2024 Oregon Alzheimer’s Disease Research Publications

Adeniyi PA, Adeyelu TT, Shrestha A, Liu CC, Lee CC. Prenatal and postnatal methamphetamine exposure alters prefrontal cortical gene expression and behavior in mice. Front Behav Neurosci 18: 1286872, 2024. doi: 10.3389/fnbeh.2024.1286872. PMID: 38505323; PMCID: PMC10949922.

Alatrany AS, Khan W, Hussain A, Kolivand H, Al-Jumeily D. An explainable machine learning approach for Alzheimer's disease classification. Sci Rep. 2024 Feb 1;14(1):2637. doi: 10.1038/s41598-024-51985-w. PMID: 38302557; PMCID: PMC10834965.

Alcázar Magaña A, Vaswani A, Brown KS, Jiang Y, Alam MN, Caruso M, Lak P, Cheong P, Gray NE, Quinn JF, Soumyanath A, Stevens JF, Maier CS. Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of C. asiatica Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity. Molecules. 2024 Feb 13;29(4):838. doi: 10.3390/molecules29040838. PMID: 38398590; PMCID: PMC10892090.

Altmann A, Aksman LM, Oxtoby NP, Young AL; ADNI; Alexander DC, Barkhof F, Shoai M, Hardy J, Schott JM. Towards cascading genetic risk in Alzheimer's disease. Brain. 2024 Aug 1;147(8):2680-2690. doi: 10.3389/fnagi.2023.1326747. PMID: 38274989; PMCID: PMC10808750.

Appleman M, Nilaver B, Weiss A, Kohama S, Urbanski H. Effect of hormone replacement therapy on amyloid beta (Aβ) plaque density in the rhesus macaque amygdala. Frontiers in Aging Neuroscience 15:1326747, 2024.  doi: 10.3389/fnagi.2023.1326747. PMID: 38274989; PMCID: PMC10808750.

Au-Yeung WM, Liu Y, Hanna R, Gothard S, Rodrigues N, Leon Guerrero C, Beattie Z, Kaye J. Feasibility of Deploying Home-Based Digital Technology, Environmental Sensors, and Web-Based Surveys for Assessing Behavioral Symptoms and Identifying Their Precipitants in Older Adults: Longitudinal, Observational Study. JMIR Form Res. 2024 May 8;8:e53192. doi: 10.2196/53192. PMID: 38717798; PMCID: PMC11112478.

Au-Yeung WM, Miller L, Wu CY, Beattie Z, Nunnerley M, Hanna R, Gothard S, Wild K, Kaye J. Examining the Relationships Between Indoor Environmental Quality Parameters Pertaining to Light, Noise, Temperature, and Humidity and the Behavioral and Psychological Symptoms of People Living With Dementia: Scoping Review. Interact J Med Res. 2024 Aug 9;13:e56452. doi: 10.2196/56452. PMID: 39121471; PMCID: PMC11344188.

Barisano G, Iv M; Alzheimer’s Disease Neuroimaging Initiative; Choupan J, Hayden-Gephart M. Cerebral perivascular spaces as predictors of dementia risk and accelerated brain atrophy. medRxiv [Preprint]. 2024 Apr 26:2024.04.25.24306324. doi: 10.1101/2024.04.25.24306324. PMID: 38712073; PMCID: PMC11071547.

Belloy ME, Guen YL, Stewart I, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL; VA Million Veteran Program; Gaziano JM, Logue M, Napolioni V, Greicius MD. The Role of X Chromosome in Alzheimer's Disease Genetics. medRxiv [Preprint]. 2024 Apr 23:2024.04.22.24306094. doi: 10.1101/2024.04.22.24306094. Update in: JAMA Neurol. 2024 Sep 9. doi: 10.1001/jamaneurol.2024.2843. PMID: 38712163; PMCID: PMC11071554.

Boeve BF, Davis AA, Ju YE, Kantarci K, Singer W, Videnovic A; NAPS co-investigators. Concerns with the new biological research criteria for synucleinopathy. Lancet Neurol. 2024 Jul;23(7):659-660. doi: 10.1016/S1474-4422(24)00213-8. PMID: 38876735.

Braun M, Sevao M, Keil SA, Gino E, Wang MX, Lee J, Haveliwala MA, Klein E, Agarwal S, Pedersen T, Rhodes CH, Jansson D, Cook D, Peskind E, Perl DP, Piantino J, Schindler AG, Iliff JJ. Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function. Brain 2024. doi: 10.1093/brain/awae065. PMID: 38802114; PMCID: PMC11146423.

Briggs AQ (NYU Langone Health), Ouedraogo Tall S, Boza-Calvo C, Bernard MA, Bubu OM, Masurkar AV. Drivers of Memory Loss Underreport in Mild Cognitive Impairment Due to Alzheimer Versus Vascular Disease. Alzheimer Dis Assoc Disord 38: 128-132, 2024. doi: 10.1097/WAD.0000000000000627. Epub 2024 May 17. PMID: 38755756; PMCID: PMC11141209.

Cervera-Juanes R, Zimmerman KD, Wilhelm L, Zhu D, Bodie J, Kohama SG, Urbanski HF. Modulation of neural gene networks by estradiol in old rhesus macaque females. bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.572105. doi: 10.1101/2023.12.18.572105. PMID: 38187564; PMCID: PMC10769303.

Chen S, Nagel CL, Liu R, Botoseneanu A, Allore HG, Newsom JT, Thielke S, Kaye J, Quiñones AR. Mental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults. PLoS One. 2024 May 14;19(5):e0303599. doi: 10.1371/journal.pone.0303599. PMID: 38743678; PMCID: PMC11093294.

Cho Y, Iliff JJ, Lim MM, Raskind M, Peskind E. A case of prazosin in treatment of rapid eye movement sleep behavior disorder. J Clin Sleep Med. 2024 Feb 1;20(2):319-321. doi: 10.5664/jcsm.10888. PMID: 37882640; PMCID: PMC10835776.

Choudhury P, Lee-Iannotti JK, Busicescu AO, Rangan P, Fantini ML, Avidan AY, Bliwise DL, Criswell SR, During EH, Elliott JE, Fields JA, Gagnon JF, Howell MJ, Huddleston DE, McLeland J, Mignot E, Miglis MG, Lim MM, Pelletier A, Schenck CH, Shprecher D, St Louis EK, Videnovic A, Ju YS, Boeve BF, Postuma R. Validation of the RBD Symptom Severity Scale in the North American Prodromal Synucleinopathy Consortium. Neurology 102:e208008, 2024. DOI: 10.1212/WNL.0000000000208008

Christopher M, Bowen S, Witkiewitz K, Grupe D, Goerling R, Hunsinger M, Oken B, Korecki T, Rosenbaum N. A multisite feasibility randomized clinical trial of mindfulness-based resilience training for aggression, stress, and health in law enforcement officers. BMC Complement Med Ther 24:142, 2024.  doi: 10.1186/s12906-024-04452-y. PMID: 38575888; PMCID: PMC10993469.

Colgan DD, Eddy A, Aulet-Leon M, Green K, Peters B, Shangraw R, Theard MA, Han SJ, Raslan A, Oken B. Compassion, communication, and the perception of control: a mixed methods study to investigate patients' perspectives on clinical practices for alleviating distress and promoting empowerment during awake craniotomies. Br J Neurosurg. 2024 Aug;38(4):911-922. doi: 10.1080/02688697.2021.2005773. Epub 2021 Dec 1. Erratum in: Br J Neurosurg. 2023 Feb;37(1):123. doi: 10.1080/02688697.2021.2019420. PMID: 34850642; PMCID: PMC9156730.

Cook L, Verbrugge J, Schwantes-An TH, Schulze J, Foroud T, Hall A, Marder KS, Mata IF, Mencacci NE, Nance MA, Schwarzschild MA, Simuni T, Bressman S, Wills AM, Fernandez HH, Litvan I, Lyons KE, Shill HA, Singer C, Tropea TF, Vanegas Arroyave N, Carbonell J, Cruz Vicioso R, Katus L, Quinn JF, Hodges PD, Meng Y, Strom SP, Blauwendraat C, Lohmann K, Casaceli C, Rao SC, Ghosh Galvelis K, Naito A, Beck JC, Alcalay RN. Parkinson's disease variant detection and disclosure: PD GENEration, a North American study. Brain. 2024 Aug 1;147(8):2668-2679. doi: 10.1093/brain/awae142. PMID: 39074992; PMCID: PMC11292896.

Corwin DJ, Myers SR, Arbogast KB, Lim MM, Elliott JE, Metzger KB, LeRoux P, Elkind J, Metheny H, Berg J, Pettijohn K, Master CL, Kirschen MP, Cohen AS. Head Injury Treatment With Healthy and Advanced Dietary Supplements: A Pilot Randomized Controlled Trial of the Tolerability, Safety, and Efficacy of Branched Chain Amino Acids in the Treatment of Concussion in Adolescents and Young Adults. J Neurotrauma. 2024 Jun;41(11-12):1299-1309. doi: 10.1089/neu.2023.0433. Epub 2024 Apr 11. PMID: 38468511; PMCID: PMC11339555.

Croff R, Aron S, Wachana A, Fuller P, Mattek N, Towns J, Kaye J. Walking and Social Reminiscence in Gentrifying Neighborhoods: Feasibility and Impact on Cognitive, Physical, and Mental Health Among Older Black Adults in the SHARP Study. Gerontologist. 2024 Feb 27:gnae019. doi: 10.1093/geront/gnae019. Epub ahead of print. PMID: 38412543.

Cunningham HA, Dovek L, Recoder N, Bryant-Ekstrand MD, Ligman BR, Piantino J, Lim MM, Elliott JE. Heart rate variability impairment during sleep in Veterans with REM sleep behavior disorder, traumatic brain injury, and posttraumatic stress disorder: An early potential window into autonomic dysfunction? bioRxiv [Preprint]. 2024 Sep 24:2024.09.20.614142. doi: 10.1101/2024.09.20.614142. PMID: 39386663; PMCID: PMC11463592.

De Lima B, Lindauer A, Eckstrom E. Age-Friendly Research: A Pilot Exploration of Tools to Facilitate Inclusion of Older Adults in Research. Gerontol Geriatr Med 10: 23337214241236037, 2024. doi: 10.1177/23337214241236037. PMID: 38435474; PMCID: PMC10906043.

DesRuisseaux LA, Guevara JE, Duff K. Examining the Stability and Predictive Utility of Across- and Within-Domain Intra-Individual Variability in Mild Cognitive Impairment. Arch Clin Neuropsychol. 2024 Jul 13:acae054. doi: 10.1093/arclin/acae054. Epub ahead of print. PMID: 39003237.

Dodge H, Yu K, Wu CY, Pruitt PJ, Asgari M, Kaye JA, Hampstead BM, Struble L, Potempa K, Lichtenberg P, Croff R, Albin RL, Silbert LC, Team IC. Internet-Based Conversational Engagement Randomized Controlled Clinical Trial (I-CONECT) Among Socially Isolated Adults 75+ Years Old With Normal Cognition or Mild Cognitive Impairment: Topline Results. Gerontologist 64: 2024. doi: 10.1093/geront/gnad147. PMID: 37935416; PMCID: PMC10943511.

Duff K. Revisiting reliable change with Iverson (2001). Clin Neuropsychol 38:412-428, 2024. DOI: 10.1080/13854046.2023.2202333

Duff K, Dixon A, Embree L. A Closer Look at Practice Effects in Mild Cognitive Impairment and Alzheimer's Disease. Arch Clin Neuropsychol 39:1-10, 2024.  PMC10802223. DOI: 10.1093/arclin/acad046

Duff K, Hammers DB, Koppelmans V, King JB, Hoffman JM. Short-Term Practice Effects on Cognitive Tests Across the Late Life Cognitive Spectrum and How They Compare to Biomarkers of Alzheimer's Disease. J Alzheimers Dis. 2024;99(1):321-332. doi: 10.3233/JAD-231392. PMID: 38669544.

Duff K, Miller JB, Cobos K, Rodrigues J, O'Bryant SE; HABS-HD Team. Derivation of Indices of Cognitive Change Among Hispanic Adults and Elders. JAMA Netw Open. 2024 Sep 3;7(9):e2431180. doi: 10.1001/jamanetworkopen.2024.31180. PMID: 39226056; PMCID: PMC11372505.

Duff K, Sevigny-Resetco D. Validation of regression-based change formulae for mild cognitive impairment and Alzheimer's disease. Alzheimers Dement (Amst). 2024 Sep 20;16(3):e70008. doi: 10.1002/dad2.70008. PMID: 39309598; PMCID: PMC11413409.

Edmonds EC (Banner Alzheimer's Institute, Tucson, Arizona), Thomas KR, Rapcsak SZ, Lindemer SL, Delano-Wood L, Salmon DP, Bondi MW. Data-driven classification of cognitively normal and mild cognitive impairment subtypes predicts progression in the NACC dataset. Alzheimers Dement, 2024.  doi: 10.1002/alz.13793. Epub 2024 Apr 4. PMID: 38574399; PMCID: PMC11095435.

Elliott JE, Bryant-Ekstrand MD, Keil AT, Ligman BR, Lim MM, Zitser J, During EH, Gagnon JF, St Louis EK, Fields JA, Huddleston DE, Bliwise DL, Avidan AY, Schenck CH, McLeland J, Criswell SR, Davis AA, Videnovic A, Lee-Iannotti JK, Postuma R, Boeve BF, Ju YS, Miglis MG; for North American Prodromal Synucleinopathy (NAPS) Consortium. Frequency of Orthostatic Hypotension in Isolated REM Sleep Behavior Disorder. Neurology. 2023 Dec 12;101(24):e2545-e2559. doi: 10.1212/WNL.0000000000207883. Epub 2023 Oct 19. PMID: 37857496; PMCID: PMC10791057.

Elliott JE, Ligman BR, Bryant-Ekstrand MD, Keil AT, Powers K, Olivo C, Neilson L, Postuma RB, Pelletier A, Gagnon JF, Gan-Or Z, Yu E, Liu L, St Louis EK, Forsberg LK, Fields JA, Ross OA, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, McLeland J, Criswell SR, Videnovic A, During EH, Miglis MG, Shprecher DR, Lee-Iannotti JK, Boeve BF, Ju YS, Lim MM. Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium. Sleep, 2024. doi: 10.1093/sleep/zsae007

Elliott JE, Brewer JS, Keil AT, Ligman BR, Bryant-Ekstrand MD, McBride AA, Powers K, Sicard SJ, Twamley EW, O'Neil ME, Hildebrand AD, Nguyen T, Morasco BJ, Gill JM, Dengler BA, Lim MM. Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI (2) sponsored protocol. medRxiv : the preprint server for health sciences 2024. doi: 10.1101/2024.05.30.24308195. PMID: 38853958; PMCID: PMC11160858.

Fecteau KM, Winchell AJ, Blue SW, Appleman ML, Urbanski HF, Erikson DW. Comparison of assay methods for quantifying sex hormone concentrations across the menstrual cycle in rhesus macaques†. Biol Reprod. 2024 Aug 15;111(2):463-471. doi: 10.1093/biolre/ioae063. PMID: 38685627; PMCID: PMC11327312.

Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium. A genome-wide association meta-analysis of all-cause and vascular dementia. Alzheimers Dement. 2024 Jul 24. doi: 10.1002/alz.14115. Epub ahead of print. PMID: 39046104.

Guan DX, Rehman T, Nathan S, Durrani R, Potvin O, Duchesne S, Pike GB, Smith EE, Ismail Z. Neuropsychiatric symptoms: Risk factor or disease marker? A study of structural imaging biomarkers of Alzheimer's disease and incident cognitive decline. Human brain mapping 45: e70016, 2024. doi: 10.1002/hbm.70016. PMID: 39254167; PMCID: PMC11386326.

Gauthreaux K, Kukull WA, Nelson KB, Mock C, Chen YC, Chan KCG, Fardo DW, Katsumata Y, Abner EL, Nelson PT. Different cohort, disparate results: Selection bias is a key factor in autopsy cohorts. Alzheimers Dement. 2024 Jan;20(1):266-277. doi: 10.1002/alz.13422. Epub 2023 Aug 17. PMID: 37592813; PMCID: PMC10843760.

Ginder DE, Tinsley CE, Kaiser ME, Lim MM. Sex-Specific Impacts of Early Life Sleep Disruption: Ethanol Seeking, Social Interaction, and Anxiety Are Differentially Altered in Adolescent Prairie Voles. bioRxiv, 2024.  PMC10802381. DOI: 10.1101/2024.01.03.574112

Goss K, Bueno-Junior LS, Stangis K, Ardoin T, Carmon H, Zhou J, Satapathy R, Baker I, Jones-Tinsley CE, Lim MM, Watson BO, Sueur C, Ferrario CR, Murphy GG, Ye B, Hu Y. Quantifying social roles in multi-animal videos using subject-aware deep-learning. bioRxiv 2024. doi: 10.1101/2024.07.07.602350. PMID: 39026890; PMCID: PMC11257443.

Gray NE, Hack W, Brandes MS, Zweig JA, Yang L, Marney L, Choi J, Magana AA, Cerruti N, McFerrin J, Koike S, Nguyen T, Raber J, Quinn JF, Maier CS, Soumyanath A. Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration. bioRxiv [Preprint]. 2024 Jan 24:2024.01.23.576700. doi: 10.1101/2024.01.23.576700. PMID: 38328129; PMCID: PMC10849617.

Hack W, Gladen-Kolarsky N, Chatterjee S, Liang Q, Maitra U, Ciesla L, Gray NE. Gardenin A treatment attenuates inflammatory markers, synuclein pathology and deficits in tyrosine hydroxylase expression and improves cognitive and motor function in A53T-α-syn mice. Biomed Pharmacother. 2024 Apr;173:116370. doi: 10.1016/j.biopha.2024.116370. Epub 2024 Mar 8. PMID: 38458012; PMCID: PMC11017674.

Hiya S, Maldonado-Díaz C, Walker JM, Richardson TE. Cognitive symptoms progress with limbic-predominant age-related TDP-43 encephalopathy stage and co-occurrence with Alzheimer disease. J Neuropathol Exp Neurol. 2023 Dec 22;83(1):2-10. doi: 10.1093/jnen/nlad098. PMID: 37966908; PMCID: PMC10746699.

Jaye S, Sandau US, McFarland TJ, Woltjer RL, Saugstad JA. A clathrin mediated endocytosis scaffolding protein, Intersectin 1, changes in an isoform, brain region, and sex specific manner in Alzheimer's disease. Front Neurosci. 2024 Jun 10;18:1426180. doi: 10.3389/fnins.2024.1426180. PMID: 38915309; PMCID: PMC11195150.

Jung M, Apostolova LG, Gao S, Burney HN, Lai D, Saykin AJ, Pressler SJ. Association of Heart Failure With Cognitive Decline and Development of Mild Cognitive Impairment and Dementia. J Cardiovasc Nurs 39: E80-E85, 2024. doi: 10.1097/JCN.0000000000001075. PMID: 39137265; PMCID: PMC11322628.

Kapoor A (University of California, Irvine), Ho JK, Jang JY, Nation DA. Robust reference group normative data for neuropsychological tests accounting for primary language use in Asian American older adults. J Int Neuropsychol Soc 30: 402-409, 2024. doi: 10.1017/S1355617723000759. Epub 2024 Mar 1. PMID: 38425303; PMCID: PMC11014765.

Karvelas N, Oh B, Wang E, Cobigo Y, Tsuei T, Fitzsimons S, Younes K, Ehrenberg A, Geschwind MD, Schwartz D, Kramer JH, Ferguson AR, Miller BL, Silbert LC, Rosen HJ, Elahi FM. Enlarged perivascular spaces are associated with white matter injury, cognition and inflammation in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain Commun 6: fcae071, 2024. doi: 10.1093/braincomms/fcae071. PMID: 38495305; PMCID: PMC10943571.

Katsumata Y, Fardo DW, Shade LMP, Wu X, Karanth SD, Hohman TJ, Schneider JA, Bennett DA, Farfel JM, Gauthreaux K, Mock C, Kukull WA, Abner EL, Nelson PT; Alzheimer's Disease Neuroimaging Initiative; National Alzheimer's Coordinating Center. Genetic associations with dementia-related proteinopathy: Application of item response theory. Alzheimers Dement. 2024 Apr;20(4):2906-2921. doi: 10.1002/alz.13741. Epub 2024 Mar 9. PMID: 38460116; PMCID: PMC11032554.

Kikuchi M, Miyashita A, Hara N, Kasuga K, Saito Y, Murayama S, Kakita A, Akatsu H, Ozaki K, Niida S, Kuwano R, Iwatsubo T, Nakaya A, Ikeuchi T, Alzheimer's Disease Neuroimaging initiative, Japanese Alzheimer's Disease Neuroimaging Initiative. Polygenic effects on the risk of Alzheimer's disease in the Japanese population. Alzheimer's research & therapy 16: 45, 2024. doi: 10.1186/s13195-024-01514-8. PMID: 38414085; PMCID: PMC10898021.

Kim KY, Kim E, Lee JY, Alzheimer's Disease Neuroimaging Initiative. Impact of amyloid and cardiometabolic risk factors on prognostic capacity of plasma neurofilament light chain for neurodegeneration. Alzheimer's research & therapy 16: 202, 2024. doi: 10.1186/s13195-024-01564-y. PMID: 39267169; PMCID: PMC11397040.

Kodali MC, Antone J, Alsop E, Jayakumar R, Parikh K, Chiot A, Sanchez-Molina P, Ajami B, Arnold SE, Jensen K, Das S, Weinberg MS. Cryopreservation of cerebrospinal fluid cells preserves the transcriptional landscape for single-cell analysis. J Neuroinflammation 21: 71, 2024. doi: 10.1186/s12974-024-03047-1. PMID: 38521932; PMCID: PMC10960996.

Koppelmans V, Ruitenberg MFL, Schaefer SY, King JB, Jacobo JM, Silvester BP, Mejia AF, van der Geest J, Hoffman JM, Tasdizen T, Duff K. Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures. Neurodegener Dis 24: 54-70, 2024. doi: 10.1159/000539800. Epub 2024 Jun 12. PMID: 38865972; PMCID: PMC11381162.

Liampas I, Dimitriou N, Siokas V, Messinis L, Nasios G, Dardiotis E. Cognitive trajectories preluding the onset of different dementia entities: a descriptive longitudinal study using the NACC database. Aging Clin Exp Res. 2024 May 23;36(1):119. doi: 10.1007/s40520-024-02769-9. PMID: 38780681; PMCID: PMC11116253. 

Li D, Farrell JJ, Mez J, Martin ER, Bush WS, Ruiz A, Boada M, de Rojas I, Mayeux R, Haines JL, Vance MAP, Wang LS, Schellenberg GD, Lunetta KL, Farrer LA. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews. Alzheimers Dement. 2023 Dec;19(12):5550-5562. doi: 10.1002/alz.13117. Epub 2023 Jun 1. PMID: 37260021; PMCID: PMC10689571.

Liampas I, Siokas V, Lyketsos CG, Dardiotis E. Cognitive Performance and Incident Alzheimer's Dementia in Men Versus Women. J Prev Alzheimers Dis 11:162-170, 2024.  PMC10794850. DOI: 10.14283/jpad.2023.90

Lila E, Zhang W, Rane Levendovszky S, Alzheimer’s Disease Neuroimaging Initiative. Interpretable discriminant analysis for functional data supported on random nonlinear domains with an application to Alzheimer's disease. J R Stat Soc Series B Stat Methodol 86: 1013-1044, 2024. doi: 10.1093/jrsssb/qkae023. PMID: 39279915; PMCID: PMC11398888.

Lindauer A, Croff R, Duff K, Mattek N, Fuller P, Pierce A, Bonds K, Kaye J. The African American Dementia and Aging Project (AADAPt): An Oregon-based Longitudinal Study. medRxiv [Preprint]. 2024 Jun 3:2024.05.06.24306831. doi: 10.1101/2024.05.06.24306831. PMID: 38766213; PMCID: PMC11100851.

Lindauer A, Croff R, Duff K, Mattek N, Fuller P, Pierce A, Bonds K, Kaye J. The African American Dementia and Aging Project (AADAPt): An Oregon-based Longitudinal Study. medRxiv [Preprint]. 2024 Jun 3:2024.05.06.24306831. doi: 10.1101/2024.05.06.24306831. PMID: 38766213; PMCID: PMC11100851.

Lomniczi A, Luna SL, Cervera-Juanes R, Appleman ML, Kohama SG, Urbanski HF. Age-related increase in the expression of 11β-hydroxysteroid dehydrogenase type 1 in the hippocampus of male rhesus macaques. Front Aging Neurosci. 2024 Mar 15;16:1328543. doi: 10.3389/fnagi.2024.1328543. PMID: 38560025; PMCID: PMC10978655.

Lyons KS, Russell LT, Bonds Johnson K, Brewster GS, Carter JH, Miller LM. Evaluating the Dyadic Benefits of Early-Phase Behavioral Interventions: An Exemplar Using Data From Couples Living With Parkinson's Disease. Gerontologist 64: 2024. doi: 10.1093/geront/gnad172. PMID: 38150330; PMCID: PMC11194630.

Mishra A, Gordon GR, MacVicar BA, Newman EA. Astrocyte Regulation of Cerebral Blood Flow in Health and Disease. Cold Spring Harb Perspect Biol. 2024 Apr 1;16(4):a041354. doi: 10.1101/cshperspect.a041354. PMID: 38316553; PMCID: PMC10982716.

Morales J, Gabriel N, Natarajan L, LaCroix AZ, Shadyab AH, Xu R, Silverman J, Feldman HH, Hernandez I, Powder for Pennies Collaboration. Pharmacoepidemiology evaluation of bumetanide as a potential candidate for drug repurposing for Alzheimer's disease. Alzheimers Dement 20: 5236-5246, 2024. doi: 10.1002/alz.13872. Epub 2024 Jun 21. PMID: 39030734; PMCID: PMC11350022.

Neilson LE, Balba NM, Elliott JE, Scott GD, Mist SD, Butler MP, Heinricher MM, Lim MM. The potential role of chronic pain and the polytrauma clinical triad in predicting prodromal PD: A cross-sectional study of U.S. Veterans. Clin Park Relat Disord 10:100253, 2024. doi: 10.1016/j.prdoa.2024.100253. PMID: 38689822; PMCID: PMC11059454.

Nguyen DD, Mansur S, Ciesla L, Gray NE, Zhao S, Bao Y. A Combined Computational and Experimental Approach to Studying Tropomyosin Kinase Receptor B Binders for Potential Treatment of Neurodegenerative Diseases. Molecules. 2024 Aug 23;29(17):3992. doi: 10.3390/molecules29173992. PMID: 39274839; PMCID: PMC11396239.

Oka T (Tokyo University of Agriculture and Technology), Matsuzawa Y, Tsuneyoshi M, Nakamura Y, Aoshima K, Tsugawa H; Alzheimer’s Disease Metabolomics Consortium. Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer's Disease Neuroimaging Initiative cohort. Sci Rep. 2024 Apr 2;14(1):6797. doi: 10.1038/s41598-024-56837-1. PMID: 38565541; PMCID: PMC10987653.

Oken BS, Kaplan J, Klee D, Gallegos AM. Contributions of loneliness to cognitive impairment and dementia in older adults are independent of other risk factors and Alzheimer's pathology: a narrative review. Frontiers in human neuroscience 18: 1380002, 2024. PMC11169707.

Peterson A, Sathe A, Zaras D, Yang Y, Durant A, Deters KD, Shashikumar N, Pechman KR, Kim ME, Gao C, Khairi NM, Li Z, Yao T, Huo Y, Dumitrescu L, Gifford KA, Wilson JE, Cambronero F, Risacher SL, Beason-Held LL, An Y, Arfanakis K, Erus G, Davatzikos C, Tosun D, Toga AW, Thompson PM, Mormino EC, Zhang P, Schilling K, Alzheimer's Disease Neuroimaging I, Team BS, Alzheimer's Disease Sequencing P, Albert M, Kukull W, Biber SA, Landman BA, Johnson SC, Schneider J, Barnes LL, Bennett DA, Jefferson AL, Resnick SM, Saykin AJ, Hohman TJ, Archer DB. Sex, racial, and APOE-epsilon4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease. bioRxiv 2024. doi: 10.1101/2024.06.10.598357. PMID: 38915636; PMCID: PMC11195046.

Pleasant T, Ono S, Gothard S, Wall R, Silbert L. Aging Veterans and a Silver Lining of Service. J Veterans Stud. 2023;9(3):98-102. doi: 10.21061/jvs.v9i3.495. Epub 2023 Dec 20. PMID: 38390452; PMCID: PMC10883328.

Polsinelli AJ, Johnson S, Crouch A, Lane KA, Pena-Garcia A, Hammers DB, Wang S, Gao S, Apostolova LG. Neuropsychiatric symptom burden in early-onset and late-onset Alzheimer's disease as a function of age. Alzheimers Dement 20: 5481-5491, 2024. doi: 10.1002/alz.14042. Epub 2024 Jul 3. PMID: 38958543; PMCID: PMC11350043.

Postuma R, Vorasoot N, St Louis EK, Pelletier A, Lim MM, Elliott J, Gagnon JF, Gan-Or Z, Forsberg LK, Fields JA, Ross OA, Singer W, Huddleston DE, Bliwise DL, Avidan AY, Howell M, Schenck CH, McLeland J, Davis AA, Criswell SR, Videnovic A, During EH, Miglis MG, Boeve BF, Ju YS, McKeon A; as the North American Prodromal Synucleinopathy (NAPS) Consortium. IGLON5 Frequency in Idiopathic REM Sleep Behavior Disorder: A Multicenter Study. Neurol Neuroimmunol Neuroinflamm. 2024 Nov;11(6):e200311. doi: 10.1212/NXI.0000000000200311. Epub 2024 Sep 13. PMID: 39270144; PMCID: PMC11404316.

Quesnel MJ, Labonte A, Picard C, Zetterberg H, Blennow K, Brinkmalm A, Villeneuve S, Poirier J, Alzheimer's Disease Neuroimaging Initiative, Prevent-Ad Research Group. Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains. Brain 147: 1680-1695, 2024. doi: 10.1093/brain/awad398. PMID: 37992295; PMCID: PMC11068109.

Raman R, Hussen K, Donohue MC, Ernstrom K, Holdridge KC, Langford O, Molina-Henry DP, Pierce AL, Sims JR, Smith A, Yaari R, Aisen PS, Sperling R, Grill JD. Pre-Randomization Predictors of Study Discontinuation in a Preclinical Alzheimer's Disease Randomized Controlled Trial. J Prev Alzheimers Dis 11: 874-880, 2024. doi: 10.14283/jpad.2024.136. PMID: 39044496; PMCID: PMC11266258.

Ray NR, Kunkle BW, Hamilton-Nelson K, Kurup JT, Rajabli F, Qiao M, Vardarajan BN, Cosacak MI, Kizil C, Jean-Francois M, Cuccaro M, Reyes-Dumeyer D, Cantwell L, Kuzma A, Vance JM, Gao S, Hendrie HC, Baiyewu O, Ogunniyi A, Akinyemi RO, Alzheimer's Disease Genetics C, Lee WP, Martin ER, Wang LS, Beecham GW, Bush WS, Xu W, Jin F, Wang L, Farrer LA, Haines JL, Byrd GS, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C. Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry. Alzheimers Dement 20: 5247-5261, 2024. doi: 10.1002/alz.13880. Epub 2024 Jul 3. PMID: 38958117; PMCID: PMC11350055.

Richmond SB, Seidler RD, Iliff JJ, Schwartz DL, Luther M, Silbert LC, Wood SJ, Bloomberg JJ, Mulder E, Lee JK, De Luca A, Piantino J. Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest. NPJ Microgravity 10: 24, 2024. doi: 10.1038/s41526-024-00368-6. PMID: 38429289; PMCID: PMC10907584.

Roh S, Lee YS, Moon H, Steele JS, Warne DK, Lee JA. Cognitive Impairment and Social Determinants of Health Among Indigenous Women. Gerontologist 64: 2024. doi: 10.1093/geront/gnae072. PMID: 38860660; PMCID: PMC11234291.

Rose EP, Osterberg VR, Banga JS, Gorbunova V, Unni VK. Alpha-synuclein regulates the repair of genomic DNA double-strand breaks in a DNA-PK (cs) -dependent manner. bioRxiv 2024. Preprint.  doi: 10.1016/j.nbd.2024.106675. PMID: 38496612; PMCID: PMC10942394.

Rowe K, Gray NE, Zweig JA, Law A, Techen N, Maier CS, Soumyanath A, Kretzschmar D. Centella asiatica and its caffeoylquinic acid and triterpene constituents increase dendritic arborization of mouse primary hippocampal neurons and improve age-related locomotion deficits in Drosophila. Front Aging 5: 1374905, 2024. doi: 10.3389/fragi.2024.1374905. PMID: 39055970; PMCID: PMC11269084.

Sandau US, Magana SM, Costa J, Nolan JP, Ikezu T, Vella LJ, Jackson HK, Moreira LR, Palacio PL, Hill AF, Quinn JF, Van Keuren-Jensen KR, McFarland TJ, Palade J, Sribnick EA, Su H, Vekrellis K, Coyle B, Yang Y, Falcon-Perez JM, Nieuwland R, Saugstad JA. Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. J Extracell Vesicles 13:e12397, 2024.  PMC10756860. DOI: 10.1002/jev2.12397

Sandau US, Wiedrick JT, McFarland TJ, Galasko DR, Fanning Z, Quinn JF, Saugstad JA. Analysis of the longitudinal stability of human plasma miRNAs and implications for disease biomarkers. Sci Rep 14:2148, 2024.  PMC10810819. DOI: 10.1038/s41598-024-52681-5

Shaw JS, Leoutsakos JM, Rosenberg PB. The Relationship Between First Presenting Neuropsychiatric Symptoms in Older Adults and Autopsy-Confirmed Memory Disorders. Am J Geriatr Psychiatry. 2024 Jan 17:S1064-7481(24)00015-0. doi: 10.1016/j.jagp.2024.01.015. Epub ahead of print. PMID: 38296755.

Shinto LH, Murchison CF, Silbert LC, Dodge HH, Lahna D, Rooney W, Kaye J, Quinn JF, Bowman GL. omega-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults: A Randomized Clinical Trial. JAMA network open 7: e2426872, 2024. doi: 10.1001/jamanetworkopen.2024.26872. PMID: 39088212; PMCID: PMC11294966.

Silbert LC, Roese NE, Krajbich V, Hurworth J, Lahna D, Schwartz DL, Dodge HH, Woltjer RL. White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old. Alzheimers Dement. 2024 Jun;20(6):3839-3851. doi: 10.1002/alz.13816. Epub 2024 Apr 17. PMID: 38629888; PMCID: PMC11180942.

Sin MK, Dowling NM, Roseman JM, Ahmed A, Zamrini E. Late-Life Blood Pressure and Cerebral Amyloid Angiopathy: Findings from the U.S. National Alzheimer's Coordinating Center Uniform Dataset. Neurol Int 16: 821-832, 2024. doi: 10.3390/neurolint16040061. PMID: 39195563; PMCID: PMC11357201.

Speers AB, Wright KM, Brandes MS, Kedjejian N, Matthews DG, Caruso M, Harris CJ, Koike S, Nguyen T, Quinn JF, Soumyanath A, Gray NE. Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered. Front Neurosci 18:1277626, 2024.  doi: 10.3389/fnins.2024.1277626. PMID: 38591068; PMCID: PMC10999680.

Struble LM, Potempa K, Lichtenberg PA, Croff RL, Ellis A, Dodge HH. Including Socially Isolated Black, Older Old Adults (Aged 80 and Above) with and without Mild Cognitive Impairment in a Clinical Trial: Recruitment Strategies and Perspectives. J Multidiscip Healthc 16: 3663-3673, 2023. doi: 10.2147/JMDH.S427946. PMID: 38046050; PMCID: PMC10693244.

Tang H, Shaaban CE, DeKosky ST, Smith GE, Hu X, Jaffee M, Salloum RG, Bian J, Guo J. Association of education attainment, smoking status, and alcohol use disorder with dementia risk in older adults: a longitudinal observational study. Alzheimers Res Ther. 2024 Sep 18;16(1):206. doi: 10.1186/s13195-024-01569-7. PMID: 39294787; PMCID: PMC11412035.

Thomas JH, Nilaver B, Lomniczi A, Brown D, Appleman M, Kohama S, Urbanski H. Pathological markers of Alzheimer’s disease and related dementia in the rhesus macaque amygdala. Journal of Alzheimer’s Disease Reports 8:25-32, 2024.  PMC10790150. DOI: 10.3233/ADR-230184

Trinh M, Shahbaba R, Stark C, Ren Y. Alzheimer's disease detection using data fusion with a deep supervised encoder. Front Dement 3: 2024. doi: 10.3389/frdem.2024.1332928. Epub 2024 Feb 12. PMID: 39055313; PMCID: PMC11271260.

d'Oleire Uquillas F, Falck RS, Oken BS. Editorial: The cognitive neuroscience of aging: where we are and where we are going. Front Hum Neurosci. 2024 Aug 28;18:1476971. doi: 10.3389/fnhum.2024.1476971. PMID: 39263561; PMCID: PMC11387160.

Vargas-Gonzalez JC, Chadha AS, Castro-Aldrete L, Ferretti MT, Tartaglia C. Informant characteristics are associated with the Clinical Dementia Rating Sum of Boxes scores in the Alzheimer's Disease patients participating in the National Alzheimer's Coordinating Center Uniform Data Set. Res Sq [Preprint]. 2024 Mar 15:rs.3.rs-3982448. doi: 10.21203/rs.3.rs-3982448/v1. PMID: 38559129; PMCID: PMC10980151.

Wang YT (McGill Research Centre for Studies in Aging, Montreal), Therriault J, Servaes S, Tissot C, Rahmouni N, Macedo AC, Fernandez-Arias J, Mathotaarachchi SS, Benedet AL, Stevenson J, Ashton NJ, Lussier FZ, Pascoal TA, Zetterberg H, Rajah MN, Blennow K, Gauthier S, Rosa-Neto P, Alzheimer’s Disease Neuroimaging Initiative. Sex-specific modulation of amyloid-beta on tau phosphorylation underlies faster tangle accumulation in females. Brain 147:1497-1510, 2024.  doi: 10.1093/brain/awad397. PMID: 37988283; PMCID: PMC10994548.

Webber TA, Woods SP, Lorkiewicz SA, Yazbeck HW, Schultz ER, Kiselica AM. Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia. Neuropsychology. 2024 Oct;38(7):637-652. doi: 10.1037/neu0000969. Epub 2024 Aug 29. PMID: 39207439; PMCID: PMC11449635.

Wilson E, Umans J, Swarovski M, Minhas P, Midttun Ø, Ulvik AA, Shahid-Besanti M, Linortner P, Mhatre S, Wang Q, Channappa D, Corso N, Tian L, Fredericks C, Kerchner G, Plowey E, Cholerton B, Ueland P, Zabetian C, Gray N, Quinn J, Montine T, Sha S, Longo F, Wolk D, Chen-Plotkin A, Henderson V, Wyss-Coray T, Wagner A, Mormino E, Aghaeepour N, Poston K, Andreasson K. Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction. Res Sq [Preprint]. 2024 Sep 26:rs.3.rs-4980210. doi: 10.21203/rs.3.rs-4980210/v1. PMID: 39399688; PMCID: PMC11469709.

Wise EA, Yan H, Oh E, Leoutsakos JM. Racial/ethnic differences in neuropsychiatric disturbances associated with incident dementia. Alzheimers Dement (Amst) 16: e12615, 2024. doi: 10.1002/dad2.12615. PMID: 38974877; PMCID: PMC11224973.

Wisse LEM, Spotorno N, Rossi M, Grothe MJ, Mammana A, Tideman P, Baiardi S, Strandberg O, Ticca A, van Westen D, Mattsson-Carlgren N, Palmqvist S, Stomrud E, Parchi P, Hansson O; Alzheimer’s Disease Neuroimaging Initiative. MRI Signature of α-Synuclein Pathology in Asymptomatic Stages and a Memory Clinic Population. JAMA Neurol. 2024 Oct 1;81(10):1051-1059. doi: 10.1001/jamaneurol.2024.2713. PMID: 39068668; PMCID: PMC11284633.

Woodworth DC, Nguyen KM, Sordo L, Scambray KA, Head E, Kawas CH, Corrada MM, Nelson PT, Sajjadi SA. Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer's Coordinating Center database. Acta Neuropathol. 2024 Jun 19;147(1):103. doi: 10.1007/s00401-024-02728-8. PMID: 38896163; PMCID: PMC11186885.

Wu CY, Yu K, Arnold SE, Das S, Dodge HH. Who Benefited Most from the Internet-Based Conversational Engagement RCT (I-CONECT)? Application of the Personalized Medicine Approach to a Behavioral Intervention Study. J Prev Alzheimers Dis. 2024;11(3):639-648. doi: 10.14283/jpad.2024.41. PMID: 38706280; PMCID: PMC11061034.

Wu LY, Real R, Martinez-Carrasco A, Chia R, Lawton MA, Shoai M, Bresner C, Blauwendraat C, Singleton AB, Ryten M, Scholz SW, Traynor BJ, Williams NM, Hu MTM, Ben-Shlomo Y, Grosset DG, Hardy J, Morris HR, International Lewy Body Dementia Genomics C. Investigation of the genetic aetiology of Lewy body diseases with and without dementia. Brain Commun 6: fcae190, 2024. doi: 10.1093/braincomms/fcae190. PMID: 38978726; PMCID: PMC11228432.

Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S; Long‐Life Family Study (LLFS); Alzheimer's Disease Genetic Consortium (ADGC); Alzheimer's Biomarkers Consortium‐Down Syndrome (ABC‐DS). Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Alzheimers Dement. 2024 Apr;20(4):2670-2679. doi: 10.1002/alz.13718. Epub 2024 Feb 21. PMID: 38380866; PMCID: PMC11032545.

Yamamoto E, Koike S, Luther M, Dennis L, Lim MM, Raskind M, Pagulayan K, Iliff J, Peskind E, Piantino J. Perivascular space burden and cerebrospinal fluid biomarkers in U.S. Veterans with blast-related mild traumatic brain injury. J Neurotrauma, 2024. DOI: 10.1089/neu.2023.0505

Yamamoto EA, Koike S, Wong C, Dennis LE, Luther MN, Scatena A, Khambadkone S, Iliff JJ, Lim MM, Levendovszky SR, Elliott JE, Barisano G, Müller-Oehring EM, Morales AM, Baker FC, Nagel BJ, Piantino J. Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces. bioRxiv [Preprint]. 2024 Aug 19:2024.08.17.608337. doi: 10.1101/2024.08.17.608337. PMID: 39229241; PMCID: PMC11370374.

Yew PY, Devera R, Liang Y, Khalifa RAE, Sun J, Chi NC, Chou YC, Tonellato PJ, Chi CL. Unraveling the multiple chronic conditions patterns among people with Alzheimer's disease and related dementia: A machine learning approach to incorporate synergistic interactions. Alzheimers Dement. 2024 Jul;20(7):4818-4827. doi: 10.1002/alz.13923. Epub 2024 Jun 11. PMID: 38859733; PMCID: PMC11247699.

Young CB, Cholerton B, Smith AM, Shahid-Besanti M, Abdelnour C, Mormino EC, Hu SC, Chung KA, Peterson A, Rosenthal L, Pantelyat A, Dawson TM, Quinn J, Zabetian CP, Montine TJ, Poston KL. The Parkinson's Disease Composite of Executive Functioning: A Measure for Detecting Cognitive Decline in Clinical Trials. Neurology. 2024 Jul 23;103(2):e209609. doi: 10.1212/WNL.0000000000209609. Epub 2024 Jun 13. PMID: 38870440; PMCID: PMC11244747. 

Zawar I, Kapur J, Mattos MK, Aldridge CM, Manning C, Quigg M. Association of Seizure Control With Cognition in People With Normal Cognition and Mild Cognitive Impairment. Neurology. 2024 Sep 24;103(6):e209820. doi: 10.1212/WNL.0000000000209820. Epub 2024 Aug 22. PMID: 39173101; PMCID: PMC11343585.

Zhang J, Song L, Miller Z, Chan KCG, Huang KL. Machine learning models identify predictive features of patient mortality across dementia types. Commun Med (Lond). 2024 Feb 28;4(1):23. doi: 10.1038/s43856-024-00437-7. PMID: 38418871; PMCID: PMC10901806.

Zhang Q, Fan C, Wang L, Li T, Wang M, Han Y, Jiang J; and for the Alzheimer’s Disease Neuroimaging Initiative. Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer's disease: an exploratory study of 18F-FDG-PET. Geroscience. 2024 Feb;46(1):1407-1420. doi: 10.1007/s11357-023-00897-0. Epub 2023 Aug 23. PMID: 37610594; PMCID: PMC10828178.

2023 Oregon Alzheimer’s Disease Research Publications

Al Olaimat M, Martinez J, Saeed F, Bozdag S. PPAD: a deep learning architecture to predict progression of Alzheimer's disease. Bioinformatics 39:i149-i157, 2023.  PMC10311312. DOI: 10.1101/2023.01.28.526045

Andruchow D, Cunningham D, Sharma MJ, Ismail Z, Callahan BL. Characterizing mild cognitive impairment to predict incident dementia in adults with bipolar disorder: What should the benchmark be? Clin Neuropsychol. 2023 Oct;37(7):1455-1478. doi: 10.1080/13854046.2022.2135605. Epub 2022 Oct 29. PMID: 36308307. DOI: 10.1080/13854046.2022.2135605

Archer DB, Eissman JM, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Gifford KA; Alzheimer's Disease Neuroimaging Initiative (ADNI); Alzheimer's Disease Genetics Consortium (ADGC); Alzheimer's Disease Sequencing Project (ADSP); Cuccaro ML, Pericak-Vance MA, Farrer LA, Wang LS, Schellenberg GD, Mayeux RP, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Dumitrescu L, Hohman TJ. Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease. Alzheimers Dement. 2023 Nov 20. doi: 10.1002/alz.13508. Epub ahead of print. PMID: 37985223. DOI: 10.1002/alz.13508

Azevedo T, Bethlehem RAI, Whiteside DJ, Swaddiwudhipong N, Rowe JB, Lio P, Rittman T, Alzheimer's Disease Neuroimaging Initiative. Identifying healthy individuals with Alzheimer's disease neuroimaging phenotypes in the UK Biobank. Commun Med (Lond) 3:100, 2023.  PMC10359360. DOI: 10.1038/s43856-023-00313-w

Babulal GM, Zhu Y, Trani JF. Racial and ethnic differences in neuropsychiatric symptoms and progression to incident cognitive impairment among community-dwelling participants. Alzheimers Dement 19:3635-3643, 2023.  DOI: 10.1002/alz.12988

Bai H, Naj AC, Benchek P, Dumitrescu L, Hohman T, Hamilton-Nelson K, Kallianpur AR, Griswold AJ, Vardarajan B, Martin ER, Beecham GW, Below JE, Schellenberg G, Mayeux R, Farrer L, Pericak-Vance MA, Haines JL, Bush WS; Alzheimer's Disease Genetics Consortium. A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease. Alzheimers Dement. 2023 Nov;19(11):4886-4895. doi: 10.1002/alz.13050. Epub 2023 Apr 12. PMID: 37051669. DOI: 10.1002/alz.13050

Berridge C, Turner NR, Liu L, Fredriksen-Goldsen KI, Lyons KS, Demiris G, Kaye J, Lober WB. Preliminary Efficacy of Let's Talk Tech: Technology Use Planning for Dementia Care Dyads. Innov Aging 7:igad018, 2023.  PMC10132307. DOI: 10.1093/geroni/igad018

Berridge C, Zhou Y, Robillard J, Kaye J. Companion robots to mitigate loneliness among older adults: Perceptions of benefit and possible deception. Frontiers:  Psychology of Aging 21:1106633, 2023. PMC9988932. DOI: 10.3389/fpsyg.2023.1106633

Berridge C, Zhou Y, Robillard J, Kaye J. AI Companion Robot Data Sharing: Preferences of an Online Cohort and Policy Implications. Journal of Elder Policy 2:19-54, 2023. 

Bocancea DI, Svenningsson AL, van Loenhoud AC, Groot C, Barkhof F, Strandberg O, Smith R, La Joie R, Rosen HJ, Pontecorvo MJ, Rabinovici GD, van der Flier WM, Hansson O, Ossenkoppele R, Alzheimer’s Disease Neuroimaging Initiative. Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis. Brain 146:3719-3734, 2023.  PMC10473572. DOI: 10.1093/brain/awad100

Bollinger RM, Gabel M, Coble DW, Chen SW, Keleman AA, Doralus J, Chin E, Lingler JH, Grill JD, Stark SL, Edwards DF. Retention of Study Partners in Longitudinal Studies of Alzheimer Disease. Journal of Alzheimer's Disease 94:189-199, 2023. DOI: 10.3233/JAD-230079

Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W, Consortium NT-OfPM, Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT, Jr., Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S. Clonal hematopoiesis is associated with protection from Alzheimer's disease. Nat Med 29:1662-1670, 2023.  PMC10353941. DOI: 10.1038/s41591-023-02397-2

Bueno-Junior LS, Jones-Tinsley CE, Milman NEP, Wickham PT, Watson BO, Lim MM. Early-life sleep disruption impairs subtle social behaviours in prairie voles: a pose-estimation study. R Soc Open Sci 10:230700, 2023.  PMC10336370. DOI: 10.1098/rsos.230700

Cannizzaro A, Ronat L, El Haffaf LM, Hanganu A. Associations between neuropsychiatric symptoms of affective and vegetative domains and brain morphology in aging people with mild cognitive impairment and Alzheimer's disease. Int J Geriatr Psychiatry 38:e5952, 2023. DOI: 10.1002/gps.5952

Chemparathy A, Guen YL, Chen S, Lee EG, Leong L, Gorzynski J, Xu G, Belloy M, Kasireddy N, Tauber AP, Williams K, Stewart I, Wingo T, Lah J, Jayadev S, Hales C, Peskind E, Child DD, Keene CD, Cong L, Ashley E, Yu CE, Greicius MD. APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology. medRxiv, 2023.  10402217. DOI: 10.1101/2023.07.20.23292771

Chen XR, Shao Y, Sadowski MJ, Alzheimer's Disease Neuroimaging Initiative. Interaction between KLOTHO-VS Heterozygosity and APOE epsilon4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease. Genes (Basel) 14, 2023.  PMC10137709. DOI: 10.3390/genes14040917

Correro Ii AN, Gauthreaux K, Perales-Puchalt J, Chen YC, Chan KCG, Kukull WA, Flatt JD. Cognitive Aging with Dementia, Mild Cognitive Impairment, or No Impairment: A Comparison of Same- and Mixed-Sex Couples. Journal of Alzheimer's Disease 92:109-128, 2023.  PMC10029351. DOI: 10.3233/JAD-220309

Dato S, De Rango F, Crocco P, Pallotti S, Belloy ME, Le Guen Y, Greicius MD, Passarino G, Rose G, Napolioni V. Sex- and APOE-specific genetic risk factors for late-onset Alzheimer's disease: Evidence from gene-gene interaction of longevity-related loci. Aging Cell 22:e13938, 2023.  PMC10497850. DOI: 10.1111/acel.13938

Dawson W, Booi L, Pintado-Caipa M, Okada de Oliveira M, Kornhuber A, Spoden N, Golonka O, Davidziuk A, Vergara Manríquez M, Cominetti M, Kochhann R, Robertson I, Eyre H, Ibáñez A. The Brain Health Diplomat’s Toolkit. Supporting Brain Health Diplomacy Leaders in Latin America and the Caribbean. Latin American Brain Health Institute (BrainLat). 2023. 

De Francesco S, Crema C, Archetti D, Muscio C, Reid RI, Nigri A, Bruzzone MG, Tagliavini F, Lodi R, D'Angelo E, Boeve B, Kantarci K, Firbank M, Taylor JP, Tiraboschi P, Redolfi A; RIN – Neuroimaging Network. Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA. Sci Rep. 2023 Oct 13;13(1):17355. doi: 10.1038/s41598-023-43706-6. Erratum in: Sci Rep. 2024 Jan 18;14(1):1603. PMID: 37833302; PMCID: PMC10575864. DOI: 10.1038/s41598-023-43706-6

DeVettori G, Troxel WM, Duff K, Baron KG. Positive airway pressure adherence among patients with obstructive sleep apnea and cognitive impairment: A narrative review. Sleep Med 111:28-35, 2023. DOI: 10.1016/j.sleep.2023.08.029

Diaz-Castro B, Robel S, Mishra A. Astrocyte Endfeet in Brain Function and Pathology: Open Questions. Annu Rev Neurosci 46:101-121, 2023.  DOI: 10.1146/annurev-neuro-091922-031205

Duff K, Dixon AM, Embree L, Hoffman JM. Change on the Repeatable Battery for the Assessment of Neuropsychological Status and its relationship to brain amyloid. Journal of Clinical and Experimental Neuropsychology 45:105-117, 2023.  DOI: 10.1080/13803395.2023.2216920

Duff K, Wan L, Embree L, Hoffman JM. Change in the Quick Dementia Rating System Across Time in Older Adults with and without Cognitive Impairment. Journal of Alzheimer's Disease 93:449-457, 2023. DOI: 10.3233/JAD-221252

Eissman JM, Archer DB, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Gifford KA; Alzheimer's Disease Neuroimaging Initiative (ADNI) | Alzheimer's Disease Genetics Consortium (ADGC) | The Alzheimer's Disease Sequencing Project (ADSP); Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang LS, Schellenberg GD, Mayeux RP, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L. Sex-specific genetic architecture of late-life memory performance. Alzheimers Dement. 2023 Nov 20. doi: 10.1002/alz.13507. Epub ahead of print. PMID: 37984853. DOI: 10.1002/alz.13507

Elliott JE, Ligman BR, Bryant-Ekstrand MD, Keil AT, Powers K, Olivo C, Neilson L, Postuma RB, Pelletier A, Gagnon JF, Gan-Or Z, Yu E, Liu L, St Louis EK, Forsberg LK, Fields JA, Ross OA, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, McLeland J, Criswell SR, Videnovic A, During EH, Miglis MG, Shprecher DR, Lee-Iannotti JK, Boeve BF, Ju YS, Lim MM; North American Prodromal Synucleinopathy (NAPS) Consortium. Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium. Sleep. 2024 Jan 5:zsae007. doi: 10.1093/sleep/zsae007. Epub ahead of print. PMID: 38181205. DOI: 10.1093/sleep/zsae007

Euler MJ, Duff K, King JB, Hoffman JM. Recall and recognition subtests of the repeatable battery for the assessment of neuropsychological status and their relationship to biomarkers of Alzheimer's disease. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2023 Sep-Nov;30(6):885-902. doi: 10.1080/13825585.2022.2124229. Epub 2022 Sep 15. PMID: 36110031; PMCID: PMC10014490. DOI: 10.1080/13825585.2022.2124229

Eyre H, Dawson W, Abbott R, Silverman K, Chen S, Ayadi R, Carnevale S, Wong S, Berk M, Nanda U, Ling G, Tempest M, Occhipinti J, Shah S, Mahfouz J, Fu E, MacRae I, Esquive G, Edmonds T, Jacka F, Hynes W, Wickerson G, Swieboda P. Toward a Comprehensive Brain Deal to Harness the Potential of Artificial Intelligence., 2023.

Eyre H, Stirland L, Jeste D, Reynolds C, Berk M, Ibanez A, Dawson W, Lawlor B, Leroi I, Yaffe K, Gatchel J, Karp J, Newhouse P, Rosand J, Letourneau N, Bayen E, Farina F, Booi L, Devanand D, Mintzer J, Madigan S, Jayapurwala I, Wong S, Falcoa V, Cummings J, Reichman W, Lock S, Bennett M, Ahuja R, Steffens D, Elkind M, Lavretsky H. Life-Course Brain Health as a Determinant of Late-Life Mental Health: American Association for Geriatric Psychiatry Expert Panel Recommendations. American Journal of Geriatric Psychiatry:1-27, 2023.

Fowe IE, Wallace NT, Kaye J. The Association of Learning Health System Practicing Hospitals and other Health Information Interested Hospitals with Patient-Generated Health Data Uptake. AMIA Jt Summits Transl Sci Proc 2023:176-185, 2023.  PMC10283141.

Fracassi A, Marcatti M, Tumurbaatar B, Woltjer R, Moreno S, Taglialatela G. TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology. Brain Pathology 33:e13108, 2023. DOI: 10.1111/bpa.13108

Guevara JE, Kurniadi NE, Duff K. Assessing Longitudinal Cognitive Change in Mild Cognitive Impairment Using Estimated Standardized Regression-Based Formulas. Journal of Alzheimer's Disease, 2023. DOI: 10.3233/JAD-230160

Hantke N, Kaye J, Mattek N, Wu C, Dodge H, Beattie Z, Woltjer R. Correlating continuously captured home-based digital biomarkers of daily function with postmortem neurodegenerative neuropathology. PLoS One 18:e0286812, 2023.  PMC10249904. DOI: 10.1371/journal.pone.0286812

Hartz SM, Mozersky J, Schindler SE, Linnenbringer E, Wang J, Gordon BA, Raji CA, Moulder KL, West T, Benzinger TLS, Cruchaga C, Hassenstab JJ, Bierut LJ, Xiong C, Morris JC. A flexible modeling approach for biomarker-based computation of absolute risk of Alzheimer's disease dementia. Alzheimers Dement 19:1452-1465, 2023.  PMC10060442. DOI: 10.1002/alz.12781

Hicks A, Sinclair B, Shultz S, Pham W, Silbert LC, Schwartz DL, Rowe CC, Ponsford JL, Law M, Spitz G. Associations of Enlarged Perivascular Spaces With Brain Lesions, Brain Age, and Clinical Outcomes in Chronic Traumatic Brain Injury. Neurology, 2023.  DOI: 10.1212/WNL.0000000000207370

Hicks B, Kaye JA, Azoulay L, Kristensen KB, Habel LA, Pottegard A. The application of lag times in cancer pharmacoepidemiology: a narrative review. Ann Epidemiol 84:25-32, 2023. DOI: 10.1016/j.annepidem.2023.05.004

Hiya S, Maldonado-Diaz C, Walker JM, Richardson TE. Cognitive symptoms progress with limbic-predominant age-related TDP-43 encephalopathy stage and co-occurrence with Alzheimer disease. Journal of Neuropathology and Experimental Neurology 83:2-10, 2023.  PMC10746699. DOI: 10.1093/jnen/nlad098

Hlauschek G, Lossius MI, Schwartz DL, Silbert LC, Hicks AJ, Ponsford JL, Vivash L, Sinclair B, Kwan P, O'Brien TJ, Shultz SR, Law M, Spitz G. Reduced total number of enlarged perivascular spaces in post-traumatic epilepsy patients with unilateral lesions - a feasibility study. Seizure. 2023 Dec;113:1-5. doi: 10.1016/j.seizure.2023.10.006. Epub 2023 Oct 13. PMID: 37847935. DOI: 10.1016/j.seizure.2023.10.006

Holden SK, Bedenfield N, Taylor AS, Bayram E, Schwilk C, Fleisher J, Duda J, Shill H, Paulson HL, Stacy K, Wood J, Corsentino P, Sha SJ, Litvan I, Irwin DJ, Quinn JF, Goldman JG, Amodeo K, Taylor JP, Boeve BF, Armstrong MJ. Research Priorities of Individuals and Caregivers With Lewy Body Dementia: A Web-based Survey. Alzheimer Disease and Associated Disorders 37:50-58, 2023.  PMC9971616. DOI: 10.1097/WAD.0000000000000545

Huie EZ, Escudero A, Saito N, Harvey D, Nguyen ML, Lucot KL, LaGrande J, Mungas D, DeCarli C, Lamar M, Schneider JA, Kapasi A, Rissman RA, Teich AF, Dugger BN. TDP-43 Pathology in the Setting of Intermediate and High Alzheimer's Disease Neuropathologic Changes: A Preliminary Evaluation Across Ethnoracial Groups. Journal of Alzheimer's Disease 91:1291-1301, 2023. DOI: 10.3233/JAD-220558

Jo T, Kim J, Bice P, Huynh K, Wang T, Arnold M, Meikle PJ, Giles C, Kaddurah-Daouk R, Saykin AJ, Nho K, Alzheimer's Disease Metabolomics Consortium, Alzheimer's Disease Neuroimaging Initiative. Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data. EBioMedicine 97:104820, 2023.  PMC10579282. DOI: 10.1016/j.ebiom.2023.104820

Kallianpur KJ, Masaki KH, Chen R, Willcox BJ, Allsopp RC, Davy P, Dodge HH. Weak Social Networks in Late Life Predict Incident Alzheimer's Disease: The Kuakini Honolulu-Asia Aging Study. J Gerontol A Biol Sci Med Sci 78:663-672, 2023.  PMC10061568. DOI: 10.1093/gerona/glac215

Kaser AN, Kaplan DM, Goette W, Kiselica AM. The impact of conventional versus robust norming on cognitive characterization and clinical classification of MCI and dementia. J Neuropsychol 17:108-124, 2023. PMC10006397. DOI: 10.1111/jnp.12289

Katsumata Y, Fardo DW, Shade LMP, Alzheimer's Disease Genetics Consortium, Nelson PT. LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry. Journal of Neuropathology and Experimental Neurology 82:760-768, 2023.  PMC10440720. DOI: 10.1093/jnen/nlad059

Keil SA, Schindler AG, Wang MX, Piantino J, Silbert LC, Elliott JE, Lim MM, Thomas RG, Willis S, Iliff JJ. Instability in longitudinal sleep duration predicts cognitive impairment in aged participants of the Seattle Longitudinal Study. medRxiv, 2023.  PMC10312848. DOI: 10.1101/2023.06.07.23291098

Keil SA, Schindler AG, Wang MX, Piantino J, Silbert LC, Elliott JE, Werhane ML, Thomas RG, Willis S, Lim MM, Iliff JJ. Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults. JAMA Netw Open 6:e2346006, 2023.  PMC10696486. DOI: 10.1001/jamanetworkopen.2023.46006

Kim H, Senders A, Simeon E, Juarez C, Huang S, Dodge H, McConnell KJ. Use of long-term services and supports among dual-eligible beneficiaries with Alzheimer's disease and related dementias. Journal of the American Geriatrics Society 71:432-442, 2023.  PMC9957784. DOI: 10.1111/jgs.18115

Klein E, Montes Daza N, Dasgupta I, MacDuffie K, Schonau A, Flynn G, Song D, Goering S. Views of stakeholders at risk for dementia about deep brain stimulation for cognition. Brain Stimul 16:742-747, 2023.DOI: 10.1016/j.brs.2023.04.007

Koppelmans V, Ruitenberg MFL, Schaefer SY, King JB, Hoffman JM, Mejia AF, Tasdizen T, Duff K. Delayed and More Variable Unimanual and Bimanual Finger Tapping in Alzheimer's Disease: Associations with Biomarkers and Applications for Classification. Journal of Alzheimer's Disease, 2023. PMC in Process.  DOI: 10.3233/JAD-221297

Lee G, Nho K, Kang B, Sohn KA, Kim D, Alzheimer's Disease Neuroimaging Initiative. Author Correction: Predicting Alzheimer's disease progression using multi-modal deep learning approach. Sci Rep 13:12466, 2023. PMC10393953. DOI: 10.1038/s41598-023-39138-x

Leese MI, Mattek N, Bernstein JPK, Dorociak KE, Gothard S, Kaye J, Hughes AM. The Survey for Memory, Attention, and Reaction Time (SMART): Preliminary normative online panel data and user attitudes for a brief web-based cognitive performance measure. Clin Neuropsychol 37:1257-1275, 2023. PMC9899293. DOI: 10.1080/13854046.2022.2103033

Lennon J, Hantke N, Mattek N, C W, Dodge H, Wall R, Beattie Z, Kaye J, Silbert L. Mood and activity changes during the Covid-19 pandemic in rural and urban Veterans and their cohabitants. Clinical Gerontologist 8:1-8, Forthcoming, 2023.  PMC10132474. DOI: 10.1080/07317115.2022.2130123

Leung Y, Barzilai N, Batko-Szwaczka A, Beker N, Boerner K, Brayne C, Brodaty H, Cheung KS, Corrada MM, Crawford JD, Galbussera AA, Gondo Y, Holstege H, Hulsman M, Ishioka YL, Jopp D, Kawas CH, Kaye J, Kochan NA, Lau BH, Lipnicki DM, Lo JW, Lucca U, Makkar SR, Marcon G, Martin P, Meguro K, Milman S, Poon LW, Recchia A, Ribeiro O, Riva E, Rott C, Sikkes SA, Skoog I, Stephan B, Szewieczek J, Teixeira L, Tettamanti M, Wilczynski K, Sachdev P. Cognition, function, and prevalent dementia in centenarians and near-centenarians: An individual participant data (IPD) meta-analysis of 18 studies. Alzheimers Dement 19:2265-2275, 2023. DOI: 10.1002/alz.12828

Li D, Farrell JJ, Mez J, Martin ER, Bush WS, Ruiz A, Boada M, de Rojas I, Mayeux R, Haines JL, Vance MAP, Wang LS, Schellenberg GD, Lunetta KL, Farrer LA. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews. Alzheimers Dement 19:5550-5562, 2023.  PMC10689571. DOI: 10.1002/alz.13117

Li H, Liu H, Lutz MW, Luo S, Alzheimer's Disease Neuroimaging I. Novel Genetic Variants in TP37, PIK3R1, CALM1, and PLCG2 of the Neurotrophin Signaling Pathway Are Associated with the Progression from Mild Cognitive Impairment to Alzheimer's Disease. Journal of Alzheimer's Disease 91:977-987, 2023. PMC9905310. DOI: 10.3233/JAD-220680

Liampas I, Siokas V, Lyketsos CG, Dardiotis E. Associations between neuropsychiatric symptoms and incident Alzheimer's dementia in men versus women. Journal of Neurology 270:2069-2083, 2023. PMC10025238. DOI: 10.1007/s00415-022-11541-w

Lindauer A, Smith S, Gothard S, Mattek N, Tran L, Mooney A. There’s no straight line… a consumer-informed intervention for FTD family care partners: the STELLA-FTD pilot study. Aging and Mental Health:1-11, 2023. DOI: 10.1080/13607863.2023.2250741

Malek-Ahmadi M, Duff K, Chen K, Su Y, King JB, Koppelmans V, Schaefer SY. Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults. Exp Gerontol 173:112087, 2023. PMC9974847. DOI: 10.1016/j.exger.2023.112087

Marquine MJ, Parks A, Perales-Puchalt J, Gonzalez DA, Rosado-Bruno M, North R, Pieper C, Werry AE, Kiselica A, Chapman S, Dodge H, Gauthreaux K, Kukull WA, Rascovsky K. Demographically-adjusted normative data among Latinos for the version 3 of the Alzheimer's Disease Centers' Neuropsychological Test Battery in the Uniform Data Set. Alzheimers Dement 19: 4174-4186, 2023. DOI: 10.1002/alz.13313

McDonough IM, Cody SL, Harrell ER, Garrett SL, Popp TE. Cognitive differences across ethnoracial category, socioeconomic status across the Alzheimer's disease spectrum: Can an ability discrepancy score level the playing field? Mem Cognit 51:543-560, 2023.  DOI: 10.3758/s13421-022-01304-3

McLachlan E, Ocal D, Burgess N, Reeves S, Howard R, Alzheimer’s Disease Neuroimaging Initiative. Association Between False Memories and Delusions in Alzheimer Disease. JAMA Psychiatry 80:700-709, 2023. PMC10209823. DOI: 10.1001/jamapsychiatry.2023.1012

Merrill NJ, Davidson WS, He Y, Diaz Ludovico I, Sarkar S, Berger MR, McDermott JE, Van Eldik LJ, Wilcock DM, Monroe ME, Kyle JE, Bruce KD, Heinecke JW, Vaisar T, Raber J, Quinn JF, Melchior JT. Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health. Sci Adv 9:eadi5571, 2023.  PMC10468133. DOI: 10.1126/sciadv.adi5571

Monin JK, McAvay G, Zang E, Vander Wyk B, Carrion CI, Allore H. Associations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study. PLoS One 18:e0289311, 2023.  PMC10431668. DOI: 10.1371/journal.pone.0289311

Muurling M, Au-Yeung WM, Beattie Z, Wu CY, Dodge H, Rodrigues NK, Gothard S, Silbert LC, Barnes LL, Steele JS, Kaye J. Differences in Life Space Activity Patterns Between Older Adults With Mild Cognitive Impairment Living Alone or as a Couple: Cohort Study Using Passive Activity Sensing. JMIR Aging 6:e45876, 2023.  PMC10600648. DOI: 10.2196/45876

Nagaraja N, Wang WE, Duara R, DeKosky ST, Vaillancourt D. Mediation of Reduced Hippocampal Volume by Cerebral Amyloid Angiopathy in Pathologically Confirmed Patients with Alzheimer's Disease. Journal of Alzheimer's Disease 93:495-507, 2023. DOI: 10.3233/JAD-220624

Nguyen HD, Clément M, Planche V, Mansencal B, Coupé P. Deep grading for MRI-based differential diagnosis of Alzheimer's disease and Frontotemporal dementia. Artif Intell Med. 2023 Oct;144:102636. doi: 10.1016/j.artmed.2023.102636. Epub 2023 Aug 18. PMID: 37783553. DOI: 10.1016/j.artmed.2023.102636

Nilaver B, Urbanski H. Mechanisms underlying TDP-43 pathology and neurodegeneration: an updated mini-review. Frontiers in Aging Neuroscience 15:1142617, 2023.  PMC in Process. DOI: 10.3389/fnagi.2023.1142617

Ohrfelt A, Benedet AL, Ashton NJ, Kvartsberg H, Vandijck M, Weiner MW, Trojanowski JQ, Shaw LM, Zetterberg H, Blennow K, Alzheimer's Disease Neuroimaging. Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive Individuals. Neurology 100:e275-e285, 2023. PMC9869758. DOI: 10.1212/WNL.0000000000201417

Pang Y, Kukull W, Sano M, Albin RL, Shen C, Zhou J, Dodge HH. Predicting Progression from Normal to MCI and from MCI to AD Using Clinical Variables in the National Alzheimer's Coordinating Center Uniform Data Set Version 3: Application of Machine Learning Models and a Probability Calculator. J Prev Alzheimers Dis 10:301-313, 2023.  PMC10033942. DOI: 10.14283/jpad.2023.10

Phongpreecha T, Godrich D, Berson E, Espinosa C, Kim Y, Cholerton B, Chang AL, Mataraso S, Bukhari SA, Perna A, Yakabi K, Montine KS, Poston KL, Mormino E, White L, Beecham G, Aghaeepour N, Montine TJ. Quantitative estimate of cognitive resilience and its medical and genetic associations. Alzheimers Res Ther. 2023 Nov 6;15(1):192. doi: 10.1186/s13195-023-01329-z. PMID: 37926851; PMCID: PMC10626669. DOI: 10.1186/s13195-023-01329-z

Piau A, Steinmeyer Z, Mattek N, Lindaeuer A, Sharma N, Bouranis N, Wild K, Kaye J. Caregiving in Older Adults; Experiences and Attitudes toward Smart Technologies. Journal of Clinical Medicine 12:1789, 2023.  PMC10003197. DOI: 10.3390/jcm12051789

Pillai JA, Bena J, Maly EF, Leverenz JB. Initial non-amnestic symptoms relate to faster rate of functional and cognitive decline compared to amnestic symptoms in neuropathologically confirmed dementias. Alzheimers Dement 19:2956-2965, 2023.  PMC10350479. DOI: 10.1002/alz.12922

Pirraglia E, Glodzik L, Shao Y. Lower mortality risk in APOE4 carriers with normal cognitive ageing. Sci Rep 13:15089, 2023.  PMC10497512. DOI: 10.1038/s41598-023-41078-5

Pleasant T, Ono S, Gothard S, Wall R, Silbert L. Aging Veterans and a Silver Lining of Service. Journal of Veterans Studies:98-102, 2023.

Polsinelli AJ, Lane KA, Manchella MK, Logan PE, Gao S, Apostolova LG. APOE epsilon4 is associated with earlier symptom onset in LOAD but later symptom onset in EOAD. Alzheimers Dement 19:2212-2217, 2023.  PMC10182241. DOI: 10.1002/alz.12955

Polsinelli AJ, Logan PE, Lane KA, Manchella MK, Nemes S, Sanjay AB, Gao S, Apostolova LG. APOE epsilon4 carrier status and sex differentiate rates of cognitive decline in early- and late-onset Alzheimer's disease. Alzheimers Dement 19:1983-1993, 2023.  PMC10182251. DOI: 10.1002/alz.12831

Prokai L, Nguyen V, Urbanski HF. Effect of estradiol replacement on hippocampal concentrations of estrogens in aged rhesus macaques maintained on an obesogenic diet. Biochem Biophys Rep 35:101548, 2023.  PMC10511332. DOI: 10.1016/j.bbrep.2023.101548

Qin Y, Han H, Li Y, Cui J, Jia H, Ge X, Ma Y, Bai W, Zhang R, Chen D, Yi F, Yu H. Estimating Bidirectional Transitions and Identifying Predictors of Mild Cognitive Impairment. Neurology 100:e297-e307, 2023. PMC9869761. DOI: 10.1212/WNL.0000000000201386

Raber J, Silbert LC. Role of white matter hyperintensity in effects of apolipoprotein E on cognitive injury. Front Hum Neurosci 17:1176690, 2023. PMC10237322. DOI: 10.3389/fnhum.2023.1176690

Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Wang LS, Farrer LA, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Jun GR, Reitz C, Naj AC, Alzheimer's Disease Genetics Consortium. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv, 2023.  PMC10350126. DOI: 10.1101/2023.07.06.23292311

Reynolds C, Tan A, Elliott  J, Tinsley C, Wall R, Kaye J, Silbert L, Lim M. Remote spectral light sensing in the home environment: Further development of the TWLITE study concept. Sensors, 2023.  PMC10143576. DOI: 10.3390/s23084134

Sabbagh MN, Taylor A, Galasko D, Galvin JE, Goldman JG, Leverenz JB, Poston KL, Boeve BF, Irwin DJ, Quinn JF. Listening session with the US Food and Drug Administration, Lewy Body Dementia Association, and an expert panel. Alzheimers Dement (N Y) 9:e12375, 2023.  PMC9983146. DOI: 10.1002/trc2.12375

Sadlon A, Takousis P, Ankli B, Alexopoulos P, Perneczky R, Alzheimer's Disease Neuroimaging Initiative. Association of chronic pain with biomarkers of neurodegeneration, microglial activation and inflammation in the CSF and impaired cognitive function. Annals of Neurology, 2023. DOI: 10.1002/ana.26804

Scott GD, Neilson LE, Woltjer R, Quinn JF, Lim MM. Lifelong Association of Disorders Related to Military Trauma with Subsequent Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society, 2023. DOI: 10.1002/mds.29457

Sepulveda-Falla D, Villegas Lanau CA, White C, Serrano GE, Acosta-Uribe J, Mejia-Cupajita B, Villalba-Moreno ND, Lu P, Glatzel M, Kofler JK, Ghetti B, Frosch MP, Lopera Restrepo F, Kosik KS, Beach TG. Comorbidities in Early-Onset Sporadic versus Presenilin-1 Mutation-Associated Alzheimer's Disease Dementia: Evidence for Dependency on Alzheimer's Disease Neuropathological Changes. medRxiv, 2023.  PMC10462216. DOI: 10.1101/2023.08.14.23294081

Shinohara M, Gheni G, Hitomi J, Bu G, Sato N. APOE genotypes modify the obesity paradox in dementia. J Neurol Neurosurg Psychiatry 94:670-680, 2023. DOI: 10.1136/jnnp-2022-331034

Shirzadi Z, Schultz SA, Yau WW, Joseph-Mathurin N, Fitzpatrick CD, Levin R, Kantarci K, Preboske GM, Jack CR, Jr., Farlow MR, Hassenstab J, Jucker M, Morris JC, Xiong C, Karch CM, Levey AI, Gordon BA, Schofield PR, Salloway SP, Perrin RJ, McDade E, Levin J, Cruchaga C, Allegri RF, Fox NC, Goate A, Day GS, Koeppe R, Chui HC, Berman S, Mori H, Sanchez-Valle R, Lee JH, Rosa-Neto P, Ruthirakuhan M, Wu CY, Swardfager W, Benzinger TLS, Sohrabi HR, Martins RN, Bateman RJ, Johnson KA, Sperling RA, Greenberg SM, Schultz AP, Chhatwal JP, Dominantly Inherited Alzheimer Network, Alzheimer's Disease Neuroimaging Initiative. Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease. JAMA Neurol 80:1353-1363, 2023. DOI: 10.1001/jamaneurol.2023.3618

Smith EE, Silbert LC. Myocardial Infarction Bends the Curve of Age-Related Cognitive Decline, but How? JAMA Neurol 80:665-667, 2023. DOI: 10.1001/jamaneurol.2023.0466

Song S, Asken B, Armstrong MJ, Yang Y, Li Z, Alzheimer's Disease Neuroimaging I. Predicting Progression to Clinical Alzheimer's Disease Dementia Using the Random Survival Forest. Journal of Alzheimer's Disease 95:535-548, 2023. DOI: 10.3233/JAD-230208

Sperling RA, Donohue MC, Raman R, Rafii MS, Johnson K, Masters CL, van Dyck CH, Iwatsubo T, Marshall GA, Yaari R, Mancini M, Holdridge KC, Case M, Sims JR, Aisen PS, A4 Study Team. Trial of Solanezumab in Preclinical Alzheimer's Disease. N Engl J Med 389:1096-1107, 2023. DOI: 10.1056/NEJMoa2305032

Tagliabue CF, Bissig D, Kaye J, Mazza V, Assecondi S. Feasibility of Remote Unsupervised Cognitive Screening With SATURN in Older Adults. J Appl Gerontol 42:1903-1910, 2023.  PMC in Process. DOI: 10.1177/07334648231166894

Teipel S, Grothe MJ, Alzheimer's Disease Neuroimaging Initiative. MRI-based basal forebrain atrophy and volumetric signatures associated with limbic TDP-43 compared to Alzheimer's disease pathology. Neurobiol Dis 180:106070, 2023. DOI: 10.1016/j.nbd.2023.106070

Ting SKS, Saffari SE, Hameed S, Chiew HJ, Ng KP, Ng AS. Clinical characteristics of pathological confirmed prodromal dementia with Lewy bodies. J Neurol Sci 453:120815, 2023.  PMC10591830. DOI: 10.1016/j.jns.2023.120815

Torso M, Ridgway GR, Valotti M, Hardingham I, Chance SA, National Alzheimer’s Coordinating Center, Alzheimer’s Disease Neuroimaging Initiative. In vivo cortical diffusion imaging relates to Alzheimer's disease neuropathology. Alzheimers Res Ther 15:165, 2023.  10548768. DOI: 10.1186/s13195-023-01309-3

Tuena C, Maestri S, Serino S, Pedroli E, Stramba-Badiale M, Riva G, Alzheimer's Disease Neuroimaging Initiative. Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment. BMC Geriatr 23:462, 2023. PMC10388514. DOI: 10.1186/s12877-023-04175-8

Tumurbaatar B, Fracassi A, Scaduto P, Guptarak J, Woltjer R, Jupiter D, Taglialatela G. Preserved autophagy in cognitively intact non-demented individuals with Alzheimer's neuropathology. Alzheimers Dement, 2023. DOI: 10.1002/alz.13074

Vasconcelos Da Silva M, Melendez-Torres GJ, Ismail Z, Testad I, Ballard C, Creese B, Alzheimer's Disease Neuroimaging Initiative. A data-driven examination of apathy and depressive symptoms in dementia with independent replication. Alzheimers Dement (Amst) 15:e12398, 2023. PMC9899765. DOI: 10.1002/dad2.12398

Vehar JV, Duff K, Rahimpour S, Dunn D, Ballard DJ, Zorn MS, Moretti P, Rolston J. The cognitive profile of essential tremor on the Repeatable Battery for the Assessment of Neuropsychological Status. Clin Neuropsychol:1-14, 2023.  DOI: 10.1080/13854046.2023.2192420

Vehar JV, Rahimpour S, Moretti P, Kassavetis P, Alshaikh J, Rolston J, Duff K. Recognition subtests of the Repeatable Battery for the Assessment of Neuropsychological Status: evidence for a cortical vs. subcortical distinction. Journal of Clinical and Experimental Neuropsychology:1-12, 2023. DOI: 10.1080/13803395.2023.2259044

Walker JM, Dehkordi SK, Schaffert J, Goette W, White Iii CL, Richardson TE, Zare H. The Spectrum of Alzheimer-Type Pathology in Cognitively Normal Individuals. Journal of Alzheimer's Disease 91:683-695, 2023.  DOI: 10.3233/JAD-220898

Walker JM, Richardson TE. Cognitive resistance to and resilience against multiple comorbid neurodegenerative pathologies and the impact of APOE status. Journal of Neuropathology and Experimental Neurology 82:110-119, 2023. PMC9852945. DOI: 10.1093/jnen/nlac115

Walters S, Contreras AG, Eissman JM, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Peterson A, Gifford KA, Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang LS, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L, Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Genetics Consortium, Alzheimer's Disease Sequencing Project. Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol, 2023.  PMC10352930. DOI: 10.1001/jamaneurol.2023.2169

Weiss AR, Urbanski HF. Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques. Neurobiol Aging. 2023 Dec;132:246-249. doi: 10.1016/j.neurobiolaging.2023.09.013. Epub 2023 Sep 27. PMID: 37866084. DOI: 10.1016/j.neurobiolaging.2023.09.013

Wiese LAK, Gibson A, Guest MA, Nelson AR, Weaver R, Gupta A, Carmichael O, Lewis JP, Lindauer A, Loi S, Peterson R, Radford K, Rhodus EK, Wong CG, Zuelsdorff M, Saidi LG, Valdivieso-Mora E, Franzen S, Pope CN, Killian TS, Shrestha HL, Heyn PC, Ng TKS, Prusaczyk B, John S, Kulshreshtha A, Sheffler JL, Besser L, Daniel V, Tolea MI, Miller J, Musyimi C, Corkey J, Yank V, Williams CL, Rahemi Z, Park J, Magzamen S, Newton RL, Jr., Harrington C, Flatt JD, Arora S, Walter S, Griffin P, Babulal GM. Global rural health disparities in Alzheimer's disease and related dementias: State of the science. Alzheimers Dement 19:4204-4225, 2023. DOI: 10.1002/alz.13104

Wood KA, Han F, Ko YA, Wharton WW. Is the association between cognitive disease progression and atrial fibrillation modified by sex? Alzheimers Dement 19:4163-4173, 2023. DOI: 10.1002/alz.13060

Wood ME, Xiong LY, Wong YY, Buckley RF, Swardfager W, Masellis M, Lim ASP, Nichols E, Joie R, Casaletto KB, Kumar RG, Dams-O'Connor K, Palta P, George KM, Satizabal CL, Barnes LL, Schneider JA, Binet AP, Villeneuve S, Pa J, Brickman AM, Black SE, Rabin JS. Sex differences in associations between APOE epsilon2 and longitudinal cognitive decline. Alzheimers Dement 19:4651-4661, 2023.  PMC10544702. DOI: 10.1002/alz.13036

Wright KM, Bollen M, David J, Mepham B, Alcazar Magana A, McClure C, Maier CS, Quinn JF, Soumyanath A. Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults. Front Pharmacol 14:1228030, 2023.  10481538. DOI: 10.3389/fphar.2023.1228030

Wu C, Tibbitts D, Beattie Z, Dodge H, Shannon J, Kaye J, Winters-Stone K. Using Continuous Passive Assessment Technology to Describe Health and Behavior Patterns Preceding and Following a Cancer Diagnosis in Older Adults: Proof-of-Concept Case Series Study. JMIR Form Res 7:e45693, 2023. PMC10450537. DOI: 10.2196/45693

Xue Y, Xie X. The Association between Metformin Use and Risk of Developing Severe Dementia among AD Patients with Type 2 Diabetes. Biomedicines 11, 2023.  PMC10669124. DOI: 10.3390/biomedicines11112935

Yi F, Yang H, Chen D, Qin Y, Han H, Cui J, Bai W, Ma Y, Zhang R, Yu H. XGBoost-SHAP-based interpretable diagnostic framework for alzheimer's disease. BMC Med Inform Decis Mak 23:137, 2023. PMC10369804. DOI: 10.1186/s12911-023-02238-9

Yuan F, Zhou W, Dodge HH, Zhao X. Short: Causal structural learning of conversational engagement for socially isolated older adults. Smart Health (Amst) 28, 2023. PMC10101035. DOI: 10.1016/j.smhl.2023.100384

Zhang Q, Fan C, Wang L, Li T, Wang M, Han Y, Jiang J, and for the Alzheimer's Disease Neuroimaging I. Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer's disease: an exploratory study of (18) F-FDG-PET. Geroscience, 2023. DOI: 10.1007/s11357-023-00897-0

Zheng L, Rubinski A, Dennecke J, Luan Y, Smith R, Strandberg O, Stomrud E, Ossenkoppele R, Svaldi DO, Higgins IA, Shcherbinin S, Pontecorvo MJ, Hansson O, Franzmeier N, Ewers M, Alzheimer's Disease Neuroimaging Initiative. Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer's Disease. Annals of Neurology, 2023. DOI: 10.1002/ana.26818

Zhou X, Chen Y, Ip F, Jiang Y, Cao H, Lv G, Zhong H, Chen J, Ye T, Chen Y, Zhang Y, Ma S, Lo RM, Tong E, Mok V, Kwok T, Guo Q, Mok K, Shoai M, Hardy J, Chen L, Fu A, Ip N, Alzheimer's Disease Neuroimaging Initiative. Deep learning-based polygenic risk analysis for Alzheimer's disease prediction. Commun Med (Lond) 3:49, 2023. PMC10079691. DOI: 10.1038/s43856-023-00269-x

2022 Oregon Alzheimer’s Disease Research Publications

Anderson VC, Tagge IJ, Doud A, Li X, Springer CS, Jr., Quinn JF, Kaye JA, Wild KV, Rooney WD. DCE-MRI of Brain Fluid Barriers: In Vivo Water Cycling at the Human Choroid Plexus. Tissue Barriers 10:1963143, 2022. PMC879425.  DOI: 10.1080/21688370.2021.1963143

Arnold MR, Coughlin DG, Brumbach BH, Smirnov DS, Concha-Marambio L, Farris CM, Ma Y, Inc A, Kim Y, Wilson EN, Kaye JA, Hiniker A, Woltjer RL, Galasko DR, Quinn JF. alpha-synuclein seed amplification in CSF and brain from patients with different brain distributions of pathological alpha-synuclein in the context of co-pathology and non-LBD diagnoses. Annals of Neurology 92:650-662, 2022.  PMC in Process. DOI: 10.1002/ana.26453

Au-Yeung WM, Miller L, Beattie Z, May R, Cray HV, Kabelac Z, Katabi D, Kaye J, Vahia IV. Monitoring Behaviors of Patients With Late-Stage Dementia Using Passive Environmental Sensing Approaches: A Case Series. Am J Geriatr Psychiatry 30:1-11, 2022.  PMC8531172. DOI: 10.1016/j.jagp.2021.04.008

Babulal GM, Zhu Y, Roe CM, Hudson DL, Williams MM, Murphy SA, Doherty J, Johnson AM, Trani JF. The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity. Alzheimers Dement 18:2593-2602, 2022.  PMC9402798. DOI: 10.1002/alz.12631

Barker MS, Gottesman RT, Manoochehri M, Chapman S, Appleby BS, Brushaber D, Devick KL, Dickerson BC, Domoto-Reilly K, Fields JA, Forsberg LK, Galasko DR, Ghoshal N, Goldman J, Graff-Radford NR, Grossman M, Heuer HW, Hsiung GY, Knopman DS, Kornak J, Litvan I, Mackenzie IR, Masdeu JC, Mendez MF, Pascual B, Staffaroni AM, Tartaglia MC, Boeve BF, Boxer AL, Rosen HJ, Rankin KP, Cosentino S, Rascovsky K, Huey ED, ALLFTD Consortium. Proposed research criteria for prodromal behavioural variant frontotemporal dementia. Brain 145:1079-1097, 2022.  PMC9050566. DOI: 10.1093/brain/awab365

Bellenguez C, Kucukali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarcon-Martin E, Alcolea D, Alegret M, Alvarez I, Alvarez V, Armstrong NJ, Tsolaki A, Antunez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bailly H, Banaj N, Baquero M, Barral S, Beiser A, Pastor AB, Below JE, Benchek P, Benussi L, Berr C, Besse C, Bessi V, Binetti G, Bizarro A, Blesa R, Boada M, Boerwinkle E, Borroni B, Boschi S, Bossu P, Brathen G, Bressler J, Bresner C, Brodaty H, Brookes KJ, Brusco LI, Buiza-Rueda D, Burger K, Burholt V, Bush WS, Calero M, Cantwell LB, Chene G, Chung J, Cuccaro ML, Carracedo A, Cecchetti R, Cervera-Carles L, Charbonnier C, Chen HH, Chillotti C, Ciccone S, Claassen J, Clark C, Conti E, Corma-Gomez A, Costantini E, Custodero C, Daian D, Dalmasso MC, Daniele A, Dardiotis E, Dartigues JF, de Deyn PP, de Paiva Lopes K, de Witte LD, Debette S, Deckert J, Del Ser T, Denning N, DeStefano A, Dichgans M, Diehl-Schmid J, Diez-Fairen M, Rossi PD, Djurovic S, Duron E, Duzel E, Dufouil C, Eiriksdottir G, Engelborghs S, Escott-Price V, Espinosa A, Ewers M, Faber KM, Fabrizio T, Nielsen SF, Fardo DW, Farotti L, Fenoglio C, Fernandez-Fuertes M, Ferrari R, Ferreira CB, Ferri E, Fin B, Fischer P, Fladby T, Fliessbach K, Fongang B, Fornage M, Fortea J, Foroud TM, Fostinelli S, Fox NC, Franco-Macias E, Bullido MJ, Frank-Garcia A, Froelich L, Fulton-Howard B, Galimberti D, Garcia-Alberca JM, Garcia-Gonzalez P, Garcia-Madrona S, Garcia-Ribas G, Ghidoni R, Giegling I, Giorgio G, Goate AM, Goldhardt O, Gomez-Fonseca D, Gonzalez-Perez A, Graff C, Grande G, Green E, Grimmer T, Grunblatt E, Grunin M, Gudnason V, Guetta-Baranes T, Haapasalo A, Hadjigeorgiou G, Haines JL, Hamilton-Nelson KL, Hampel H, Hanon O, Hardy J, Hartmann AM, Hausner L, Harwood J, Heilmann-Heimbach S, Helisalmi S, Heneka MT, Hernandez I, Herrmann MJ, Hoffmann P, Holmes C, Holstege H, Vilas RH, Hulsman M, Humphrey J, Biessels GJ, Jian X, Johansson C, Jun GR, Kastumata Y, Kauwe J, Kehoe PG, Kilander L, Stahlbom AK, Kivipelto M, Koivisto A, Kornhuber J, Kosmidis MH, Kukull WA, Kuksa PP, Kunkle BW, Kuzma AB, Lage C, Laukka EJ, Launer L, Lauria A, Lee CY, Lehtisalo J, Lerch O, Lleo A, Longstreth W, Jr., Lopez O, de Munain AL, Love S, Lowemark M, Luckcuck L, Lunetta KL, Ma Y, Macias J, MacLeod CA, Maier W, Mangialasche F, Spallazzi M, Marquie M, Marshall R, Martin ER, Montes AM, Rodriguez CM, Masullo C, Mayeux R, Mead S, Mecocci P, Medina M, Meggy A, Mehrabian S, Mendoza S, Menendez-Gonzalez M, Mir P, Moebus S, Mol M, Molina-Porcel L, Montrreal L, Morelli L, Moreno F, Morgan K, Mosley T, Nothen MM, Muchnik C, Mukherjee S, Nacmias B, Ngandu T, Nicolas G, Nordestgaard BG, Olaso R, Orellana A, Orsini M, Ortega G, Padovani A, Paolo C, Papenberg G, Parnetti L, Pasquier F, Pastor P, Peloso G, Perez-Cordon A, Perez-Tur J, Pericard P, Peters O, Pijnenburg YAL, Pineda JA, Pinol-Ripoll G, Pisanu C, Polak T, Popp J, Posthuma D, Priller J, Puerta R, Quenez O, Quintela I, Thomassen JQ, Rabano A, Rainero I, Rajabli F, Ramakers I, Real LM, Reinders MJT, Reitz C, Reyes-Dumeyer D, Ridge P, Riedel-Heller S, Riederer P, Roberto N, Rodriguez-Rodriguez E, Rongve A, Allende IR, Rosende-Roca M, Royo JL, Rubino E, Rujescu D, Saez ME, Sakka P, Saltvedt I, Sanabria A, Sanchez-Arjona MB, Sanchez-Garcia F, Juan PS, Sanchez-Valle R, Sando SB, Sarnowski C, Satizabal CL, Scamosci M, Scarmeas N, Scarpini E, Scheltens P, Scherbaum N, Scherer M, Schmid M, Schneider A, Schott JM, Selbaek G, Seripa D, Serrano M, Sha J, Shadrin AA, Skrobot O, Slifer S, Snijders GJL, Soininen H, Solfrizzi V, Solomon A, Song Y, Sorbi S, Sotolongo-Grau O, Spalletta G, Spottke A, Squassina A, Stordal E, Tartan JP, Tarraga L, Tesi N, Thalamuthu A, Thomas T, Tosto G, Traykov L, Tremolizzo L, Tybjaerg-Hansen A, Uitterlinden A, Ullgren A, Ulstein I, Valero S, Valladares O, Broeckhoven CV, Vance J, Vardarajan BN, van der Lugt A, Dongen JV, van Rooij J, van Swieten J, Vandenberghe R, Verhey F, Vidal JS, Vogelgsang J, Vyhnalek M, Wagner M, Wallon D, Wang LS, Wang R, Weinhold L, Wiltfang J, Windle G, Woods B, Yannakoulia M, Zare H, Zhao Y, Zhang X, Zhu C, Zulaica M, Farrer LA, Psaty BM, Ghanbari M, Raj T, Sachdev P, Mather K, Jessen F, Ikram MA, de Mendonca A, Hort J, Tsolaki M, Pericak-Vance MA, Amouyel P, Williams J, Frikke-Schmidt R, Clarimon J, Deleuze JF, Rossi G, Seshadri S, Andreassen OA, Ingelsson M, Hiltunen M, Sleegers K, Schellenberg GD, van Duijn CM, Sims R, van der Flier WM, Ruiz A, Ramirez A, Lambert JC. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics, 2022. DOI: 10.1038/s41588-022-01024-z

Belloy ME, Eger SJ, Le Guen Y, Damotte V, Ahmad S, Ikram MA, Ramirez A, Tsolaki AC, Rossi G, Jansen IE, de Rojas I, Parveen K, Sleegers K, Ingelsson M, Hiltunen M, Amin N, Andreassen O, Sanchez-Juan P, Kehoe P, Amouyel P, Sims R, Frikke-Schmidt R, van der Flier WM, Lambert JC, He Z, Han SS, Napolioni V, Greicius MD. Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping. Alzheimers Res Ther 14:22, 2022.  PMC8815198. DOI: 10.1186/s13195-022-00962-4

Benge JF, Artz JD, Kiselica AM. The ecological validity of the Uniform Data Set 3.0 neuropsychological battery in individuals with mild cognitive impairment and dementia. Clin Neuropsychol 36:1453-1470, 2022.  PMC8071839. DOI: 10.1080/13854046.2020.1837246

Bernstein JP, Mattek N, Dorociak KE, Beattie ZT, Kaye JA, Ferguson JE, Hughes AM. Age Predicts Older Adults’ Driving Self-Regulation but Not Dangerous Driving Behaviors after Controlling for Executive Function. Gerontology 68:98-105, 2022. DOI: 10.1159/000515497

Bernstein JPK, Dorociak K, Mattek N, Leese M, Trapp C, Beattie Z, Kaye J, Hughes A. Unobtrusive, in-home assessment of older adults' everyday activities and health events: associations with cognitive performance over a brief observation period. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 29:781-798, 2022.  PMC8522171. DOI: 10.1080/13825585.2021.1917503

Berridge C, Zhou Y, Lazar  A, Porwal A, Mattek N, Gothard S, Kaye  J. Control Matters in Elder Care Technology: Evidence and Direction for Designing It In. In: ACM, ed. Designing Interactive Systems Conference,. Australia, 2022: 1831-1848. DOI: 10.1145/3532106.3533471

Breitner J, Dodge H, Khachaturian ZS, Khachaturian A. Exceptions that prove the rule–Why have clinical trials failed to show efficacy of risk factor interventions suggested by observational studies of the dementia-Alzheimer's disease syndrome? Alzheimer's Dement 18:389-392, 2022.  PMC8940699. DOI: 10.1002/alz.12633

Buckles VD, Xiong C, Bateman RJ, Hassenstab J, Allegri R, Berman SB, Chhatwal JP, Danek A, Fagan AM, Ghetti B, Goate A, Graff-Radford N, Jucker M, Levin J, Marcus DS, Masters CL, McCue L, McDade E, Mori H, Moulder KL, Noble JM, Paumier K, Preische O, Ringman JM, Fox NC, Salloway S, Schofield PR, Martins R, Voglein J, Morris JC. Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease. Alzheimers Dement 18:1754-1764, 2022.  PMC9160203. DOI: 10.1002/alz.12505

Cothran FA, Alto R, Tomaszewski Farias S, Johnson DK, Lara E, Whitmer RA, DeCarli C, Meyer OL. Caring for the Caregivers: An Alzheimer Disease Research Center Call to Action. Alzheimer Disease and Associated Disorders 36:92-95, 2022. DOI: 10.1097/WAD.0000000000000483

Dawson W, et al. Build Back Brainier: Base Policies on Brain Science. In: Hynes W, Linkov I, Love P, eds. A Systemic Recovery, New Approaches to Economic Challenges. Paris: OECD Publishing, 2022.

Dawson W, Smith E, Booi L, Mosse M, Lavretsky H, Reynolds C, Cummings J, Brannelly P, Hynes W, Lenze E, Manes F, Ayadi R, Frank L, Chapman S, Robertson I, Rubenstein L, Jraissati J, Ibáñez A, Fillit H, Jeste  D, Rao A, Berk M, Storch E, Chadha A, Eyre H. Investing in Late-Life Brain Capital. Innovation in Aging 6:2022, 2022.  DOI: 10.1093/geroni/igac016

Dissanayake AS, Tan YB, Bowie CR, Butters MA, Flint AJ, Gallagher D, Golas AC, Herrmann N, Ismail Z, Kennedy JL, Kumar S, Lanctot KL, Mah L, Mulsant BH, Pollock BG, Rajji TK, Tau M, Maraj A, Churchill NW, Tsuang D, Schweizer TA, Munoz DG, Fischer CE, Group PA-MS. Sex Modifies the Associations of APOEvarepsilon4 with Neuropsychiatric Symptom Burden in Both At-Risk and Clinical Cohorts of Alzheimer's Disease. Journal of Alzheimer's Disease 90:1571-1588, 2022. DOI: 10.3233/JAD-220586

Duong MT, Das SR, Lyu X, Xie L, Richardson H, Xie SX, Yushkevich PA, Wolk DA, Nasrallah IM, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer's disease. Nat Commun 13:1495, 2022. DOI: 10.1038/s41467-022-28941-1

Elliott JE, Tinsley CE, Reynolds C, Olson RJ, Weymann KB, Au-Yeung WM, Wilkerson A, Kaye JA, Lim MM. Tunable White Light for Elders (TWLITE): A Protocol Demonstrating Feasibility and Acceptability for Deployment, Remote Data Collection, and Analysis of a Home-Based Lighting Intervention in Older Adults. Sensors (Basel) 22, 2022.  PMC9320387. DOI: 10.3390/s22145372

Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol 143:33-53, 2022.  PMC8786260. DOI: 10.1007/s00401-021-02379-z

Fracassi A, Marcatti M, Tumurbaatar B, Woltjer R, Moreno S, Taglialatela G. TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology. Brain Pathology:e13108, 2022.  DOI: 10.1111/bpa.13108

Gabel M, Bollinger RM, Coble DW, Grill JD, Edwards DF, Lingler JH, Chin E, Stark SL. Retaining Participants in Longitudinal Studies of Alzheimer's Disease. Journal of Alzheimer's Disease 87:945-955, 2022. DOI: 10.3233/JAD-215710

Galvin-McLaughlin D, Klee D, Memmott T, Peters B, Wiedrick J, Fried-Oken M, Oken B, Consortium for Accessible Multimodal Brain-Body Interfaces (CAMBI). Methodology and Preliminary Data on Feasibility of a Neurofeedback Protocol to Improve Visual Attention to Letters in Mild Alzheimer’s Disease. Contemporary Clinical Trials 28:100950, 2022.  PMC9228283. DOI: 10.1016/j.conctc.2022.100950

Godrich D, Martin ER, Schellenberg G, Pericak-Vance MA, Cuccaro M, Scott WK, Kukull W, Montine T, Beecham GW. Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population. Alzheimers Dement 18:2403-2412, 2022.  PMC9360193. DOI: 10.1002/alz.12516

Gonzalez DA, Gonzales MM, Resch ZJ, Sullivan AC, Soble JR. Comprehensive Evaluation of the Functional Activities Questionnaire (FAQ) and Its Reliability and Validity. Assessment 29:748-763, 2022.  PMC8339133. DOI: 10.1177/1073191121991215

Gonzalez DA, Resch ZJ, Gonzales MM, Soble JR. A Novel Method for Establishing Functional Change in Older Adults With Cognitive Impairment. Alzheimer Disease and Associated Disorders 36:238-243, 2022.  PMC9420747. DOI: 10.1097/WAD.0000000000000507

Graves LV, Edmonds EC, Thomas KR, Weigand AJ, Cooper S, Stickel AM, Zlatar ZZ, Clark AL, Bondi MW. Diagnostic accuracy and differential associations between ratings of functioning and neuropsychological performance in non-Hispanic Black and White older adults. Clin Neuropsychol 36:287-310, 2022.  PMC8849565. DOI: 10.1080/13854046.2021.1971766

Heath L, Earls JC, Magis AT, Kornilov SA, Lovejoy JC, Funk CC, Rappaport N, Logsdon BA, Mangravite LM, Kunkle BW, Martin ER, Naj AC, Ertekin-Taner N, Golde TE, Hood L, Price ND. Alzheimer’s Disease Genetics Consortium. Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90. Sci Rep 12:6117, 2022.  PMC9005657. DOI: 10.1038/s41598-022-09825-2

Hepburn K, Nocera J, Higgins M, Epps F, Brewster GS, Lindauer A, Morhardt D, Shah R, Bonds K, Nash R, Griffiths PC. Results of a Randomized Trial Testing the Efficacy of Tele-Savvy, an Online Synchronous/Asynchronous Psychoeducation Program for Family Caregivers of Persons Living with Dementia. Gerontologist 62:616-628, 2022.  PMC7989248. DOI: 10.1093/geront/gnab029

Hong Y, Zeng X, Zhu CW, Neugroschl J, Aloysi A, Sano M, Li C. Evaluating the Beijing Version of Montreal Cognitive Assessment for Identification of Cognitive Impairment in Monolingual Chinese American Older Adults. Journal of Geriatric Psychiatry and Neurology 35:586-593, 2022.  PMC8831672. DOI: 10.1177/08919887211036182

Hupfeld KE, Richmond SB, McGregor HR, Schwartz DL, Luther MN, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Wood SJ, Bloomberg JJ, Mulavara AP, Silbert LC, Iliff JJ, Seidler RD, Piantino J. Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight. Sci Rep 12:7238, 2022.  PMC072425.

Hwangbo N, Zhang X, Raftery D, Gu H, Hu SC, Montine TJ, Quinn JF, Chung KA, Hiller AL, Wang D, Fei Q, Bettcher L, Zabetian CP, Peskind E, Li G, Promislow DEL, Franks A. A Metabolomic Aging Clock Using Human Cerebrospinal Fluid. J Gerontol A Biol Sci Med Sci 77:744-754, 2022.  PMC8974344. DOI: 10.1038/s41598-022-11593-y

Hwangbo N, Zhang X, Raftery D, Gu H, Hu SC, Montine TJ, Quinn JF, Chung KA, Hiller AL, Wang D, Fei Q, Bettcher L, Zabetian CP, Peskind ER, Li G, Promislow DEL, Davis MY, Franks A. Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid. Metabolites 12:277, 2022.  PMC9029812. DOI: 10.3390/metabo12040277]

Inglese M, Patel N, Linton-Reid K, Loreto F, Win Z, Perry RJ, Carswell C, Grech-Sollars M, Crum WR, Lu H, Malhotra PA, Aboagye EO. Alzheimer’s Disease Neuroimaging Initiative. A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer's disease. Commun Med (Lond) 2:70, 2022.  PMC9209493. DOI: 10.1038/s43856-022-00133-4

Jiang J, Sheng C, Chen G, Liu C, Jin S, Li L, Jiang X, Han Y, Alzheimer's Disease Neuroimaging Initiative. Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment. Geroscience 44:2319-2336, 2022.  PMC9616982. DOI: 10.1007/s11357-022-00588-2

Jicha GA, Abner EL, Arnold SE, Carrillo MC, Dodge HH, Edland SD, Fargo KN, Feldman HH, Goldstein LB, Hendrix J, Peters R, Robillard JM, Schneider LS, Titiner JR, Weber CJ. Committee on High-quality Alzheimer's Disease Studies (CHADS) consensus report. Alzheimers Dement 18:1109-1118, 2022. PMC8960469. DOI: 10.1002/alz.12461

Jin B, Capra JA, Benchek P, Wheeler N, Naj AC, Hamilton-Nelson KL, Farrell JJ, Leung YY, Kunkle B, Vadarajan B, Schellenberg GD, Mayeux R, Wang LS, Farrer LA, Pericak-Vance MA, Martin ER, Haines JL, Crawford DC, Bush WS. An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns. Genome Res 32:778-790, 2022.  PMC8997344. DOI: 10.1101/gr.276069.121

Johnson EEH, Alexander C, Lee GJ, Angers K, Ndiaye D, Suhr J. Examination of race and gender differences in predictors of neuropsychological decline and development of Alzheimer's disease. Clin Neuropsychol 36:327-352, 2022.  DOI: 10.1080/13854046.2021.1940299

Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W, Alzheimer's Disease Genetics C, Bennett DA, Foroud TM, Wang LS, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Au R, Lunetta KL, Ikezu T, Stein TD, Farrer LA, Alzheimer's Disease Genetics Consortium. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE varepsilon2 for Alzheimer's disease. Alzheimers Dement 18:2042-2054, 2022. PMC9360190. DOI: 10.1002/alz.12607

Katsumata Y, Shade LM, Hohman TJ, Schneider JA, Bennett DA, Farfel JM, Alzheimer's Disease Genetics C, Kukull WA, Fardo DW, Nelson PT. Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities. Neurobiol Dis 174:"105880", 2022.  DOI: 10.1016/j.nbd.2022.105880

Kim H, Senders A, Simeon E, Juarez C, Huang S, Dodge H, McConnell KJ. Use of long-term services and supports among dual-eligible beneficiaries with Alzheimer's disease and related dementias. Journal of the American Geriatrics Society, 2022.  DOI: 10.1111/jgs.18115

Kondo T, Hara N, Koyama S, Yada Y, Tsukita K, Nagahashi A, Ikeuchi T, Ishii K, Asada T, Arai T, Yamada R, Alzheimer's Disease Neuroimaging Initiative, Japanese Alzheimer's Disease Neuroimaging Initiative, Inoue H. Dissection of the polygenic architecture of neuronal Abeta production using a large sample of individual iPSC lines derived from Alzheimer's disease patients. Nat Aging 2:125-139, 2022. DOI: 10.1038/s43587-021-00158-9

Kundu P, Zimmerman B, Quinn JF, Kaye J, Mattek N, Westaway SK, Raber J. Serum Levels of alpha-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function. Journal of Alzheimer's Disease, 2022. DOI: 10.3233/JAD-215719

Lahna D, Roese N, Woltjer R, Boespflug E, Schwartz D, Grinstead J, Dodge H, Wall R, Kaye J, Rooney W, Silbert L. Postmortem  7T MRI for Guided Histopathology and Evaluation of Cerebrovascular Disease. Journal of Neuropathology & Experimental Neurology 82:57-70, 2022.  PMC9764082. DOI: 10.1093/jnen/nlac103

Lahna D, Schwartz DL, Woltjer R, Black SE, Roese N, Dodge H, Boespflug EL, Keith J, Gao F, Ramirez J, Silbert LC. Venous Collagenosis as Pathogenesis of White Matter Hyperintensity. Annals of Neurology, 2022.  DOI: 10.1002/ana.26487

Lan G, Cai Y, Li A, Liu Z, Ma S, Guo T, Alzheimer's Disease Neuroimaging Initiative. Association of presynaptic loss with Alzheimer's disease and cognitive decline. Annals of Neurology, 2022. DOI: 10.1002/ana.26492

Leese M, Mattek N, Bernstein J, Dorociak K, Gothard S, Kaye J, Seelye A. The Survey for Memory, Attention, and Reaction Time (SMART): Preliminary Normative Online Panel Data and User Attitudes for a Brief Web-Based Cognitive Performance Measure. The Clinical Neuropsychologist 5:1-19, 2022. DOI: 10.1080/13854046.2022.2103033

Lennon JC, Aita SL, Bene V, Rhoads T, Resch ZJ, Eloi JM, Walker KA. Black and White individuals differ in dementia prevalence, risk factors, and symptomatic presentation. Alzheimers Dement 18:1461-1471, 2022. PMC9160212. DOI: 10.1002/alz.12509

Liew TM. Subjective cognitive decline, APOE e4 allele, and the risk of neurocognitive disorders: Age- and sex-stratified cohort study. Aust N Z J Psychiatry 56:1664-1675, 2022.  PMC9433458. DOI: 10.1177/00048674221079217

Lilly C, Wang Z, Dunlap D, Kaye J, Gohtard S, Teebagy S, Hafer N, Rogers E, Buchholz B, McManus D. 2021 Patient Preferences for Point of Care Testing Survey: More Acceptance and Less Concern. J Appl Lab Med, 2022. DOI: 10.1093/jalm/jfac070

Lindauer A, Wild K, Natonson A, Mattek N, Wolf M, Steeves-Reece A, Messecar D. Dementia 360 ECHO: Using technology to facilitate diagnosis and treatment. Gerontol Geriatr Educ 43:202-208, 2022. PMC8581834. DOI: 10.1080/02701960.2020.1835658

Liu H, Lutz M, Luo S, Alzheimer's Disease Neuroimaging Initiative. Genetic Association Between Epigenetic Aging-Acceleration and the Progression of Mild Cognitive Impairment to Alzheimer's Disease. J Gerontol A Biol Sci Med Sci 77:1734-1742, 2022.  PMC9434458. DOI: 10.1093/gerona/glac138

Lutz MW, Khachaturian AS, Zetterberg H, Blennow K, Willette AA, Mielke MM, Hayden KM, Dodge HH, Tang Y, Greenberg BD, Kukull WA, Khachaturian ZS. Biomarkers of Alzheimer syndrome and related dementias: A&D author's guide. Alzheimers Dement 18:1595-1601, 2022. DOI: 10.1002/alz.12772

McDonough IM, Cody SL, Harrell ER, Garrett SL, Popp TE. Cognitive differences across ethnoracial category, socioeconomic status across the Alzheimer's disease spectrum: Can an ability discrepancy score level the playing field? Mem Cognit, 2022. DOI: 10.3758/s13421-022-01304-3

McGirr A, Nathan S, Ghahremani M, Gill S, Smith EE, Ismail Z. Progression to Dementia or Reversion to Normal Cognition in Mild Cognitive Impairment as a Function of Late-Onset Neuropsychiatric Symptoms. Neurology 98:e2132-e2139, 2022.  DOI: 10.1212/WNL.0000000000200256

Milicic L, Vacher M, Porter T, Dore V, Burnham SC, Bourgeat P, Shishegar R, Doecke J, Armstrong NJ, Tankard R, Maruff P, Masters CL, Rowe CC, Villemagne VL, Laws SM, Alzheimer’s Disease Neuroimaging Initiative. Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume. Geroscience 44:1807-1823, 2022. PMC9213584. DOI: 10.1007/s11357-022-00558-8

Milicic L, Vacher M, Porter T, Dore V, Burnham SC, Bourgeat P, Shishegar R, Doecke J, Armstrong NJ, Tankard R, Maruff P, Masters CL, Rowe CC, Villemagne VL, Laws SM, Alzheimer’s Disease Neuroimaging Initiative (ADNI, Australian Imaging Biomarkers and Lifestyle (AIBL) Study. Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume. Geroscience, 2022. DOI: 10.1007/s11357-022-00558-8

Miller LM, Solomon DN, Whitlatch CJ, Hiatt SO, Wu CY, Reynolds C, Au-Yeung WM, Kaye J, Steele JS. The Remote Assessment and Dynamic Response Program: Development of an In-Home Dementia-Related Care Needs Assessment to Improve Well-Being. Innov Aging 6:igac006, 2022.  PMC8985764. DOI: 10.1093/geroni/igac006

Miller LM, Steele JS, Wu CY, Kaye J, Dodge HH, Gonzales MM, Lyons KS. Depressive symptoms in older adult couples: Associations with dyadic physical health, social engagement, and close friends. Front Psychiatry 13:989182, 2022.  PMC9513127. DOI: 10.3389/fpsyt.2022.98918260. Morrow CB, Leoutsakos JS, Onyike CU. Functional Disabilities and Psychiatric Symptoms in Primary Progressive Aphasia. Am J Geriatr Psychiatry 30:372-382, 2022. DOI: 10.1016/j.jagp.2021.07.013

Moses J, Sinclair B, Schwartz D, Silbert L, O’Brien T, Law M, Vivash L. Perivascular spaces as a marker of disease severity and neurodegeneration in patients with behavioral variant frontotemporal dementia. Frontiers in Neuroscience 16:1003522, 2022.  PMC9633276. DOI: 10.3389/fnins.2022.1003522

Neupane A, Lenny B, Budde JP, Wang F, Norton J, Morris JC, Cruchaga C, Fernandez MV. Replication study of AD-associated rare variants. Alzheimers Dement 18:858-862, 2022.  PMC8986593. DOI: 10.1002/alz.12583

Nunnerley M, Kaye J, Beattie Z, Mattek N. Preferences of NIA Alzheimer’s Disease Research Center Participants Regarding Remote Assessment During the COVID-19 Pandemic. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2022:e12373, 2022.  PMC9677364. DOI: 10.1002/dad2.12373

Page ML, Vance EL, Cloward ME, Ringger E, Dayton L, Ebbert MTW, Miller JB, Kauwe JSK, Alzheimer's Disease Neuroimaging initiative. The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores. Commun Biol 5:899, 2022.  DOI: 10.1038/s42003-022-03795-x

Peters R, Dodge HH, James S, Jicha GA, Meyer PF, Richards M, Smith AD, Yassine HN, Abner E, Hainsworth AH. The epidemiology is promising, but the trial evidence is weak. Why pharmacological dementia risk reduction trials haven't lived up to expectations, and where do we go from here? Alzheimer's & Dementia 18:507-512, 2022. DOI: 10.1002/alz.12393

Pichet Binette A, Franzmeier N, Spotorno N, Ewers M, Brendel M, Biel D, Strandberg O, Janelidze S, Palmqvist S, Mattsson-Carlgren N, Smith R, Stomrud E, Ossenkoppele R, Hansson O. Alzheimer’s Disease Neuroimaging Initiative. Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer's disease. Nat Commun 13:6635, 2022.  PMC9636262. DOI: 10.1038/s41467-022-34129-4

Pillai JA, Bena J, Rothenberg K, Boron B, Leverenz JB. Association of Variation in Behavioral Symptoms With Initial Cognitive Phenotype in Adults With Dementia Confirmed by Neuropathology. JAMA Netw Open 5:e220729, 2022.  PMC8895258. DOI: 10.1001/jamanetworkopen.2022.0729

Qiu J, Goldstein FC, Hanfelt JJ. An Exploration of Subgroups of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Their Risks of Conversion to Dementia or Death. Am J Geriatr Psychiatry 30:925-934, 2022.  PMC9250542. DOI: 10.1016/j.jagp.2021.12.016

Quinn JF, Kelly MJ, Harris CJ, Hack W, Gray NE, Kulik V, Bostick Z, Brumbach BH, Copenhaver PF. The novel estrogen modulator STX attenuates Amyloid-beta neurotoxicity in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Dis:105888, 2022. DOI: 10.1016/j.nbd.2022.105888

Quinones AR, Chen S, Nagel CL, Botoseneanu A, Allore HG, Newsom JT, Thielke S, Kaye J. Trajectories of cognitive functioning in later life: Disparities by race/ethnicity, educational attainment, sex, and multimorbidity combinations. SSM Popul Health 18:101084, 2022.  PMC8987641. DOI: 10.1016/j.ssmph.2022.101084

Quinones AR, Nagel CL, Botoseneanu A, Newsom JT, Dorr DA, Kaye J, Thielke SM, Allore HG. Multidimensional trajectories of multimorbidity, functional status, cognitive performance, and depressive symptoms among diverse groups of older adults. J Multimorb Comorb 12:26335565221143012, 2022.  PMC9720836. DOI: 10.1177/26335565221143012

Reynolds C, Mattek N, Lim MM, Beattie Z, Dodge HH, Kaye J. Association Between Mild Cognitive Impairment and Seasonal Rest-Activity Patterns of Older Adults. Front Digit Health 4:809370, 2022.  PMC8904352. DOI: 10.3389/fdgth.2022.809370

Ruthirakuhan M, Ismail Z, Herrmann N, Gallagher D, Lanctot KL. Mild behavioral impairment is associated with progression to Alzheimer's disease: A clinicopathological study. Alzheimers Dement 18:2199-2208, 2022.  PMC9339594. DOI: 10.1002/alz.12519

Sandau US, McFarland TJ, Smith SJ, Galasko DR, Quinn JF, Saugstad JA. Differential Effects of APOE Genotype on MicroRNA Cargo of Cerebrospinal Fluid Extracellular Vesicles in Females With Alzheimer's Disease Compared to Males. Front Cell Dev Biol 10:864022, 2022.  PMC9092217. DOI: 10.3389/fcell.2022.864022

Schaffert J, LoBue C, Hynan LS, Hart J, Rossetti H, Carlew AR, Lacritz L, White CL, Cullum CM. Predictors of Life Expectancy in Autopsy-Confirmed Alzheimer's Disease. Journal of Alzheimer's Disease 86:271-281, 2022.  PMC8966055. DOI: 10.3233/JAD-215200

Shinto LH, Raber J, Mishra A, Roese N, Silbert LC. A Review of Oxylipins in Alzheimer's Disease and Related Dementias (ADRD): Potential Therapeutic Targets for the Modulation of Vascular Tone and Inflammation. Metabolites 12:826, 2022.  PMC9501361. DOI: 10.3390/metabo12090826

Sternberg Z, Podolsky R, Nir A, Yu J, Nir R, Halvorsen SW, Quinn JF, Kaye J, Kolb C. Elevated spermidine serum levels in mild cognitive impairment, a potential biomarker of progression to Alzheimer dementia, a pilot study. J Clin Neurosci 100:169-174, 2022.  DOI: 10.1016/j.jocn.2022.04.028

Tahami Monfared AA, Lenderking WR, Savva Y, Ladd MK, Zhang Q, Alzheimer’s Disease Neuroimaging Initiative. Assessing the Clinical Meaningfulness of the Alzheimer's Disease Composite Score (ADCOMS) Tool. Neurol Ther, 2022. DOI: 10.1007/s40120-022-00352-w

Tang F, Chen J, Dodge HH, Zhou J. The Joint Effects of Acoustic and Linguistic Markers for Early Identification of Mild Cognitive Impairment. Front Digit Health 3:702772, 2022.  PMC8878676. DOI: 10.3389/fdgth.2021.702772

Teng E, Manser PT, Pickthorn K, Brunstein F, Blendstrup M, Sanabria Bohorquez S, Wildsmith KR, Toth B, Dolton M, Ramakrishnan V, Bobbala A, Sikkes SAM, Ward M, Fuji RN, Kerchner GA, Tauriel Investigators. Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol 79:758-767, 2022.  PMC9194753. DOI: 10.1001/jamaneurol.2022.1375

Thomas N, Bhati D, Ault L, BEng L, Lariviere-Chartier J, Petriu M, Beng W, Knoefel F, Kaye J, Goubran R. Smart Home Tech: an interface to provide feedback to caregivers of persons living with cognitive impairment. Alzheimer & Dementia 18:2:e067374, 2022. 

Tian C, Stewart T, Hong Z, Guo Z, Aro P, Soltys D, Pan C, Peskind ER, Zabetian CP, Shaw LM, Galasko D, Quinn JF, Shi M, Zhang J, Alzheimer's Disease Neuroimaging Initiative. Blood extracellular vesicles carrying synaptic function- and brain-related proteins as potential biomarkers for Alzheimer's disease. Alzheimers Dement, 2022.  DOI: 10.1002/alz.12723

Tran L, Nunnerley M, Gothard S, Golonka O, Pierce A, Lindauer A. An Analysis of Factors Influencing Dementia Study Enrollment: Focus Groups with Diverse Community Members Viewing the ACTNOW Research Registry Website. Alzheimers Dement 18 Suppl 2:e064247, 2022.

Wang H, Kirby R, Pierce A, Barbaro M, Ho AF, Blalock J, Schrader CD. Patient Portal Use Among Diabetic Patients With Different Races and Ethnicities. J Clin Med Res 14:400-408, 2022.  PMC9635808. DOI: 10.14740/jocmr4822

Wang M, Greenberg M, Forkert ND, Chekouo T, Afriyie G, Ismail Z, Smith EE, Sajobi TT. Dementia risk prediction in individuals with mild cognitive impairment: a comparison of Cox regression and machine learning models. BMC Med Res Methodol 22:284, 2022.  PMC9628121. DOI: 10.1186/s12874-022-01754-y

Weintraub S, Karpouzian-Rogers T, Peipert JD, Nowinski C, Slotkin J, Wortman K, Ho E, Rogalski E, Carlsson C, Giordani B, Goldstein F, Lucas J, Manly JJ, Rentz D, Salmon D, Snitz B, Dodge HH, Riley M, Eldes F, Ustsinovich V, Gershon R. ARMADA: Assessing reliable measurement in Alzheimer's disease and cognitive aging project methods. Alzheimers Dement 18:1449-1460, 2022.  PMC9110564. DOI: 10.1002/alz.12497

Wen J, Fu CHY, Tosun D, Veturi Y, Yang Z, Abdulkadir A, Mamourian E, Srinivasan D, Skampardoni I, Singh A, Nawani H, Bao J, Erus G, Shou H, Habes M, Doshi J, Varol E, Mackin RS, Sotiras A, Fan Y, Saykin AJ, Sheline YI, Shen L, Ritchie MD, Wolk DA, Albert M, Resnick SM, Davatzikos C, iSTAGING Consortium, Alzheimer’s Disease Neuroimaging Initiative. Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression. JAMA Psychiatry 79:464-474, 2022.  PMC8908227. DOI: 10.1001/jamapsychiatry.2022.0020

Weston LJ, Bowman AM, Osterberg VR, Meshul CK, Woltjer RL, Unni VK. Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism. International Journal of Molecular Sciences 23, 2022.  PMC9736441. DOI: 10.3390/ijms232315294

Wild K, Marcoe J, Mattek  N, Sharma N, Loewy E, Tischler H, Kaye J, Karlawish J. Online monitoring of financial capacity in older adults: Feasibility and initial findings. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring 14:e12282, 2022.  PMC8911546. DOI: 10.1002/dad2.12282

Wilson EN, Young CB, Ramos Benitez J, Swarovski MS, Feinstein I, Vandijck M, Le Guen Y, Kasireddy NM, Shahid M, Corso NK, Wang Q, Kennedy G, Trelle AN, Lind B, Channappa D, Belnap M, Ramirez V, Skylar-Scott I, Younes K, Yutsis MV, Le Bastard N, Quinn JF, van Dyck CH, Nairn A, Fredericks CA, Tian L, Kerchner GA, Montine TJ, Sha SJ, Davidzon G, Henderson VW, Longo FM, Greicius MD, Wagner AD, Wyss-Coray T, Poston KL, Mormino EC, Andreasson KI. Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease. Alzheimers Res Ther 14:172, 2022.  PMC9652927. DOI: 10.1186/s13195-022-01116-2

Winter S, Angler D, Dawson W, Bennett V, Lee C, Freeman M, Hynes W, Berk M, Sarnyai Z, Ng C, Abbott R, Ibañez A, Smith E, Hackett J, Storch E, Jraissati J, Corner L, Chen S, Carlo A, Bilder R, Moutier C, Soares J, Ayadi R, Santuccione C, Manes F, Rommelfanger K, Oertel W, Jeste D, Destrebecq F, Robertson I, D’Esposito M, Matthews M, Graham C, Eyre H. Brain health-Directed Policymaking: A New Concept to Strengthen Democracy. Washington, DC., 2022

Wright KM, Bollen M, David J, Speers AB, Brandes MS, Gray NE, Alcazar Magana A, McClure C, Stevens JF, Maier CS, Quinn JF, Soumyanath A. Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial. Antioxidants (Basel) 11, 2022. PMC8868383. DOI: 10.3390/antiox11020215

Wu CY, Dodge HH, Gothard S, Mattek N, Wright K, Barnes LL, Silbert LC, Lim MM, Kaye JA, Beattie Z. Unobtrusive Sensing Technology Detects Ecologically Valid Spatiotemporal Patterns of Daily Routines Distinctive to Persons with Mild Cognitive Impairment. J Gerontol A Biol Sci Med Sci, 2022. PMC9536445. DOI: 10.1093/gerona/glab293

Wu CY, Mattek N, Wild K, Miller LM, Kaye JA, Silbert LC, Dodge HH. Can changes in social contact (frequency and mode) mitigate low mood before and during the COVID-19 pandemic? The I-CONECT project. Journal of the American Geriatrics Society 70:669-676, 2022. PMC8904274. DOI: 10.1111/jgs.17607

Yan T, Liang J, Gao J, Wang L, Fujioka H, Zhu X, Wang X, Alzheimer Disease Neuroimaging Initiative. FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nat Commun 11:4006, 2022. DOI: 10.1038/s41467-019-13962-0

Yang Z, Caldwell JZK, Cummings JL, Ritter A, Kinney JW, Cordes D, Alzheimer's Disease Neuroimaging Initiative. Sex Modulates the Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment. Front Psychiatry 13:804168, 2022.  PMC9037326. DOI: 10.3389/fpsyt.2022.804168

Yildiz S, Grinstead J, Hildebrand A, Oshinski J, Rooney WD, Lim MM, Oken B. Immediate impact of yogic breathing on pulsatile cerebrospinal fluid dynamics. Sci Rep 12:10894, 2022. PMC9240010. DOI: 10.1038/s41598-022-15034-8

Yu K, Wild K, Dowling M, Kaye J, Silbert L, Dodge H. Emotional Characteristics of Socially Isolated Older Adults with MCI Using Tablet Administered NIH Toolbox: I-CONECT study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 14:e12372, 2022.  PMC9652485. DOI: 10.1002/dad2.12372

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Xie, B., Charness, N., Fingerman, K., Kaye, J., Kim, M. T., & Khurshid, A. (2020). When Going Digital Becomes a Necessity: Ensuring Older Adults' Needs for Information, Services, and Social Inclusion During COVID-19. Journal of aging & social policy, 32(4-5), 460–470.

Xiong, C., Luo, J., Coble, D., Agboola, F., Kukull, W., & Morris, J. C. (2020). Complex interactions underlie racial disparity in the risk of developing Alzheimer's disease dementia. Alzheimer's & dementia: the journal of the Alzheimer's Association, 16(4), 589–597.

Xu, C., Apostolova, L. G., Oblak, A. L., & Gao, S. (2020). Association of Hypercholesterolemia with Alzheimer's Disease Pathology and Cerebral Amyloid Angiopathy. Journal of Alzheimer's disease : JAD, 73(4), 1305–1311. https://doi.org/10.3233/JAD-191023

Yan T., Liang J., Gao J., et al. FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nature Communications. 2020. 11 (411). doi.org/10.1038/s41467-019-13962-0. 

Zhang, F., Gannon, M., Chen, Y., Yan, S., Zhang, S., Feng, W., Tao, J., Sha, B., Liu, Z., Saito, T., Saido, T., Keene, C. D., Jiao, K., Roberson, E. D., Xu, H., & Wang, Q. (2020). β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science translational medicine, 12(526), eaay6931. https://doi.org/10.1126/scitranslmed.aay6931

2024 Oregon Alzheimer’s Disease Research Publications

Appleman M, Nilaver B, Weiss A, Kohama S, Urbanski H. Effect of hormone replacement therapy on amyloid beta (Aβ) plaque density in the rhesus macaque amygdala. Frontiers in Aging Neuroscience 15:1326747, 2024.  PMC10808750. DOI: 10.3389/fnagi.2023.1326747

Choudhury P, Lee-Iannotti JK, Busicescu AO, Rangan P, Fantini ML, Avidan AY, Bliwise DL, Criswell SR, During EH, Elliott JE, Fields JA, Gagnon JF, Howell MJ, Huddleston DE, McLeland J, Mignot E, Miglis MG, Lim MM, Pelletier A, Schenck CH, Shprecher D, St Louis EK, Videnovic A, Ju YS, Boeve BF, Postuma R. Validation of the RBD Symptom Severity Scale in the North American Prodromal Synucleinopathy Consortium. Neurology 102:e208008, 2024. DOI: 10.1212/WNL.0000000000208008

Duff K. Revisiting reliable change with Iverson (2001). Clin Neuropsychol 38:412-428, 2024. DOI: 10.1080/13854046.2023.2202333

Duff K, Dixon A, Embree L. A Closer Look at Practice Effects in Mild Cognitive Impairment and Alzheimer's Disease. Arch Clin Neuropsychol 39:1-10, 2024.  PMC10802223. DOI: 10.1093/arclin/acad046

Elliott JE, Ligman BR, Bryant-Ekstrand MD, Keil AT, Powers K, Olivo C, Neilson L, Postuma RB, Pelletier A, Gagnon JF, Gan-Or Z, Yu E, Liu L, St Louis EK, Forsberg LK, Fields JA, Ross OA, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, McLeland J, Criswell SR, Videnovic A, During EH, Miglis MG, Shprecher DR, Lee-Iannotti JK, Boeve BF, Ju YS, Lim MM. Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium. Sleep, 2024. DOI: 10.1093/sleep/zsae007

Ginder DE, Tinsley CE, Kaiser ME, Lim MM. Sex-Specific Impacts of Early Life Sleep Disruption: Ethanol Seeking, Social Interaction, and Anxiety Are Differentially Altered in Adolescent Prairie Voles. bioRxiv, 2024.  PMC10802381. DOI: 10.1101/2024.01.03.574112

Kaye J, Mattek N, Dodge H, Sharma N, Riley T, Beattie Z, Woltjer R. Continuously Captured Home-Based Digital Biomarkers of Daily Function Are Significantly Correlated with Post Mortem Neurodegenerative Neuropathology. In: AAIC. Los Angeles, CA, Forthcoming, 2019.

Liampas I, Siokas V, Lyketsos CG, Dardiotis E. Cognitive Performance and Incident Alzheimer's Dementia in Men Versus Women. J Prev Alzheimers Dis 11:162-170, 2024.  PMC10794850. DOI: 10.14283/jpad.2023.90

Sandau US, Magana SM, Costa J, Nolan JP, Ikezu T, Vella LJ, Jackson HK, Moreira LR, Palacio PL, Hill AF, Quinn JF, Van Keuren-Jensen KR, McFarland TJ, Palade J, Sribnick EA, Su H, Vekrellis K, Coyle B, Yang Y, Falcon-Perez JM, Nieuwland R, Saugstad JA. Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies. J Extracell Vesicles 13:e12397, 2024.  PMC10756860. DOI: 10.1002/jev2.12397

Sandau US, Wiedrick JT, McFarland TJ, Galasko DR, Fanning Z, Quinn JF, Saugstad JA. Analysis of the longitudinal stability of human plasma miRNAs and implications for disease biomarkers. Sci Rep 14:2148, 2024.  PMC10810819. DOI: 10.1038/s41598-024-52681-5

Thomas JH, Nilaver B, Lomniczi A, Brown D, Appleman M, Kohama S, Urbanski H. Pathological markers of Alzheimer’s disease and related dementia in the rhesus macaque amygdala. Journal of Alzheimer’s Disease Reports 8:25-32, 2024.  PMC10790150. DOI: 10.3233/ADR-230184

Yamamoto E, Koike S, Luther M, Dennis L, Lim MM, Raskind M, Pagulayan K, Iliff J, Peskind E, Piantino J. Perivascular space burden and cerebrospinal fluid biomarkers in U.S. Veterans with blast-related mild traumatic brain injury. J Neurotrauma, 2024. DOI: 10.1089/neu.2023.0505

Andrews JS, Desai U, Kirson NY, Zichlin ML, Ball DE, Matthews BR. Disease severity and minimal clinically important differences in clinical outcome assessments for Alzheimer's disease clinical trials. Alzheimer’s & Dementia (New York, NY). 2019.  5:354-363.

Bardach, S. H., Jicha, G. A., Karanth, S., Zhang, X., & Abner, E. L. Genetic Sample Provision Among National Alzheimer's Coordinating Center Participants. Journal of Alzheimer's disease: JAD. 2019. 69(1), 123–133. 

Bayram, E., Shan, G., & Cummings, J. L. Associations between Comorbid TDP-43, Lewy Body Pathology, and Neuropsychiatric Symptoms in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2019. 69(4), 953–961. 

Besser, L. M., Mock, C., Teylan, M. A., Hassenstab, J., Kukull, W. A., & Crary, J. F. (2019). Differences in Cognitive Impairment in Primary Age-Related Tauopathy Versus Alzheimer Disease. Journal of neuropathology and experimental neurology, 78(3), 219–228.

Bowman G, Gouskova N, Dodge H, Donohue J, Bichsel A, Silbert L, Quinn J, Kaye J. Pre-Analytical and Within-Person Reproducibility of Nutritional Metabolomics over 2 Years in Elders at Risk for Dementia. Current Developments in Nutrition. 2019. 3. PMC6574566.

Bowman, G. L., Dodge, H. H., Guyonnet, S., Zhou, N., Donohue, J., Bichsel, A., Schmitt, J., Hooper, C., Bartfai, T., Andrieu, S., Vellas, B., & MAPT/DSA Study Group (2019). A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial. Alzheimer's & dementia (New York, N. Y.), 5, 953–963.

Bowman B, Silbert L, Dodge H, Lahna D, Hagen K, Murchison C, Howieson H, Kaye J, Quinn J, Shinto L. Randomized trial of n-3 polyunsaturated fatty acids for the prevention of cerebral small vessel disease and inflammation in aging (PUFA trial):  Rationale, design and baseline results. Nutrients. 2019. 11:1-18.

Burke, S. L., Hu, T., Fava, N. M., Li, T., Rodriguez, M. J., Schuldiner, K. L., Burgess, A., & Laird, A. (2019). Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. Journal of women & aging, 31(2), 140–164. 

Burke, S. L., Hu, T., Naseh, M., Fava, N. M., O'Driscoll, J., Alvarez, D., Cottler, L. B., & Duara, R. (2019). Factors influencing attrition in 35 Alzheimer's Disease Centers across the USA: a longitudinal examination of the National Alzheimer's Coordinating Center's Uniform Data Set. Aging clinical and experimental research, 31(9), 1283–1297.

Cerino ES, Hooker K, Goodrich E, Dodge HH. Personality Moderates Intervention Effects on Cognitive Function: A 6-Week Conversation-Based Intervention. The Gerontologist. 2019. PMC31112605

Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, et al. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. 2019. [Epub ahead of print].

Cho H, Matthews GJ, Harel O. Confidence Intervals for the Area Under the Receiver Operating Characteristic Curve in the Presence of Ignorable Missing Data. International Statistical Review. 2019. 87:152-177. PMC6472951.

Consel C, Kaye J. Aging with the Internet of Things. The Bridge (Spring 2019 edition: Technologies for Aging). 2019. 49:6-10, 2019. Not peer reviewed.

Croff R, Witter P, Walker M, Francois E, Quinn C, Riley T, Sharma N, J Kaye. Things Are Changing so Fast: Integrative Technology for Preserving Cognitive Health and Community History. The Gerontologist. 2019. 59:147-157. PMC6326255.

Curcio N, Wilmoth K, LoBue C, Cullum CM. Reliability of Medical History Reporting in Older Adults With and Without Cognitive Impairment. Journal of Central Nervous System Disease. 2019. 11:1179573519843874. PMC6477758.

Dallaire-Théroux, C., Beheshti, I., Potvin, O., Dieumegarde, L., Saikali, S., Duchesne, S., & Alzheimer's Disease Neuroimaging Initiative (2019). Braak neurofibrillary tangle staging prediction from in vivo MRI metrics. Alzheimer's & dementia (Amsterdam, Netherlands), 11, 599–609.

Duggan EC, Piccinin AM, Clouston S, Koval AV, Robitaille A, Zammit AR, Wu C, Brown CL, Lee LO, Finkel D, Beasley WH, Kaye J. et al. A Multi-Study Coordinated Meta-Analysis of Pulmonary Function and Cognition in Aging. The Journals of Gerontology, Series A: Biological Sciences & Medical Sciences. 2019. 

Franzmeier N, Rubinski A, Neitzel J, Ewers M. The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory. Nature Communications. 2019. 10(1):1766. PMC6467911.

Giebel, C., Flanagan, E., & Sutcliffe, C. (2019). Predictors of finance management in dementia: managing bills and taxes matters. International psychogeriatrics, 31 2, 277-286.

Goudey B, Fung BJ, Schieber C, Faux NG, Alzheimer’s Disease Metabolomics Consortium, Alzheimer’s Disease Neuroimaging Initiative. A blood-based signature of cerebrospinal fluid Abeta1-42 status. Scientific Reports. 2019. 9:4163.

Gouskova N, Bichsel A, Dodge H, Donohue J, Silbert L, Kaye J, Bowman G. Blood-based Nutritional Risk Index for Cognition in the Nutrition and Brain Aging Study (NBAS): Emphasis on n-3 PUFA, Vitamin D and Homocysteine. Current Developments in Nutrition. 2019. 3(1): P14-005-19. PMC6574722.

Grill, J. D., Kwon, J., Teylan, M. A., Pierce, A., Vidoni, E. D., Burns, J. M., Lindauer, A., Quinn, J., Kaye, J., Gillen, D. L., & Nan, B. (2019). Retention of Alzheimer Disease Research Participants. Alzheimer disease and associated disorders, 33(4), 299–306.

Gupta, Y., Lama, R. K., Kwon, G. R., & Alzheimer's Disease Neuroimaging Initiative (2019). Prediction and Classification of Alzheimer's Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers. Frontiers in computational neuroscience, 13, 72.

Han, J. Y., Besser, L. M., Xiong, C., Kukull, W. A., & Morris, J. C. (2019). Cholinesterase Inhibitors May Not Benefit Mild Cognitive Impairment and Mild Alzheimer Disease Dementia. Alzheimer disease and associated disorders, 33(2), 87–94.

Hett, K., Ta, V. T., Catheline, G., Tourdias, T., Manjón, J. V., Coupé, P., & Alzheimer’s Disease Neuroimaging Initiative (2019). Multimodal Hippocampal Subfield Grading For Alzheimer's Disease Classification. Scientific Reports, 9(1), 13845.

Horgusluoglu-Moloch, E., Risacher, S.L., Crane, P.K. et al. (2019.) Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways. Scientific Reports. 9, 14498.

Insel P, Weirner M, MacKin S, Mornino E, Lim Y, Stomrud E, Palmqvist S, Masters C, Marfuff P, Hansson O, Mattsson N. Determining clinically meaningful decline in preclinical Alzheimer disease. Neurology. 2019. 93(4):e322-e333. 

Irimata, KM, Broatch, J, Wilson, JR. (2019). Partitioned GMM logistic regression models for longitudinal data. Statistics in Medicine. 38: 2171– 2183

Katsumata, Y., Nelson, P. T., Estus, S., Alzheimer's Disease Neuroimaging Initiative (ADNI), & Fardo, D. W. (2019). Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs. Neurobiology of aging. 74, 135–146.

Kaye, J. Silbert, L. Beattie, Z. Mattek, N. et al. High compliance, continuous long-term home monitoring of sleep activity in diverse populations differentiates lower cognitive functioning older adults. Alzheimer's and Dementia. 2019. 15(7): P152-P153

Koo, K., Schweizer, T. A., Fischer, C. E., & Munoz, D. G. (2019). Abnormal Sleep Behaviours Across the Spectrum of Alzheimer's Disease Severity: Influence of APOE Genotypes and Lewy Bodies. Current Alzheimer research, 16(3), 243–250.

Kornak, J., Fields, J., Kremers, W., Farmer, S., Heuer, H. W., Forsberg, L., Brushaber, D., Rindels, A., Dodge, H., Weintraub, S., Besser, L., Appleby, B., et al. ARTFL/LEFFTDS Consortium (2019). Nonlinear Z-score modeling for improved detection of cognitive abnormality. Alzheimer's & dementia (Amsterdam, Netherlands), 11, 797–808.

Kundu, S., Lukemire, J., Wang, Y., Guo, Y., & Alzheimer’s Disease Neuroimaging Initiative (2019). A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer's Disease Data. Scientific reports, 9(1), 19589.

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau immunity and lipid processing. Nature Genetics. 2019. 51(3): 414-430.

Lee G, Nho K, Kang B, Sohn KA, Kim D, for Alzheimer’s Disease Neuroimaging Initiative. Predicting Alzheimer's disease progression using multi-modal deep learning approach. Scientific Reports. 2019. 9(1):1952.

Leoutsakos JS, Wise EA, Lyketsos CG, Smith GS. (2019). Trajectories of neuropsychiatric symptoms over time in healthy volunteers and risk of MCI and dementia. International Journal of Geriatric Psychiatry. Dec;34(12):1865-1873.

Li, Y., Yao, Z., Yu, Y., Fu, Y., Zou, Y., Hu, B., & Alzheimer’s Disease Neuroimaging Initiative (2019). The Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory. Frontiers in aging neuroscience, 11, 208.

Lindauer A, McKenzie G, LaFazia D, McNeill L, Mincks K, Spoden N, Myers M, Mattek N, Teri LL. Using Technology to Facilitate Fidelity Assessments: The Tele-STAR Caregiver Intervention. Journal of Medical Internet Research. 2019. 21(5): e13599. PMC6555120.

Liew T. M. (2019). Depression, subjective cognitive decline, and the risk of neurocognitive disorders. Alzheimer's research & therapy, 11(1), 70.

Ma, Y., Jun, G. R., Chung, J., Zhang, X., Kunkle, B. W., Naj, A. C., White, C. C., Bennett, D. A., De Jager, P. L., Alzheimer’s Disease Genetics Consortium, Mayeux, R., Haines, J. L., Pericak-Vance, M. A., Schellenberg, G. D., Farrer, L. A., & Lunetta, K. L. (2019). CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease. Aging cell, 18(4), e12964.

Mattek N, Thomas N, Sharma N, Beattie Z, Marcoe J, Dodge H, Kaye J. Home Based Digital Activity Biomarkers Remotely Monitor Relevant Activities of MCI and Alzheimer’s Disease Patients and Their Care Partners, Abstract #34490. In: Alzheimer’s Association International Conference. Forthcoming, 2019.

Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019). Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice. Antioxidants (Basel, Switzerland), 8(12), 630.

Meguro K, Dodge H. Vascular Mild Cognitive Impairment: Identifying Disease in Community- Dwelling Older Adults, Reducing Risk Factors, and Providing Support. The Osaki-Tajiri and Kurihara Projects. Journal of Alzheimer's Disease: JAD. 2019. 70(s1): S293 – S302.

Mejia Maza, A., Carmen-Orozco, R. P., Carter, E. S., Dávila-Villacorta, D. G., Castillo, G., Morales, J. D., Mamani, J., Gavídia, C. M., Alroy, J., Sterling, C. R., Gonzalez, A. E., García, H. H., Woltjer, R. L., Verástegui, M. R., Gilman, R. H., & Cysticercosis Working Group in Peru (2019). Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis. Brain pathology (Zurich, Switzerland), 29(3), 425–436.

Milani, S. A., Marsiske, M., & Striley, C. W. (2019). Discriminative Ability of Montreal Cognitive Assessment Subtests and Items in Racial and Ethnic Minority Groups. Alzheimer disease and associated disorders, 33(3), 226–232.

Miller L, Kaye J, Lyons K, Lee C, Whitlatch C, Caserta M. Well-being in dementia: a cross-sectional dyadic study of the impact of multiple dimensions of strain on persons living with dementia and their family care partners. International Psychogeriatrics. 2019. [Epub ahead of print].   

Miller, L. Beattie, Z., Kaye, J., et al. Days and nights of dyads: Examining behavioral interdependence in co-residing couples using actigraphy. Innovation in Aging. 2019. 3, S767-S767. 

Oh, G., Abner, E. L., Fardo, D. W., Freeman, P. R., & Moga, D. C. (2019). Patterns and predictors of chronic opioid use in older adults: A retrospective cohort study. PloS one, 14(1), e0210341.

Opel, R. A., Christy, A., Boespflug, E. L., Weymann, K. B., Case, B., Pollock, J. M., Silbert, L. C., & Lim, M. M. (2019). Effects of traumatic brain injury on sleep and enlarged perivascular spaces. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 39(11), 2258–2267.

Perales-Puchalt, J., Gauthreaux, K., Flatt, J., Teylan, M. A., Resendez, J., Kukull, W. A., Chan, K., Burns, J., & Vidoni, E. D. (2019). Risk of dementia and mild cognitive impairment among older adults in same-sex relationships. International journal of geriatric psychiatry, 34(6), 828–835.

Piau A, Mattek N, Crissey R, Beattie Z, Dodge H, Kaye J. When will my patient fall? Sensor-based in-home walking speed identifies future falls in older adults. The Journals of Gerontology, Series A: Biological Sciences & Medical Sciences. 2019. [Epub ahead of print].

Piau A, Mattek N, Duncan C, Sharma N, Riley T, Kaye J. The five W's of falls - weekly online health survey of community-dwelling older adults: analysis of four years prospective follow-up. The Journals of Gerontology, Series A: Biological Sciences & Medical Sciences. 2019. [Epub ahead of print].

Piau A, Wild K. Performance of eHealth devices for frailty evaluation in real life settings is far from being demonstrated. Gerontology. 2019. 65(3): 309-310.

Piau A, Wild K, Mattek N, Kaye J. Current state of digital biomarker technologies for real life in-home monitoring of cognitive function for MCI to mild AD and implications for clinical care: systematic review. Journal of Medical Internet Research. 2019. 21(8):e12785.   

Puzo, C., Labriola, C., Sugarman, M. A., Tripodis, Y., Martin, B., Palmisano, J. N., Steinberg, E. G., Stein, T. D., Kowall, N. W., McKee, A. C., Mez, J., Killiany, R. J., Stern, R. A., & Alosco, M. L. (2019). Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer's Coordinating Center Uniform Data Set. Alzheimer's research & therapy, 11(1), 64.

Qian W, Schweizer TA, Churchill NW, et al. (2019.) Gray Matter Changes Associated With the Development of Delusions in Alzheimer Disease. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry. May;27(5):490-498.

Saif MW, Parikh R, Ray D, Kaye JA, Kurosky SK, Thomas K, Ramirez RA, Halfdanarson TR, Beveridge TJR, Mirakhur B, Nagar SP, Soares HP. Medical record review of transition to lanreotide following octreotide for neuroendocrine tumors. Journal of Gastrointestinal Oncology. 2019. 10(4): 674-687.

Sano M, Zhu CW, Kaye J, Mundt JC, Hayes TL, Ferris S, Thomas RG, Sun CK, Jiang Y, Donohue MC, et al. A randomized clinical trial to evaluate home-based assessment of people over 75 years old. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2019. [Epub ahead of print].

Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, Weston LJ, Owen N, Weissman TA, Luna E. et al. Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Scientific Reports. 2019. 9(1): 10919.

Schenning K, Murchison C, Mattek N, Kaye J, Quinn J. Sex and genetic differences in postoperative cognitive dysfunction: a longitudinal cohort analysis. Biology of Sex Differences. 2019. 10:14.

Schwartz, D. L., Boespflug, E. L., Lahna, D. L., Pollock, J., Roese, N. E., & Silbert, L. C. (2019). Autoidentification of perivascular spaces in white matter using clinical field strength T1 and FLAIR MR imaging. NeuroImage, 202, 116126.

Specketer K, Zabetian CP, Edwards KL, Tian L, Quinn JF, Peterson-Hiller AL, Chung KA, Hu SC, Montine TJ, Cholerton BA. Visuospatial functioning is associated with sleep disturbance and hallucinations in nondemented patients with Parkinson's disease. Journal of Clinical and Experimental Neuropsychology. 2019. 41(8): 803-813.

Stasenko, A., Jacobs, D. M., Salmon, D. P., & Gollan, T. H. (2019). The Multilingual Naming Test (MINT) as a Measure of Picture Naming Ability in Alzheimer's Disease. Journal of the International Neuropsychological Society : JINS, 25(8), 821–833.

Sternberg Z, Podolsky R, Nir A, Yu J, Nir R, Halvorsen SW, Chadha K, Quinn JF, Kaye J, Kolb C. Increased free prostate specific antigen serum levels in Alzheimer's disease, correlation with cognitive decline. Journal of Neurological Sciences. 2019. 400:188-193.  

Stuart S, Belluscio V, Quinn JF, Mancini M. Pre-frontal cortical activity during walking and turning Is reliable and differentiates across young, older adults and people with Parkinson's disease. Frontiers in Neurology. 2019. 10:536. PMC6540937.

Sugarman, M. A., McKee, A. C., Stein, T. D., Tripodis, Y., Besser, L. M., Martin, B., Palmisano, J. N., Steinberg, E. G., et al. (2019). Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association, 15(5), 686–698.

Sullivan KJ, Liu A, Dodge HH, Andreescu C, Chang CH, Ganguli M. Depression Symptoms Declining Among Older Adults: Birth Cohort Analyses From the Rust Belt. The American Journal of Geriatric Psychiatry. 2019. [Epub ahead of print].

Teylan, M., Besser, L. M., Crary, J. F., Mock, C., Gauthreaux, K., Thomas, N. M., Chen, Y. C., & Kukull, W. A. (2019). Clinical diagnoses among individuals with primary age-related tauopathy versus Alzheimer's neuropathology. Laboratory investigation; a journal of technical methods and pathology, 99(7), 1049–1055.

Thomas NWD, Lindauer A, Kaye J. EVALUATE-AD and Tele-STAR: Novel Methodologies for Assessment of Caregiver Burden in a Telehealth Caregiver Intervention - A Case Study. Dementia and Geriatric Cognitive Disorders. 2019. 47(3): 176-184.

Umegaki, H., Makino, T., Uemura, K., Shimada, H., Cheng, X. W., Dodge, H., & Kuzuya, M. (2020). Falls in community-dwelling prefrail older adults. Health & social care in the community, 28(1), 110–115.

van Dyck CH, Nygaard HB, Chen K, Donohue MC, Raman R, Rissman RA, Brewer JB, Koeppe RA, Chow TW, Rafii MS, Gessert D, Choi J, Turner RS, Kaye JA, et al. Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurology. 2019. [Epub ahead of print].

Varatharajah Y, Ramanan VK, Iyer R, Vemuri P, Alzheimer's Disease Neuroimaging Initiative. Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics. Scientific Reports. 2019. 9(1): 2235.

Vöglein, J., Paumier, K., Jucker, M., Preische, O., McDade, E., Hassenstab, J., Benzinger, T. L., Noble, J. M., Berman, S. B., et al. Dominantly Inherited Alzheimer Network (2019). Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease. Brain: a journal of neurology, 142(5), 1429–1440.

Wang Y, Haaksma ML, Ramakers I, Verhey FRJ, van de Flier WM, Scheltens P, van Maurik I, Olde Rikkert MGM, Leoutsakos JS, Melis RJF. Cognitive and functional progression of dementia in two longitudinal studies. International Journal of Geriatric Psychiatry. 2019. [Epub ahead of print].   

Werry, A. E., Daniel, M., & Bergström, B. (2019). Group differences in normal neuropsychological test performance for older non-Hispanic White and Black/African American adults. Neuropsychology, 33(8), 1089–1100.

Wiedrick, J. T., Phillips, J. I., Lusardi, T. A., McFarland, T. J., Lind, B., Sandau, U. S., Harrington, C. A., Lapidus, J. A., Galasko, D. R., Quinn, J. F., & Saugstad, J. A. (2019). Validation of MicroRNA Biomarkers for Alzheimer's Disease in Human Cerebrospinal Fluid. Journal of Alzheimer's disease: JAD, 67(3), 875–891.

Wild, K. Mattek, N. Sharma, N. Marcoe, J. Wall, R. Kaye, J. Use of technology by four diverse cohorts of older adults: Findings from the CART study. Innovation in Aging. 2019. 3(Suppl 1): S328. 

Wingo, T. S., Cutler, D. J., Wingo, A. P., Le, N. A., Rabinovici, G. D., Miller, B. L., Lah, J. J., & Levey, A. I. (2019). Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB. JAMA neurology, 76(7), 809–817.

Wise EA, Rosenberg PB, Lyketsos CG, Leoutsakos JM. Time course of neuropsychiatric symptoms and cognitive diagnosis in National Alzheimer's Coordinating Centers volunteers. Alzheimer’s & Dementia (Amsterdam, Netherlands). 2019. 11:333-339.

Yang Z, Zhuang X, Bird C, Sreenivasan K, Mishra V, Banks S, Cordes D. Performing sparse regularization and dimension reduction simultaneously in multimodal data fusion. Frontiers in Neuroscience. 2019. 13:642.

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Jun G., et al.,  A Novel Alzheimer Disease Locus Located Near the Gene Encoding Tau Protein. Molecular Psychiatry. 2016. 21(1): 108-117.

Karch C, Ezerskiy LA, Bertelsen S, Goate A.  Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One. 2016. 11(2) :e0148717.

Kryscio R,. et al.,  The Effect of Vascular Neuropathology on Late-Life Cognition: Results from the SMART Project. The Journal of Prevention of Alzheimer's Disease. 2016. 3(2): 85-91.

Lindauer A, Harvath T, Berry P, Wros P.  The Meanings African American Caregivers Ascribeto Dementia-Related Changes: The Paradox of Hanging on to Loss. The Gerontologist. 2016. 56(4): 733-742.

Liu H, Zhou X, Jiang H, He H, Liu X.  A Semi-Mechanism Approach Based on MRI and Proteomics for Prediction of Conversion from Mild Cognitive Impairment to Alzheimer's Disease. Scientific Reports. 6: 26712.

Mancini M, Schlueter H, El-Gohary M, Mattek N, Duncan C, Kaye J, Horak F.  Continuous Monitoring of Turning Mobility and Its Association to Falls and Cognitive Function: A Pilot Study. The Journals of Gerontology: Series A, Biological Sciences and Medical Sciences. 2016. 71(8): 1102-1108.

Mazzo F, Zwart R, Serratto G, Gardinier K, Porter W, Reel J, Maraula G, Sher E.  Reconstitution of Synaptic Ion Channels from Rodent and Human Brain in Xenopus Oocytes: a Biochemical and Electrophysiological Characterization. Journal of Neurochemistry. 2016. 138(3): 384-396.

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Monsell A, Dodge H, Zhou A, Bu Y, Besser L, Mock C, Hawes S, Kukull W, Weintraub A.  Results from the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study. Alzheimer's Disease and Associated Disorders. 2016. 30(2): 134-139.

Nishihira J, Tokashiki T, Higashiuesato Y, Willcox D, Mattek N, Shinto L, Ohya Y, Dodge H.  Associations between Serum Omega-3 Fatty Acid Levels and Cognitive Functions among Community-Dwelling Octogenarians in Okinawa, Japan: The KOCOA Study. Journal of Alzheimer's Disease. 2016. 51(3): 857-866.

Petersen J, Kaye J, Jacobs P, Quinones A, Dodge H, Arnold A, Thielke S.  Longitudinal Relationship Between Loneliness and Social Isolation in Older Adults: Results From the Cardiovascular Health Study. Journal of Aging and Health. 2016. 28(5):775-795.

Promjunyakul N, Lahna D, Kaye J, Dodge H, Erten-Lyons D, Rooney W, Silbert L.  Comparison of Cerebral Blood Flow and Structural Penumbras in Relation to White Matter Hyperintensities: A Multi-Modal Magnetic Resonance Imaging Study. Journal of Cerebral Blood Flow and Metabolism. 2016. 36(9): 1528-1536.

Quinn J.  Gene-Environment Interactions in Dementia-: Not Just Another Fish Story. Neurology. 2016. 86(22): 2069.

Quinn J.  Do Omega-3 Fatty Acids Regulate Cerebral beta Amyloid? JAMA Neurology. 2016. 73(10): 1183-1184.

Rana R, Austin A, Jacobs P, Karunanithi M, Kaye J. Gate Velocity Estimation Using Time-Interleaved Between Consecutive Passive IR Sensor Activations. IEEE Sensors Journal. 2016. 16(16): 6351-6358.

Ridge P, Hoyt K, Boehme K, Mukherjee S, Crane P, Haines J, Mayeux R, Farrer L, Pericak-Vance M, Schellenberg G, Kauwe J. Assessment of the Genetic Variance of Late-Onset Alzheimer's Disease. Neurobiology of Aging. 2016. 41: 200.

Ringman J, et al.,  Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. Journal of Neuropathology and Experimental Neurology. 2016. 75(3): 284-290.

Ronquillo J, Baer M, Lester W. Sex-Specific Patterns and Differences in Dementia and Alzheimer's Disease Using
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Schenning K, Murchison C, Mattek N, Silbert L, Kaye J, Quinn J.  Surgery is Associated with Ventricular Enlargement as Well as Cognitive and Functional Decline. Alzheimer's and Dementia: The Journal of the Alzheimer's Association. 2016.12(5): 590-597.

Seelye A, Mattek N, Howieson D, Austin D, Wild K, Dodge H, Kaye J.  Embedded Online Questionnaire Measures are Sensitive to Identifying Mild Cognitive Impairment. Alzheimer Disease and Associated Disorders. 2016. 30(2):152-159.

Shi M, et al.,  CNS Tau Efflux via Exosomes is Likely Increased in Parkinson's Disease but not in Alzheimer Disease. Alzheimer's and Dementia: The Journal of the Alzheimer's Association. 2016. 12(11): 1125-1131.

Silbert L, Dodge H, Lahna D, Promjunyakul N, Austin D, Mattek N, Erten-Lyons D, Kaye J.  Less Daily Computer Use is Related to Smaller Hippocampal Volumes in Cognitively Intact Elderly. Journal of Alzheimer's Disease. 2016. 52(2): 713-717.

Sundermann E, Biegon A, Rubin L, Lipton R, Mowrey W, Landau S, Maki P. Better Verbal Memory in Women Than Men in MCI Despite Similar Levels of Hippocampal Atrophy. Neurology. 2016. 86(15): 1368-1376.

Teipel S, Babiloni C, Hoey J, Kaye J, Kirste T, Burmeister O.  Information and Communication Technology Solutions for Outdoor Navigation in Dementia. Alzheimers and Dementia: The Journal of the Alzheimer's Association. 2016. 12(6): 695-707.

Wahbeh H, Goodrich E., Oken, B.  Internet Mindfulness Meditation for Cognition andMood in Older Adults: A Pilot Study. Alternative Therapies in Health and Medicine. 2015. 22(2): 44–53.

Yassine H, Rawat V, Mack W, Quinn J, Yurko-Mauro K, Bailey-Hall E, Aisen P, Chui H, Schneider L.  The Effect of APOE Genotype on the Delivery of DHA to Cerebrospinal Fluid in Alzheimer's Disease. Alzheimers Research and Therapy. 2016. 8:25.

Zhu F, Panwar B, Dodge H, Li H, Hampstead B, Albin R, Paulson H, Guan Y.  COMPASS: A Computational Model to Predict Changes in MMSE Scores 24-Months After Initial Assessment of Alzheimer's Disease. Scientific Reports. 2016. 6: 34567.

Abner, E., et al., The Statistical Modeling of Aging and Risk of Transition Project: Data Collection and Harmonization Across 11 Longitudinal Cohort Studies of Aging, Cognition, and Dementia. Observational Studies. 2015. 1(2015): 56-73.

Akl A, Taati B, & Mihailidis A. Autonomous Unobtrusive Detection of Mild Cognitive Impairment in Older Adults. IEEE Transactions on Bio-Medical Engineering. 2015. 62(5): 1383–1394.

Albers M., et al., At the Interface of Sensory and Motor Dysfunctions and Alzheimer's Disease. Alzheimer's and Dementia: The Journal of the Alzheimer's Association. 2015. 11(1): 70-98.

Allen M, Kachadoorian M, Quicksall Z, et al. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2015. 11(6): 658-71.

Apostolova L, et al., Brain Amyloidosis Ascertainment from Cognitive, Imaging, and Peripheral Blood Protein Measures. Neurology. 2015. 84(7): 729-737.

Austin D, Dinwoodie I. Monomials and Basin Cylinders for Network Dynamics. SIAM Journal on Applied Dynamical Systems. 2015. 14(1): 25-42.

Austin J, Kaye J, Austin D, Mattek N. Time Out-of-Home and Cognitive, Physical, and Emotional Wellbeing of Older Adults: A Longitudinal Mixed Effects Model. PLoS One.2015.10(10):e0139643.

Brendel M, Hogenauer M, Delker A, Sauerbeck J, Bartenstein P, Seibyl J, Rominger A,. Improved Longitudinal [(18)F]-AV45 Amyloid PET by White Matter Reference and VOI-Based Partial Volume Effect Correction. NeuroImage.2015.108:450-459.

Caroli A,. et al., Mild Cognitive Impairment with Suspected Nonamyloid Pathology (SNAP): Prediction of Progression. Neurology. 2015.84(5): 508-515.

Chamine, I., & Oken, B. S. Expectancy of Stress-Reducing Aromatherapy Effect and Performance on a Stress-Sensitive Cognitive Task. Evidence-Based Complementary and Alternative Medicine: eCAM. 2015.419812.

Chung E, Babulal G, Monsell S, Cairns N, Roe C, Morris J. Clinical Features of Alzheimer Disease With and Without Lewy Bodies. JAMA Neurology. 72(7): 789-796.

Dodge H, Kaye J, Mattek N, Bowman M, Gregor M, Ybarra' O, Wild K. Web-Enabled Conversational Interactions as a Means to Improve Cognitive Functions: Results of a 6-Week Randomized Controlled Trial. Alzheimer's & Dementia: Translational Research & Clinical Interventions.2015.1(1):1-12.

Dodge H, MattekN, Gregor M, Bowman M, Seelye A, Ybarra O, Asgari M, Kaye J. Social Markers of Mild Cognitive Impairment: Proportion of Word Counts in Free Conversational Speech. Current Alzheimer Research.2015.12(6):513-519.

Dodge H, Zhu J, Mattek N, Austin D, Kornfeld J, Kaye J. Use of High-Frequency In-Home Monitoring Data May Reduce Sample Sizes Needed in Clinical Trials. PLoS One.2015. 10(9): e0138095.

Erten-Lyons D, Silbert L. Depressive Symptoms are Associated with Late Life Cognitive Decline Independent of Common age-Related Pathologies. Evidence-Based Mental Health. 2015.18(2): 50.

Favela J, Kaye J, Skubic M, Rantz M, Tentori M. Living Labs for Pervasive Healthcare Research. IEEE Pervasive Computing. 2015.14(2): 86-89.

Frisoni, G. et al., The EADC-ADNI Harmonized Protocol for Hippocampal Segmentation on Magnetic Resonance: Evidence of Validity.Alzheimer's and Dementia : The Journal of the Alzheimer's Association. 2015. 11(2):111-125.

Gray N, Sampath H, Zweig J, Quinn J, Soumyanath A. Centella asiatica Attenuates Amyloid-beta-Induced Oxidative Stress and Mitochondrial Dysfunction. Journal of Alzheimer's Disease. 2015. 45(3): 933-946.

Hibar D., et al., Common Genetic Variants Influence Human Subcortical Brain Structures. Nature.2015.520(7546):224-229.

Howieson D, Mattek N, Dodge H, Erten-Lyons D, Zitzelberger T, Kaye J. Memory Complaints in the Older Adults:Prognostic Value and Stability in Reporting Over Time. SAGE Open Medicine. 2015. 3.

Jacobs P, Kaye J. Ubiquitous Real-World Sensing and Audiology-Based Health Informatics. Journal of theAmerican Academy ofAudiology. 2015. 26(9):777-783.

Jones L., et al., Convergent Genetic and Expression DataImplicate Immunity in Alzheimer's Disease. Alzheimer's and Dementia: The Journal of the Alzheimer's Association. 2015. 11(6): 658-671.

Li G, Xiong K, Korff A, Pan C, Quinn J, Galasko D, Liu C, Montine T, Peskind E, Zhang J. Increased CSF E-Selectin in Clinical Alzheimer's Disease without Altered CSF Abeta42 and Tau. Journal of Alzheimer's Disease.2015.47 (2015): 883-887.

Lunsford R, Heeman P. Using Linguistic Indicators of Difficulty to Identify Mild Cognitive Impairment. 16th Annual Conference of the International Speech Communication Association, INTERSPEECH. 2015. 658-662.

Lyons B, Austin D, Seelye A, Petersen J, Yeargers J, Riley T, Sharma N, Mattek N, Wild K, Dodge H, Kaye J. Pervasive Computing Technologies to Continuously Assess Alzheimer's Disease Progression and Intervention Efficacy. Frontiers inAging Neuroscience.2015. 7:102.

Mattsson N, Insel P, Aisen P, Jagust W, Mackin S, Weiner M. Brain Structure and Function as Mediators of the Effects of Amyloid on Memory. Neurology. 2015.84(11): 1136-1144.

Osterberg V, Spinelli K, Weston L, Luk K, Woltjer R, Unni V. Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism. Cell Reports.2015.10(8):1252-1260.

Pan C, Korff A, Galasko D, Ginghina C, Peskind E, Li G, Quinn J, Montine TJ, Cain K, Shi M, Zhang J. Diagnostic Values of Cerebrospinal Fluid T-Tau and Abeta(4)(2) using Meso Scale Discovery Assays for Alzheimer's Disease. Journal of Alzheimer's Disease. 2015. 45(3): 709-719.

Petersen J, Thielke S, Austin D, Kaye J. Phone Behavior and its Relationship to Loneliness in Older Adults. Aging and Mental Health. 2015. 20(10): 1084-1091.

Promjunyakul N, Lahna D, Kaye J, Dodge H, Erten-Lyons D, Rooney W, Silbert L. Characterizing the White Matter Hyperintensity Penumbra with Cerebral Blood Flow Measures. NeuroImage: Clinical.2015.8: 224-229.

Quinn J.,etal., Extracellular RNAs: Development as Biomarkers of Human Disease. JournalofExtracellular Vesicles. 2015. 4: 27495.

Romero K,.et al., The Future is Now: Model-Based Clinical Trial Design for Alzheimer's Disease. Clinical Pharmacology andTherapeutics. 2015.97(3):210-214.

Sachdev P,.et al., The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. PLoS One.2015. 10(11):e0142388.

Schreiber S, Landau S, Fero A, Schreiber F, Jagust W. Comparison of Visual and Quantitative Florbetapir F 18 Positron Emission Tomography Analysis in Predicting Mild Cognitive Impairment Outcomes. JAMA Neurology.2015.72(10):1183-1190.

Seelye A, Mattek N, Howieson D, Riley T, Wild K, Kaye J. The Impact of Sleep on Neuropsychological Performance in Cognitively Intact Older Adults Using a Novel In-Home Sensor-Based Sleep Assessment Approach. The Clinical Neuropsychologist. 2015. 29(1): 53-66.

Seelye A, Mattek N, Kaye J, Wild K, Howieson H, Dodge H, Hagler S. Computer Mouse Movement Patterns: A Potential Marker of Mild Cognitive Impairment. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2015. 1(4): 472-480.

Wang L, et al., Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States. JAMA Neurology.2015.72(2):209-216.

Wild K, Mattek N, Austin D, Kaye J. Are you sure?: Lapses in Self-Reported Activities Among Healthy Older Adults Reporting Online. Journal of Applied Gerontology. 2015. 35 (6): 627-641.

Wood P, Barnette B, Kaye J, Quinn J, Woltjer R. Non-Targeted Lipidomics of CSF and Frontal Cortex Grey and White Matter in Control, Mild Cognitive Impairment, and Alzheimer's Disease Subjects. Acta Neuropsychiatra. 2015. 27(5): 270-278.

Wood P, Medicherla S, Sheikh N, Terry B, Phillipps A, Kaye J, Quinn J, Woltjer R. Targeted Lipidomics of Fontal Cortex and Plasma Diacylglycerols (DAG) in Mild Cognitive Impairment and Alzheimer's Disease: Validation of DAG Accumulation Early in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's Disease.2015.48(2):537-546.

Allen M, Kachadoorian M, Quicksall Z, et al. Association of MAPT Haplotypes with Alzheimer's Disease Risk and MAPT Brain Gene Expression Levels. Alzheimer's Research and Therapy. 2014. 6:39.

Anderson V, Obayashi J, Kaye J, Quinn J, Berryhill P, Riccelli L, Peterson D, Rooney, W. Longitudinal Relaxographic Imaging of White Matter Hyperintensities in the Elderly. Fluids and Barriers of the CNS. 2014. 11: 24.

Austin D, Cross R, Hayes T, Kaye J. Regularity and Predictability of Human Mobility in Personal Space. PLoS One. 2014. 9(2): e90256.

Boise L. Ethnicity and Dementia. In: Downs M, Bowers B, eds. Excellence in Dementia Care: Research into practice, 2nd edition. Berkshire, England: McGraw Hill, 2014.

Davis M, Currey J, Howk S, DeSordi M, Boise L, Fagnan L, Vuckovic N. A Qualitative Study of Rural Primary Care Clinician Views on Remote Monitoring Technologies. The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association.2014.30(1):10.1111.

Davis M, Freeman M, Kaye J, Vuckovic N, Buckley D. A Systematic Review of Clinician and Staff Views on the Acceptability of Incorporating Remote Monitoring Technology into Primary Care. Telemed JournalandE-Health.2014. 20(5): 428-438.

Dodge H, Katsumata Y, Zhu J, Mattek N, Bowman B, Gregor B, Wild K, Kaye J. Characteristics Associated with Willingness to Participate in a Randomized Controlled Behavioral Clinical Trial using Home-Based Personal Computers and a Webcam. Trials.2014.15:508.

Dodge H, Zhu J, Harvey D, Saito N, Silbert L, Kaye J, Koeppe R, Albin R. Biomarker Progressions Explain Higher Variability in Stage-Specific Cognitive Decline than Baseline Values in Alzheimer Disease. Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association.2014.10(6): 690-703.

Dodge H, Ybarra O, Kaye J. Tools for Advancing Research into Social Networks and Cognitive Function in Older Adults. International Psychogeriatrics.2014. 26(4): 533-539.

Dodge H, Zhu J, Lee C, Chang C, Ganguli M. Cohort Effects in Age-Associated Cognitive Trajectories. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences.2014.69(6):687-694.

Hagler S, Jimison H, Pavel M. Assessing executive function using a computer game: Computational modeling of 
cognitive processes. IEEE Journal of Biomedical and Health Informatics. 2014. 18(4): 1442-1452.

Escott-Price V, et al., Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease. PLoS One.2014.9(6):e94661.

Fonareva I, Oken BS. Physiological and Functional Consequences of Caregiving for Relatives with Dementia. International Psychogeriatrics.2014. 26(5): 725-747.

Frisoni G, et al., The EADC-ADNI Harmonized Protocol for Manual Hippocampal Segmentation on Magnetic Resonance: Evidence of Validity. Alzheimer's and Dementia:The Journalof theAlzheimer'sAssociation. 2014. Epub. Sep. 27.

Gallagher M,etal., TMEM106B is a Genetic Modifier of Frontotemporal Lobar Degeneration with C9orf72 Hexanucleotide Repeat Expansions. Acta Neuropathologica. 2014. 127(3): 407-418.

Gray N, Morre J, Kelley J, Maier C, Stevens J, Quinn J, Soumyanath A. Caffeoylquinic Acids in Centella Asiatica Protect Against Amyloid-beta Toxicity. Journal of Alzheimer's Disease. 2014. 40(2): 359-373.

Harris C, Voss K, Murchison C, Ralle M, Frahler K, Carter R, Rhoads A, Lind B, Robinson E, Quinn J. Oral Zinc Reduces Amyloid Burden in Tg2576 Mice. Journal of Alzheimer's Disease. 2014. 41(1): 179-192.

Harrison F, Bowman G, Polidori M. Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline. Nutrients. 2014. 6(4): 1752-1781.

Hill-Burns E, Wissemann W, Hamza T, Factor S, Zabetian C, Payami H. Identification of a Novel Parkinson's Disease Locus via Stratified Genome-Wide Association Study. BMC Genomics.2014.Feb10(15):118.

Jacobs P, Wan E, Schafermeyer E, Adenwala F, Paul A, Preiser N, Kaye J. Measuring In-Home Walking Speed using Wall-Mounted RF Transceiver Arrays. Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE. 2014.Aug. 2014: 914-917.

Kaye J, Mattek N, Dodge H, Campbell I, Hayes T, Austin D, Hatt W, Wild K, Jimison H, Pavel M. Unobtrusive Measurement of Daily Computer Use to Detect Mild Cognitive Impairment. Alzheimer's and Dementia:The Journalof theAlzheimer'sAssociation.2014. 10(1): 10-17.

Kilgour A, Todd O, Starr J. A Systematic Review of the Evidence that Brain Structure is Related to Muscle Structure and Their Relationship to Brain and Muscle Function in Humans over the Lifecourse. BMC Geriatrics. 2014. 14: 85.

Li G. et al., Cross-Sectional and Longitudinal Relationships Between Cerebrospinal Fluid Biomarkers and Cognitive Function in People Without Cognitive Impairment from Across the Adult Life Span. JAMA Neurology. 2014. 71(6): 742-751.

Linnertz C, et al., The Cis-Regulatory Effect of an Alzheimer's Disease-Associated Poly-T Locus on Expression of TOMM40 and Apolipoprotein E Genes. Alzheimer's and Dementia: The Journal of the Alzheimer's Association. 2014. 10(5): 541-551.

Miller L, Dieckmann N, Mattek N, Lyons K, Kaye J. Social Activity Decreases Risk of Placement in a Long-Term Care Facility for a Prospective Sample of Community-Dwelling Older Adults. Research inGerontological Nursing.2014. 7(3): 106-112.

Naj A,etal., Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease:A Genome-Wide Association Study. JAMA Neurology. 2014. 71 (11): 1394-1404.

Nelson J, Young J, Borkar R, Woltjer R, Quinn J, Silbert L, Grafe M, Alkayed N. Role of Soluble Epoxide Hydrolase in Age-Related Vascular Cognitive Decline. Prostaglandins and Other Lipid Mediators. 2014.113-115: 30-37.

Peskind E, Li G, Shofer J, Millard S, Leverenz J, Yu C, Raskind M, Quinn J, Galasko D, Montine T. Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain.JAMA Neurology. 2014. 71(9):1150-1154.

Petersen J, Austin D, Kaye J, Pavel M, Hayes T. Unobtrusive In-Home Detection of Time Spent Out-of-Home with Applications to Loneliness and Physical Activity. IEEE Journal of Biomedical and Health Informatics. 2014. 18(5):1590-1596.

Shinto L, Quinn J, Montine T, Dodge HH, Woodward W, Baldauf-Wagner S, Waichunas D, Bumgarner L, Bourdette D, Silbert L, Kaye J. A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease. Journal of Alzheimer's Disease.2014.38(1):111-120.

Stark A, Shafran I, Kaye J. Inferring Social Nature of Conversations from Words:Experiments on a Corpous of Everyday Telephone Conversations. Computer Speech and Language. 2014. 28(1): 224-239.

Thielke S, Mattek N, Hayes T, Dodge H, Quinones A, Austin D, Petersen J, Kaye J. Associations Between Observed In-Home Behaviors and Self-Reported Low Mood in Community-Dwelling Older Adults. Journal of the American Geriatrics Society. 2014.62 (4): 685-689.

Wang L,et al. Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States. JAMA Neurology. 2014.72(2): 209-16.

Wertheimer AM, Bennett MS, Park B, Uhrlaub JL, Martinez C,Pulko V, Currier NL, Nikolich-Zugich D, Kaye J, Nikolich-Zugich J. Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans. Journal of Immunology. 2014. 192 (5): 2143-2155.

Wild K, Musser E. The Cambridge Neuropsychological Test Automated Battery in the Assessment of Executive Functioning. Handbook of Executive Functioning: Springer. 2014: 171-190.

Beattie ZT, Hayes TL, Guilleminault C, Hagen CC. Accurate scoring of the apnea-hypopnea index using a simple non-contact breathing sensor. Journal of Sleep Research 22:356-362, 2013.  PMC3641178.

Boise L, Wild K, Mattek N, Ruhl M, Dodge H, Kaye J. Willingness to share data and privacy concerns of Older Adults after exposure to unobtrusive In-home Monitoring. Gerontechnology 11:428-435, 2013.  PMC3604979.

Bowman G, Dodge H, Mattek N, Barbey A, Silbert L, Shinto L, Howieson D, Kaye J, Quinn J. Plasma omega 3 PUFA and white matter mediated executive decline in older adults.  . Frontiers in Aging Neuroscience 5, 2013.  PMC3863786.

Davis M, Freeman M, Kaye J, Vuckovic N, Buckley D. A systematic review of clinician and staff views of the acceptability and feasibility of incorporating remote monitoring technologies into primary care. Telemedicine and e-Health, Forthcoming, 2013.
Dodge H, Ybara O, Kaye J. Tools for advancing research into social networks and cognitive functions in older adults. International Psychogeriatrics International Psychogeriatrics 23:1-7, 2013.

Eskildsen SF, Coupe P, Garcia-Lorenzo D, Fonov V, Pruessner JC, Collins DL. Prediction of Alzheimer's disease in subjects with mild cognitive impairment from the ADNI cohort using patterns of cortical thinning. Neuroimage 65:511-521, 2013.   

Fjell A, McEvoy L, Holland D, Dale A, Walhovd K. Brain changes in older adults at very low risk for Alzheimer's disease. Journal of Neuroscience 33:8237-8242, 2013.  PMC3570420
Fonareva I, Oken B. Physiological and functional consequences of caregiving for relatives with dementia. International Psychogeriatrics. International Psychogeriatrics, Forthcoming, 2013.

Frisoni G, Bocchetta M, Chételat G, Rabinovici G, de Leon M, Kaye J, Reiman E, Scheltens P, Barkhof F, Black S, Brooks D, Carrillo M, Fox N, Herholz K, Nordberg A, Jack C, Jagust W, Johnson K, Rowe C, Sperling R, Thies W, Wahlund L, Weiner M, Pasqualetti P, DeCarli C. Imaging Markers for Alzheimer’s Disease: Which versus How. Neurology 81:5, 2013.  PMC3776529.

Gray KR, Aljabar P, Heckemann RA, Hammers A, Rueckert D. Random forest-based similarity measures for multi-modal classification of Alzheimer's disease. Neuroimage 65:167-175, 2013.  PMC3516432.
Hayes T, Riley T, Mattek N, Pavel M, Kaye J. Sleep Habits in Mild Cognitive Impairment. Alzheimer Disease and Associated Disorders, Forthcoming, 2013.

Hogarth P, Gregory A, Kruer MC, Sanford L, Wagoner W, Natowicz MR, Egel RT, Subramony SH, Goldman JG, Berry-Kravis E, Foulds NC, Hammans SR, Desguerre I, Rodriguez D, Wilson C, Diedrich A, Green S, Tran H, Reese L, Woltjer RL, Hayflick SJ. New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN. Neurology 80:268-275, 2013.  PMC3589182.

Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, Crehan H, Gibbs JR, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Ramirez-Restrepo M, Engel A, Myers AJ, Corneveaux JJ, Huentelman MJ, Dillman A, Cookson MR, Reiman EM, Singleton A, Hardy J, Guerreiro R, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach TG, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Cotman CW, Crane PK, Crocco EA, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dickson DW, Duara R, Ellis WG, Ertekin-Taner N, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Naj AC, Nowotny P, Parisi JE, Peskind E, Petersen RC, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Shelanski ML, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Valladares O, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Ann Hum Genet 77:85-105, 2013.  PMC3578142.

Huckans M, Hutson L, Twamley E, Jak A, Kaye J, Storzbach D. Efficacy of Cognitive Rehabilitation Therapies for Mild Cognitive Impairment (MCI) in Older Adults: Working Toward a Theoretical Model and Evidence-Based Interventions. Neuropsychol Rev 23:63-80, 2013.  PMC3640648.

Katsumata Y, Todoriki H, Higashiuesato Y, Yasura S, Ohya Y, Willcox DC, Dodge HH. Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA Project. Journal of Alzheimer's Disease 34:273-279, 2013.  PMC3586553.

Kaye J, Dodge H, Hayes T, Mattek N, Howieson D, Austin D, H J, Pavel M. Person-specific change in home computer use predicts the development of mild cognitive impairment (MCI). In: AAIC, 2013.

Klein EP, Kaye J. Dementia specialists and early adoption of amyloid imaging. Journal of Alzheimer's Disease 33:445-450, 2013.  PMC3640311.

Kurtz T, Mogle J, Sliwinski MJ, Hofer SM. Individual differences in task-specific paired associates learning in older adults: the role of processing speed and working memory. Exp Aging Res 39:493-514, 2013.  PMC3891359.

Linnertz C, Anderson L, Gottschalk W, Crenshaw D, Lutz M, Allen J, Saith S, Mihovilovic M, Burke J, Welsh-Bohmer K, Roses A, Chiba-Falek O. The cis-regulatory effect of an Alzheimer’s disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes. Alzheimer's and Dementia, Forthcoming, 2013.

Liu Y, Mattila J, Ruiz MA, Paajanen T, Koikkalainen J, van Gils M, Herukka SK, Waldemar G, Lotjonen J, Soininen H. Predicting AD conversion: comparison between prodromal AD guidelines and computer assisted PredictAD tool. PLoS One 8:e55246, 2013.  PMC3570420.

Martinez-Murcia FJ, Gorriz JM, Ramirez J, Puntonet CG, Illan IA. Functional activity maps based on significance measures and Independent Component Analysis. Comput Methods Programs Biomed 111:255-268, 2013.

Millard SP, Lutz F, Li G, Galasko DR, Farlow MR, Quinn JF, Kaye JA, Leverenz JB, Tsuang D, Yu CE, Peskind ER, Bekris LM. Association of cerebrospinal fluid Abeta with A2M gene in cognitively normal subjects. Neurobiology of Aging, 2013.  PMC3859300.

Miller JA, Woltjer RL, Goodenbour JM, Horvath S, Geschwind DH. Genes and pathways underlying regional and cell type changes in Alzheimer's disease. Genome Med 5:48, 2013.  PMC3706780.

Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One 8:e58618, 2013.  PMC3614978.

Nation D, Edland S, Bondi M, Salmon D, Delano-Wood L, Peskind E, Quinn J, Galasko D. Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults? Neurology 81:2024-2027, 2013.  PMC3854831.

Nikolich-Zugich J, Bennett M, Park B, Currier N, Uhrlaub J, Vesnam P, Martinez C, Kaye J, Wertheimer A. Aging and cytomegalovirus (CMV) infection differentially and jointly affect distinct circulating T cell subsets in humans. Journal of Immunology, Forthcoming, 2013. 

Pavel M, Jimison HB, Wactlar HD, Hayes TL, Barkis W, Skapik J, Kaye J. The role of technology and engineering models in transforming healthcare. IEEE Rev Biomed Eng 6:156-177, 2013.

Petersen J, Austin D, Kaye J, Pavel M, Hayes T. Unobtrusive in-home detection of time spent out-of-home with applications to loneliness and physical activity. IEEE Journal of Biomedical and Health Informatics, Forthcoming, 2013.

Quinn JF. Biomarkers for Alzheimer's disease: showing the way or leading us astray? Journal of Alzheimer's Disease 33:S371-376, 2013.  PMC3587291.

Rajagopalan P, Toga AW, Jack CR, Weiner MW, Thompson PM. Fat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly. NeuroReport 24:58-62, 2013.  PMC3635486.

Ramaker JM, Swanson TL, Copenhaver PF. Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration. J Neurosci 33:10165-10181, 2013.  3682380.

Rana R, Austin D, Jacobs P, Karunanithi M, Kaye J. Passive In-home Estimation of Gait Velocity From Motion Sensors. Forthcoming, 2013. 

Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4,and the risk of late-onset Alzheimer disease in African Americans. JAMA: The Journal of the American Medical Association 309:1483-1492, 2013.  PMC3667653.

Reitz C, Mayeux R. TREM2 and neurodegenerative disease. N Engl J Med 369:1564-1565, 2013.

Reitz C, Tosto G, Vardarajan B, Rogaeva E, Ghani M, Rogers RS, Conrad C, Haines JL, Pericak-Vance MA, Fallin MD, Foroud T, Farrer LA, Schellenberg GD, George-Hyslop PS, Mayeux R. Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP). Translational Psychiatry 3:e256, 2013.  PMC3669917.

Ridge P, Mukherjee S, Crane P, Kauwe J, Consortium AsDG. Alzheimer's disease: Analyzing the missing heritability. PLoS One, Forthcoming, 2013.

Rosso AL, Studenski SA, Chen WG, Aizenstein HJ, Alexander NB, Bennett DA, Black SE, Camicioli R, Carlson MC, Ferrucci L, Guralnik JM, Hausdorff JM, Kaye J, Launer LJ, Lipsitz LA, Verghese J, Rosano C. Aging, the central nervous system, and mobility. J Gerontol A Biol Sci Med Sci 68:1379-1386, 2013.  PMC3805295.

Scimemi A, Meabon JS, Woltjer RL, Sullivan JM, Diamond JS, Cook DG. Amyloid-beta1-42 slows clearance of synaptically released glutamate by mislocalizing astrocytic GLT-1. J Neurosci 33:5312-5318, 2013.

Tong T, Wolz R, Coupe P, Hajnal JV, Rueckert D. Segmentation of MR images via discriminative dictionary learning and sparse coding: application to hippocampus labeling. Neuroimage 76:11-23, 2013.

Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, Irwin DJ, Rick J, Schellenberg GD, Watson GS, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Quinn JF, Chung KA, Yearout D, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP. APOE 4 Increases Risk for Dementia in Pure Synucleinopathies. JAMA Neurol 70:223-228, 2013.  PMC3580799.

Umegaki H, Takechi H, Dodge HH. Care for Alzheimer's Disease. Int J Alzheimers Dis 2013:516852, 2013.  PMC3654367.

Wild K, Mattek N, Stone B, Kaye J. Self-reported activity in older adults: Challenges and innovations. In: Alzheimer Association International Conference. July ed. Boston, MA: Alzheimer's & Dementia, 2013: P342.

Wu X, Li J, Ayutyanont N, Protas H, Jagust W, Fleisher A, Reiman E, Yao L, Chen K. The receiver operational characteristic for binary classification with multiple indices and its application to the neuroimaging study of Alzheimer's disease. IEEE/ACM Trans Comput Biol Bioinform 10:173-180, 2013.

Wyman BT, Harvey DJ, Crawford K, Bernstein MA, Carmichael O, Cole PE, Crane PK, DeCarli C, Fox NC, Gunter JL, Hill D, Killiany RJ, Pachai C, Schwarz AJ, Schuff N, Senjem ML, Suhy J, Thompson PM, Weiner M, Jack CR, Jr. Standardization of analysis sets for reporting results from ADNI MRI data. Alzheimers Dement 9:332-337, 2013.

Aggarwal NT, Tripathi M, Dodge HH, Alladi S, Anstey KJ. Trends in Alzheimer's disease and dementia in the asian-pacific region. Interntational Journal of Alzheimers Disease 2012:171327, 2012.  PMC3523465.

Anderson V, Lenar D, Berryhill P, Quinn J, Kaye J, Rooney W. Quantitative 7T detection of gadoteridol in the ventricles of the aging human brain Proceedings of the International Society for Magentic Resonane in Medicine 20:3760, 2012.  PMC Journal in Process.

Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A 109:3985-3990, 2012.  PMC3309762.

Bekris L, Lutz F, Li G, Galasko D, Farlow M, Quinn J, Kaye J, Leverenz J, Tsuang D, Montine T, Peskind E, Yu C. ADAM10 expression and promoter haplotype in Alzheimer's disease. Neurobiology of Aging 33:2229e2221-2229e2229, 2012.  PMC3391324.

Bekris LM, Millard S, Lutz F, Li G, Galasko DR, Farlow MR, Quinn JF, Kaye JA, Leverenz JB, Tsuang DW, Yu CE, Peskind ER. Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 159B:874-883, 2012.

Bjorklund NL, Reese LC, Sadagoparamanujam VM, Ghirardi V, Woltjer RL, Taglialatela G. Absence of amyloid beta oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer's disease neuropathology. Mol Neurodegener 7:23, 2012.  PMC3403985.

Bonner-Jackson A, Okonkwo O, Tremont G, Initiative AsDN. Apolipoprotein E epsilon2 and functional decline in amnestic mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry 20:584-593, 2012.  PMC3188382.

Bowman GL. Ascorbic acid, cognitive function, and Alzheimer's disease: A current review and future direction. Biofactors 38:114-122, 2012.

Bowman GL, Kaye JA, Quinn JF. Dyslipidemia and blood-brain barrier integrity in Alzheimer's disease. Curr Gerontol Geriatr Res 2012:184042, 2012.  PMC3359662.

Bowman GL, Silbert LC, Howieson D, Dodge HH, Traber MG, Frei B, Kaye JA, Shannon J, Quinn JF. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology 78:241-249, 2012.  PMC3280054.

Chu C, Hsu AL, Chou KH, Bandettini P, Lin C. Does feature selection improve classification accuracy? Impact of sample size and feature selection on classification using anatomical magnetic resonance images. Neuroimage 60:59-70, 2012.

Damoiseaux JS, Seeley WW, Zhou J, Shirer WR, Coppola G, Karydas A, Rosen HJ, Miller BL, Kramer JH, Greicius MD. Gender modulates the APOE epsilon4 effect in healthy older adults: convergent evidence from functional brain connectivity and spinal fluid tau levels. Journal of Neuroscience 32:8254-8262, 2012.  PMC3394933.

Desikan RS, McEvoy LK, Thompson WK, Holland D, Brewer JB, Aisen PS, Sperling RA, Dale AM. Amyloid-beta--associated clinical decline occurs only in the presence of elevated P-tau. Archives of Neurology 69:709-713, 2012.  PMC3423526.

Dodge HH, Mattek NC, Austin D, Hayes TL, Kaye JA. In-home walking speeds and variability trajectories associated with Mild Cognitive Impairment. Neurology 78:1946-1952, 2012.  PMC3369505.

Erten-Lyons D, Dodge H, Woltjer R, Silbert L, Howieson D, Kramer P, Kaye J. Neuropathological Basis of Age-Associated Brain Atrophy. Archives of Neurology, Forthcoming, 2012.  NIHMS#440270.

Erten-Lyons D, Sherbakov LO, Piccinin AM, Hofer SM, Dodge HH, Quinn JF, Woltjer RL, Kramer PL, Kaye JA. Review of selected databases of longitudinal aging studies. Alzheimers and Dementia 8:584-589, 2012.  PMC3483563.

Fonareva I, Amen A, Ellison R, Oken B. Differences in stress-related ratings between research center and home environments in dementia caregivers using ecological momentary assessment. International Psychogeriatrics 24:90-98, 2012.  PMC3353126.

Fried-Oken M, Rowland C, Daniels D, Dixon M, Fuller B, Mills C, Noethe G, Small J, Still K, Oken B. AAC to Support Conversation in Persons with Moderate Alzheimer's Disease. Augment Altern Commun 28:219-231, 2012.

Gagyi E, Kormos B, Castellanos KJ, Valyi-Nagy K, Korneff D, LoPresti P, Woltjer R, Valyi-Nagy T. Decreased oligodendrocyte nuclear diameter in Alzheimer's disease and Lewy body dementia. Brain Pathology 22:803-810, 2012.  PMC Journal in Process.

Galasko DR, Peskind E, Clark CM, Quinn JF, Ringman JM, Jicha GA, Cotman C, Cottrell B, Montine TJ, Thomas RG, Aisen P. Antioxidants for Alzheimer Disease: A Randomized Clinical Trial With Cerebrospinal Fluid Biomarker Measures. Archives of Neurology, 2012.

Gibbons C, Oken B, Fried-Oken M. Augmented input reveals word deafness in a man with frontotemporal dementia. Behav Neurol 25:151-154, 2012.  PMC3552095.

Haley GE, Berteau-Pavy F, Berteau-Pavy D, Raber J. Novel image-novel location object recognition task sensitive to age-related cognitive decline in nondemented elderly. Age (Dordr) 34:1-10, 2012.  PMC3260359.

Han SD, Gruhl J, Beckett L, Dodge HH, Stricker NH, Farias S, Mungas D. Beta amyloid, tau, neuroimaging, and cognition: sequence modeling of biomarkers for Alzheimer's Disease. Brain Imaging Behav, 2012.

Holland D, Desikan RS, Dale AM, McEvoy LK. Rates of decline in Alzheimer disease decrease with age. PLoS One 7:e42325, 2012.  PMC3410919.

Hurko O, Black SE, Doody R, Doraiswamy PM, Gamst A, Kaye J, Obisesan TO, Rusinek H, Scharre D, Sperling R, Weiner MW, Green RC. The ADNI Publication Policy: commensurate recognition of critical contributors who are not authors. Neuroimage 59:4196-4200, 2012.

Irizarry MC, Jin S, He F, Emond JA, Raman R, Thomas RG, Sano M, Quinn JF, Tariot PN, Galasko DR, Ishihara LS, Weil JG, Aisen PS. Incidence of new-onset seizures in mild to moderate Alzheimer disease. Archives of Neurology 69:368-372, 2012.

Johnstone D, Milward EA, Berretta R, Moscato P. Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease neuroimaging initiative (ADNI) plasma proteome dataset. PLoS One 7:e34341, 2012.  PMC3317783.

Jun G, Vardarajan BN, Buros J, Yu CE, Hawk MV, Dombroski BA, Crane PK, Larson EB, Mayeux R, Haines JL, Lunetta KL, Pericak-Vance MA, Schellenberg GD, Farrer LA. Comprehensive search for Alzheimer disease susceptibility loci in the APOE region. Archives of Neurology 69:1270-1279, 2012.  PMC3579659.

Katsumata Y, Todoriki H, Higashiuesato Y, Yasura S, Ohya Y, Wilcox D, Dodge H. Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA project. Journal of Alzheimer's Disease, Forthcoming, 2012.  NIHMS# 442202.

Katsumata Y, Todoriki H, Higashiuesato Y, Yasura S, Willcox D, Ohya Y, Willcox B, Dodge H. Metabolic Syndrome and Cognitive Decline among the Oldest-Old in Okinawa: in Search of a Mechanism. The KOCOA Project. The Journal of Gerontology: Biological Sciences 67:126-134, 2012.  PMC3261441.

Klein EP, Kaye J. Dementia Specialists and Early Adoption of Amyloid Imaging. Journal of Alzheimer's Disease, 2012.  Not funded by the NIH.

Koikkalainen J, Polonen H, Mattila J, van Gils M, Soininen H, Lotjonen J. Improved classification of Alzheimer's disease data via removal of nuisance variability. PLoS One 7:e31112, 2012.  PMC3278425.

Martin ZS, Neugebauer V, Dineley KT, Kayed R, Zhang W, Reese LC, Taglialatela G. alpha-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. J Neurochem 120:440-452, 2012.  PMC3253169.

Mata IF, Checkoway H, Hutter CM, Samii A, Roberts JW, Kim HM, Agarwal P, Alvarez V, Ribacoba R, Pastor P, Lorenzo-Betancor O, Infante J, Sierra M, Gomez-Garre P, Mir P, Ritz B, Rhodes SL, Colcher A, Van Deerlin V, Chung KA, Quinn JF, Yearout D, Martinez E, Farin FM, Wan JY, Edwards KL, Zabetian CP. Common variation in the LRRK2 gene is a risk factor for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 2012.

Mattila J, Koikkalainen J, Virkki A, van Gils M, Lotjonen J. Design and application of a generic clinical decision support system for multiscale data. IEEE Transactions on Biomedical Engineering 59:234-240, 2012.

Meyer DJ, Messer J, Singh T, Thomas PJ, Woyczynski WA, Kaye J, Lerner AJ. Random local temporal structure of category fluency responses. J Comput Neurosci 32:213-231, 2012.

Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kovari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology 71:362-381, 2012.

Petersen J, Larimer N, Kaye J, Pavel M, Hayes T. SVM to detect the presence of visitors in a smart home environment Engineering in Medicine and Biology Society:5850-5853, 2012.

Peterson A, Mattek N, Clemons A, Bowman G, Buracchio T, Kaye J, Quinn J. Serum vitamin D concentrations are associationed with falling and cognitive function in older adults. The Journal of Nutrition, Health & Aging 16:898-901, 2012.  PMC3593063.

Rasmussen JM, Lakatos A, van Erp TG, Kruggel F, Keator DB, Fallon JT, Macciardi F, Potkin SG. Empirical derivation of the reference region for computing diagnostic sensitive (1)(8)fluorodeoxyglucose ratios in Alzheimer's disease based on the ADNI sample. Biochim Biophys Acta 1822:457-466, 2012. 

Reitz C, Tosto G, Vardarajan B, Rogaeva E, Robert R, Christopher C, Haines J, Pericak-Vance M, Fallin M, Foroud T, Farrer L, Schellenberg G, St. George-Hyslop P, Mayeux R, Consortium AsDG. Independent and epistatic effects of variants in VPS10 sortilin receptors on Alzheimer’s disease risk and processing of the amyloid precursor protein (APP). Annal of Neurology, Forthcoming, 2012.

Rodgers MM, Cohen ZA, Joseph L, Rossi W. Workshop on personal motion technologies for healthy independent living: executive summary. Archives of Physical Medicine and Rehabilitation 93:935-939, 2012.

Seelye AM, Wild KV, Larimer N, Maxwell S, Kearns P, Kaye JA. Reactions to a remote-controlled video-communication robot in seniors' homes: a pilot study of feasibility and acceptance. Telemed J E Health 18:755-759, 2012.  PMC3523242.

Silbert LC, Dodge HH, Perkins LG, Sherbakov L, Lahna D, Erten-Lyons D, Woltjer R, Shinto L, Kaye JA. Trajectory of white matter hyperintensity burden preceding mild cognitive impairment. Neurology 79:741-747, 2012.  PMC3421153.

Silver M, Montana G. Fast identification of biological pathways associated with a quantitative trait using group lasso with overlaps. Stat Appl Genet Mol Biol 11:Article 7, 2012.  PMC3491888.

Soumyanath A, Zhong YP, Henson E, Wadsworth T, Bishop J, Gold BG, Quinn JF. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action. International Journal of Alzheimer's Disease 2012:9 pages, 2012.  PMC3296229.

Stark A, Shafran I, Kaye J. Hello, Who is Calling?:  Can Words Reveal the Social Nature of Conversations? . In: Proceedings of the 2012 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies; Montreal, Canada: The Association for Computational Linguistics, Forthcoming, 2012: 112-119.

Stricker NH, Dodge HH, Dowling NM, Han SD, Erosheva EA, Jagust WJ. CSF biomarker associations with change in hippocampal volume and precuneus thickness: implications for the Alzheimer's pathological cascade. Brain Imaging Behav, 2012.  PMC Journal in Process.
Tractenberg RE, Yumoto F, Aisen PS, Kaye JA, Mislevy RJ. Using the Guttman Scale to Define and Estimate Measurement Error in Items over Time: The Case of Cognitive Decline and the Meaning of "Points Lost". PLoS One 7:e30019, 2012.  PMC3281811.

Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Trojanowski JQ, Schellenberg GD, Yearout D, Huston H, Fritts-Penniman A, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP. GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology. Neurology 79:1944-1950, 2012.  PMC3484986.

Wild K, Mattek N, Maxwell S, Dodge H, Jimison H, Kaye J. Computer related self-efficacy and anxiety in older adults with and without mild cognitive impairment. Alzheimer’s & Dementia 8:544-552, 2012.  PMC3483565

Yuan L, Wang Y, Thompson PM, Narayan VA, Ye J. Multi-source feature learning for joint analysis of incomplete multiple heterogeneous neuroimaging data. Neuroimage 61:622-632, 2012.  PMC3358419.

Zou F, Chai HS, Younkin CS, Allen M, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Kouri N, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet 8:e1002707, 2012.  PMC3369937.

Anderson V, Lenar D, Quinn J, Rooney W. The blood -brain barrier adn microvascular water exchange in Alzheimer's disease. Cardiovascular Psychiatry and Neurology, 2011: 615829, 2011. PMC3114411

Anekonda T, Wadsworth T, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn J. Phytic acid as a potential treatment for Alzheimer's pathology:  Evidence from animal and in vitro models. Journal of Alzheimer's Disease 23:21-35, 2011.  PMC3021000.

Austin D, Hayes TL, Kaye J, Mattek N, Pavel M. On the Disambiguation of Passively Measured In-home Gait Velocities from Multi-person Smart Homes. J Ambient Intell Smart Environ 3:165-174, 2011.  PMC3093199

Austin D, Jimison H, Hayes T, Mattek N, Kaye J, Pavel M. Measuring motor speed through typing: a surrogate for the finger tapping test. Behav Res Methods, 43(4):903-909, 2011.  PMC3151309

Bowman GL, Shannon J, Ho E, Traber MG, Frei B, Oken BS, Kaye JA, Quinn JF. Reliability and Validity of Food Frequency Questionnaire and Nutrient Biomarkers in Elders With and Without Mild Cognitive Impairment. Alzheimer Disease and Associated Disorders 25:49-57, 2011.  PMC3042482.

Britschgi M, Rufibach K, Bauer S, Clar C, Kaye J, Li G, Peskind E, Quinn J, Galasko D, Wyss-Coray T. Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome. Molecular & Cellular Proteomics, Forthcoming, 2011. PMC3205866

Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL, 3rd, Brooks WS, Halliday GM, Kril JJ, Gearing M, Beach TG, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Pickering-Brown SM, Snowden J, van Swieten JC, Heutink P, Seelaar H, Murrell JR, Ghetti B, Spina S, Grafman J, Kaye JA, Woltjer RL, Mesulam M, Bigio E, Llado A, Miller BL, Alzualde A, Moreno F, Rohrer JD, Mackenzie IR, Feldman HH, Hamilton RL, Cruts M, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bird TD, Cairns NJ, Goate A, Frosch MP, Riederer PF, Bogdanovic N, Lee VM, Trojanowski JQ, Van Deerlin VM. Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Archives of Neurology 68:488-497, 2011.  PMC3160280

Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Jr., Weiner MW. Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes. Radiology 259:844-851, 2011.  PMC3099048.

Copenhaver PF, Anekonda TS, Musashe D, Robinson KM, Ramaker JM, Swanson TL, Wadsworth TL, Kretzschmar D, Woltjer RL, Quinn JF. A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug. Dis Model Mech, 2011.  PMC3180227

Dodge H, Chang C, Kamboh I, Ganguli M. Risk of Alzheimer’s Disease Incidence Attributable to Vascular Disease in the Population.  . Alzheimer’s & Dementia 7:356-360, 2011.  PMC21575878.

Elias-Sonnenschein LS, Viechtbauer W, Ramakers IH, Verhey FR, Visser PJ. Predictive value of APOE-{varepsilon}4 allele for progression from MCI to AD-type dementia: a meta-analysis. Journal of Neurology, Neurosurgery, and Psychiatry, 2011.  PMC Journal in Process.

Erten-Lyons D, Wilmot B, Anur P, McWeeney S, Westaway S, Silbert L, Kramer P, Kaye J. Microcephaly Genes and Risk of Late-onset Alzheimer Disease. Alzheimer Disease and Associated Disorders, 25(3): 276-282, 2011.  PMC3136560

Evans DA, Grodstein F, Loewenstein D, Kaye J, Weintraub S. Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 2. Alzheimers Dement 7:110-123, 2011.  PMC3033654.

Fonareva I, Amen A, Zajdel D, Ellingson R, Oken B. Assessing sleep architecture in demential caregivers at home using an ambulatory polysomnographic system. Journal of Geriatric Psychiatry and Neurology 24:50-59, 2011.  NIHMSID#371227

Fried-Oken M, Rowland C, Oken B. Evidence to support augmentative communication treatment for primary progressive aphasia. In: Neurology, 2011: A76.

Howieson D, Mattek N, Seelye A, Dodge H, Wasserman D, Zitzelberger T, Kaye J. Serial Position Effects in Mild Cognitive Impairment. Journal of Clinical and Experimental Neuropsychology 2:1-8, 2011.  PMC3058855.
Hurko O, Black S, Doody R, Doraiswamy P, Gamst A, Kaye J, Obisesan T, Rusinek H, Scharre D, Sperling R, Weiner M, Green R. The ADNI Publication Policy:  Commensurate recognition of critical contributors who are not authors. Neuroimage, Forthcoming, 2011.  PMC Journal in Process.

Katsumata Y, Todoriki H, Higashiuesato Y, Yasura S, Willcox D, Ohya Y, Willcox B, Dodge H. Metabolic Syndrome and Cognitive Decline among the Oldest-Old in Okinawa: in Search of a Mechanism. The KOCOA Project. The Journal of Gerontology: Biological Sciences, 67(2): 126-134, 2011.  PMC3261441

Kaye, J, Mattek N, Dodge H, Buracchio T, Austin D, Hagler S, Pavel M, Hayes T. One Walk a Year to 1000 Within a Year: Continuous In-home Unobtrusive Gait Assessment of Older Adults. Gait and Posture, 35(2): 197-202, 2011. PMC3278504
 
Kaye J, Maxwell S, Mattek N, Hayes T, Dodge H, Pavel M, Jimison H, Wild K, Boise L, Zitzelberger T. Intelligent systems for assessing aging changes: Home-based, unobtrusive, and continuous assessment of aging. Journal of Gerontology:  Psychological Sciences, 66 Suppl 1, i180-i190, 2011.  PMC3132763

Kim S, Swaminathan S, Shen L, Risacher SL, Nho K, Foroud T, Shaw LM, Trojanowski JQ, Potkin SG, Huentelman MJ, Craig DW, DeChairo BM, Aisen PS, Petersen RC, Weiner MW, Saykin AJ. Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology 76:69-79, 2011.  PMC2964649

Lu Z, Leen TK, Kaye J. Kernels for longitudinal data with variable sequence length and sampling intervals. Neural Comput 23:2390-2420, 2011.  PMC Journal in Process

Montine TJ, Peskind ER, Quinn JF, Wilson AM, Montine KS, Galasko D. Increased Cerebrospinal Fluid F(2)-Isoprostanes are Associated with Aging and Latent Alzheimer's Disease as Identified by Biomarkers. Neuromolecular Medicine 13:37-42, 2011.  PMC3000441

Naj A, Jun  G, G B, L W, Vardarajan B, Buros J, Gallins P, Buxbaum  J, Jarvik G, Crane P, Larson E, Bird T, Boeve B, Graff-Radford N, De Jager P, Evans D, Schneider J, Carrasquillo M, Ertekin-Taner N, Younkin S, Cruchaga C, Kauwe J, Nowotny P, Kramer P, Hardy J, Huentelman M, Myers A B, M , Demirci F, Baldwin C, Green R, Rogaeva E, P G-H, Consortium ADG. Common variants in MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics, 2011.  PMC3090745

Oken B, Amen A. Electroencephalography and Evoked Potentials in Geriatrics. In: Knoefe lJ, Albert M, eds. Clinical Neurology of Aging: Oxford University Press; 113-127, 2011.

Oken B, Fonareva I, Wahbeh H. Stress-related cognitive dysfunction in dementia caregivers. In: Neurology, 2011: A511.

Oken B, Fonareva I, Wahbeh H. Stress-related cognitive dysfunction in dementia caregivers. Journal of Geriatric Psychiatry and Neurology, 24(4): 191-198,  2011. NIHMSID#370251

Perrin R, Craig-Schapiro R, Malone J, Shah A, Gilmore P, David A, Roe C, Peskind E, Li G, Galasko D, Clark C, Quinn J, Kaye J, Morris J, Holtzman D, Townsend R, Fagan A. Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease. PLoS ONE 6:e16032, 2011.  PMC3020224

Roark B, Mitchell M, Hosom J, Hollingshead K, Kaye J. Spoken language derived measures for detecting mild cognitive impairment. Transactions on Audio, Speech and Language Processing, 19(7):2081-2090, 2011.  PMC3244269

Shulman JM, Chipendo P, Chibnik LB, Aubin C, Tran D, Keenan BT, Kramer PL, Schneider JA, Bennett DA, Feany MB, De Jager PL. Functional Screening of Alzheimer Pathology Genome-wide Association Signals in Drosophila. The American Journal of Human Genetics 88:232-238, 2011.  PMC3035702

Snyder PJ, Jackson CE, Petersen RC, Khachaturian AS, Kaye J, Albert MS, Weintraub S. Assessment of cognition in mild cognitive impairment: A comparative study. Alzheimers Dement 7:338-355, 2011.  PMC Journal in Process.

Sonnen J, Santa Cruz K, Hemmy L, Woltjer R, Leverenz J, Montine K, Jack C, Kaye J, Lim K, Larson E, White L, Montine T. Ecology of aging human brain. Archives of Neurology 68:1049-1056, 2011.  PMC3218566

Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH. Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging and the Alzheimer's Association workgroup. Alzheimers Dement, 2011. PMC3220946

Tosun D, Schuff N, Mathis C, Jagust W, Weiner M, Alzheimer's Disease Neuroimaging Initiative . Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment.  Brain 134:1077-1088, 2011.  PMC3069703

Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Despres S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477:90-94, 2011. PMC3170097
 
Wang Y, Hancock AM, Bradner J, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Zabetian CP, Kim HM, Leverenz JB, Montine TJ, Ginghina C, Edwards KL, Snapinn KW, Goldstein DS, Shi M, Zhang J. Complement 3 and factor h in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy. The American Journal of Pathology 178:1509-1516, 2011.  PMC Journal in Process.  PMC3078443

Katsumata Y, Todoriki H, Yasura S, Dodge H. Timed Up & Go Test Predicts Cognitive Decline among Healthy Elderly Aged 80 and Older in Okinawa: KOCOA project. Journal of American Geriatrics Society,59(11): 2188-2189, 2011. PMC3291095

Austin D, Leen T, Hayes TL, Kaye J, Jimison H, Mattek N, Pavel M. Model-based inference of cognitive processes from unobtrusive gait velocity measurements. Conference Proceedings : Engineering in Medicine and Biology Society 1:5230-5233, 2010.

Boise L, Eckstrom E, Fagnan L, King A, Goubaud M, Buckley DI, Morris C. The rural older adult memory (ROAM) study: A practice-based intervention to improve dementia screening and diagnosis. Journal of the American Board of Family Medicine 23:486-498, 2010.  PMC Journal in Progress.

Bowman GL, Shannon J, Frei B, Kaye JA, Quinn JF. Uric acid as a CNS antioxidant. Journal of Alzheimer's Disease 19:1331-1336, 2010.  PMC2859185.

Bowman GL, Shannon J, Ho E, Traber MG, Frei B, Oken BS, Kaye JA, Quinn JF. Reliability and Validity of Food Frequency Questionnaire and Nutrient Biomarkers in Elders With and Without Mild Cognitive Impairment. Alzheimer Disease and Associated Disorders, 2010. PMC3042482

Buracchio T, Arvanitakis Z, Leurgans S, Bennett DA. Parkinsonian signs and incident falls in older persons without Parkinson's disease. In: Journal of the American Geriatrics Society. 2010/02/04 ed, 2010: 205-206.

Buracchio T, Dodge H, Howieson D, Wasserman D, Kaye J. The trajectory of gait speed preceding mild cognitive impairment. Archives of Neurology 67:980-986, 2010.  PMC2921227.

Chaves ML, Camozzato AL, Kohler C, Kaye J. Predictors of the progression of dementia severity in brazilian patients with Alzheimer's disease and vascular dementia. Int J Alzheimer Dis 2010, 2010.  PMC2925083.

Craig-Schapiro R, Perrin RJ, Roe CM, Xiong C, Carter D, Cairns NJ, Mintun MA, Peskind ER, Li G, Galasko DR, Clark CM, Quinn JF, D'Angelo G, Malone JP, Townsend RR, Morris JC, Fagan AM, Holtzman DM. YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry 68:903-912, 2010.  PMC3011944.

Dodge HH, Katsumata Y, Todoriki H, Yasura S, Willcox DC, Bowman GL, Willcox B, Leonard S, Clemons A, Oken BS, Kaye JA, Traber MG. Comparisons of Plasma/Serum Micronutrients Between Okinawan and Oregonian Elders: A Pilot Study. J Gerontol A Biol Sci Med Sci, 2010.  PMC3031451

Hare J. Trafficking of amyloid beta-precursor protein products C83 and C99 on the endocytic pathway. Biochem Biophys Res Commun 401:219-224, 2010.  PMC Journal In Process.

Hayes TL, Riley T, Pavel M, Kaye JA. Estimation of rest-activity patterns using motion sensors. Conference Proceedings : Engineering in Medicine and Biology Society 1:2147-2150, 2010. PMC3057896

Ho AJ, Stein JL, Hua X, Lee S, Hibar DP, Leow AD, Dinov ID, Toga AW, Saykin AJ, Shen L, Foroud T, Pankratz N, Huentelman MJ, Craig DW, Gerber JD, Allen AN, Corneveaux JJ, Stephan DA, DeCarli CS, DeChairo BM, Potkin SG, Jack CR, Jr., Weiner MW, Raji CA, Lopez OL, Becker JT, Carmichael OT, Thompson PM. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A 107:8404-8409, 2010.  PMC2889537.

Hong Z, Shi M, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Zabetian CP, Leverenz JB, Baird G, Montine TJ, Hancock AM, Hwang H, Pan C, Bradner J, Kang UJ, Jensen PH, Zhang J. DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain 133:713-726, 2010.  PMC2842513.

Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P, Arnold SE, Baldwin CT, Barber R, Beach T, Bigio EH, Bird TD, Boxer A, Burke JR, Cairns N, Carroll SL, Chui HC, Clark DG, Cotman CW, Cummings JL, Decarli C, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Gearing M, Geschwind DH, Ghetti B, Gilman S, Giordani B, Glass J, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman A, Lopez OL, Mack WJ, Markesbery W, Marson DC, Martiniuk F, Masliah E, McKee AC, Mesulam M, Miller JW, Miller BL, Miller CA, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon W, Quinn JF, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Smith CD, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Woltjer RL, Younkin SG, Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD. Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes. Archives of Neurology, 67(12): 1473-1484, 2010. PMC3048805

Kramer PL, Xu H, Woltjer RL, Westaway SK, Clark D, Erten-Lyons D, Kaye JA, Welsh-Bohmer KA, Troncoso JC, Markesbery WR, Petersen RC, Turner RS, Kukull WA, Bennett DA, Galasko D, Morris JC, Ott J. Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study. Neurobiology of Aging, 32(12): 2113-2122, 2010. PMC2990809.

Kruer MC, Koch TK, Bourdette DN, Chabas D, Waubant E, Mueller S, Moscarello MA, Dalmau J, Woltjer RL, Adamus G. Nmda receptor encephalitis mimicking seronegative neuromyelitis optica. Neurology 74:1473-1475, 2010.  PMC2872802.

Montine TJ, Peskind ER, Quinn JF, Wilson AM, Montine KS, Galasko D. Increased Cerebrospinal Fluid F(2)-Isoprostanes are Associated with Aging and Latent Alzheimer's Disease as Identified by Biomarkers. Neuromolecular Medicine [Epub ahead of print, 2010.  NIHMS203909.

Montine TJ, Shi M, Quinn JF, Peskind ER, Craft S, Ginghina C, Chung KA, Kim H, Galasko DR, Jankovic J, Zabetian CP, Leverenz JB, Zhang J. CSF Abeta(42) and tau in Parkinson's disease with cognitive impairment. Movement Disorders : Official Journal of the Movement Disorder Society, 25(15): 2682-2685, 2010.  PMC2978754

Quinn JF, Harris CJ, Cobb KE, Domes C, Ralle M, Brewer G, Wadsworth TL. A Copper-Lowering Strategy Attenuates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease, 2010.  PMC2931577.

Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR, Jr., Weiner M, Shinto L, Aisen PS. Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA: The Journal of the American Medical Association 304:1903-1911, 2010.  PMC3259852

Shi M, Zabetian CP, Hancock AM, Ginghina C, Hong Z, Yearout D, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Leverenz JB, Zhang J. Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson disease. Neurosci Lett,480(1): 78-82, 2010. PMC2943649

Silbert LC, Kaye J. Neuroimaging and cognition in Parkinson's disease dementia. Brain Pathology 20:646-653, 2010.  NIHMS# 165062.

Sonnen JA, Montine KS, Quinn JF, Breitner JC, Montine TJ. Cerebrospinal Fluid Biomarkers in Mild Cognitive Impairment and Dementia. Journal of Alzheimer's Disease 19:301-309, 2010.  PMC2891184.

Subramanian S, Ayala P, Wadsworth TL, Harris CJ, Vandenbark AA, Quinn JF, Offner H. CCR6: A Biomarker for Alzheimer's-like Disease in a Triple Transgenic Mouse Model. Journal of Alzheimer's Disease, 22(2): 619-629, 2010. PMC2988888

Takechi H, Dodge HH. Scenery Picture Memory Test: a new type of quick and effective screening test to detect early stage Alzheimer's disease patients. Geriatr Gerontol Int 10:183-190, 2010.  PMC2892033.

Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, 3rd, Ferrer I, Llado A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, de Munain AL, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, Decarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tunon MT, Martinez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics 43:234-239, 2010.  PMC2828525.

Wolk DA, Dickerson BC, Weiner M, Aiello M, Aisen P, Albert MS, Alexander G, Anderson HS, Anderson K, Apostolova L, Arnold S, Ashford W, Assaly M, Asthana S, Bandy D, Bartha R, Bates V, Beckett L, Bell KL, Benincasa AL, Bergman H, Bernick C, Bernstein M, Black S, Blank K, Borrie M, Brand C, Brewer J, Brown AD, Burns JM, Cairns NJ, Caldwell C, Capote H, Carlsson CM, Carmichael O, Cellar JS, Celmins D, Chen K, Chertkow H, Chowdhury M, Clark D, Connor D, Correia S, Crawford K, Dale A, de Leon MJ, De Santi SM, Decarli C, Detoledo-Morrell L, Devous M, Diaz-Arrastia R, Dolen S, Donohue M, Doody RS, Doraiswamy PM, Duara R, Englert J, Farlow M, Feldman H, Felmlee J, Fleisher A, Fletcher E, Foroud TM, Foster N, Fox N, Frank R, Gamst A, Given CA, 2nd, Graff-Radford NR, Green RC, Griffith R, Grossman H, Hake AM, Hardy P, Harvey D, Heidebrink JL, Hendin BA, Herring S, Honig LS, Hosein C, Robin Hsiung GY, Hudson L, Ismail MS, Jack CR, Jr., Jacobson S, Jagust W, Jayam-Trouth A, Johnson K, Johnson H, Johnson N, Johnson KA, Johnson S, Kachaturian Z, Karlawish JH, Kataki M, Kaye J, Kertesz A, Killiany R, Kittur S, Koeppe RA, Korecka M, Kornak J, Kozauer N, Lah JJ, Laubinger MM, Lee VM, Lee TY, Lerner A, Levey AI, Longmire CF, Lopez OL, Lord JL, Lu PH, Macavoy MG, Malloy P, Marson D, Martin-Cook K, Martinez W, Marzloff G, Mathis C, Mc-Adams-Ortiz C, Mesulam M, Miller BL, Mintun MA, Mintzer J, Molchan S, Montine T, Morris J, Mulnard RA, Munic D, Nair A, Neu S, Nguyen D, Norbash A, Oakley M, Obisesan TO, Ogrocki P, Ott BR, Parfitt F, Pawluczyk S, Pearlson G, Petersen R, Petrella JR, Potkin S, Potter WZ, Preda A, Quinn J, Rainka M, Reeder S, Reiman EM, Rentz DM, Reynolds B, Richard J, Roberts P, Rogers J, Rosen A, Rosen HJ, Rusinek H, Sabbagh M, Sadowsky C, Salloway S, Santulli RB, Saykin AJ, Scharre DW, Schneider L, Schneider S, Schuff N, Shah RC, Shaw L, Shen L, Silverman DH, Simpson DM, Sink KM, Smith CD, Snyder PJ, Spann BM, Sperling RA, Spicer K, Stefanovic B, Stern Y, Stopa E, Tang C, Tariot P, Taylor-Reinwald L, Thai G, Thomas RG, Thompson P, Tinklenberg J, Toga AW, Tremont G, Trojanowki JQ, Trost D, Turner RS, van Dyck CH, Vanderswag H, Varon D, Villanueva-Meyer J, Villena T, Walter S, Wang P, Watkins F, Williamson JD, Wolk D, Wu CK, Zerrate M, Zimmerman EA. Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease. Proc Natl Acad Sci U S A, 2010.  PMC2890481.

Woltjer R, Duerson K, Fullmer F, Mookherjee P, Ryan A, Montine T, Kaye J, Quinn J, Silbert L, Erten-Lyons D, Leverenz J, Bird T, Pow D, Watson G, Cook D. Aberrant Detergent-insoluble EAAT2 accumulates in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 69:667-676, 2010.  PMC3097122

Yu C, Bird T, Bekris L, Montine T, Leverenz J, Steinbart E, Galloway N, Feldman H, Woltjer R, Miller C, McCarthy Wood E, Grossman M, McCluskey L, Clark C, Neumann M, Danek A, Galasko D, Arnold S, Chen-Plotkin A, Karydas A, Miller B, Trojanowski J, Lee V, Schellenberg G, Van Deerlin V. The spectrum of mutations in progranulin:  A collaborative study screening 545 cases of neurodegeneration. Archives of Neurology 67:161-170, 2010.  PMC2901991.

Bowman G, Dodge H, Calabrese C, Oken B, Frei B, Kaye J, Quinn J. Ascorbic acid and rates of cognitive decline in Alzheimer's disease. The Journal of Alzheimer's Disease 16:93-98, 2009.  PMC2674290.

Britschgi M, Olin CE, Johns HT, Takeda-Uchimura Y, LeMieux MC, Rufibach K, Rajadas J, Zhang H, Tomooka B, Robinson WH, Clark CM, Fagan AM, Galasko DR, Holtzman DM, Jutel M, Kaye JA, Lemere CA, Leszek J, Li G, Peskind ER, Quinn JF, Yesavage JA, Ghiso JA, Wyss-Coray T. Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Proc Natl Acad Sci U S A 106:12145-12150, 2009.  PMC2715538.

Calvert JF, Jr., Kaye J, Leahy M, Hexem K, Carlson N. Technology use by rural and urban oldest old. Technol Health Care 17:1-11, 2009.  PMC2830255.

Carmine-Simmen K, Proctor T, Tschape J, Poeck B, Triphan T, Strauss R, Kretzschmar D. Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. Neurobiol Dis 33:274-281, 2009. 

Chaves ML, Camozzato AL, Eizirik CL, Kaye J. Predictors of Normal and Successful Aging Among Urban-Dwelling Elderly Brazilians. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences 64:597-602, 2009.  PMC2800815.

Chaves ML, Camozzato AL, Godinho C, Piazenski I, Kaye J. Incidence of Mild Cognitive Impairment and Alzheimer Disease in Southern Brazil. Journal of Geriatric Psychiatry and Neurology 22:181-187, 2009.  PMC Journal in Process.

Dodge H. The early detection of cognitive impairment:  Two approaches to assess longitudinal trajectories. In: National Alzheimer's Coordinating Center (NACC). Baltimore, MD, 2009.

Dodge H, Katsumata Y, Todoriki H, Willcox D, Leahy M, Michael Y, Kaye J. Social interaction as a potential key to optimal cognitive aging:  Okinawa-Oregon comparative study of sucessful aging. In: The Gerontological Society of America. Atlanta, GA, 2009.

Dodge H, Traber M, Leonard S, Katsumata Y, Todoriki H, Bowman G, Suzuki M, Willcox D, Yasura S, Oken B, Kaye J. Circulating micronutrients in Okinawan and Oregonian elderly. In: Linus Pauling Diet and Optinal Aging Annual Meeting; Portland, Oregon  2009.

Dodge HH, Meguro K, Ishii H, Yamaguchi S, Saxton JA, Ganguli M. Cross-cultural comparisons of the Mini-mental State Examination between Japanese and U.S. cohorts. Int Psychogeriatr 21:113-122, 2009. PMC2639652.

Duerson K, Woltjer RL, Mookherjee P, Leverenz JB, Montine TJ, Bird TD, Pow DV, Rauen T, Cook DG. Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients. Brain Pathology 19:267-278, 2009.  PMC2657182.

Erten-Lyons D, McWeeney S, Wilmot B, Kramer P, Kaye J. A polymorphism in ASPM and brain size. In: American Academy of Neurology: Neurology, 2009.

Erten-Lyons D, Woltjer RL, Dodge H, Nixon R, Vorobik R, Calvert JF, Leahy M, Montine T, Kaye J. Factors associated with resistance to dementia despite high Alzheimer disease pathology. Neurology 72:354-360, 2009.  PMC275065.

Hagler S, Austin D, Hayes T, Kaye J, Pavel M. Unobtrusive and Ubiquitous In-Home Monitoring: A Methodology for Continuous Assessment of Gait Velocity in Elders. IEEE Transactions on Biomedical Engineering, 2009.  PMC2846826

Hatt WJ, Vanbaak EA, Jimison HB, Hagler S, Hayes TL, Pavel M, Kaye J. The exploration & forensic analysis of computer usage data in the elderly. Conference Proceedings : Engineering in Medicine and Biology Society 2009:1216-1219, 2009.  PMC284625

Hayes T, Kaye J. Gathering the evidence:  Supporting large-sale research deployments.  . Intel Technology Journal 13:148-167, 2009. Not a peer-reviewed journal article.

Hayes TL, Cobbinah K, Dishongh T, Kaye JA, Kimel J, Labhard M, Leen T, Lundell J, Ozertem U, Pavel M, Philipose M, Rhodes K, Vurgun S. A study of medication-taking and unobtrusive, intelligent reminding. Telemed J E Health 15:770-776, 2009. Not an NIH Funded Manuscript.

Hayes TL, Hagler S, Austin D, Kaye J, Pavel M. Unobtrusive assessment of walking speed in the home using inexpensive PIR sensors. Conference Proceedings : Engineering in Medicine and Biology Society 1:7248-7251, 2009.  PMC2664300

Hayes TL, Larimer N, Adami A, Kaye JA. Medication adherence in healthy elders: small cognitive changes make a big difference. Journal of Aging Health 21:567-580, 2009.  PMC2910516

Holland D, Brewer JB, Hagler DJ, Fenema-Notestine C, Dale AM, Weiner M, Thal L, Petersen R, Jack CR, Jr., Jagust W, Trojanowki J, Toga AW, Beckett L, Green RC, Gamst A, Potter WZ, Montine T, Anders D, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, Bandy D, Koeppe RA, Foster N, Reiman EM, Chen K, Shaw L, Lee VM, Korecka M, Crawford K, Neu S, Harvey D, Kornak J, Kachaturian Z, Frank R, Snyder PJ, Molchan S, Kaye J, Vorobik R, Quinn J, Schneider L, Pawluczyk S, Spann B, Fleisher AS, Vanderswag H, Heidebrink JL, Lord JL, Johnson K, Doody RS, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig LS, Bell KL, Morris JC, Mintun MA, Schneider S, Marson D, Griffith R, Badger B, Grossman H, Tang C, Stern J, Detoledo-Morrell L, Shah RC, Bach J, Duara R, Isaacson R, Strauman S, Albert MS, Pedroso J, Toroney J, Rusinek H, de Leon MJ, De Santi SM, Doraiswamy PM, Petrella JR, Aiello M, Clark CM, Pham C, Nunez J, Smith CD, Given CA, 2nd, Hardy P, Dekosky ST, Oakley M, Simpson DM, Ismail MS, Porsteinsson A, McCallum C, Cramer SC, Mulnard RA, McAdams-Ortiz C, Diaz-Arrastia R, Martin-Cook K, Devous M, Levey AI, Lah JJ, Cellar JS, Burns JM, Anderson HS, Laubinger MM, Bartzokis G, Silverman DH, Lu PH, Fletcher R, Parfitt F, Johnson H, Farlow M, Herring S, Hake AM, van Dyck CH, Macavoy MG, Bifano LA, Chertkow H, Bergman H, Hosein C, Black S, Graham S, Caldwell C, Feldman H, Assaly M, Hsiung GY, Kertesz A, Rogers J, Trost D, Bernick C, Gitelman D, Johnson N, Mesulam M, Sadowsky C, Villena T, Mesner S, Aisen PS, Johnson KB, Behan KE, Sperling RA, Rentz DM, Johnson KA, Rosen A, Tinklenberg J, Ashford W, Sabbagh M, Connor D, Obradov S, Killiany R, Norbash A, Obisesan TO, Jayam-Trouth A, Wang P, Auchus AP, Huang J, Friedland RP, Decarli C, Fletcher E, Carmichael O, Kittur S, Mirje S, Johnson SC, Borrie M, Lee TY, Asthana S, Carlsson CM, Potkin SG, Highum D, Preda A, Nguyen D, Tariot PN, Hendin BA, Scharre DW, Kataki M, Beversdorf DQ, Zimmerman EA, Celmins D, Brown AD, Gandy S, Marenberg ME, Rovner BW, Pearlson G, Blank K, Anderson K, Saykin AJ, Santulli RB, Pare N, Williamson JD, Sink KM, Potter H, Ashok Raj B, Giordano A, Ott BR, Wu CK, Cohen R, Wilks KL, Safirstein BE. Subregional neuroanatomical change as a biomarker for Alzheimer's disease. Proceedings of the National Academy of Science USA 106:20954-20959, 2009.  PMC2791580.

Hosom J. Speaker-independent phoneme alignment using transition-dependent states. Speech Communication 51:352-368, 2009.  PMC2682710

Kaye J. Ginkgo biloba prevention trials:  More than an ounce of prevention learned. Archives of Neurology 66:652-654, 2009.  Not a peer-reviewed journal article.

Kaye J, Micheal Y, Calvert J, Leahy M, Crawford D, Kramer P. Exceptional brain aging in rural population-based cohort. Journal of Rural Health 25:320-325, 2009. NIHMSID#371470

Khachaturian ZS, Snyder PJ, Doody R, Aisen P, Comer M, Dwyer J, Frank RA, Holzapfel A, Khachaturian AS, Korczyn AD, Roses A, Simpkins JW, Schneider LS, Albert MS, Egge R, Deves A, Ferris S, Greenberg BD, Johnson C, Kukull WA, Poirier J, Schenk D, Thies W, Gauthier S, Gilman S, Bernick C, Cummings JL, Fillit H, Grundman M, Kaye J, Mucke L, Reisberg B, Sano M, Pickeral O, Petersen RC, Mohs RC, Carrillo M, Corey-Bloom JP, Foster NL, Jacobsen S, Lee V, Potter WZ, Sabbagh MN, Salmon D, Trojanowski JQ, Wexler N, Bain LJ. A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimers Dement 5:85-92, 2009.  PMC2544623.

Lavery L, Dodge H, Snitz B, Ganguli M. Cognitive decline and mortality in a community-based cohort: The Monongahela Valley independent elders survey Journal of the American Geriatrics Society 57:94-100, 2009.  PMC2768614

Leverenz JB, Quinn JF, Zabetian C, Zhang J, Montine KS, Montine TJ. Cognitive impairment and dementia in patients with Parkinson disease. Curr Top Med Chem 9:903-912, 2009.  PMC2804995.

Michael YL, Keast EM, Chaudhury H, Day K, Mahmood A, Sarte AF. Revising the senior walking environmental assessment tool. Preventative Medicine 48:247-249, 2009.  NIHMS106679.

Price JL, McKeel DW, Jr., Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiology of Aging 30:1026-1036, 2009.  PMC2737680.

Quinn J, Clark C. Failure of biomarkers in clinical trials of Alzheimer's disease:  Blaming the messenger? Journal of  Alzheimers Disease Epub ahead of print 2009. Not a peer-reviewed journal article.

Quinn J, Crane S, Harris C, Wadworth T. Copper in Alzheimer’s disease: too much or too little? . Expert Reviews in Neurotherapeutics 9:631-639, 2009.  PMC Journal in Process.

Roher AE, Esh CL, Kokjohn TA, Castano EM, Van Vickle GD, Kalback WM, Patton RL, Luehrs DC, Daugs ID, Kuo YM, Emmerling MR, Soares H, Quinn JF, Kaye J, Connor DJ, Silverberg NB, Adler CH, Seward JD, Beach TG, Sabbagh MN. Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease. Alzheimers Dement 5:18-29, 2009. PMC2663406.

Seelye A, Howieson D, Wild K, Sauceda L, Kaye J. Living well with MCI:  Behavioral interventions for older adults with mild cognitive impairment. In: Brougham R, ed. New Directions in Aging Research:  Health and Cognition. New York: Nova Scient Publishers, Inc., 2009.

Silbert LC, Howieson DB, Dodge H, Kaye JA. Cognitive impairment risk: white matter hyperintensity progression matters. Neurology 73:120-125, 2009.  PMC2713187.

Sonnen JA, Larson EB, Brickell K, Crane PK, Woltjer R, Montine TJ, Craft S. Different Patterns of Cerebral Injury in Dementia With or Without Diabetes. Archives of Neurology 66:315-322, 2009.  PMC2766529.

Sonnen JA, Montine KS, Quinn JF, Breitner JC, Montine TJ. Cerebrospinal Fluid Biomarkers in Mild Cognitive Impairment and Dementia. Journal of Alzheimer's Disease, 2009.  PMC2891184

Tian W, Fu Y, Garcia-Elias A, Fernandez-Fernandez JM, Vicente R, Kramer PL, Klein RF, Hitzemann R, Orwoll ES, Wilmot B, McWeeney S, Valverde MA, Cohen DM. A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A 106:14034-14039, 2009.  PMC2729015.

Bekris LM, Millard SP, Galloway NM, Vuletic S, Albers JJ, Li G, Galasko DR, DeCarli C, Farlow MR, Clark CM, Quinn JF, Kaye JA, Schellenberg GD, Tsuang D, Peskind ER, Yu CE. Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels. Journal of Alzheimers Disease 13:255-266, 2008.

Boise L. Ethnicity and the experience of dementia. Berkshire: McGraw-Hill; 52-69, 2008.

Bowman G, Quinn J. Alzheimer's disease and the blood-brain barrier:  Past present and future. Aging Health 4:47-57, 2008.  PMC2778025.

Buenafe AC, Zwickey H, Moes N, Oken B, Jones RE. A telemetric study of physiologic changes in mice with induced autoimmune encephalomyelitis. Lab Animal 37:361-368, 2008.

Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: A randomized, double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine 14:707-713, 2008.

Carlson NE, Moore MM, Dame A, Howieson D, Silbert LC, Quinn JF, Kaye JA. Trajectories of brain loss in aging and the development of cognitive impairment. Neurology 70:828-833, 2008.

Dodge H, Shen C, Ganguli M. Application of the pattern-mixture latent trajectory model in an epidemiological study with non-ignorable missingness. The Journal of Data Science 6:231-246, 2008.

Dodge HH, Kita Y, Takechi H, Hayakawa T, Ganguli M, Ueshima H. Healthy cognitive aging and leisure activities among the oldest old in Japan: Takashima study. J Gerontol A Biol Sci Med Sci 63:1193-1200, 2008.  PMC2646000.

Dodge HH, Zitzelberger T, Oken BS, Howieson D, Kaye J. A randomized placebo-controlled trial of ginkgo biloba for the prevention of cognitive decline. Neurology 70:1809-1817, 2008.  PMC2639649.

Erten-Lyons D. When should patients with Alzheimer disease stop driving? Neurology 70:e45-47, 2008.

Erten-Lyons D, Jacobs A, Kramer P, Grupe A, Kaye J. The FAS gene is associated with brain volume in mild cogntive Impairment and Alzheimer's disease. Neurology 70:A103, 2008.

Erten-Lyons D, Oken B, Woltjer RL, Quinn J. Relapsing polychondritis: an uncommon cause of dementia. Journal of Neurology, Neurosurgery, and Psychiatry 79:609-610, 2008.

Fleisher AS, Raman R, Siemers ER, Becerra L, Clark CM, Dean RA, Farlow MR, Galvin JE, Peskind ER, Quinn JF, Sherzai A, Sowell BB, Aisen PS, Thal LJ. Phase II safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. Archives of Neurology 65:1031-1038, 2008.  PMC2682361.

Hayes T, Pavel M, Kaye J. An approach for deriving continuous health assessment indicators from in-home sensor data. In: Mihailidis A, Boger J, Kautz H, Normie L, eds. Technology and Aging: Selected papers from the 2007 International Conference on Technology and Aging. Amsterdam, The Netherlands: IOS Press; 130-137, 2008.

Hayes TL, Abendroth F, Adami A, Pavel M, Zitzelberger TA, Kaye JA. Unobtrusive assessment of activity patterns associated with mild cognitive impairment. Alzheimers and  Dementia 4:395-405, 2008.  PMC2664300.

Hill JM, Ball MJ, Neumann DM, Azcuy AM, Bhattacharjee PS, Bouhanik S, Clement C, Lukiw WJ, Foster TP, Kumar M, Kaufman HE, Thompson HW. The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender. Journal of Virology 82:8230-8234, 2008.  PMC2519549.

Howieson DB, Carlson NE, Moore MM, Wasserman D, Abendroth CD, Payne-Murphy J, Kaye JA. Trajectory of mild cognitive impairment onset. Journal of the International Neuropsychological Society 14:192-198, 2008.

Hutter CM, Samii A, Factor SA, Nutt JG, Higgins DS, Bird TD, Griffith A, Roberts JW, Leis BC, Montimurro JS, Kay DM, Edwards KL, Payami H, Zabetian CP. Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease. European Journal of Neurology 15:134-139, 2008.

Kay DM, Factor SA, Samii A, Higgins DS, Griffith A, Roberts JW, Leis BC, Nutt JG, Montimurro JS, Keefe RG, Atkins AJ, Yearout D, Zabetian CP, Payami H. Genetic association between alpha-synuclein and idiopathic Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet 147B:1222-1230, 2008.

Kaye J. Home-based technologies: A new paradigm for conducting dementia prevention trials. Alzheimer's & Dementia 4:S60-S66, 2008.

Kaye J, Hayes T, Zitzelberger T, Yeargers J, Pavel M, Jimison H, Larimer N, Payne-Murphy J, Earl E, Wild K, Boise L, Williams D, Lundell J, Dishman E. Deploying wide scale in-home assessment technology. In: Mihailidis A, Boger J, Kautz H, Normie L, eds. Technology and Aging: Selected papers from the 2007 International Conference on Technology and Aging. Amsterdam, The Netherlands: IOS Press; 19-26, 2008.

Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, Hyman B, Kuller L, Schenk D, Snyder S, Thomas RG, Tuszynski MH, Vellas B, Wurtman RJ, Snyder PJ, Frank RA, Albert M, Doody R, Ferris S, Kaye J, Koo E, Morrison-Bogorad M, Reisberg B, Salmon DP, Gilman S, Mohs R, Aisen PS, Breitner JC, Cummings JL, Kawas C, Phelps C, Poirier J, Sabbagh M, Touchon J, Khachaturian AS, Bain LJ. A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimer's & Dementia 4:156-163, 2008.  PMC2544623.

Lee JH, Cheng R, Graff-Radford N, Foroud T, Mayeux R. Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci. Archives of Neurology 65:1518-1526, 2008.  PMC2694670.

Leverenz JB, Hamilton R, Tsuang DW, Schantz A, Vavrek D, Larson EB, Kukull WA, Lopez O, Galasko D, Masliah E, Kaye J, Woltjer R, Clark C, Trojanowski JQ, Montine TJ. Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient. Brain Pathology 18:220-224, 2008.  PMC2689097.

Liu C, Takahashi M, Li Y, Song S, Dillon TJ, Shinde U, Stork PJ. Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2. Mol Cell Biol 28:7109-7125, 2008.  PMC2593374.

Lovell MA, Lynn BC, Xiong S, Quinn JF, Kaye J, Markesbery WR. An aberrant protein complex in CSF as a biomarker of Alzheimer disease. Neurology 70:2212-2218, 2008.

Michael Y, McGregor E, Allen J, Fickas S. Observing outdoor activity using global positioning system-enabled cell phones. In: Helal S, Mitra S, Wong J, Chang C, Mokhtari M, eds. Smart Homes and Health Telematics. Ames, IA: Springer, Berlin, Heidelberg; 177-184, 2008.

Nagel CL, Carlson NE, Bosworth M, Michael YL. The relation between neighborhood built environment and walking activity among older adults. American Journal of Epidemiology 168:461-468, 2008.

Oken BS. Placebo effects: Clinical aspects and neurobiology. Brain 131:2812-2823, 2008.

Oken BS, Flegal K, Zajdel D, Kishiyama S, Haas M, Peters D. Expectancy effect: Impact of pill administration on cognitive performance in healthy seniors. Journal of Clinical and Experimental Neuropsychology 30:7-17, 2008.

Pan S, Rush J, Peskind ER, Galasko D, Chung K, Quinn J, Jankovic J, Leverenz JB, Zabetian C, Pan C, Wang Y, Oh JH, Gao J, Zhang J, Montine T, Zhang J. Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platform. Journal of Proteome Research 7:720-730, 2008.

Pavel M, Jimison H, Hayes T, Kaye J, Dishman E, WIld K, Williams D. Continuous, Unobtrusive Monitoring for the Assessment of Cognitive Function. In: Hofer SM, Alwin DF, eds. Handbook of Cognitive Aging: Interdisciplinary Perspetives. Thousand Oaks, CA: Sage Publications, Inc.; Chapter 31, 2008.

Pavel M, Jimison H, Hayes T, Kaye J, Dishman E, Wild K, Williams D. Continuous, unobtrusive monitoring for the assessment of cognitive function. In: Hofer S, Alwin D, eds. Handbook of Cognitive Aging: Interdisciplinary Perspectives. Thousand Oaks, CA.: Sage Publications, Inc., 2008.

Powers KM, Kay DM, Factor SA, Zabetian CP, Higgins DS, Samii A, Nutt JG, Griffith A, Leis B, Roberts JW, Martinez ED, Montimurro JS, Checkoway H, Payami H. Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk. Movement Disorders : Official Journal of the Movement Disorder Society 23:88-95, 2008.

Quinn J, Sabbagh MN. Detecting Alzheimer disease before it happens: The key to prevention? Neurology 71:78-79, 2008.

Raber J. AR, apoE, and cognitive function. Horm Behav 53:706-715, 2008.  PMC2409114.

Reddy PH. Mitochondrial medicine for aging and neurodegenerative diseases. Neuromolecular Medicine 10:291-315, 2008.

Reddy PH, Beal MF. Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 14:45-53, 2008.

Seelye AM, Howieson DB, Wild KV, Moore MM, Kaye JA. Wechsler Memory Scale-III Faces test performance in patients with mild cognitive impairment and mild Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology:1-7, 2008.  NIHMS# 97312.

Sheldahl LC, Shapiro RA, Bryant DN, Koerner IP, Dorsa DM. Estrogen induces rapid translocation of estrogen receptor beta, but not estrogen receptor alpha, to the neuronal plasma membrane. Neuroscience 153:751-761, 2008.  PMC2587260.

Shinto L, Calabrese C, Morris C, Yadav V, Griffith D, Frank R, Oken BS, Baldauf-Wagner S, Bourdette D. A randomized pilot study of naturopathic medicine in multiple sclerosis. Journal of Alternative and Complementary Medicine 14:489-496, 2008.

Silbert LC, Nelson C, Howieson DB, Moore MM, Kaye JA. Impact of white matter hyperintensity volume progression on rate of cognitive and motor decline. Neurology 71:108-113, 2008.  PMC2676966.

Sonnen JA, Breitner JC, Lovell MA, Markesbery WR, Quinn JF, Montine TJ. Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models. Free Radic Biol Med 45:219-230, 2008.  PMC2459222.

Sonnen JA, Montine KS, Quinn JF, Kaye JA, Breitner JC, Montine TJ. Biomarkers for cognitive impairment and dementia in elderly people. Lancet Neurology 7:704-714, 2008.  PMC2710375.

Szekely CA, Green RC, Breitner JC, Ostbye T, Beiser AS, Corrada MM, Dodge HH, Ganguli M, Kawas CH, Kuller LH, Psaty BM, Resnick SM, Wolf PA, Zonderman AB, Welsh-Bohmer KA, Zandi PP. No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology 70:2291-2298, 2008.

Wadsworth TL, Bishop JA, Pappu AS, Woltjer RL, Quinn JF. Evaluation of coenzyme q as an antioxidant strategy for Alzheimer's disease. Journal of  Alzheimers Disease 14:225-234, 2008.  NIHMS#102025.

Wahbeh H, Elsas SM, Oken BS. Mind-body interventions: Applications in neurology. Neurology 70:2321-2328, 2008.

Wahbeh H, Kishiyama SS, Zajdel D, Oken BS. Salivary cortisol awakening response in mild Alzheimer disease, caregivers, and noncaregivers. Alzheimer's Disease and Associated Disorders 22:181-183, 2008.  PMC - Journal in Process.

Wang W, Shinto L, Connor WE, Quinn JF. Nutritional biomarkers in Alzheimer's disease: The association between carotenoids, n-3 fatty acids, and dementia severity. Journal of  Alzheimers Disease 13:31-38, 2008.

Wild K, Boise L, Lundell J, Foucek A. Unobtrusive in-home monitoring of cognitive and physical health: Reactions and perceptions of Older Adults. Journal of Applied Gerontology 27:181-200, 2008.  PMC2629437.

Wild K, Howieson D, Webbe F, Seelye A, Kaye J. The status of computerized cognitive testing in aging: A systematic review. Alzheimers and  Dementia 4:428-437, 2008.  PMC2645803.

Wilmot B, McWeeney SK, Nixon RR, Montine TJ, Laut J, Harrington CA, Kaye JA, Kramer PL. Translational gene mapping of cognitive decline. Neurobiology of Aging 29:524-541, 2008.  PMC2684335.

Woltjer RL, Sonnen JA, Sokal I, Rung LG, Yang W, Kjerulf JD, Klingert D, Johnson C, Rhew I, Tsuang D, Crane PK, Larson EB, Montine TJ. Quantitation and Mapping of Cerebral Detergent-Insoluble Proteins in the Elderly. Brain Pathology:Epub ahead of print, 2008.  NIHMSID #69069.

Zhang J, Sokal I, Peskind ER, Quinn JF, Jankovic J, Kenney C, Chung KA, Millard SP, Nutt JG, Montine TJ. CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases. American Journal of Clinical Pathology 129:526-529, 2008.  PMC2688655.

Borenstein AR, Mortimer JA, Schofield E, Wu Y, Salmon DP, Gamst A, Olichney J, Thal LJ, Silbert L, Kaye J, Craig UL, Schellenberg GD, and Galasko DR. Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Neurology. 68(21): p. 1764-71, 2007.

Bowman GL, Kaye JA, Moore M, Waichunas D, Carlson NE, Quinn JF. Blood-brain barrier impairment in Alzheimer's disease: stability and functional significance. Neurology. 2007 May 22;68(21):1809-14.

Carlson N, Moore M, Dame A, Howieson D, Silbert L, Quinn J, and Kaye J. Trajectories of brain loss in aging and the development of cognitive impairment. Neurology. In Press, 2007.

Chaves ML, Camozzato AL, Godinho C, Kochhann R, Schuh A, de Almeida VL, Kaye J. Validity of the clinical dementia rating scale for the detection and staging of dementia in Brazilian patients. Alzheimer Dis Assoc Disord. 21(3): p. 210-7, 2007.

Chun LS, Samii A, Hutter CM, Griffith A, Roberts JW, Leis BC, Mosley AD, Wander PL, Edwards KL, Payami H, and Zabetian CP. DBH -1021C-->T does not modify risk or age at onset in Parkinson's disease. Ann Neurol. 62(1): p. 99-101, 2007.

Coehlo DP, Hooker K, Bowman S. Institutional placement of persons with dementia: what predicts occurrence and timing? J Fam Nurs. 2007 May;13(2):253-77.

Dodge H, Zitzelberger T, Oken B, Howieson D, and Kaye J. A Randomized Placebo-Controlled Trial of Ginkgo Biloba for the Prevention of Cognitive Decline. Neurology. In Press, 2007.

Galasko D, Salmon D, Gamst A, Olichney J, Thal LJ, Silbert L, Kaye J, Brooks P, Adonay R, Craig UK, Schellenberg G, and Borenstein AR. Prevalence of dementia in Chamorros on Guam: relationship to age, gender, education, and APOE. Neurology. 68(21): p. 1772-81, 2007.

Gordon D, Haynes C, Yang Y, Kramer PL, and Finch SJ. Linear trend tests for case-control genetic association that incorporate random phenotype and genotype misclassification error. Genet Epidemiol. 31(8): p. 853-70, 2007.

Hayes T, Pavel M, and Kaye J. An approach for deriving continuous health assessment indicators from in-home sensor data. Technology and Aging (IOS Press). In Press, 2007.

Kay DM, Moran D, Moses L, Poorkaj P, Zabetian CP, Nutt J, Factor SA, Yu CE, Montimurro JS, Keefe RG, Schellenberg GD, Payami H. Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients.  Ann Neurol. 2007 Jan;61(1):47-54.

Kaye J. Home-based technologies: a new paradigm for conducting dementia prevention trials. Alzheimer's & Dementia. In Press, 2007.

Kaye J, Hayes T, Zitzelberger T, Yeargers J, Pavel M, Jimison H, Larimer N, Payne-Murphy J, Wild K, Boise L, Williams D, Lundell J, and Dishman E. Deploying wide scale in-home assessment technology. Technology and Aging (IOS Press). In Press, 2007.

Kaye JA, Moore MM, Galasko D, Craig UK, Adonay R, and Silbert LC. Brain volumes in Guam dementia vs. Parkinson dementia complex vs. aging Charmorro adults. Neurology. 69(2): p. 196-199, 2007.

Kaye J, Zitzelberger T.  Living laborabory tests new models of home assessment.  Aging Today, 28 (5): p. 7-10, 2007.

Leen T, Zhengdong L, Hayes T, and Kaye J. Detection of early cognitive loss from medication adherence behavior. Technology and Aging (IOS Press). In Press.

Li G, Sokal I, Quinn J, Leverenz J, Brodey M, Schellenberg G, Kaye J, Raskind M, Zhang J, Peskind E, and Montine T. CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment:  A follow-up study. Neurology. 69(7): p. 631-639, 2007.

Lundell J, Hayes TL, Vurgun S, Ozertem U, Kimel J, Kaye J, Guilak F, Pavel M. Continuous activity monitoring and intelligent contextual prompting to improve medication adherence.  Conf Proc IEEE Eng Med Biol Soc. 2007;1:6286-9, 2007.

Montine TJ, Quinn J, Kaye J, Morrow JD.F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease. J Mol Neurosci. 33(1):p. 114-9, 2007.

Nakashima-Yasuda H, Uryu K, Robinson J, Xie S, Hurtig H, Duda J, Arnold S, Siderowf A, Grossman M, Leverenz J, Lopez O, Hamilton R, Tsuang D, Galasko D, Masliah E, Kaye J, Woltjer R, Clark C, Montine T, Lee V, and Trojanowski J. Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases. Acta Neuropathologica. 114: p. 221-229, 2007.

Pan S, Zhu D, Quinn JF, Peskind ER, Montine TJ, Lin B, Goodlett DR, Taylor G, Eng J, Zhang J. A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometry. Proteomics. 2007 Feb;7(3):469-73. Review.
Quinn JF, Bussiere JR, Hammond RS, Montine TJ, Henson E, Jones RE, and Stackman RW, Jr. Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. Neurobiol Aging. 28(2): p. 213-25, 2007.

Raber J. Role of apolipoprotein E in anxiety. Neural Plast. p. 91236, 2007.

Ray S, Britschgi M, Herbert C, Takeda-Uchimura Y, Boxer A, Blennow K, Friedman LF, Galasko DR, Jutel M, Karydas A, Kaye JA, Leszek J, Miller BL, Minthon L, Quinn JF, Rabinovici GD, Robinson WH, Sabbagh MN, So YT, Sparks DL, Tabaton M, Tinklenberg J, Yesavage JA, Tibshirani R, and Wyss-Coray T. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med. 13(11): p. 1359-62, 2007.

Roark B, Hosom J, Mitchell M, and Kaye J. Automatically derived spoken language markers for detecting mild cognitive impairment. Technology and Aging (IOS Press). In Press, 2007.

Roark B, Mitchell M, and Hollingshead K. Syntactic complexity measures for detecting Mild Cognitive Impairment, in BioNLP: Biological, Translational and Clinical  Language Processing. The Association for Computational Linguistics: Prague. p. 1-8, 2007.

Sheng P, Zhu D, Quinn JF, Peskind E, Montine TJ, Lin B, Goodlett DR, Taylor G, Eng J, and Zhang J. A combined dataset of human cerebrospinal fluid proteins identified by multidimensional chromatography and tandem mass spectroscopy. Proteomics. 7(3): p. 469-473, 2007.

Shie F and Woltjer R. Manipulation of microglial activation as a therapeutic strategy in Alzheimer's disease. Current Medicinal Chemistry. In Press, 2007.

Sumic A, Michael YL, Carlson NE, Howieson DB, Kaye JA.  Physical Activity and the Risk of Dementia in Oldest Old Journal Of Aging Health.  2007; Apr;19(2): 242-259.

Taylor JP, Hulihan MM, Kachergus JM, Melrose HL, Lincoln SJ, Hinkle KM, Stone JT, Ross OA, Hauser R, Aasly J, Gasser T, Payami H, Wszolek ZK, Farrer MJ. Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease.  Neurogenetics. 2007Apr;8(2):95102. Epub 2007 Jan 16. PMID: 17225181 [PubMed - in process].

Wahbeh H, Kishiyama S, Zajdel D, and Oken B. Salivary cortisol awakening response in mild Alzheimer's disease, caregivers and non-caregivers. Alzheimer's Disease and Related Disorders. In Press, 2007.

Yang W, Woltjer RL, Sokal I, Pan C, Wang Y, Brodey M, Peskind ER, Leverenz JB, Zhang J, Perl DP, Galasko DR, and Montine TJ. Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy. Am J Pathol. 171(3): p. 993-1002, 2007.

Zabetian CP, Hutter CM, Factor SA, Nutt JG, Higgins DS, Griffith A, Roberts JW, Leis BC, Kay DM, Yearout D, Montimurro JS, Edwards KL, Samii A, and Payami H. Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease. Ann Neurol. 62(2): p. 137-44, 2007.

Abdi F, Quinn JF, Jankovic J, McIntosh M, Leverenz JB, Peskind E, Nixon R,Nutt J, Chung K, Zabetian C, Samii A, Lin M, Hattan S, Pan C, Wang Y, Jin J, Zhu D, Li GJ, Liu Y, Waichunas D, Montine TJ, Zhang J. Detection of biomarkers with a multiplex quantitative proteomic platform incerebrospinal fluid of patients with neurodegenerative disorders. Journal of Alzheimer's Disease. 2006 Aug;9(3):293-348.

Ball M. The essential lesion of Alzheimer's disease:  A surprise in retrospect. Journal of Alzheimer's Disease. 9(3  suppl): p. 29-33, 2006.

Brickell KL, Steinbart EJ, Rumbaugh M, Payami H, Schellenberg GD, Van Deerlin V, Yuan W, Bird TD.    Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease. Archives of Neurology  2006 Sep;63(9):1307-11. PMID: 16966510

Calvert JF Jr, Hollander-Rodriguez J, Kaye J, Leahy M. Dementia-free survival among centenarians: an evidence-based review. J Gerontol A Biol Sci Med Sci. 2006 Sep;61(9):951-6.

Cotrell V, Wild K, and Bader T. Medication management and adherence among cognitively impaired older adults. J Gerontol Soc Work. 47(3-4): p. 31-46, 2006.

Elbaz A, Nelson LM, Payami H, Ioannidis JP, Fiske BK, Annesi G, Carmine Belin A, Factor SA, Ferrarese C, Hadjigeorgiou GM, Higgins DS, Kawakami H, Kruger R, Marder KS, Mayeux RP, Mellick GD, Nutt JG, Ritz B, Samii A, Tanner CM, Van Broeckhoven C, Van Den Eeden SK, Wirdefeldt K, Zabetian CP, Dehem M, Montimurro JS, Southwick A, Myers RM, and Trikalinos TA. Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Lancet Neurol. 5(11): p. 917-23, 2006.

Erten-Lyons D, Howieson D, Moore MM, Quinn J, Sexton G, Silbert L, Kaye J. Brain volume loss in MCI predicts dementia. Neurology. 2006 Jan 24;66(2):233-5.

Galasko D, Bennett DA, Sano M, Marson D, Kaye J, and Edland SD. ADCS prevention instrument project: Assessment of instrumental activities of daily living for community-dwelling elderly individuals in dementia prevention clinical trials. Alzheimer Disease and Associated Disorders. 20 Suppl 3(3): p. S152-S169, 2006.

Hare JF. Intracellular pathways of folded and misfolded amyloid precursor protein degradation. Arch Biochem Biophys. 451(1): p. 79-90, 2006.

Hayes TL, Hunt JM, Adami A, Kaye JA. An electronic pillbox for continuous monitoring of medication adherence. Conf Proc IEEE Eng Med Biol Soc.1: p. 6400-3, 2006.

Kammerman E, Neumann D, Ball M, Lukiw W, and Hill J. Senile plaques in Alzheimer's diseased brains: Possible association of beta-amyloid with herpes simplex virus type 1 (HSV-1) L-particles. Medical  Hypotheses. 66: p. 294-9, 2006.

Kay DM, Bird TD, Zabetian CP, Factor SA, Samii A, Higgins DS, Nutt J, Roberts JW, Griffith A, Leis BC, Montimurro JS, Philpott S, and Payami H. Validity and utility of a LRRK2 G2019S mutation test for the diagnosis of Parkinson's disease. Genet Test. 10(3): p. 221-7, 2006.
Kay DM, Moran D, Moses L, Poorkaj P, Zabetian CP, Nutt J, Factor SA, Yu CE, Montimurro JS, Keefe RG, Schellenberg GD, and Payami H. Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients. Ann Neurol. 22: p. 22, 2006.

Kay DM, Zabetian CP, Factor SA, Nutt JG, Samii A, Griffith A, Bird TD, Kramer P, Higgins DS, Payami H. Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics. Mov Disord. 2006 Apr;21(4):519-23
Kaye JA and Hayes T. Home health monitoring:  A system to assess motor and cognitive function. Generations. 30(2): p. 61-63, 2006.

Li D, Parks SB, Kushner JD, Nauman D, Burgess D, Ludwigsen S, Partain J, Nixon RR, Allen CN, Irwin RP, Jakobs PM, Litt M, and Hershberger RE. Mutations of presenilin genes in dilated cardiomyopathy and heart failure. Am J Hum Genet. 79(6): p. 1030-9, 2006.

Lovera J, Bagert B, Smoot KH, Wild K, Frank R, Bogardus K, Oken BS, Whitham RH, Bourdette DN. Correlations of Perceived Deficits Questionnaire of Multiple Sclerosis Quality of Life Inventory with Beck Depression Inventory and neuropsychological tests. J Rehabil Res Dev. 2006 Jan-Feb;43(1):73-82.

Maia AL, Godinho C, Ferreira ED, Almeida V, Schuh A, Kaye J, Chaves ML. Application of the Brazilian version of the CDR scale in samples of dementia patients Arq Neuropsiquiatr. 2006 Jun;64 2B:485-9. Portuguese.

Manczak, Maria Thimmappa S. Anekonda, Edward Henson, Byung S. Park, Joseph Quinn, and P. Hemachandra Reddy Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression Human Molecular Genetics, 1 May 2006; 15: 1437 - 1449.

Michael Y, Beard T, Choi D, Farquhar S, and Carlson N. Measuring the influence of built neighborhood environments on walking in older adults. J Aging Phys Act. 14(3): p. 302-12, 2006.

Morgan NV, Westaway SK, Morton JE, Gregory A, Gissen P, Sonek S, Cangul H, Coryell J, Canham N, Nardocci N, Zorzi G, Pasha S, Rodriguez D, Desguerre I, Mubaidin A, Bertini E, Trembath RC, Simonati A, Schanen C, Johnson CA, Levinson B, Woods CG, Wilmot B, Kramer P, Gitschier J, Maher ER, Hayflick SJ. PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron. Nat Genet. 2006 Jul;38(7):752-4. PMID: 16783378

Oken BS, Flegal K, Zajdel D, Kishiyama SS, Lovera J, Bagert B, Bourdette DN. Cognition and fatigue in multiple sclerosis: Potential effects of medications with central nervous system activity. J Rehabil Res Dev. 2006 Jan-Feb;43(1):83-90.

Oken BS, Salinsky MC, Elsas SM. Vigilance, alertness, or sustained attention: physiological basis and measurement. Clin Neurophysiol. 2006 Sep;117(9):1885-1901.

Oken BS, Zajdel D, Kishiyama S, Flegal K, Dehen C, Haas M, Kraemer DF, Lawrence J, Leyva J. Randomized, controlled, six-month trial of yoga in healthy seniors: effects on cognition and quality of life. Altern Ther Health Med. 2006 Jan-Feb;12(1):40-7.

Pan S, Wang Y, Quinn JF, Peskind ER, Waichunas D, Wimberger JT, Jin J, Li JG, Zhu D, Pan C, Zhang J. Identification of Glycoproteins in Human Cerebrospinal Fluid with a Complementary Proteomic Approach. J Proteome Res. 2006 Oct 6;5(10):2769-2779.

Pavel M, Hayes TL, Adami A, Jimison H, Kaye J.  Unobtrusive assessment of mobility. Conf Proc IEEE Eng Med Biol Soc.1: p. 6277-80, 2006.

Peskind ER, Li G, Shofer J, Quinn JF, Kaye JA, Clark CM, Farlow MR, DeCarli C, Raskind MA, Schellenberg GD, Lee VM, Galasko DR. Age and apolipoprotein E4;allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition. Arch Neurol. 2006 Jul;63(7):936-9.

Plassman B, Khachaturian A, Townsend J, Ball M, Steffens D, Leslie C, Tschanz J, Norton M, Burke J, Welsh-Bohmer K, Hulette C, R N, Tyrey M, and Breitner J. Comparison of clinical and neuropathological  diagnoses of AD in three epidemiological samples. Alzheimer's & Dementia. 2(1): p. 2-11, 2006.

Quinn JF, Bussiere JR, Hammond RS, Montine TJ, Henson E, Jones RE, Stackman RW Jr. Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. Neurobiol Aging. 2006 Jan 28;

Quinn J and Kaye J. Healthy Brain Aging, in Handbook of Dementing Illnesses (second addition), J Morris, J Galvin, and D Holtzman, Editors.  Marecel-Dekker: New York, 2006.

Reddy P. Amyloid precursor protein-mediated free radicals and oxidative damage: Implications for the development and progression of Alzheimer's disease. Journal of Neurochemistry. 96: p. 1-13, 2006.

Reddy PH. Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. J Biomed Biotechnol. 2006(3): p. 31372, 2006.

Rizk-Jackson AM, Acevedo SF, Inman D, Howieson D, Benice TS, Raber J. Effects of sex on object recognition and spatial navigation in humans. Behav Brain Res. 2006 Oct 16;173(2):181-90. Epub 2006 Aug 2.

Siemers ER, Quinn JF, Kaye J, Farlow MR, Porsteinsson A, Tariot P, Zoulnouni P, Galvin JE, Holtzman DM, Knopman DS, Satterwhite J, Gonzales C, Dean RA, May PC. Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease. Neurology. 2006 Feb 28;66(4):602-4.

Silbert LC, Nelson C, Holman S, Eaton R, Oken BS, Lou JS, Kaye JA. Cortical excitability and age-related volumetric MRI changes. Clin Neurophysiol. 2006 May;117(5):1029-36. Epub 2006 Mar 27.

Tandon R, Adak S, Kaye JA. Neural networks for longitudinal studies in Alzheimer's disease. Artif Intell Med. 2006 Mar;36(3):245-55. Epub 2006 Jan 19.

Tractenberg RE, Singer CM, Kaye JA. Characterizing sleep problems in persons with Alzheimer's disease and normal elderly. J Sleep Res. 2006 Mar;15(1):97-103.

Wilmot B, McWeeney SK, Nixon RR, Montine TJ, Laut J, Harrington CA, Kaye JA, and Kramer PL. Translational gene mapping of cognitive decline. Neurobiology of  Aging. 13(Dec 13): p. 1558-1497, 2006.

Zabetian CP, Hutter CM, Yearout D, Lopez AN, Factor SA, Griffith A, Leis BC, Bird TD, Nutt JG, Higgins DS, Roberts JW, Kay DM, Edwards KL, Samii A, Payami H. LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago. American Journal of Human Genetics 2006 Oct;79(4):752-8. PMID: 16960813

Zabetian CP, Lauricella CJ, Tsuang DW, Leverenz JB, Schellenberg GD, and Payami H. Analysis of the LRRK2 G2019S mutation in Alzheimer's Disease. Arch Neurol. 63(1): p. 156-7, 2006.

Anderson VC, Litvack ZN, Kaye JA. Magnetic resonance approaches to brain aging and Alzheimer disease-associated neuropathology. Topics in Magnetic Resonance Imaging 16:439-452, 2005.  

Boise L. Improving dementia care through physician education:  Some challenges. Clinical Gerontologist 29:3-10, 2005.  

Boise L. Diagnosing dementia: What to tell the patient and family. Geriatrics and Aging 8:48-51, 2005.  

Cui JG, Zhao Y, Lukiw WJ. Isolation of high spectral quality RNA using run-on gene transcription; application to gene expression profiling of human brain. Cell Mol Neurobiol 25:789-794, 2005. 

Dowling GA, Mastick J, Colling E, Carter JH, Singer CM, Aminoff MJ. Melatonin for sleep disturbances in Parkinson's disease. Sleep Med 6:459-466, 2005.  

Erten-Lyons D, Ferguson F, Howieson D, Moore M, Silbert L, Quinn J, Kaye J. Elderly with more medical illneses have smaller brains and are more resistant to cognitive decline. Neurology 64 (suppl 1):A230, 2005. 

Fleisher A, Grundman M, Jack CR, Jr., Petersen RC, Taylor C, Kim HT, Schiller DH, Bagwell V, Sencakova D, Weiner MF, DeCarli C, DeKosky ST, van Dyck CH, Thal LJ. Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment. Archives of Neurology 62:953-957, 2005.  

Hall DA, Leehey MA, Filley CM, Steinbart E, Montine T, Schellenberg GD, Bosque P, Nixon R, Bird T. PRNP H187R mutation associated with neuropsychiatric disorders in childhood and dementia. Neurology 64:1304-1306, 2005.  

Hill J, Gebhardt B, Azcuy A, Matthews K, Lukiw W, Steiner I, Thompson H, Ball M. Can a herpes simplex virus type 1 neuroinvasive score be correlated to other risk factors in Alzheimer's disease? Medical  Hypotheses 64:320-327, 2005.  

Hill J, Steiner I, Matthews K, Trahan S, Foster T, Ball M. Statins lower the risk of developing Alzheimer's disease by limiting lipid raft endocytosis and decreasing the neuronal spread of Herpes simplex virus type 1. Medical  Hypotheses 64:53-58, 2005.  

Kay DM, Kramer P, Higgins D, Zabetian CP, Payami H. Escaping Parkinson's disease: a neurologically healthy octogenarian with the LRRK2 G2019S mutation. Movement Disorders : Official Journal of the Movement Disorder Society 20:1077-1078, 2005.  

Kaye J, Carlson N, Moore M, Dame A, Howieson D. The clinical transition to dementia is characterized by a two-phase process of accelerating brain loss. Neurology 64 (suppl 1):A390, 2005.  

Kaye J, Moore M, Galasko D, Miller F, Craig U, Silbert L, Adonay R. Healthy Chamorro adults and those with Marianas dementia (MD) are distinguished by patterns of cortical atrophy which differ from European and African American elderly. Neurology (suppl) 64:A391, 2005.  

Kaye JA, Moore MM, Dame A, Quinn J, Camicioli R, Howieson D, Corbridge E, Care B, Nesbit G, Sexton G. Asynchronous regional brain volume losses in presymptomatic to moderate AD. Journal of Alzheimer's Disease 8:51-56, 2005.  

Kishiyama SS, Leahy MJ, Zitzelberger TA, Guariglia R, Zajdel DP, Calvert JF, Jr., Kaye JA, Oken BS. Patterns of dietary supplement usage in demographically diverse older people. Altern Ther Health Med 11:48-53, 2005.  PMC1255934.

Leahy MJ, Thurber D, Calvert JF, Jr. Benefits and challenges of research with the oldest old for participants and nurses. Geriatric nursing (New York, N.Y.) 26:21-28, 2005.  

Montine T, Quinn J, Montine K, Kaye J, Breitner J. Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease. Journal of Alzheimer's Disease 8:359-367, 2005.  

Montine TJ, Montine KS, McMahan W, Markesbery WR, Quinn JF, Morrow JD. F2-isoprostanes in Alzheimer and other neurodegenerative diseases. Antioxid Redox Signal 7:269-275, 2005.  

Morris J, Quaid K, Holtzman D, Kantarcic K, Kaye J, Reiman E, Klunk W, Siemers E. Role of biomarkers in studies of presymptomatic Alzheimer's disease. Alzheimer's & Dementia 1:145-151, 2005.  

Nixon RR. Prion-associated increases in Src-family kinases. The Journal of Biological Chemistry 280:2455-2462, 2005.  

Payami H, Zhu M, Montimurro J, Keefe R, McCulloch CC, Moses L. One step closer to fixing association studies: evidence for age- and gender-specific allele frequency variations and deviations from Hardy-Weinberg expectations in controls. Hum Genet 118:322-330, 2005.  

Peskind ER, Riekse R, Quinn JF, Kaye J, Clark CM, Farlow MR, Decarli C, Chabal C, Vavrek D, Raskind MA, Galasko D. Safety and acceptability of the research lumbar puncture. Alzheimer Disease and Associated Disorders 19:220-225, 2005.  

Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 352:2379-2388, 2005.  

Quinn J, Kulhanek D, Nowlin J, Jones R, Pratico D, Rokach J, Stackman R. Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials. Brain Res 1037:209-213, 2005.  

Reddy PH, Beal MF. Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain research. Brain Research Reviews 49:618-632, 2005.  

Reddy PH, Mani G, Park BS, Jacques J, Murdoch G, Whetsell W, Jr., Kaye J, Manczak M. Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction. Journal of Alzheimer's Disease 7:103-117; discussion 173-180, 2005.  

Robertson J, Curley J, Kaye J, Quinn J, Pfankuch T, Raber J. ApoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice. Neurobiology of Aging 26:637-643, 2005.  

Tractenberg RE, Singer CM, Kaye JA. Symptoms of sleep disturbance in persons with Alzheimer's disease and normal elderly. Journal of Sleep Research 14:177-185, 2005.  

Vuletic S, Peskind ER, Marcovina SM, Quinn JF, Cheung MC, Kennedy H, Kaye JA, Jin LW, Albers JJ. Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro. J Neurosci Res 80:406-413, 2005.  

Woltjer RL, Cimino PJ, Boutte AM, Schantz AM, Montine KS, Larson EB, Bird T, Quinn JF, Zhang J, Montine TJ. Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 19:1923-1925, 2005.  

Zhang J, Goodlett DR, Peskind ER, Quinn JF, Zhou Y, Wang Q, Pan C, Yi E, Eng J, Aebersold RH, Montine TJ. Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid. Neurobiology of Aging 26:207-227, 2005.  

Zhang J, Goodlett DR, Quinn JF, Peskind E, Kaye JA, Zhou Y, Pan C, Yi E, Eng J, Wang Q, Aebersold RH, Montine TJ. Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease. Journal of Alzheimer's Disease 7:125-133; discussion 173-180, 2005.

Adair JC, Charlie J, Dencoff JE, Kaye JA, Quinn JF, Camicioli RM, Stetler-Stevenson WG, Rosenberg GA. Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease. Stroke 35:e159-162, 2004.

Adak S, Illouz K, Gorman W, Tandon R, Zimmerman EA, Guariglia R, Moore MM, Kaye JA. Predicting the rate of cognitive decline in aging and early Alzheimer disease. Neurology 63:108-114, 2004.

Boise L, Neal M, Kaye J. Dementia assessment in primary care: Results from a study in three managed care systems. Journal of Gerontology:  Medical Sciences 59:M621-622, 2004.

Boise L, White D. The Family’s role in person-centered care:  Practice considerations. Journal of Psychosocial Nursing 42:12-20, 2004.

Bongers G, Leurs R, Robertson J, Raber J. Role of H(3)-receptor-mediated signaling in anxiety and cognition in wild-type and Apoe(-/-) mice. Neuropsychopharmacology 29:441-449, 2004.

Connell C, Boise L, Stuckey J, Holmes S, Hudson M. Attitudes toward the diagnosis and disclosure of dementia among primary care physicians and family caregivers. The Gerontologist 44:500-507, 2004.

Goddard K, Olson J, Payami H, van der Voet M, Kuivaniemi H, Tromp G. Evidence of linkage and association on chromosome 20 for late onset Alzheimer disease. Neurogenetics 5:121-128, 2004.

Grundman M, Petersen R, Ferris S, Thomas R, Aisen P, Bennett D, Foster N, Jack C, Galasko D, Doody R, Kaye J, Sano M, Mohs R, Gautheir S, Kim H, Jin S, Schultz A, Schafer K, Mulnard R, van Dyck C, Mintzer J, Zamrini E, Cahn-Weiner D, Thal L, Study AsDC. Mild cognitive impairment can be distinguished from Alzheimer’s disease and normal aging for clinical trials. Archives of Neurology 61:59-66, 2004.

Gutala R, Reddy H. The use of real-time analysis in a gene expression study of Alzheimer's disease post-mortem brains. Journal of Neuroscience Methods 132:101-107, 2004.
Hayes T, Pavel M, Kaye J. An unobtrusive in-home monitoring system for detection of key motor changes preceding cognitive decline. In: 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society; San Francisco, California, 2004: 2480-2483.

Howieson D, Moore M, King N, Quinn J, Camicioli R, Silbert L, Dame A, Sexton G, Kaye J. Temporal lobe correlates of episodic and semantic word retrieval in Alzheimer’s disease. Neurology 62 (suppl 5):A236, 2004.

Itzhaki R, Wozniak M, Appelt D, Balin B. Infiltration of the brain by pathogens causes Alzheimer's disease. Neurobiology of Aging 25:619-627, 2004.

Kaye J, Moore M, Galasko D, Craig U, Adonay R, Silbert L. Family history of Mariana's dementia (MD) or parkinsonism-dementia complex (PDC) is associated with differences in brain volume among chamoro adults. Neurology 62 (suppl 5):A344, 2004.

Kaye J, Samit P, Sudeshna A, Gorman W, Zimmerman E, Moore M, Silbert L. High signal intensity volume predicts the time to dementia among normal aging and early cognitive impairment. Neurology 62 (suppl 5):A254, 2004.

Lezak M, Howieson D, Loring D. Neuropsychological assessment; 2004.

Manczak M, Park BS, Jung Y, Reddy PH. Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage. Neuromolecular Medicine 5:147-162, 2004.

Meuser T, Boise L, Morris J. Clinician beliefs and practices in dementia care: Implications for health educators. Educational Gerontology 30:491-516, 2004.

Montine K, Quinn J, Zhang J, Fessel J, Roberts L, Morrow J, Montine T. Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases. Chemistry and Physics of Lipids 128:117-124, 2004.

Quinn J, Kaye J, Montine T, Stackman R. Phytochemicals in Alzheimer Disease: The Development of Clinical Trials. Archives Of Physiology And Biochemistry 42:64-73, 2004.
Quinn JF, Montine KS, Moore M, Morrow JD, Kaye JA, Montine TJ. Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease. Journal of Alzheimer's Disease 6:93-97, 2004.

Reddy P, McWeeney S, Park B, Manczak M, Gutala R, Jung J, Yau V, Searles R, Mori M, Quinn J. Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: Up-regulation of mitochondrial metabolism and apoptotic genes Is an early cellular change in Alzheimer’s disease. Human Molecular Genetics 13:1225-1240, 2004.

Wijsman E, Daw E, Yu C, Payami H, Steinbart E, Nochlin D, Conlon E, Bird T, Schellenberg G. Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2. American Journal of Human Genetics 75:398-409, 2004.

Aisen PS, Schafer KA, Grundman M, Pfeiffer E, Sano M, Davis KL, Farlow MR, Jin S, Thomas RG, Thal LJ. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA: The Journal of the American Medical Association 289:2819-2826, 2003. 

Camicioli R, Moore M, Kinney A, Corbridge E, Glassberg K, Kaye J. Parkinson's disease is associated with hippocampal atrophy. Movement Disorders 18:784-790, 2003. 

Clark C, Xie S, Chittams J, Ewbank D, Peskind E, Galasko D, Morris J, McKeel Jr D, Farlow M, Weitlauf S, Quinn J, Kaye J, Knopman D, Arai H, Doody R, DeCarli C, Leight S, Lee Y, Trojanoski J. Cerebrospinal fluid tau and beta-amyloid: How well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Archives of Neurology 60:1696-1702, 2003. 

Grundman M, Jack Jr. C, Petersen R, Kim H, Tayloer C, Datvian M, Weiner M, DeCarli C, DeKosky S, van Dyck C, Darvesh S, Yaffe K, Kaye J, Thomas R, Thal L. Hippocampal volume is associated with memory but not non-memory cognitive performance in patients with mild cognitive impairment. Journal of Molecular Neuroscience 20:241-248, 2003. 

Hansen L, Kaye J, Dorn R, Benson H, Davies V, Clark D, Ball M. Families' experiences permitting brain autopsy for the Oregon Brain Bank in the context of the neuropathology report. Brain Aging 3:28-35, 2003. 

Howieson D, Camicioli R, Quinn J, Silbert L, Care B, Moore M, Dame A, Sexton G, Kaye J. Natural history of cognitive decline in the old old. Neurology 60:1489-1494, 2003. 

Kaye J, Moore M, Dame A, Howieson D, Quinn J, Silbert L, Zitzelberger T, Friedman D. Distinguishing features of the oldest old with elite memory function. Neurology (Suppl) 60:A79, 2003. 

Payami H, Nutt J, Gancher S, Bird T, Gonzales McNeal M, Seltzer W K, Hussey J, Lockhart P, Gwinn-Hardy K, Singleton A, Singleton A, Hardy J, Farrer M. SCA2 may present as levodopa responsive Parkinsonism. Movement Disorders 18:425-429, 2003. 

Quinn J. Vascular Dementia. Journal of the American Medical Director Association 4:S155-161, 2003. 

Quinn J, Montine T, Morrow J, Woodward WR, Kulhanek D, Eckenstein F. Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease. J Neuroimmunol 137:32-41, 2003. 

Quinn J, Suh J, Moore M, Kaye J, Frei B. Antioxidants in Alzheimer's disease; Vitamin C delivery to a demanding brain. Journal of Alzheimer's Disease 5:309-313, 2003. 

Silbert L, Quinn J, Moore M, Corbridge E, Ball M, Murdock G, Sexton G, Kaye J. Changes in premorbid brain volume predict AD pathology. Neurology 61:487-492, 2003. 

Silbert LC, Quinn JF, Moore MM, Corbridge E, Ball MJ, Murdoch G, Sexton G, Kaye JA. Changes in premorbid brain volume predict Alzheimer's disease pathology. Neurology 61:487-492, 2003. 

Singer C, Tractenberg R, Kaye J, Schafer K, Gamst A, Grundman M, Thomas R, Thal L. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer' disease. Sleep 26:893-901, 2003. 

Soderling S, Langeberg L, Soderling J, Davee S, Simerly R, Raber J, Schott J. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proceedings of the National Academy of Sciences of USA 100:1723-1728, 2003. 

Spencer D, Spielman D, Zitzelberger T, Kaye J. Magnetic resonance spectroscopy in the "oldest old" may predict progression to dementia. Neurology 58:A402, 2003. 

Spencer D, Zitzelberger T, Spielman D, Kaye J. MRS in relation to hippocampal volume in the oldest old. Neurology 60:1194-1196, 2003. 

Stackman R, Eckenstein F, Frei B, Kulhanek D, Nowlin J, Quinn J. Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic ginkgo biloba treatment. Experimental Neurology 184:510-520, 2003. 

Tractenberg R, Singer C, Cummings J, Thal L. The Sleep Disorders Inventory: an instrument for studies of sleep disturbance in persons with Alzheimer's disease. Journal of Sleep Research 12:331-337, 2003. 

Wild K, Cotrell V. Identifying driving impairment in Alzheimer disease:  A comparison of self and observer reports versus driving evaluation. Alzheimer Disease and Associated Disorders 17:27-34, 2003. 

Wilmot B, Sheridan B, Fife D, O'Malley J, Murdoch G, Nagalla S, Kaye J, Kramer P. Effect of apolipoprotein e genotype on differential gene expression in control and Alzheimer's disease brain. Neurology 60 (suppl 1):A455, 2003. 

Yesavage J, Friedman L, Ancoli-Israel S, Bliwise D, Singer C, Vitiello M, Monjan A, Lebowitz B. Development of diagnostic criteria for defining sleep disturbance in Alzheimer's disease. Journal of Gertiatric, Psychiatry and Neurology 16:131-139, 2003. 

Colangelo V, Schurr J, Ball M, Pelaez R, Bazan N, Lukiw W. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-Inflammatory signaling. Journal of Neuroscience Research 70:462-473, 2002. 

Erten-Lyons D, Camicioli R, Kaye J, Silbert L, Frank E, Quinn J. Lumbo-peritoneal shunt as a diagnostic aid in the management of normal pressure hydrocephalus: The Oregon Aging and Alzheimer Center experience. Canadian Journal of Neurological Sciences 29:S40, 2002. 

Friedman D, Moore M, Quinn J, Howieson D, Kaye J. Use it or lose it: A prospective evaluation of intellectual activity and the development of dementia. Neurology 58:A103, 2002. 

Haan M, Jagust W, Galasko D, Kaye J. Effect of extrapyramidal signs and lewy bodies on survival in patients with Alzheimer disease. Archives of Neurology 59:588-593, 2002. 

Hooker K, Bowman S, Coehlo D, Lim S, Kaye J, Guariglia R, Li F. Behavioral change in persons with dementia:  Relationships with mental and physical health of caregivers. Journal of Gerontology:  Psychological Sciences 57:453-460, 2002. 

Howieson D, Lezak M. Separating memory from other cognitive problems. In: (Eds.) ABaBW, ed. Handbook of Memory Disorders: John Wiley & Sons, 2002.

Howieson D, Lezak M. The neuropsychological evaluation. In: (Eds.) HaY, ed. The American Psychiatric Press Textbook of Neuropsychiatry: American Psychiatric Association, 2002.

Hussey J, Lockhart P, Seltzer W, Zbigniew K, Wszolek Z, Payami H, Hanson M, Gwinn-Hardy K, Farrer M. Accurate determination of ataxin-2 polyglutamine expansion in patients with intermediate-range repeats. Genetic Testing 6:217-220, 2002. 

Kaye J. Healthy Brain Aging. Archives of Neurology 59:1721-1723, 2002. 

Kaye J, Dame A, Moore M, Quinn J, Howieson D, Camicioli R, Sexton G. Hippocampal volume predicts dementia-free survival up to 12 years before symptom onset. Neurology 58:A400, 2002. 

Kaye J, Syms M, Thurber D, Calvert J, White S, Russell L. Exceptional survival is rarely associated with intact cognition in a rural population-based cohort. Neurobiology of Aging 23:S448, 2002. 

Kaye JA. Healthy brain aging. Archives of Neurology 59:1721-1723, 2002. 

Marquis S, Moore MM, Howieson DB, Sexton G, Payami H, Kaye JA, Camicioli R. Independent predictors of cognitive decline in healthy elderly persons. Archives of Neurology 59:601-606, 2002. 

Messecar D, Archbold P, Stewart B, Kirschling J. Home environmental modification strategies used by caregivers of elders. Research in Nursing and Health 25:357-370, 2002. 

Montine K, Montine T, Morrow J, Frei B, Milatovic D, Eckenstein F, Quinn J. Mouse cerebral prostaglandins, but not oxidative damage, change with age and are responsive to indomethacin treatment. Brain Research 930:75-82, 2002. 

Montine T, Neely M, Quinn J, Beal M, Markesbery W, Roberts L, Morrow J. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radical Biology and Medicine 33:620-626, 2002. 

Montine TJ, Quinn JF, Milatovic D, Silbert LC, Dang T, Sanchez S, Terry E, Roberts LJ, 2nd, Kaye JA, Morrow JD. Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease. Annals of Neurology 52:175-179, 2002. 

Payami H, Zareparsi S, James D, Nutt J. Familial aggregation of Parkinson's disease: A comparative study of early-onset and late-onset disease. Archives of Neurology 59:848-850, 2002. 

Quinn J, Kulhanek D, Nowlin J, Murdoch G. Brain tissue expression of antioxidant enzymes in an animal model of Alzheimer's disease: Cellular specificity and changes with age. In: Society for Neuroscience Abstracts, 2002.

Quinn J, Montine T, Dang T, Rask T, Corbridge E, Moore M, Desrochers K, Coakley B, Kaye J. Rate of ventricular enlargement is the best biomarker predicting clinical progression of Alzheimer's disease over one year. Neurology 58:A142, 2002. 

Quinn J, Moore M, Benson DF, Clark CM, Doody R, Jagust W, Knopman D, Kaye JA. A videotaped CIBIC for dementia patients: validity and reliability in a simulated clinical trial. Neurology 58:433-437, 2002. 

Riviere G, Riviere K, Smith K. Molecular and immunologic evidence of oral treponema in human brain and their association with Alzheimer's disease. Oral Microbiology and Immunology 17:113-118, 2002. 

Salat DH, Kaye JA, Janowsky JS. Greater orbital prefrontal volume selectively predicts worse working memory performance in older adults. Cereb Cortex 12:494-505, 2002. 

Singer C, Tractenberg R, Kaye J, Schafer K, Gamst A, Grundman M, Thomas R, Thal L. ADCS clinical trial of melatonin for the sleep disturbance of Alzheimer's:  Case report of an unusual sleep/wake cycle and response to melatonin. American Journal of  Geriatric Psychiatry 10:92, 2002. 

Zareparsi S, Camicioli R, Sexton G, Bird T, Swanson P, Kaye J, Nutt J, Payami H. Age at onset of Parkinson disease and apolipoprotein E genotypes. American Journal of Medical Genetics 107:156-161, 2002. 

Zareparsi S, James D, Kaye J, Bird T, Schellenberg G, Payami H. HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer's disease. Neurology 58:973-975, 2002.