Sirolimus Quantitation
Orderable EAP code:
Billable EAP Codes:
CPT Codes:
Lab Section:
Turnaround Time:
Routine: 1 day
Test Schedule:
Monday through Friday.
Units:
Specimen Requirements:
3 mL blood in a LAVENDER top (EDTA) tube; redraw if the specimen is clotted.
Stable for 48 hours at room temperature or for 7 days refrigerated (2 to 8 degrees Celsius). If testing is delayed more than 7 days, store frozen at -10 degrees Celsius or less.
Pediatric Specimen Requirements:
0.5 mL blood in a pediatric LAVENDER top (EDTA) tube.
Reference Range:
4 to 12 ng/mL
Comments:
Test performed by immunoassay using Abbott Architect i2000.
Kidney transplant (in combination with Cyclosporine): 4 to 12 ng/mL
Toxic value: greater than 25 ng/mL
Interpretive Data: A range of 12 to 20 ng/mL has been suggested for liver transplant. Samples for analysis of Sirolimus should be collected 30 minutes to 1 hour prior to the next dose so that the measured concentration of drug represents trough levels. The optimal therapeutic range for a given patient may differ from this suggested range based on the indication for therapy, treatment phase (initiation or maintenance), use in combination with other drugs, time of specimen collection relative to prior dose and/or type of transplanted organ.
Synonyms:
Rapamune
Rapamycin