Leena Kadam

Biography

Dr. Kadam earned her Ph.D. in Reproductive Physiology from Wayne State University School of Medicine. She is a placental molecular biologist by training with extensive experience working in the field across rodent, mice and human models of investigation. Her research focuses on understanding trophoblast function and development of placental diseases as well as developing use of trophoblast cells as markers for pregnancy status and for prenatal genetic diagnosis. She is currently working on understanding how disruptions in mitochondrial energetics affect placental function in pregnancy disorders.

Selected publications

Armistead B, Johnson E, VanderKamp R, Kula-Eversole E, Kadam L, Drewlo S, Kohan-Ghadr HR. Placental Regulation of Energy Homeostasis During Human Pregnancy. Endocrinology. 2020 Jul 1;161(7):bqaa076. doi: 10.1210/endocr/bqaa076. PMID: 32417921.

Armistead B, Kadam L, Drewlo S, Kohan-Ghadr HR. The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight. Int J Mol Sci. 2020 Mar 5;21(5):1775. doi: 10.3390/ijms21051775. PMID: 32150832; PMCID: PMC7084575.

Kadam L, Kohan-Ghadr HR, Drewlo S. The balancing act - PPAR-γ's roles at the maternal-fetal interface. Syst Biol Reprod Med. 2015 Apr;61(2):65-71. doi: 10.3109/19396368.2014.991881. Epub 2014 Dec 5. PMID: 25475254; PMCID: PMC6364849.

Bucher M, Kadam L, Ahuna K, Myatt L. Differences in Glycolysis and Mitochondrial Respiration between Cytotrophoblast and Syncytiotrophoblast In-Vitro: Evidence for Sexual Dimorphism. Int J Mol Sci. 2021 Oct 8;22(19):10875. doi: 10.3390/ijms221910875. PMID: 34639216; PMCID: PMC8509198.

Armistead B, Kadam L, Siegwald E, McCarthy FP, Kingdom JC, Kohan-Ghadr HR, Drewlo S. Induction of the PPARγ (Peroxisome Proliferator-Activated Receptor γ)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta. Hypertension. 2021 Jul;78(1):230-240. doi: 10.1161/HYPERTENSIONAHA.121.17267. Epub 2021 May 24. PMID: 34024123; PMCID: PMC8312350.

Contact

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