BENFRA poster presentations

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International Congress on Natural Products Research, Krakow, Poland, July 13–17, 2024

Ashwagandha improves cognition and attenuates depressive-like behavior in an Alzheimer’s disease mouse model
Noah Gladen Kolarsky, Wyatt Hack, Olivia Monestime, Melissa Bollen, Amala Soumyanath, Nora Gray

72nd Annual ASMS Mass Spectrometry and Allied Topics, Anaheim, June 2–6, 2024

Discovering bioactive compounds in Centella asiatica by chromatographic fractionation, flow-injection ion-mobility mass spectrometry, ARE/NRF2 response, and ensemble elastic net regression
Luke Marney, Vera Alenicheva, Bailey Keefe, Jaewoo Choi, Liping Yang, Nora Gray, Amala Soumyanath, Kevin Brown, Jan F. Stevens, Claudia S. Maier
 
Knowledge-based data strategies bridge the gap for automated data analysis of phytochemical diversity in Withania somnifera
Luke Marney, Rudranil Dutta, Jaewoo Choi, Liping Yang, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier
 

OHSU Research Week, Portland, OR, May 6–10, 2024

Evaluating the effects of Centella asiatica water extract on cerebrovascular function in mice.
Zimmerman, B., Soumyanath, A., Gray, N., Pike, M., Mishra, A.

CAW attenuates microglial activation in the hippocampus and reduces B-amyloid plaque burden in the cortex of female 5XFAD mice.
Olivia Monestime, Alex Speers, Nareg Kedjejian, Mikah Brandes, Dos Matthews, Maya Caruso, and Amala Soumyanath, Nora Gray.

Ashwagandha improves cognition and attenuates depressive-like behavior in 5xFAD mice.
Noah Gladen-Kolarsky, Wyatt Hack, Nora Gray, Amala Soumyanath, and Olivia Monestime.

American Society for Neurochemistry 2024 Annual Meeting, Portland, OR, April 14–18, 2024 

Effects of Centella asiatica water extract on cerebrovascular function in mice. 
Zimmerman, B., Soumyanath, A., Gray, N., Pike, M., Mishra, A.

Metabolomic Profiling of Greenhouse-Grown Cultivars of Centella asiatica, a Herb Touted for Improving Memory and Preventing Cognitive Decline.
Md Nure Alam, Luke Marney, Liping Yang, Jaewoo Choi, Natasha Cerruti , Natascha Techen, Samuel Bassett, James Smith, Kevin Brown,  Kadine Cabey, Ramya Viswanathan, Sumanaa Rajagopal, Amala Soumyanath, Jan F. Stevens, and Claudia S. Maier.

Neuroactive Effects of Ashwagandha: From Ayurvedic Medicine to Cellular Bioactivity and Mass Spectrometry.
Emily Georges, Luke Marney, Jaewoo Choi, Liping Yan, Md Alam Nure, Rudranil Dutta, Armando Alcazar Magana, Amala Soumyanath, Bailey Keefe, Jan F. Stevens, Claudia S. Maier.

2024 International Congress on Integrative Medicine & Health, Cleveland, OH, April 9–14, 2024

Investigating the effects of Centella asiatica water extract on cerebrovascular function in mice.
Zimmerman, B., Soumyanath, A., Gray, N., Pike, M., Mishra, A.

Society for Neuroscience Oregon/SW Washington Chapter Meeting, Troutdale, OR, March 8–9, 2024

Evaluating the effects of Centella asiatica water extract on cerebrovascular function in mice.
Zimmerman, B., Soumyanath, A., Gray, N., Pike, M., Mishra, A.

Centella asiatica reduces anxiety in aged female mice, accompanied by elevated levels of GABA, and reduced levels of corticosterone in blood samples. 
Olivia Monestime, Wyatt Hack, Jon Zweig, Mikah Brandes, Amala Soumyanath, Nora Gray.

A water extract of the plant Centella asiatica increases cortical BDNF levels in aged mice. 
Brooke Rogers, Sam Varada, Wyatt Hack, Jon Zweig, Mikah Brandes, Amala Soumyanath, Nora Gray.

Linus Pauling Institute Conference on Diet and Optimum Health, Septmeber 19 and 20, 2023

Centella asiatica administered in the drinking water attenuates age-related changes in cognition, anxiety and sleep-deprived cognition more robustly than when administered in the diet.
Hack W, Brandes MS, Zweig JA,  Koike S, Nguyen T, Raber J, Quinn JF, Soumyanath A, Gray NE.

Chemical profiling of Centella asiatica greenhouse-grown cultivars by high resolution mass spectrometry
Md Nure Alam, Luke Marney, Liping Yang, Jaewoo Choi, Natasha Cerruti, Natascha Techen, Samuel Bassett, James Smith, Kevin Brown, Kadine Cabey, Ramya Viswanathan, Sumanaa Rajagopal, Amala Soumyanath, Jan F. Stevens, and Claudia S. Maier.
 
Computational Approaches to Outline Compositional Difference of Ashwagandha Root and Leaf Extracts
Rudranil Dutta, Luke Marney, Md Alam Nure, Jaewoo Choi, Vera Alenicheva, Emily Georges, Armando Alcazar Magana, Liping Yang, Mikah Brandes, Doris Kretzschmar, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier.

American Society of Pharmacognosy Annual Meeting, Bethesda MD, July 22–26, 2023

Chemical profiling of greenhouse grown Centella asiatica cultivars by high resolution 
mass spectrometry
Md Nure Alam, Luke Marney, Liping Yang, Jaewoo Choi, Natasha Cerruti, Samuel Bassett, Kadine Cabey, Ramya Viswanathan, Sumanaa Rajagopal, Amala Soumyanath, Jan F. Stevens, and Claudia S. Maier. 

Centella asiatica administered in the drinking water attenuates age-related changes in cognition, anxiety and sleep-deprived cognition more robustly than when administered in the diet.
Wyatt Hack, Mikah Brandes, Jon Zweig, Seiji Koike, Thuan Nguyen, Jacob Raber, Joseph F. Quinn, Amala Soumyanath, Nora E. Gray.

Evaluation of botanical extracts for cytochrome P450 mediated drug interactions.
Zarna Raichura, Kabre Heck, Jaewoo Choi, Mikah Brandes, Cody Neff, Claudia Maier, Amala Soumyanath, Robert Arnold, and Angela I Calderón.

LC-MS and Proton NMR Spin Network Fingerprint Databases of Secondary Metabolites for Identification and Standardization of the Botanical Supplement Centella asiatica. 
Harinantenaina L. Rakotondraibe, Luke C. Marney, Jaewoo Choi, Liping Yang, Nora Gray, Jan F. Stevens, Claudia S. Maier, Amala Soumyanath.

Phytochemical Society of North America Meeting, East Lansing MI, July 16–20, 2023

Phytochemical characterization of Ashwagandha, a best-selling botanical supplement for stress relief and improvement of sleep
Luke Marney, Jaewoo Choi,  Armando Alcazar Magana, Liping Yang, Md Alam Nure, Mikah Brandes, Doris Kretzschmar, Amala Soumyanath,  Jan F. Stevens, Claudia S. Maier.

American Society of Mass Spectrometry, Houston TX, June 4–8, 2023

Dimensionality reduction methods and GNPS for plant metabolomics of Centella asiatica cultivars
Luke Marney, Md Alam Nure, Liping Yang, Jaewoo Choi, Natasha Cerruti, Armando Alcazar Magana, Corey De la Cruz, Gerrad Jones, Kadine Cabey, Ramya Viswanathan, Sumanaa Rajagopal, James Smith, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier

Delineating the natural product composition of Ashwagandha extracts by combining electrophile trapping with untargeted chemical fingerprinting and GNPS networking 
Md Nure Alam, Armando Alcazar Magana, Jaewoo Choi, Luke Marney, Paul Cheong, Mikah Brandes, Cody Neff, Amala Soumyanath, Jan F. Stevens, and Claudia S. Maier.

OHSU Research Week and OHSU Neurology Research Day, May 2023

Sex specific effects of Centella asiatica on age-related sleep deficits in an aged mouse model
Carolyn E. Tinsley, Katelyn Gutowsky, Matthias Ruffins, Noah E.P. Milman, Claire Wong, Christina Reynolds, Amala Soumyanath, Nora E. Gray, Miranda M. Lim.

An ex vivo mouse brain slice model to study acute cerebral vasoactivity of Centella asiatica water extract.
Benjamin Zimmerman, Amala Soumyanath, Anusha Mishra.

NIH CARBON Program Annual Meeting, Bethesda, MD, September 29–30, 2022

Untargeted Transcriptomic Analysis Reveals a High Degree of Pathway Activation in Mouse Primary Cortical Neurons by Centella asiatica extract and compounds. 
Steve Chamberlin, Jonathan Zweig, Cody Neff, Dan Bottomly, Amala Soumyanath, Shannon McWeeney, Claudia Maier, Nora Gray.

American Society of Pharmacognosy Annual Meeting, Charleston SC, July 23–28, 2022

Withania somnifera (WS) extracts exhibit extract-dependent neurotropic activities
Kadine Cabey, Christine McClure, Jonathan Zweig, Nareg Kedjejian,  Mikah S. Brandes, Cody Neff, Alexander Law, Luke Marney, Armando Alcazar-Magana, Jaewoo Choi, Liping Yang, Jan F. Stevens, Claudia S. Maier, Nora Gray, Doris Kretzschmar, and Amala Soumyanath.
 
Centella asiatica extract provides resilience against age related behavior changes in Drosophila melanogaster
Karon Rowe, Kadine Cabey, Armando Alcazar-Magana, Jaewoo Choi, Liping Yang, Jan F. Stevens, Claudia S. Maier, Doris Kretzschmar and Amala Soumyanath.
 
Untargeted Transcriptomic Analysis of the Effects of Centella asiatica in Cortical Neurons
Steve Chamberlin, Jonathan Zweig, Dan Bottomly, Claudia Maier, Amala Soumyanath, Shannon McWeeney, Nora Gray.

Alzheimer’s Association International Conference, Amsterdam, Netherlands and Online, July 16–20, 2022

Investigating the Effects of Centella asiatica on Neuroinflammation in Beta-Amyloid Overexpressing Mice
Alex B. Speers, Mikah S. Brandes, Nareg Kedjejian, Donald G. Matthews, Maya Caruso, Kirsten M. Wright, Christopher J. Harris, Joseph F. Quinn, Amala Soumyanath, Nora E. Gray.

Intelligent Systems for Molecular Biology (ISMB), Madison, WI and online, July, 10–14, 2022

Untargeted Transcriptomic Analysis of the Effects of Centella asiatica in Cortical Neurons
Steve Chamberlin, Jonathan Zweig, Dan Bottomly, Claudia Maier, Amala Soumyanath, Shannon McWeeney, Nora Gray.

American Society of Mass Spectrometry, Minneapolis, MN, June 5–9, 2022

Contrasting the quantifiability of Centella asiatica marker compounds in extracts and formulations using LC-HRMS/MS and LC-MRM-MS
Liping Yang, Luke Marney, Armando Alcazar Magana, Jaewoo Choi, Md Alam Nure, Mikah Brandes, Christine McClure, Nora Gray, Doris Kretzschmar, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier
 
Establishing a characterization and quantitation strategy for Withania somnifera extracts using LC-HRMS/MS and LC-MRM-MS
Jaewoo Choi, Luke C. Marney, Armando Alcazar Magana, Liping Yang, Md Alam Nure, Mikah Brandes, Christine McClure, Doris Kretzschmar, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier.

American Society of Pharmacognosy- Vanguards of Natural Product Research 2021, July 30, 2021 (virtual poster session)

Centella asiatica and Withania somnifera improve resilience in older Drosophila melanogaster flies
Christine McClure, Mikah Brandes, Doris Kretzschmar, Parnian Lak, Maya Caruso, Armando Alcazar Magana, Kadine Cabey, Alex Speers, Kirsten Wright, Claudia Maier, Jan F. Stevens, Amala Soumyanath.

Chemometric Analysis for the Classification and Characterization of Withania somnifera Extracts Using LC-HRMS/MS
Armando Alcazar Magana, Md Nure Alam, Mikah Brandes, Christine McClure, Amala Soumyanath, Jan F. Stevens, and Claudia S. Maier.

Metabolomic investigation into the cognitive-enhancing effects of Centella asiatica in a 5xFAD mouse model of β-amyloid accumulation
Alex B. Speers, Manuel García-Jaramillo, Alicia Feryn, Donald G. Matthews, Talia Lichtenberg, Joseph F. Quinn, Jan F. Stevens, Claudia S. Maier, Amala Soumyanath, Nora E. Gray.

60th Annual Meeting of the Phytochemical Society of North America, Canada virtually from July 25–30, 2021

Establishing a characterization strategy for Withania somnifera extracts using LC-HRMS/MS in combination with GNPS networking analysis. 
Armando Alcazar Magana, Mikah Brandes, Christine Mcclure,  Amala Soumyanath, Jan F. Stevens, And Claudia S. Maier.
Best poster award

International Conference on Traditional Medicine and Phytochemistry, Jul 12–14, 2021, (virtual, organizers in Melbourne, AU)

Centella asiatica and Withania somnifera improve resilience in older Drosophila melanogaster flies
Christine McClure, Mikah Brandes, Doris Kretzschmar, Lak P, Maya Caruso, Armando Alcazar Magana, Kadine Cabey, Alex Speers, Kirsten Wright, Claudia Maier, Jan F. Stevens, Amala Soumyanath.

OHSU Neurology Research Day, May 1, 2021 (virtual meeting)

Centella asiatica and Withania somnifera improve resilience in older Drosophila melanogaster flies
Christine McClure, Mikah Brandes, Doris Kretzschmar, Parnian Lak, Maya Caruso, Armando Alcazar Magana, Kadine Cabey, Alex Speers, Kirsten Wright, Claudia Maier, Jan F. Stevens, Amala Soumyanath.

Metabolomic investigation into the cognitive-enhancing effects of Centella asiatica in a 5xFAD mouse model of β-amyloid accumulation  
Alex B. Speers, Manuel García-Jaramillo, Alicia Feryn, Donald G. Matthews, Talia Lichtenberg, Joseph F. Quinn, Jan F. Stevens, Claudia S. Maier, Amala Soumyanath, Nora E. Gray.

Society for Neuroscience, Oregon Chapter. April 15, 2021 (virtual meeting)

Metabolomic investigation into the cognitive-enhancing effects of Centella asiatica in a 5xFAD mouse model of β-amyloid accumulation 
Alex B. Speers, Manuel García-Jaramillo, Alicia Feryn, Donald G. Matthews, Talia Lichtenberg, Joseph F. Quinn, Jan F. Stevens, Claudia S. Maier, Amala Soumyanath, Nora E. Gray
Best poster award

OHSU Research Week and OHSU Neurology Research Day, Portland OR, May 2–5, 2022

Effects of Untargeted Transcriptomic Analysis of the Effects of Centella asiatica in Cortical Neurons.
Steve Chamberlin, Jonathan Zweig, Cody Neff, Dan Bottomly, Amala Soumyanath, Shannon McWeeney, Claudia Maier, Nora Gray.