Lupus Inhibitor Evaluation with Reflexes
Orderable EAP code:
Billable EAP Codes:
CPT Codes:
Lab Section:
Includes:
DRVV Confirm Normalized Ratio; SCT Confirm Normalized Ratio, if indicated: SCT Mix, DRVVT Mix.
To exclude anticoagulant effects, a reflex Heparin, Thrombin Time, and INR will be performed when the lupus panel screens or normalized ratios are prolonged. Additional Charges will apply.
Turnaround Time:
5 days
Test Schedule:
Tuesday and Thusday
Specimen Requirements:
Three full 2.7 mL LIGHT BLUE top tubes, 3.2% sodium citrate. Specimens must be processed and frozen within 2 hours of specimen collection.
Send 3- 1.5ml aliquots of platelet poor plasma, samples must remain frozen during storage and shipment.
Stability is 14 days at -20 C.
Detailed specimen collection and processing instructions are located under Lab Sections and then the Hemostasis and Thrombosis (Opens in a new window) section.
Pediatric Specimen Requirements:
Three full pediatric 1.3 mL LIGHT BLUE top tubes, 3.2% sodium citrate. Specimens must be processed and frozen within 2 hours of specimen collection.
Send 2- 1.5ml aliquots of platelet poor plasma, samples must remain frozen during storage and shipment.
Stability is 14 days at -20 C.
For pediatric patients requiring multiple coagulation tests, please call 503-494-7383 regarding draw volumes.
Reference Range:
dRVVConfirm Normalized Ratio: less than or equal to 1.20
SCT Confirm Normalized Ratio: less than or equal to 1.23
Comments:
Testing for lupus inhibitors is not recommended while a patient is on anticoagulation therapy because heparins, direct Xa inhibitors, warfarin, and direct thrombin inhibitors variably confound the parent test systems (SCT, dRVVT, and mixing studies).
The Lupus Inhibitor panel does not include serologic studies (anti-cardiolipin and anti-beta 2 glycoprotein 1) which are also useful in evaluating anti-phospholipid syndrome (APS). For comprehensive APS evaluation follow ISTH guidelines.
Synonyms:
Dilute Viper Venom Time (DVVT) with Reflex to DVV Confirm Ratio
Lupus Anticoagulant
Lupus Panel