Heart Valve Disease Clinical Trials
The heart valve clinical trials team is interested in seeing how exciting new heart valves and drugs can help to improve the outcomes and quality of life for those living with the heart valve diseases.
Feel free to call or e-mail the Knight Cardiovascular Institute research team at 503-418-1964 or by emailing heartresearch@ohsu.edu. You will then be forwarded to the appropriate research team member who will be able to see if you qualify for any of the clinical trials being offered at OHSU.
You can also find all the of heart failure clinical trials, that are currently enrolling patients, below.
ACTIVE
Annular Reduction for Transcatheter Treatment of Insufficient Mitral Valve: A prospective multi-center, randomized, controlled pivotal trial to assess transcatheter mitral valve repair with Edwards Cardioband System and guideline directed medical therapy (GDMT) compared to GDMT alone in patients with functional mitral regurgitation (FMR) and heart failure.
Primary investigator:
Sub investigators:
- Cristina Fuss, M.D.
- Howard Song, M.D., Ph.D.
- Scott Chadderdon, M.D.
Protocol number:
IRB00017653
Study purpose:
The purpose of this study is to learn more about the safety and effectiveness of the Edward Cardioband System in subjects with moderate to severe functional mitral regurgitation. The reason for this study is to learn if the Edwards Cardioband System is as safe and effective as treating patients with the current standard medical procedure.
Contact:
Sarah Fishbein (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu
APOLLO
Transcatheter Mitral Valve Replacement with the Medtronic Intrepid TMVR System in Patients with Severe Symptomatic Mitral Regurgitation - APOLLO Trial
Primary investigator:
Sub investigators:
- Albert Camacho, M.D.
- Cristina Fuss, M.D.
- Scott Chadderdon, M.D.
Protocol number:
IRB00017730
Study purpose:
The purpose of this study is to learn more about treatment for patients with mitral valve regurgitation with the use of the Medtronic Intrepid™ device. This study is designed to learn if the Medtronic Intrepid™ device is safe and effective enough to become a standard of care for patients with mitral valve regurgitation.
Contact:
Sarah Fishbein (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu
COAPT-CAS
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional MR (COAPT) Continuing Access Study
Primary investigator:
Sub investigators:
- Albert Camacho, M.D.
- Frederick Tibayan, M.D.
- Howard Song, M.D., Ph.D.
- Scott Chadderdon, M.D.
Protocol number:
IRB00017739
Study purpose:
The purpose of this study is to learn about treatments for patients with mitral valve regurgitation and heart failure with the use of the MitraClip device. This study is designed to learn more about the safety and effectiveness of the MitraClip device. Only patients with Medicare as their primary insurer are being enrolled for this study at this time.
Contact:
Sarah Fishbein (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu
TAVR Low Risk
Transcatheter Aortic Valve Replacement (TAVR) in Patients with the Medtronic Transcatheter Aortic Valve Replacement System (TAVR) in Patients at Low Risk for Surgical Aortic Valve Replacement (SAVR)
Primary investigator:
Sub investigators:
- Albert Camacho, M.D.
- Cristina Fuss, M.D.
- Frederick Tibayan, M.D.
Protocol number:
IRB00015782
Study purpose:
The purpose of this study is to learn more about treatment for patients with severe aortic stenosis with the use of the Medtronic TAVR System. This study is designed to learn if the Medtronic TAVR System is safe and effective for patients who are at a low risk for open heart surgical replacement of their aortic valve.
Contact:
Sarah Fishbein (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu
TAVR UNLOAD
Transcatheter Aortic Valve Replacement to Unload the LEft Ventricle in Patients with Advanced Heart Failure: A Randomized Trial (TAVR UNLOAD)
Primary investigator:
Sub investigators:
- Albert Camacho, M.D.
- Cristina Fuss, M.D.
- Scott Chadderdon, M.D.
Protocol number:
IRB00015224
Study purpose:
The purpose of this study is to learn more about treatment for patients with heart failure and moderate aortic valve stenosis with the use of the TAVR System. This study is designed to compare the safety and effectiveness of the TAVR system versus the current standard of care for heart failure patients.
Contact:
Sarah Fishbein (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu