Recent publications and preprints

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses
Matsui A*, Spangler CJ*, Elferich J, Shiozaki M, Jean N, Zhao X, Qin M, Zhong H, Yu Z, Gouaux E. (2024) eLife. 13:RP98458. (*contributed equally)

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses
Matsui A*, Spangler CJ*, Elferich J, Shiozaki M, Jean N, Zhao X, Qin M, Zhong H, Yu Z, Gouaux E. (2024) bioRxiv. Aug5:2024.04.01.587595. Pre-print. (*contributed equally)

Structure of the human dopamine transporter and mechanisms of inhibition
Srivastava DK, Navratna V, Tosh DK, Chinn A, Sk MF, Tajkhorshid E, Jacobson KA, Gouaux E. (2024) Nature. 632(8025):672-677.

The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction
Clark S, Jeong H, Posert R, Goehring A, Gouaux E. (2024) Proc Natl Acad Sci U S A. Feb 20;121(8):e2314096121.

Structure of C. elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction
Clark S, Jeong H, Posert R, Goehring A, Gouaux E. (2023) bioRxiv. Aug 17:2023.08.16.553618.  Pre-print.

Large-scale growth of C. elegans and isolation of membrane protein complexes
Clark S, Jeong H, Goehring A, Kang Y, Gouaux E. (2023) Nat Protoc. Sep;18(9):2699-2716. 

Quantitative DNA-PAINT imaging of AMPA receptors in live neurons
Youn Y, Lau GW, Lee Y, Maity BK, Gouaux E, Chung HJ, Selvin PR. (2023) Cell Rep Methods. 3(2):100408.

Purification and biochemical analysis of native AMPA receptors from three different mammalian species
Rao P, Gouaux E. (2023) PLoS One. 18(3):e0275351.

Cryo-EM structures reveal native GABA_A receptor assemblies and pharmacology
Sun C, Zhu H, Clark S, Gouaux E. (2023) Nature. Oct;622(7981):195-201.  

Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants
Yang D, Zhao Z, Tajkhorshid E, Gouaux E. (2022) Proc Natl Acad Sci. Jul;120(29):e2304602120.

Structures of the TMC-1 complex illuminate mechanosensory transduction
Jeong H, Clark S, Goehring A, Dehghani-Ghahnaviyeh S, Tajkhorshid E, Gouaux E. (2022) Nature. Oct;610: 796-803.

Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor
Ivica J, Zhu H, Lape R, Gouaux E, Sivilotti LG. (2022) eLife. Aug 17;11:e79148.

Isolation, cryo-laser scanning confocal microscope imaging and cryo-FIB milling of mouse glutamatergic synaptosomes
Gogoi P, Shiozaki M, Gouaux E. (2022) PLoS One. Aug 12;17(8):e0271799.

Selected publications

Structure of the human dopamine transporter and mechanisms of inhibition
Srivastava DK, Navratna V, Tosh DK, Chinn A, Sk MF, Tajkhorshid E, Jacobson KA, Gouaux E. (2024) Nature. 632(8025):672-677.

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
Yu J*, Rao P*, Clark S, Mitra J, Ha T, Gouaux E. (2021) Nature. 594:448-453. (*contributed equally)

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5
Ge J*, Elferich J*, Goehring A, Zhao J, Schuck P, Gouaux E. (2018) eLife. 7:e38770. (*contributed equally)

Glycine receptor mechanism elucidated by electron cryo-microscopy
Du J*, Lü W*, Wu S, Cheng Y, Gouaux E. (2015) Nature. 526:224-229. (*contributed equally)

Neurotransmitter and psychostimulant recognition by the dopamine transporter
Wang KH*, Penmatsa A*, Gouaux E. (2015) Nature. 521:322-327. (*contributed equally)

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism
Chen L, Dürr KL, Gouaux E. (2014) Science. 345:1021-1026.

NMDA receptor structures reveal subunit arrangement and pore architecture
Lee CH, Lü W, Michel JC, Goehring A, Du J, Song X, Gouaux E. (2014) Nature. 511:191-197.

X-ray structure of dopamine transporter elucidates antidepressant mechanism
Penmatsa A*, Wang KH*, Gouaux E. (2013) Nature. 503:85-90. (*contributed equally)

Molecular mechanism of ATP binding and ion channel activation in P2X receptors
Hattori M and Gouaux E. (2012) Nature. 485:207-212.

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
Krishnamurthy H and Gouaux E. (2012) Nature. 481:469-474.

Principles of activation and permeation in an anion-selective Cys-loop receptor
Hibbs RE and Gouaux E. (2011) Nature. 474:54-60.