EAC Publications

Learn more about uses of ICP-MS and research by Core Users and by our lab

  1. Cheng, W.C.D., Li, Y., Nakashima, M., Moenne-Loccoz, P., Rush, K.W., Glasfeld, A., (2025). The activation of the metal-containing regulatory protein NiaR from Thermotoga maritima by its effector, nicotinic acid. J Biol Inorg Chem 30, 169–179.
  2. Messina M.S., Torrente L., Pezacki A.T., Humpel H.I., Li E.L., Miller S.G., Verdejo-Torres O., Padilla-Benavides T., Brady D.C., Killilea D.W., Killilea A.N., Ralle M., Ward N.P., Ohata J., DeNicola G.M., Chang C.J., (2025).  A histochemical approach to activity-based copper sensing reveals cuproplasia-dependent vulnerabilities in cancer. Proceedings of the National Academy of Sciences. 122(3), e2412816122.  
  3. Chaudhry, K.A., Rajanayake, K.K., Carroll, R.T., Isailovic, D., Funk, M.O., (2025). Iron–sulfur cluster redox chemistry and dimer dissociation in the outer mitochondrial membrane protein, mitoNEET. J Biol Inorg Chem 30, 3–11.
  4. Craven, G.B., Chu, H., Sun, J.D., Carelli, J.D., Coyne, B., Chen, H., Chen, Y., Ma, X., Das, S., Kong, W., Zajdlik, A.D., Yang, K. S., Reisberg, S.H., Thompson, P.A., Lipford, J.R., Taunton, J., (2025). Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation. Nature 637, 205–214.
  5. Anderson, D.E.J., Le, H.H., Vu, H., Johnson, J., Aslan, J.E., Goldman, J., Hinds, M.T., (2024). Thrombogenicity of biodegradable metals. Bioactive Materials, 38, 411-421.
  6. Srivastava, D.K., Navratna, V., Tosh, D.K. et al. (2024) Structure of the human dopamine transporter and mechanisms of inhibition. Nature 632, 672–677.
  7. Pezacki, A. T. et al. A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools. Proceedings of the National Academy of Sciences 121, e2401579121 (2024).
  8. Peng, E. D., Lyman, L. R. & Schmitt, M. P. (2024) Identification and characterization of zinc importers in Corynebacterium diphtheriae. Journal of Bacteriology 206, e00124-24.
  9. Verbout N.G., Lorentz C.U., Markway B.D., Wallisch M., Marbury T.C., Di Cera E., Shatzel J.J., Gruber A., Tucker E.I (2024). Safety and tolerability of the protein C activator AB002 in end-stage renal disease patients on hemodialysis: a randomized phase 2 trial. Communications Medicine. 4(1):153.
  10. Anderson, D. E. J. et al. Thrombogenicity of biodegradable metals. Bioactive Materials 38, 411–421 (2024).
  11. Dolgova, N., Uhlemann, E.-M.E., Boniecki, M.T., Vizeacoumar, F.S., Ara, A., Nouri, P., Ralle, M., Tonelli, M., Abbas, S.A., Patry, J., Elhasasna, H., Freywald, A., Vizeacoumar, F., Dmitriev, O.Y. (2024) MEMO1 binds iron and modulates iron homeostasis in cancer cells. eLife 13, e86354 – Old S10
  12. Soini, S.A., Feliciano, S.M., Duersch, B.G., Merk, V.M. (2024) Nanocrystalline iron hydroxide lignocellulose filters for arsenate remediation. RSC Sustain. 2, 626–634 – new S10
  13. Harper, B.J., Engstrom, A.M., Harper, S.L., Mackiewicz, M.R., (2024) Impacts of Differentially Shaped Silver Nanoparticles with Increasingly Complex Hydrophobic Thiol Surface Coatings in Small-Scale Laboratory Microcosms. Nanomaterials (Basel) 14, 654 – old S10
  14. Kabin, E., Dong, Y., Roy, S., Smirnova, J., Smith, J.W., Ralle, M., Summers, K., Yang, H., Dev, S., Wang, Y., Devenney, B., Cole, R.N., Palumaa, P., Lutsenko, S. (2023) α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance. PNAS 120, e2305961120
  15. Y. Park, A. A. Demessie, A. Luo, O. R. Taratula, A. S. Moses, P. Do, L. Campos, Y. Jahangiri, C. R. Wyatt, H. A. Albarqi, K. Farsad, O. D. Slayden, Taratula, O. (2022) Targeted Nanoparticles with High Heating Efficiency for the Treatment of Endometriosis with Systemically Delivered Magnetic Hyperthermia. Small, 18, 2107808
  16. Probst, C., Garcia-Santamarina, S., Brooks, J.T., Kloet, I.V.D., Baars, O., Ralle, M., Thiele, D.J., Alspaugh, J.A. (2022) Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance. PLOS Pathogens 18, e1010195
  17. Li, Z., Ferguson, L., Deol, K.K., Roberts, M.A., Magtanong, L., Hendricks, J.M., Mousa, G.A., Kilinc, S., Schaefer, K., Wells, J.A., Bassik, M.C., Goga, A., Dixon, S.J., Ingolia, N.T., Olzmann, J.A. (2022) Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability. Nat Chem Biol 18, 751–761
  18. Liu, Z., Huang, J., Gu, Y., Clark, D.S., Mukhopadhyay, A., Keasling, J.D., Hartwig, J.F. (2022) Assembly and Evolution of Artificial Metalloenzymes within E. coli Nissle 1917 for Enantioselective and Site-Selective Functionalization of C─H and C═C Bonds. J. Am. Chem. Soc. 144, 883–890.
  19. Huang, J., Liu, Z., Bloomer, B.J., Clark, D.S., Mukhopadhyay, A., Keasling, J.D., Hartwig, J.F. (2021) Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme. Nat. Chem. 13, 1186–1191
  20. Cunningham, B., Engstrom, A.M., Harper, B.J., Harper, S.L., Mackiewicz, M.R. (2021) Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo. Nanomaterials (Basel) 11, 1516
  21. Hunsaker, E.W., Yu, C.-H.A., Franz, K.J. (2021) Copper Availability Influences the Transcriptomic Response of Candida albicans to Fluconazole Stress. G3 Genes|Genomes|Genetics 11, jkab065
  22. Salcedo-Sora, J.E., Robison, A.T.R., Zaengle-Barone, J., Franz, K.J., Kell, D.B., (2021) Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli. Molecules 26, 582
  23. Smith, A. D., Garcia-Santamarina, S., Ralle, M., Loiselle, D. R., Haystead, T. A., and Thiele, D. J. (2021) Transcription factor-driven alternative localization of Cryptococcus neoformans superoxide dismutase. J Biol Chem, 100391
  24. Paul, J. S., and Small, B. C. (2021) Chronic exposure to environmental cadmium affects growth and survival, cellular stress, and glucose metabolism in juvenile channel catfish (Ictalurus punctatus). Aquat Toxicol 230, 105705
  25. Victor, T. W., O'Toole, K. H., Easthon, L. M., Ge, M., Smith, R. J., Huang, X., Yan, H., Chu, Y. S., Chen, S., Gursoy, D., Ralle, M., Imperiali, B., Allen, K. N., and Miller, L. M. (2020) Lanthanide-Binding Tags for 3D X-ray Imaging of Proteins in Cells at Nanoscale Resolution. J Am Chem Soc 142, 2145-2149
  26. Roy, S., McCann, C. J., Ralle, M., Ray, K., Ray, J., Lutsenko, S., and Jayakanthan, S. (2020) Analysis of Wilson disease mutations revealed that interactions between different ATP7B mutants modify their properties. Scientific Reports 10, 13487
  27. Morrell, A., Tripet, B. P., Eilers, B. J., Tegman, M., Thompson, D., Copié, V., and Burkhead, J. L. (2020) Copper modulates sex-specific fructose hepatoxicity in nonalcoholic fatty liver disease (NALFD) Wistar rat models. The Journal of nutritional biochemistry 78, 108316
  28. Miesen, T. J., Engstrom, A. M., Frost, D. C., Ajjarapu, R., Ajjarapu, R., Lira, C. N., and Mackiewicz, M. R. (2020) A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution. RSC Advances 10, 15677-15693
  29. Hartmann, A. K., Gudipati, S., Pettenuzzo, A., Ronconi, L., and Rouge, J. L. (2020) Chimeric siRNA-DNA Surfactants for the Enhanced Delivery and Sustained Cytotoxicity of a Gold(III) Metallodrug. Bioconjug Chem 31, 1063-1069
  30. Harris, C. J., Gray, N. E., Caruso, M., Hunter, M., Ralle, M., and Quinn, J. F. (2020) Copper Modulation and Memory Impairment due to Hippocampal Tau Pathology. Journal of Alzheimer's Disease Preprint, 1-12
  31. Gudekar, N., Shanbhag, V., Wang, Y., Ralle, M., Weisman, G. A., and Petris, M. J. (2020) Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess. Scientific Reports 10, 7856
  32. Edwards, S., Zhao, G., Tran, J., Patten, K. T., Valenzuela, A., Wallis, C., Bein, K. J., Wexler, A. S., Lein, P. J., and Rao, X. (2020) Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution. Environ Health Perspect 128, 127003
  33. Yantasee, W., Fryxell, G. E., Pattamakomsan, K., Sangvanich, T., Wiacek, R. J., Busche, B., Addleman, R. S., Timchalk, C., Ngamcherdtrakul, W., and Siriwon, N. (2019) Selective capture of radionuclides (U, Pu, Th, Am and Co) using functional nanoporous sorbents. Journal of Hazardous Materials 366, 677-683
  34. Yang, H., Liu, C.-N., Wolf, R. M., Ralle, M., Dev, S., Pierson, H., Askin, F., Steele, K. E., Magnuson, T. H., Schweitzer, M. A., Wong, G. W., and Lutsenko, S. (2019) Obesity is associated with copper elevation in serum and tissues. Metallomics : integrated biometal science 11, 1363-1371
  35. Ngamcherdtrakul, W., Sangvanich, T., Goodyear, S., Reda, M., Gu, S., Castro, D. J., Punnakitikashem, P., and Yantasee, W. (2019) Lanthanide-Loaded Nanoparticles as Potential Fluorescent and Mass Probes for High-Content Protein Analysis. Bioengineering (Basel) 6
  36. Ngamcherdtrakul, W., Morry, J., Sangvanich, T., Reda, M., Bejan, D. S., Fryxell, G. E., and Yantasee, W. (2019) Removal of a gadolinium based contrast agent by a novel sorbent hemoperfusion in a chronic kidney disease (CKD) rodent model. Scientific reports 9, 709-709
  37. Jeong, S. Y., Hogarth, P., Placzek, A., Gregory, A. M., Fox, R., Zhen, D., Hamada, J., van der Zwaag, M., Lambrechts, R., Jin, H., Nilsen, A., Cobb, J., Pham, T., Gray, N., Ralle, M., Duffy, M., Schwanemann, L., Rai, P., Freed, A., Wakeman, K., Woltjer, R. L., Sibon, O. C., and Hayflick, S. J. (2019) 4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN. EMBO Mol Med 11, e10489
  38. Hunsaker, E. W., and Franz, K. J. (2019) Candida albicans reprioritizes metal handling during fluconazole stress. Metallomics 11, 2020-2032
  39. Albarqi, H. A., Wong, L. H., Schumann, C., Sabei, F. Y., Korzun, T., Li, X., Hansen, M. N., Dhagat, P., Moses, A. S., Taratula, O., and Taratula, O. (2019) Biocompatible Nanoclusters with High Heating Efficiency for Systemically Delivered Magnetic Hyperthermia. ACS nano 13, 6383-6395
  40. Yadav, R., and Scott, E. E. (2018) Endogenous insertion of non-native metalloporphyrins into human membrane cytochrome P450 enzymes. The Journal of biological chemistry 293, 16623-16634
  41. Toro, T. B., Edenfield, S. A., Hylton, B. J., and Watt, T. J. (2018) Chelatable trace zinc causes low, irreproducible KDAC8 activity. Analytical biochemistry 540-541, 9-14
  42. Prola-Netto, J., Woods, M., Roberts, V. H. J., Sullivan, E. L., Miller, C. A., Frias, A. E., and Oh, K. Y. (2018) Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure. Radiology 286, 122-128
  43. Meacham, K. A., Cortés, M. P., Wiggins, E. M., Maass, A., Latorre, M., Ralle, M., and Burkhead, J. L. (2018) Altered zinc balance in the Atp7b(-/-) mouse reveals a mechanism of copper toxicity in Wilson disease. Metallomics : integrated biometal science 10, 1595-1606
  44. Jalali-Yazdi, F., Chowdhury, S., Yoshioka, C., and Gouaux, E. (2018) Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell 175, 1520-1532.e1515
  45. Brown, A. L., Kai, M. P., DuRoss, A. N., Sahay, G., and Sun, C. (2018) Biodistribution and Toxicity of Micellar Platinum Nanoparticles in Mice via Intravenous Administration. Nanomaterials (Basel) 8
  46. Rupp, J. C., Locatelli, M., Grieser, A., Ramos, A., Campbell, P. J., Yi, H., Steel, J., Burkhead, J. L., and Bortz, E. (2017) Host Cell Copper Transporters CTR1 and ATP7A are important for Influenza A virus replication. Virology journal 14, 11-11
  47. Torti, S. V., Lemler, E., Mueller, B. K., Popp, A., and Torti, F. M. (2016) Effects of Anti-repulsive Guidance Molecule C (RGMc/Hemojuvelin) Antibody on Hepcidin and Iron in Mouse Liver and Tumor Xenografts. Clin Exp Pharmacol 6, 223
  48. Krey, J. F., Drummond, M., Foster, S., Porsov, E., Vijayakumar, S., Choi, D., Friderici, K., Jones, S. M., Nuttall, A. L., and Barr-Gillespie, P. G. (2016) Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and Function. Scientific reports 6, 27221-27221
  49. Chu, Y. H., Sibrian-Vazquez, M., Escobedo, J. O., Phillips, A. R., Dickey, D. T., Wang, Q., Ralle, M., Steyger, P. S., and Strongin, R. M. (2016) Systemic Delivery and Biodistribution of Cisplatin in Vivo. Mol Pharm 13, 2677-2682
  50. Bhattacharjee, A., Yang, H., Duffy, M., Robinson, E., Conrad-Antoville, A., Lu, Y. W., Capps, T., Braiterman, L., Wolfgang, M., Murphy, M. P., Yi, L., Kaler, S. G., Lutsenko, S., and Ralle, M. (2016) The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria. J Biol Chem 291, 16644-16658
  51. Tallino, S., Duffy, M., Ralle, M., Cortes, M. P., Latorre, M., and Burkhead, J. L. (2015) Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease. The Journal of nutritional biochemistry
  52. Oh, K. Y., Roberts, V. H. J., Schabel, M. C., Grove, K. L., Woods, M., and Frias, A. E. (2015) Gadolinium Chelate Contrast Material in Pregnancy: Fetal Biodistribution in the Nonhuman Primate. Radiology 276, 110-118
  53. Bonnemaison, M. L., Back, N., Duffy, M. E., Ralle, M., Mains, R. E., and Eipper, B. A. (2015) Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine alpha-Amidating Monooxygenase, a Luminal Cuproenzyme. J Biol Chem 290, 21264-21279
  54. Voss, K., Harris, C., Ralle, M., Duffy, M., Murchison, C., and Quinn, J. F. (2014) Modulation of tau phosphorylation by environmental copper. Translational neurodegeneration 3, 24
  55. Gaier, E. D., Kleppinger, A., Ralle, M., Covault, J., Mains, R. E., Kenny, A. M., and Eipper, B. A. (2014) Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum. BMC endocrine disorders 14, 58
  56. Gaier, E. D., Miller, M. B., Ralle, M., Aryal, D., Wetsel, W. C., Mains, R. E., and Eipper, B. A. (2013) Peptidylglycine alpha-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. J Neurochem 127, 605-619
  57. Yeh, S., Ralle, M., Phan, I. T., Francis, P. J., Rosenbaum, J. T., and Flaxel, C. J. (2012) Occult intraocular foreign body masquerading as panuveitis: inductively coupled mass spectrometry and electrophysiologic analysis. J Ophthalmic Inflamm Infect 2, 99-103
  58. Vyleta, M. L., Wong, J., and Magun, B. E. (2012) Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome. PloS one 7, e36044-e36044
  59. Gray, L. W., Peng, F., Molloy, S. A., Pendyala, V. S., Muchenditsi, A., Muzik, O., Lee, J., Kaplan, J. H., and Lutsenko, S. (2012) Urinary copper elevation in a mouse model of Wilson's disease is a regulated process to specifically decrease the hepatic copper load. PloS one 7, e38327-e38327
  60. Gaier, E. D., Kleppinger, A., Ralle, M., Mains, R. E., Kenny, A. M., and Eipper, B. A. (2012) High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics. Exp Gerontol 47, 491-496
  61. Quinn, J. F., Harris, C., Kaye, J. A., Lind, B., Carter, R., Anekonda, T., and Ralle, M. (2011) Gender effects on plasma and brain copper. Int J Alzheimers Dis 2011, 150916
  62. Burkhead, J. L., Ralle, M., Wilmarth, P., David, L., and Lutsenko, S. (2011) Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease. J Mol Biol 406, 44-58
  63. Anekonda, T. S., Wadsworth, T. L., Sabin, R., Frahler, K., Harris, C., Petriko, B., Ralle, M., Woltjer, R., and Quinn, J. F. (2011) Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis 23, 21-35
  64. Quinn, J. F., Harris, C. J., Cobb, K. E., Domes, C., Ralle, M., Brewer, G., and Wadsworth, T. L. (2010) A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis 21, 903-914