Adolescent and Adult Eczema Study (ages 12+)
The purpose of this study is to learn how well and how safe an investigational drug called amlitelimab may help treat atopic dermatitis while also using topical corticosteroids (a medication applied to the skin).

Adult Eczema Study (ages 18-64)
The purpose of the study is to learn how effective Upadacitinib (a tablet, taken by mouth) is in reducing the signs and symptoms of atopic dermatitis in adults who previously tried the Dupilumab drug without success.

Adolescent Plaque Psoriasis Study (ages 6-17)
The purpose of the study is to learn more about an investigational drug, apremilast (called AMG 407 in the study), for use in children and adolescents with mild to moderate plaque psoriasis. We are hoping to find out how safe this drug is for pediatric participants with plaque psoriasis.

A study of Patidegib Gel 2% in Subjects with Gorlin Syndrome (ages 18+)
The purpose of this study is to learn more about the use of the study drug, Patidegib Gel 2%, which may be helpful in reducing the disease burden of persistently developing basal cell carcinomas (BCCs) in patients with Gorlin syndrome.

Isolation and analysis of circulating tumor cells (CTCs) and nucleic acids from patient blood specimens (ages 18+)
The purpose of this study is to collect blood specimens to study with the purpose of identifying circulating markers of cancer for early detection.

War on Melanoma: Enlisting a cohort of melanoma survivors and their families (ages 18+)
The purpose of this data repository, called the Melanoma Community Registry, is to develop a prospective cohort of melanoma patients, family members and friends (controls). This registry will serve as a data repository for future IRB-approved research and thus will collect, store and share data with melanoma researchers for an indeterminate period of time. In addition, our repository will contain identifying codes/numbers that are links to data/samples in other relevant databases. Additionally, it is intended to deliver a ready-to-act group of volunteers to participate in the War on Melanoma campaign to include such things as attending educational symposiums and using their networks to increase awareness of the issue. There is no existing nationwide registry for melanoma research. As patient-centered research advances, a resource like this is needed and can serve as a model.

Melanoma Tissue Bank Consortium: A Multi-Center Repository of Biospecimens and Data for Future Use (ages 18+)
The purpose of this study is for the Melanoma Tissue Bank Consortium to create a repository of leftover tissue and other human biospecimens (such as skin, blood, urine, saliva, and stool) and medical and annotating data (such as test and treatment results, age, gender, and history of sun exposure) in order to study melanoma.

Hidradenitis Suppurativa Study (ages 12+)
The purpose of the study is to learn more about the investigational drug, upadacitinib, that may be helpful in treating Hidradenitis Suppurativa, also commonly known as HS. We are hoping to find out how effective upadacitinib (a pill taken by mouth) is in reducing the signs and symptoms of HS, if it is safe and what side effects the study drug may cause in people who have failed to respond to or are intolerant of anti-tumor necrosis factor (TNF) therapy.

Teen and Adult Acne Study (ages 16-40)
The research study is being conducted to compare the effectiveness of spironolactone and doxycycline hyclate in the treatment of acne in women ages 16-40. Both are common treatments for acne that are considered effective, but it is not known if one works better than the other.

Adult Pyoderma Gangrenosum (PG) Study (ages 18+)
The purpose of the study is to learn more about an investigational drug Guselkumab that may be helpful in treating Pyoderma Gangrenosum (PG). We are hoping to find out how effective the study drug (an injection) is in healing wounds, if the study drug is safe, what side effects may be caused by the study drug.

A clinical trial is an organized activity to learn more about a problem or answer questions. Many different kinds of studies are conducted. For example studies may be done to:

• Test if a product, such as a drug or equipment, is safe and effective.
• Find out what education practices work best.
• Determine the best way to treat or prevent an illness.
• Survey or an interview to understand needs, problems, or feelings people have about an important topic.

Frequently asked questions (FAQ's) about clinical trials.

There are many reasons to take part in research. You may want to:

• Help other people.
• Help find a cure for an illness.
• Help scientists find out more about how the human body and mind work.

If you decide to take part in a research study, you do so as a volunteer. That means you decide whether or not you will take part. You can say "no". If you choose to do so, you have many important rights, including the right to decide that you want to quit the study at any time.

Find out more about clinical trial studies on the ClinicalTrials.gov site, created by the U.S. National Institutes of Health.

Visit the Clinical Trials website.