Recent publications and preprints

Structure of the human dopamine transporter and mechanisms of inhibition.
Dushyant Kumar Srivastava, Vikas Navratna, Dilip K. Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid, Kenneth A. Jacobson, Eric Gouaux. (2024) Nature. doi: 10.1038/s41586-024-07739-9.

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses.
Matsui A, Spangler C, Elferich J, Shiozaki M, Jean N, Zhao X, Qin M, Zhong H, Yu Z, Gouaux E. (2024) eLife. 13:RP98458.

The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
Clark S, Jeong H, Posert R, Goehring A, Gouaux E. (2024) Proc Natl Acad Sci U S A. Feb 20;121(8):e2314096121.

Structure of C. elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction
Clark S, Jeong H, Posert R, Goehring A, Gouaux E. (2023) bioRxiv. Aug 17:2023.08.16.553618.  Pre-print.

Large-scale growth of C. elegans and isolation of membrane protein complexes
Clark S, Jeong H, Goehring A, Kang Y, Gouaux E. (2023) Nat Protoc. Sep;18(9):2699-2716. 

Quantitative DNA-PAINT imaging of AMPA receptors in live neurons
Youn Y, Lau GW, Lee Y, Maity BK, Gouaux E, Chung HJ, Selvin PR. (2023) Cell Rep Methods. 3(2):100408

Purification and biochemical analysis of native AMPA receptors from three different mammalian species
Rao P, Gouaux E. (2023) PLoS One. 18(3):e0275351.

Cryo-EM structures reveal native GABA_A receptor assemblies and pharmacology
Sun C, Zhu H, Clark S, Gouaux E. (2023) Nature. Oct;622(7981):195-201.  

Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants
Yang, D., Zhao, Z., Tajkhorshid, E., Gouaux, E. (2022) Proc Natl Acad Sci. Jul;120(29):e2304602120.

Structures of the TMC-1 complex illuminate mechanosensory transduction
Jeong, H., Clark, S., Goehring, A., Dehghani-Ghahnaviyeh, S., Tajkhorshid, E., Gouaux, E. (2022) Nature Oct;610: 796-803.

Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor
Ivica J, Zhu H, Lape R, Gouaux E, Sivilotti LG. (2022) Elife Aug 17;11:e79148.

Isolation, cryo-laser scanning confocal microscope imaging and cryo-FIB milling of mouse glutamatergic synaptosomes
Gogoi P, Shiozaki M, Gouaux E. (2022) PLoS One Aug 12;17(8):e0271799.

Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography
Elferich, J., Clark, S., Ge, J., Goehring, A., Matsui, A., Gouaux, E. (2021) Elife Dec 29; 1;10:e74512.

Selected publications

Structure of the human dopamine transporter and mechanisms of inhibition.
Dushyant Kumar Srivastava, Vikas Navratna, Dilip K. Tosh, Audrey Chinn, Md Fulbabu Sk, Emad Tajkhorshid, Kenneth A. Jacobson, Eric Gouaux. (2024) Nature. doi: 10.1038/s41586-024-07739-9.

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
Yu J*, Rao P*, Clark S, Mitra J, Ha T, Gouaux E. (2021) Nature 594:448-453. (*contributed equally)

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5
Ge J*, Elferich J*, Goehring A, Zhao J, Schuck P, Gouaux E. (2018) eLife 7:e38770. (*contributed equally)

Glycine receptor mechanism elucidated by electron cryo-microscopy
Du J*, Lü W*, Wu S, Cheng Y, Gouaux E. (2015) Nature 526:224-229. (*contributed equally)

Neurotransmitter and psychostimulant recognition by the dopamine transporter
Wang KH*, Penmatsa A*, Gouaux E. (2015) Nature 521:322-327. (*contributed equally)

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism
Chen L, Dürr KL, Gouaux E. (2014) Science 345:1021-1026.

NMDA receptor structures reveal subunit arrangement and pore architecture
Lee CH, Lü W, Michel JC, Goehring A, Du J, Song X, Gouaux E. (2014) Nature 511:191-197.

X-ray structure of dopamine transporter elucidates antidepressant mechanism
Penmatsa A*, Wang KH*, Gouaux E. (2013) Nature 503:85-90. (*contributed equally)

Molecular mechanism of ATP binding and ion channel activation in P2X receptors
Hattori M and Gouaux E. (2012) Nature 485:207-212.

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
Krishnamurthy H and Gouaux E. (2012) Nature 481:469-474.

Principles of activation and permeation in an anion-selective Cys-loop receptor
Hibbs RE and Gouaux E. (2011) Nature 474:54-60.