May 2024  Congratulations to Project 1 lead, Dr. Nora Gray and team for their paper recently published in Frontiers in Aging: Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration

May 2024  BENFRA team members had a busy Spring presenting their work at multiple conferences between March and May 2024.
See photos on our photos page here

April 2024  The work of the BENFRA Center is highlighted in the April 2024 Message from the Director of the NIH Office of Dietary Supplements

April 2024  Congratulations to Dr. Dani Long, who has received a T32 postdoctoral training grant (NCCIH AT002688; CAM Research Training in Neuroscience and Stress). Dani will continue to work with BENFRA on age-related Drosophila melanogaster phenotypes, expanding the research to include additional botanicals.

April 2024  Congratulations to first author Dr. Alex Speers on his paper recently published in Frontiers in Neuroscience: Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered

April 2024  Congratulations to Dr. Ben Zimmerman who won an award for his poster on Evaluating the effects of Centella asiatica water extract on cerebrovascular function in mice presented at the Society for Neuroscience Oregon/SW Washington Chapter annual meeting on March 9, 2024.

Feb. 2024  Congratulations to first author Armando Alcázar Magaña on his paper recently published in Molecules: Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of C. asiatica Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity

BENFRA Director Dr. Amala Soumyanath was interviewed by Medical News Today about Ashwagandha. Read the article, published October 24, 2023.

Congratulations to the Fall 2023 Neurology Department Pilot Awardees Olivia Monestime and Rachel Morrill! Olivia will be working with Dr. Nora Gray on a project titled “Assessing microglial phenotypes in 5xFAD mice following oral botanical administration” and Rachel will be working with Dr Doris Kretzschmar on the project “Investigating neuroprotective effects of Centella asiatica in a Drosophila Tauopathy model.”

Congratulations to first author Helen Holvoet on her paper recently published in Nutrients: Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila melanogaster.

Congratulations to first author Dr. Liping Yang and the BENFRA Botanical Research Core team on their paper recently published in the Journal of Chromatography Open:
Quantification of caffeoylquinic acids and triterpenes as targeted bioactive compounds of Centella asiatica in extracts and formulations by liquid chromatography mass spectrometry.

BENFRA and associated R03’s were well represented at the recent American Society of Pharmacognosy conference and the NIH CARBON meeting in Bethesda MD, July 2023 . View photos

August 2023 Congratulations to three of our Postdoctoral Scholars who have obtained Career development awards linked to their work at BENFRA!

• Dr. Alex Speers has been awarded a NIH/NCATS KL2 training grant through the Oregon Clinical and Translational Research Institute at OHSU. The title of his project is: Safety, tolerability, and pharmacokinetics of an oral Withania somnifera product in older adults. 
• Dr. Ben Zimmerman received a Medical Research Foundation Early Clinical Investigator award. The title of his  project is: Effect of Centella asiatica on Vascular Endothelial Function in Older Adults. This study will be conducted at the National University of Natural Medicine, Portland.
• Dr. Steven Chamberlin was awarded a K08 grant from the National Center of Complementary and Integrative Health (NIH/NCCIH). The title of his project is: Network models to capture multiple outcomes resulting from multi-component, salutogenic interventions.

July 2023  Congratulations to BENFRA Co-Investigator Dr. Anusha Mishra, promoted to Associate Professor!

July 2023  BENFRA welcomes a new R03 collaborator, Dr. Wendy Strangman, from the University of North Carolina, Wilmington who will be evaluating metabolic stability of Ashwagandha extracts using in vitro laboratory models simulating the gastrointestinal environment. Welcome Dr. Strangman and lab!

May 2023  Congratulations to the joint first authors Dr. Alex Speers and Kadine Cabey!
 review written by BENFRA authors (Speers et al, 2021) is cited as a “key reference” on the NCCIH’s public information sheet on Ashwagandha.

May 2023  Congratulations Ben!
BENFRA’s Dr. Ben Zimmerman won the “Best Post-doc poster award” at the Oregon & Southwest Washington Chapter of the Society for Neuroscience Meeting (May 12-13, 2023), for his poster on “An ex vivo mouse brain slice model to study acute cerebral vasoactivity of Centella asiatica water” extract.  

May 2023  Congratulations Amala!
Dr. Amala Soumyanath was interviewed and quoted in this Huff Post article about ashwagandha and stress.