Aaron J. Janowsky, Ph.D.

  • Professor of Psychiatry, School of Medicine
  • Professor of Behavioral Neuroscience, School of Medicine
  • Senior Research Career Scientist, Portland VA Medical Center
  • Behavioral Neuroscience Graduate Program, School of Medicine
  • Neuroscience Graduate Program, School of Medicine

Biography

My laboratory is involved in characterizing drug interactions with neurotransmitter transporters and receptors. A major goal is to identify potential therapeutic agents for the treatment of neuropsychiatric disorders including Parkinson's disease, alcohol and drug abuse, depression, and schizophrenia. Methods we use include determining the effects of drugs on radioligand binding to, on neurotransmitter uptake and release by cells expressing cloned DNA for the respective human transporters, and on receptor activation and second messenger system function.    

In addition, we are characterizing recently-discovered receptor/second messenger systems that may play a role in the development of symptoms of potential subtypes of schizophrenia, as well as the role of exogenous substances on disease development .  Alteration of these systems may serve as medical, as opposed to behavioral, diagnostic criteria for the disorder(s).  

Publications

Publications

  • Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia

    Diabetes
    1. Alessandro Bonifazi
    2. Michael Ellenberger
    3. Zachary J. Farino
    4. Despoina Aslanoglou
    5. Rana Rais
    6. Sandra Pereira
    7. Josée O. Mantilla-Rivas
    8. Comfort A. Boateng
    9. Amy J. Eshleman
    10. Aaron Janowsky
    11. Margaret K. Hahn
    12. Gary J. Schwartz
    13. Barbara S. Slusher
    14. Amy Hauck Newman
    15. Zachary Freyberg

  • Pharmacologic Characterization of Substituted Nitazenes at l, j, and ∆ Opioid Receptors Suggests High Potential for Toxicity

    Journal of Pharmacology and Experimental Therapeutics
    1. Laura B. Kozell
    2. Amy J. Eshleman
    3. Katherine M. Wolfrum
    4. Tracy L. Swanson
    5. Shelley H. Bloom
    6. Sheila Benware
    7. Jennifer L. Schmachtenberg
    8. Kamryn A. Schutzer
    9. William E. Schutzer
    10. Aaron Janowsky
    11. Atheir I. Abbas

  • Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT1A and 5-HT7A Receptors

    ACS Omega
    1. Barbara A. Bricker
    2. Chandrashekhar Voshavar
    3. Edem K. Onyameh
    4. Uma M. Gonela
    5. Xinsong Lin
    6. Tracy L. Swanson
    7. Laura B. Kozell
    8. Jennifer L. Schmachtenberg
    9. Shelley H. Bloom
    10. Aaron J. Janowsky
    11. Seth Y. Ablordeppey

  • MicroRNA137-loaded lipid nanoparticles regulate synaptic proteins in the prefrontal cortex

    Molecular Therapy
    1. Michelle C. Palumbo
    2. Milan Gautam
    3. Alex Sonneborn
    4. Kilsun Kim
    5. Phillip A. Wilmarth
    6. Ashok P. Reddy
    7. Xiao Shi
    8. Daniel L. Marks
    9. Gaurav Sahay
    10. Atheir I. Abbas
    11. Aaron Janowsky

  • Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids after Persistent Inflammation

    Journal of Neuroscience
    1. Courtney A. Bouchet
    2. Kylie B. McPherson
    3. Basile Coutens
    4. Aaron Janowsky
    5. Susan L. Ingram

  • Pharmacologic Activity of Substituted Tryptamines at 5-Hydroxytryptamine (5-HT)2AReceptor (5-HT2AR), 5-HT2CR, 5-HT1AR, and Serotonin Transporter

    Journal of Pharmacology and Experimental Therapeutics
    1. Laura B. Kozell
    2. Amy J. Eshleman
    3. Tracy L. Swanson
    4. Shelley H. Bloom
    5. Katherine M. Wolfrum
    6. Jennifer L. Schmachtenberg
    7. Randall J. Olson
    8. Aaron Janowsky
    9. Atheir I. Abbas

  • A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder

    Neuropsychopharmacology
    1. Ewa Galaj
    2. Guo Hua Bi
    3. Benjamin Klein
    4. Briana Hempel
    5. Anver Basha Shaik
    6. Emma S. Gogarnoiu
    7. Jacob Friedman
    8. Jenny Lam
    9. Rana Rais
    10. John F. Reed
    11. Shelley H. Bloom
    12. Tracy L. Swanson
    13. Jennifer L. Schmachtenberg
    14. Amy J. Eshleman
    15. Aaron Janowsky
    16. Zheng Xiong Xi
    17. Amy Hauck Newman

  • Development of a Translational Model to Assess the Impact of Opioid Overdose and Naloxone Dosing on Respiratory Depression and Cardiac Arrest

    Clinical pharmacology and therapeutics
    1. John Mann
    2. Mohammadreza Samieegohar
    3. Anik Chaturbedi
    4. Joel Zirkle
    5. Xiaomei Han
    6. S. Farzad Ahmadi
    7. Amy Eshleman
    8. Aaron Janowsky
    9. Katherine Wolfrum
    10. Tracy Swanson
    11. Shelley Bloom
    12. Albert Dahan
    13. Erik Olofsen
    14. Jeffry Florian
    15. David G. Strauss
    16. Zhihua Li

  • Fentanyl causes naloxone-resistant vocal cord closure

    Drug and Alcohol Dependence
    1. Nicholas B. Miner
    2. William E. Schutzer
    3. Yalda Zarnegarnia
    4. Aaron Janowsky
    5. Randy Torralva

  • New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263

    European Journal of Medicinal Chemistry
    1. Edward Ofori
    2. Edem K. Onyameh
    3. Uma M. Gonela
    4. Chandrashekhar Voshavar
    5. Barbara Bricker
    6. Tracy L. Swanson
    7. Amy J. Eshleman
    8. Jennifer L. Schmachtenberg
    9. Shelley H. Bloom
    10. Aaron J. Janowsky
    11. Seth Y. Ablordeppey

  • Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors

    Biochemical Pharmacology
    1. Amy J. Eshleman
    2. Shanthi Nagarajan
    3. Katherine M. Wolfrum
    4. John F. Reed
    5. Aaron Nilsen
    6. Randy Torralva
    7. Aaron Janowsky

  • Fentanyl but not morphine interacts with nonopioid recombinant human neurotransmitter receptors and transporters

    Journal of Pharmacology and Experimental Therapeutics
    1. Randy Torralva
    2. Amy J. Eshleman
    3. Tracy L. Swanson
    4. Jennifer L. Schmachtenberg
    5. William E. Schutzer
    6. Shelley H. Bloom
    7. Katherine M. Wolfrum
    8. John F. Reed
    9. Aaron Janowsky

  • Methamphetamine use alters human plasma extracellular vesicles and their microRNA cargo

    Journal of Extracellular Vesicles
    1. Ursula S. Sandau
    2. Erika Duggan
    3. Xiao Shi
    4. Sierra J. Smith
    5. Marilyn Huckans
    6. William E. Schutzer
    7. Jennifer M. Loftis
    8. Aaron Janowsky
    9. John P. Nolan
    10. Julie A. Saugstad

  • Activation of trace amine-associated receptor 1 stimulates an antiapoptotic signal cascade via extracellular signal-regulated kinase 1/2

    Molecular pharmacology
    1. Xiao Shi
    2. Tracy L. Swanson
    3. Nicholas B. Miner
    4. Amy J. Eshleman
    5. Aaron Janowsky

  • Noradrenergic mechanisms in fentanyl-mediated rapid death explain failure of naloxone in the opioid crisis

    Journal of Pharmacology and Experimental Therapeutics
    1. Randy Torralva
    2. Aaron Janowsky

  • Structure-activity relationships of bath salt components

    Psychopharmacology
    1. Amy J. Eshleman
    2. Shanthi Nagarajan
    3. Katherine M. Wolfrum
    4. John F. Reed
    5. Tracy L. Swanson
    6. Aaron Nilsen
    7. Aaron Janowsky

  • Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

    eLife
    1. Alexandra M. Stafford
    2. Cheryl Reed
    3. Harue Baba
    4. Nicole A.R. Walter
    5. John R.K. Mootz
    6. Robert W. Williams
    7. Kim A. Neve
    8. Lev M. Fedorov
    9. Aaron J. Janowsky
    10. Tamara J. Phillips

  • The role of biogenic amine transporters in trace amine–associated receptor 1 regulation of methamphetamine-induced neurotoxicity

    Journal of Pharmacology and Experimental Therapeutics
    1. Nicholas B. Miner
    2. Tamara J. Phillips
    3. Aaron Janowsky

  • Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence

    PloS one
    1. Jennifer M. Loftis
    2. Michael Lasarev
    3. Xiao Shi
    4. Jodi Lapidus
    5. Aaron Janowsky
    6. William F. Hoffman
    7. Marilyn Huckans

  • Characterization of the neurochemical and behavioral effects of solriamfetol (JZP-110), a selective dopamine and norepinephrine reuptake inhibitor

    Journal of Pharmacology and Experimental Therapeutics
    1. Michelle G. Baladi
    2. Michael J. Forster
    3. Michael B. Gatch
    4. Richard B. Mailman
    5. Danielle L. Hyman
    6. Lawrence P. Carter
    7. Aaron Janowsky

  • Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines

    Biochemical Pharmacology
    1. Amy J. Eshleman
    2. Katherine M. Wolfrum
    3. John F. Reed
    4. Sunyoung O. Kim
    5. Robert A. Johnson
    6. Aaron Janowsky

  • Repurposing of a nucleoside scaffold from adenosine receptor agonists to opioid receptor antagonists

    ACS Omega
    1. Dilip K. Tosh
    2. Antonella Ciancetta
    3. Philip Mannes
    4. Eugene Warnick
    5. Aaron Janowsky
    6. Amy J. Eshleman
    7. Elizabeth Gizewski
    8. Tarsis F. Brust
    9. Laura M. Bohn
    10. John A. Auchampach
    11. Zhan Guo Gao
    12. Kenneth A. Jacobson

  • Synthesis and Discovery of Arylpiperidinylquinazolines

    Journal of Medicinal Chemistry
    1. Brian A. Provencher
    2. Amy J. Eshleman
    3. Robert A. Johnson
    4. Xiao Shi
    5. Olga Kryatova
    6. Jared Nelson
    7. Jianhua Tian
    8. Mario Gonzalez
    9. Peter C. Meltzer
    10. Aaron Janowsky

  • Verification of a genetic locus for methamphetamine intake and the impact of morphine

    Mammalian Genome
    1. Emily C. Eastwood
    2. Amy J. Eshleman
    3. Aaron Janowsky
    4. Tamara J. Phillips

  • Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists)

    Journal of Medicinal Chemistry
    1. Dilip K. Tosh
    2. Aaron Janowsky
    3. Amy J. Eshleman
    4. Eugene Warnick
    5. Zhan Guo Gao
    6. Zhoumou Chen
    7. Elizabeth Gizewski
    8. John A. Auchampach
    9. Daniela Salvemini
    10. Kenneth A. Jacobson

  • Structure-activity relationships of substituted cathinones, with transporter binding, uptake, and release

    Journal of Pharmacology and Experimental Therapeutics
    1. Amy J. Eshleman
    2. Katherine M. Wolfrum
    3. John F. Reed
    4. Sunyoung O. Kim
    5. Tracy Swanson
    6. Robert A. Johnson
    7. Aaron Janowsky

  • The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity

    Neurotoxicology and Teratology
    1. Nicholas B. Miner
    2. James P. O'Callaghan
    3. Tamara J. Phillips
    4. Aaron Janowsky

  • Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity

    NeuroToxicology
    1. Nicholas B. Miner
    2. Josh S. Elmore
    3. Michael H. Baumann
    4. Tamara J. Phillips
    5. Aaron Janowsky

  • Genetic polymorphisms affect mouse and human trace amine-associated receptor 1 function

    PloS one
    1. Xiao Shi
    2. Nicole A.R. Walter
    3. John H. Harkness
    4. Kim A. Neve
    5. Robert W. Williams
    6. Lu Lu
    7. John K. Belknap
    8. Amy J. Eshleman
    9. Tamara J. Phillips
    10. Aaron Janowsky

  • Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

    Journal of Medicinal Chemistry
    1. Mu Fa Zou
    2. Thomas M. Keck
    3. Vivek Kumar
    4. Prashant Donthamsetti
    5. Mayako Michino
    6. Caitlin Burzynski
    7. Catherine Schweppe
    8. Alessandro Bonifazi
    9. R. Benjamin Free
    10. David R. Sibley
    11. Aaron Janowsky
    12. Lei Shi
    13. Jonathan A. Javitch
    14. Amy Hauck Newman