About the Biophysics Core
Proteins are involved in every aspect of cellular life. By virtue of their catalytic and structural functions, and their interactions with cellular molecules such as nucleic acids, carbohydrates, lipids, and membranes, proteins enable the growth, development and reproduction of an organism. Proteins play a key role in human health and disease, and are exploited as both therapeutic-targets and therapeutic-agents. As therapeutic-targets researchers examine the interaction of proteins with other biomolecules and small molecule ligands, while as therapeutic-agents, researchers purify and administer proteins as biologics.
The main goal of the Biophysics Core will be to provide researchers at OHSU with the biophysical and structural tools to
- Ensure purified proteins and other biomolecules of interest are uncompromised in terms of their structure and stability.
- Facilitate analyses of catalytic activities and functional interactions.
- Examine the thermodynamic and kinetic parameters for association between proteins and small molecules.
- Facilitate hypothesis generation through the coalescence of experimental data and computational modeling.
- Assist in setting up protein crystallization assays.
Core leadership
Dr. Ujwal Shinde, PhD
Associate Professor and Director
Phone: 503-494-8683
Email: shindeu@ohsu.edu
Location
Medical Research Building Room # 631
3181 SW Sam Jackson Park Rd.
Portland, OR 97229
Hours of operation
Access will be available to trained individuals 24/7 and the core will be staffed Monday-Friday 9AM - 5PM.