Organic Synthesis

Our highly experienced core staff has used their organic synthesis and purification expertise to produce a variety of compounds that are not commercially available With the aid of our instrumentation for synthesis, purification, and analyses we aim to deliver these compounds with >95 % purity and will provide a Certificate of Analysis.

  • Synthesizing known organic compounds with well-characterized literature-based synthetic routes that are not commercially available or prohibitively expensive.
  • Scaling up synthesis (>1g) for known compounds with well-characterized literature-based synthetic routes.
  • Connecting you to a CRO, if we are not able to process your request due to time, price, or scale issues.
  • Providing you, upon request, with written synthetic procedures and additional characterization of synthesized compounds for publications and grants.

Coming soon!

Pou S, Dodean RA, Frueh L, Liebman KM, Gallagher RT, Jin H, Jacobs RT, Nilsen A, Stuart DR, Doggett JS, Riscoe MK, Winter RW. A New Scalable Synthesis of ELQ-300, ELQ-316, and other Antiparasitic Quinolones. Org Process Res Dev. 2021 Aug 20;25(8):1841-1852. doi: 10.1021/acs.oprd.1c00099. Epub 2021 Aug 4. PubMed PMID: 35110959; PubMed Central PMCID: PMC8802981.

Jeong SY, Hogarth P, Placzek A, Gregory AM, Fox R, Zhen D, Hamada J, van der Zwaag M, Lambrechts R, Jin H, Nilsen A, Cobb J, Pham T, Gray N, Ralle M, Duffy M, Schwanemann L, Rai P, Freed A, Wakeman K, Woltjer RL, Sibon OC, Hayflick SJ. 4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN. EMBO Mol Med. 2019 Dec;11(12):e10489. doi: 10.15252/emmm.201910489. Epub 2019 Oct 29. PubMed PMID: 31660701; PubMed Central PMCID: PMC6895607.

Contract synthesis

  • Synthesis of known and unknown organic compounds with well-characterized literature-based synthetic routes.
  • Cost estimates are based on time required for synthesis and purification and cost of material.
  • Cost includes a Certificate of Analysis with purity and identity confirmation.

$Z000 (X hours x 100/hour + $Y00 material costs)

Research synthesis

  • Synthesis of known and unknown organic compounds with no or poorly characterized literature-based synthetic routes.
  • Cost estimates are based on time required for synthesis and purification and cost of materials and are presented as a range with the higher number including a case-by-case research buffer.
  • Cost includes a Certificate of Analysis with purity and identity confirmation.

$Z1000 - $Z2000 (X1 – X2 hours x 100/hour + $Y00 material costs)

Written procedures and additional analysis

  • Collection of additional analytical data and writing procedures for publications or grants.
  • Cost estimates are based on time required for additional analysis and writing.

$Z00 (X hours x 100/hour)

Material costs

  • These are pass-through costs.
  • Material costs can vary from the original cost estimate if we need to order more or different chemicals for the synthesis. We will contact you before making any additional purchases.

$Y00 material costs