centers

    JAMA Surgery
    1. Thomas L. Sutton
    2. Blake Beneville
    3. Alicia J. Johnson
    4. Skye Mayo
    5. Erin Gilbert
    6. Charles Lopez
    7. Aaron Grossberg
    8. Flavio Rocha
    9. Brett C. Sheppard

  • Characterizing 30-d Postoperative Acute Care Visits

    Journal of Surgical Research
    1. Ashley L. Sweet
    2. Thomas L. Sutton
    3. Krista A. Curtis
    4. Nathan Knapp
    5. Brett C. Sheppard
    6. Karen A. Zink

  • Complications in Distal Pancreatectomy versus Radical Antegrade Modular Pancreatosplenectomy

    World journal of surgery
    1. Thomas L. Sutton
    2. Kristin C. Potter
    3. Skye C. Mayo
    4. Rodney Pommier
    5. Erin W. Gilbert
    6. Brett C. Sheppard

  • Disparities in Electronic Screening for Cancer-Related Psychosocial Distress May Promote Systemic Barriers to Quality Oncologic Care

    JNCCN Journal of the National Comprehensive Cancer Network
    1. Thomas L. Sutton
    2. Marina Affi Koprowski
    3. Jeffrey A. Gold
    4. Benjamin Liu
    5. Alison Grossblatt-Wait
    6. Caroline Macuiba
    7. Andrea Lehman
    8. Susan Hedlund
    9. Flavio G. Rocha
    10. Jonathan R. Brody
    11. Brett C. Sheppard

  • Hepatic metastases in gastrointestinal stromal tumors

    HPB
    1. Thomas L. Sutton
    2. Brett S. Walker
    3. Kevin Billingsley
    4. Brett C. Sheppard
    5. Christopher L. Corless
    6. Michael C. Heinrich
    7. Skye C. Mayo

  • Intensive care unit observation after pancreatectomy

    Journal of surgical oncology
    1. Thomas L. Sutton
    2. Kristin C. Potter
    3. Jack O'Grady
    4. Michael Aziz
    5. Skye C. Mayo
    6. Rodney Pommier
    7. Erin W. Gilbert
    8. Flavio Rocha
    9. Brett C. Sheppard

  • Intraoperative Bile Culture in Pancreaticoduodenectomy

    Journal of Gastrointestinal Surgery
    1. Thomas L. Sutton
    2. Jack O’Grady
    3. Robert Martindale
    4. Skye C. Mayo
    5. Erin W. Gilbert
    6. Brett C. Sheppard

  • Microfluidics Formulated Liposomes of Hypoxia Activated Prodrug for Treatment of Pancreatic Cancer

    Pharmaceutics
    1. Vidhi M. Shah
    2. Craig Dorrell
    3. Adel Al-Fatease
    4. Brittany L. Allen-Petersen
    5. Yeonhee Woo
    6. Yuliya Bortnyak
    7. Rohi Gheewala
    8. Brett C. Sheppard
    9. Rosalie C. Sears
    10. Adam W.G. Alani

  • Neoadjuvant Therapy Is Associated with Improved Chemotherapy Delivery and Overall Survival Compared to Upfront Resection in Pancreatic Cancer without Increasing Perioperative Complications

    Cancers
    1. Christopher Ryan Deig
    2. Thomas Lee Sutton
    3. Blake Beneville
    4. Kristin Trone
    5. Amanda Stratton
    6. Ali N. Gunesch
    7. Amy Ivy Liu
    8. Alaaeddin Alrohaibani
    9. Maedeh Mohebnasab
    10. Solange Bassale
    11. Alison Grossblatt-Wait
    12. Dove Keith
    13. Fouad Attia
    14. Erin W. Gilbert
    15. Charles D. Lopez
    16. Adel Kardosh
    17. Emerson Y. Chen
    18. Kenneth G. Bensch
    19. Nima Nabavizadeh
    20. Charles R. Thomas
    21. Skye C. Mayo
    22. Brett C. Sheppard
    23. Aaron Grossberg

  • Neoadjuvant tyrosine kinase inhibitor therapy for patients with gastrointestinal stromal tumor

    American journal of surgery
    1. Liam H. Wong
    2. Thomas L. Sutton
    3. Brett C. Sheppard
    4. Christopher L. Corless
    5. Michael C. Heinrich
    6. Skye C. Mayo

  • Patency for autologous vein is superior to cadaveric vein in portal-mesenteric venous reconstruction

    HPB
    1. Thomas L. Sutton
    2. Victor Sandoval
    3. David Warner
    4. Gregory Moneta
    5. Erin Gilbert
    6. Skye C. Mayo
    7. Amani D. Politano
    8. Erin Maynard
    9. Brett C. Sheppard
    10. C. Kristian Enestvedt