Chen Lab

Mission

We strive to cultivate a diverse, equitable and vibrant academic environment that promotes innovative scientific discovery with collaborative teamwork and supports career advancement of all members with different career goals.

Research Overview

To discover novel molecular and cellular mechanisms regulating vascular smooth muscle cell phenotypic modulation and transdifferentiation and its cross-talk with other cells in the pathogenesis of cardiovascular diseases and aging.

Figure: Arterioscler Thromb Vasc Biol. 2023 Jan, 43(1), 15-29

Research Projects

Elucidate an essential role of oxidative stress-induced Runx2 in regulating vascular smooth muscle cell osteogenic differentiation and vascular calcification in atherosclerosis, diabetic vasculopathy and vascular aging.
Discover the novel mechanisms underlying vascular osteoclasts in atherosclerotic vascular calcification.
Discover the regulation of protein O-GlcNAcylation in vascular smooth muscle cell osteogenic differentiation and calcification in diabetes.
Elucidate the molecular mechanisms underlying vascular smooth muscle cell phenotypic switch in pan-vascular pathology and their contribution to cognitive impairments and dementia.

Join Our Team

We are recruiting Research Staff, Graduate Students and Postdocs!

Graduate Student

Contact

Richard Jones Hall
Room 1386
3222 SW Research Dr
Portland, OR 97239
P: 503.494.1547

Personnel

Yabing Chen, PhD, MBA, FAHA
Professor and Vice Chair for Research
Department of Pathology and Laboratory Medicine
chenyab@ohsu.edu

Yong Sun
Ph.D. Candidate
sunyo@ohsu.edu

Erandi Velazquez-Miranda
Postdoctoral Fellow
velazqer@ohsu.edu

Zhehao Zhu
Ph.D. Student (Biomedical Engineering)
zhuz@ohsu.edu

School of Medicine Department of Pathology and Laboratory Medicine

Department of Pathology and Laboratory Medicine