BENFRA publications

Marney L, Choi J, Magana A, Yang L, Techen N, Alam M, Brandes M, Soumyanath A, Stevens J, Maier C. Liquid Chromatography-Mass Spectrometry Quantification of Phytochemicals in Withania somnifera Using Data-Dependent Acquisition, Multiple-Reaction-Monitoring, and Parallel-Reaction-Monitoring with an Inclusion List. Front. Chem., 16 July 2024 DOI.

Rowe K, Gray N, Zweig J, Law A, Techen N, Maier C, Soumyanath A, Kretzschmar D. Centella asiatica and its caffeoylquinic acid and triterpene constituents increase dendritic arborization of mouse primary hippocampal neurons and improve age-related locomotion deficits in Drosophila. Front. Aging, 10 July 2024 DOI.

Gray NE, Hack W, Brandes MS, Zweig JA, Yang L, Marney L, Choi J, Magana AA, Cerruti N, McFerrin J, Koike S, Nguyen T, Raber J, Quinn JF, Maier CS, Soumyanath A. Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration. Front Aging. 2024 May 6;5:1357922. DOI.

Speers, AB, Wright KM, Brandes, MS, Kedjejian, N, Matthews, DG, Caruso, M, Harris, CJ, Koike, S, Nguyen, T, Quinn, JF, Soumyanath A, Gray, NE (2024). Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered. Front. Neurosci, 18:1277626. DOI.

Holvoet H, Long DM, Yang L, Choi J, Marney L, Poeck B, Maier CS, Soumyanath A, Kretzschmar D, Strauss R. Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila melanogaster. Nutrients. 2023; 15(18):4016. DOI.

Yang, L, Marney, L, Alcázar Magaña A, Choi, J, Wright, K, McFerrin, J, Gray, NE, Soumyanath A, Stevens JF, Maier CS. Quantification of caffeoylquinic acids and triterpenes as targeted bioactive compounds of Centella asiatica in extracts and formulations by liquid chromatography mass spectrometry J of Chromatography Open 2023; 4:100091. DOI.

Holvoet H, Long DM, Law A, McClure C, Choi J, Yang L, Marney L, Poeck B, Strauss R, Stevens JF, Maier CS, Soumyanath A, Kretzschmar D. Withania somnifera Extracts Promote Resilience against Age-Related and Stress-Induced Behavioral Phenotypes in Drosophila melanogaster; a Possible Role of Other Compounds besides Withanolides. Nutrients. 2022; 14(19):3923. DOI.

Cabey K, Long DM, Law A, Gray, NE, McClure C, Caruso M, Lak P, Wright KM, Stevens JF, Maier CS, Soumyanath A and Kretzschmar D. (2022). Withania somnifera and Centella asiatica extracts ameliorate behavioral deficits in an in vivo Drosophila melanogaster model of oxidative stress. Antioxidants 11(1),121; DOI.

Speers, AB, Cabey KA, Soumyanath A, Wright KM (2021). Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Current Neuropharmacology, 19(9), 1468-1495.

Alcázar Magaña A, Kamimura N, Soumyanath A, Stevens JF, Maier CS. Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity. Plant J. 2021;107(5):1299-1319. DOI.

Related publications by BENFRA Researchers

Alcázar Magaña A, Vaswani A, Brown KS, Jiang Y, Alam MN, Caruso M, Lak P, Cheong P, Gray NE, Quinn JF, Soumyanath A, Stevens JF, Maier CS. Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of C. asiatica Extract Associates Dicaffeoylquinic Acids with Protection against Amyloid-β Toxicity. Molecules. 2024 Feb 13;29(4):838. DOI. PMID: 38398590; PMCID: PMC10892090.

Wright, KM, Bollen, M, David, J, Mepham, B, Alcazar Magaña, A, McClure, C, Maier, CS, Quinn, J, Soumyanath, A. Bioanalytical Method Validation and Application to a Phase 1, Double-Blind, Randomized Pharmacokinetic Trial of a Standardized Centella asiatica (L.) Urban Water Extract Product in Healthy Older Adults. Front. Pharmacol. 2023; 14. DOI.

Khorani M, Bobe G, Matthews DG, Alcazar Magana A, Caruso M, Gray NE, Quinn JF, Stevens JF, Soumyanath A, Maier CS. (2022).  The impact of the HAPP695SW transgene and associated amyloid-β accumulation on murine hippocampal biochemical pathways. J Alzheimers Dis. 2022; 85(4):1601-1619. DOI. PMID: 34958022.

Wright KM, Bollen M, David J, Speers AB, Brandes MS, Gray, NE, Alcazar Magana A, McClure C, Stevens JF, Maier CS, Quinn JF, and Soumyanath, A. (2022). Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial. Antioxidants 2022, 11, 215. DOI.

Wright KM, McFerrin J, Alcazar Magana A, Roberts J, Caruso M, Kretzschmar D, Stevens JF, Maier CS, Quinn JF, and Soumyanath, A. (2022). Developing a rational, optimized product of Centella asiatica for examination in clinical trials: real world challenges. Front. Nutr. (Methodology), Vol 8, 14 January 2022; DOI.

Speers AB, García-Jaramillo M, Feryn A, Matthews DG, Lichtenberg T, Caruso M, Wright KM, Quinn JF, Stevens JF, Maier CS, Soumyanath A, Gray NE. (2021). Centella asiatica alters metabolic pathways associated with Alzheimer's disease in the 5xFAD mouse model of ß-Amyloid Accumulation.  Front Pharmacol. 2021 Dec 16;12:788312. PMID: 34975484. PMCID: PMC8717922. DOI.

Zweig, J.A., Brandes, M.S., Brumbach, B.H., Caruso, M., Wright, K.M., Quinn, J.F., Soumyanath, A., Gray, N.E., Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction and is required for the cognitive enhancing effects of Centella asiatica during aging., Neurobiology of Aging (2021), DOI.

Matthews DG, Caruso M, Alcazar Magana A, Wright KM, Maier CS, Stevens JF, Gray NE, Quinn JF, Soumyanath A. Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice. Nutrients. 2020; 12(11):3488. DOI.

Wright KM, Alcazar Magaña A, Laethem RM, et al. Centella asiatica water extract shows low potential for CYP-mediated drug interactions. Drug Metab Dispos. June 24, 2020, dmd.120.090860; DOI.

Alcazar Magana A, Wright K, Vaswani A, et al. Integration of mass spectral fingerprinting analysis with precursor ion (MS1) quantification for the characterisation of botanical extracts: application to extracts of Centella asiatica (L.) Urban. Phytochem Anal. 2020 Apr 12. doi: 10.1002/pca.2936.

Matthews DG, Caruso M, Murchison CF, et al. Centella Asiatica improves memory and promotes antioxidative signaling in 5XFAD mice. Antioxidants (Basel). 2019;8(12):630. doi: 10.3390/antiox812063.

Gray NE, Zweig JA, Caruso M, et al. Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice. Brain Behav. 2018;8(7):e01024.

Gray NE, Zweig JA, Caruso M, et al. Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in beta-amyloid overexpressing mice. Mol Cell Neurosci. 2018;93:1-9.

Gray NE, Zweig JA, Matthews DG, Caruso M, Quinn JF, Soumyanath A. Centella asiatica Attenuates Mitochondrial Dysfunction and Oxidative Stress in Abeta-Exposed Hippocampal Neurons. Oxid Med Cell Longev. 2017;2017:7023091.

Gray NE, Zweig JA, Murchison C, et al. Centella asiatica attenuates Abeta-induced neurodegenerative spine loss and dendritic simplification. Neurosci Lett. 2017;646:24-29.

Gray NE, Harris CJ, Quinn JF, Soumyanath A. Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice. J Ethnopharmacol. 2016;180:78-86.

Gray NE, Sampath H, Zweig JA, Quinn JF, Soumyanath A. Centella asiatica Attenuates Amyloid-beta-Induced Oxidative Stress and Mitochondrial Dysfunction. J Alzheimers Dis. 2015;45:933-946.

Gray NE, Morré J, Kelley J, et al. Caffeoylquinic acids in centella asiatica protect against amyloid-ß toxicity. Journal of Alzheimer's Disease. 2014;40(2):359-373.

Soumyanath A, Zhong YP, Henson E, et al. Centella asiatica extract improves behavioral deficits in a mouse model of Alzheimer's disease: Investigation of a possible mechanism of action. International Journal of Alzheimer's Disease. 2012.

Soumyanath A, Zhong, Y.P., Gold, S.A., Yu, X., Koop, D.R., Bourdette, D. & Gold, B.G.,. Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in vitro. Journal of Pharmacy & Pharmacology. 2005;57(9):1221-1229.