Dr. Orwoll specializes in the evaluation and care of patients with osteoporosis, other forms of metabolic bone disorders, and abnormalities of calcium metabolism. He is professor of medicine and attending physician in the bone and mineral section of the Division of Endocrinology, Diabetes, and Clinical Nutrition, and has been the director of the Bone and Mineral Clinic, and of the Bone Density Lab.

He is an internationally recognized expert in the area of bone biology and metabolic bone disease, and has considerable experience in basic, clinical, and epidemiological investigation. Major areas of research interest include the epidemiology, etiology and therapy of osteoporosis in men, the evaluation of new diagnostics and therapeutics, osteogenesis imperfecta, effects of sex steroids on skeletal biology, and skeletal genetics/proteomics.

He has been the principle investigator for many projects supported by the National Institutes of Health, VA and foundations, and is the author of more than 400 peer reviewed publications, reviews, books, and book chapters. He is also an experienced leader in academic medicine who has had extensive responsibility for clinical and translational research planning and management. He has been the associate vice-president for research at OHSU, associate dean for clinical research in the School of Medicine, and the director of the Oregon Clinical and Translational Research Institute. Dr. Orwoll receives research support from the National Institutes of Health, the Osteogenesis Imperfecta Foundation, Merck, and Eli Lilly.