Aimee L. Pierce, M.D.
- Associate Professor of Neurology, School of Medicine
Biography
Dr. Pierce’s clinical practice is focused on the diagnosis, treatment, and prevention of all forms of memory loss and dementia, including Alzheimer’s disease, vascular dementia, frontotemporal dementia, and dementia with Lewy Bodies/Parkinson’s disease dementia.
She is also experienced in rare forms of dementia including atypical dementia, early-onset dementia, familial Alzheimer’s disease and other hereditary dementias (Huntington’s disease), progressive supranuclear palsy, FTD-ALS, prion diseases (CJD), and autoimmune encephalopathies (limbic encephalitis, NMDA, VGKC). She has experience utilizing advanced diagnostic techniques including neuropsychological testing, genetic testing, cerebrospinal fluid analysis, MRI imaging, FDG-PET, amyloid PET, and tau PET.
Dr. Pierce has led multiple clinical trials for Alzheimer’s disease diagnosis, treatment, and prevention, and is focused on testing novel compounds and treatment strategies (including immunotherapy). Patients are offered the opportunity to participate in clinical trials and other research for dementia diagnosis, treatment, and prevention in the OHSU Layton Aging and Alzheimer’s Disease Center.
Education and training
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Degrees
- M.D., 2004, Columbia University College of Physicians and Surgeons
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Residency
- Neurology, UCLA, Los Angeles, CA, 2008
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Fellowship
- Geriatric Neurology, VA San Diego / UC San Diego, La Jolla, CA 2011
Memberships and associations:
- American Board of Psychiatry and Neurology
Areas of interest
- Geriatric Neurology
- Dementia
- Alzheimer’s Disease
- Clinical Trials
- Brain Health
- Parkinson’s Disease
- Memory Loss
Publications
Elsevier pure profilePublications
Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease
NeurologyPre-Randomization Predictors of Study Discontinuation in a Preclinical Alzheimer’s Disease Randomized Controlled Trial
The journal of prevention of Alzheimer's diseaseCircular-SWAT for deep learning based diagnostic classification of Alzheimer's disease
EBioMedicinePrognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment
BMC GeriatricsRegional Neuroanatomic Effects on Brain Age Inferred Using Magnetic Resonance Imaging and Ridge Regression
Journals of Gerontology - Series A Biological Sciences and Medical SciencesA predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease
Communications MedicineManifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90
Scientific ReportsNew insights into the genetic etiology of Alzheimer’s disease and related dementias
Nature geneticsAssociation of Initial β-Amyloid Levels with Subsequent Flortaucipir Positron Emission Tomography Changes in Persons without Cognitive Impairment
JAMA NeurologyHigher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
Nature communicationsPlasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status
Translational PsychiatryStaging tau pathology with tau PET in Alzheimer’s disease
Translational PsychiatryExceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
Nature communicationsFAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease
Nature communicationsGenetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Nature geneticsRetention of Alzheimer Disease Research Participants
Alzheimer Disease and Associated DisordersConstructing a Local Potential Participant Registry to Improve Alzheimer's Disease Clinical Research Recruitment
Journal of Alzheimer's DiseaseGenetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
Alzheimer's and Dementia: Diagnosis, Assessment and Disease MonitoringParticipant satisfaction with learning Alzheimer disease clinical trial results
Alzheimer Disease and Associated DisordersSex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau
JAMA NeurologySex-specific genetic predictors of Alzheimer’s disease biomarkers
Acta NeuropathologicaAttitudes toward Potential Participant Registries
Journal of Alzheimer's DiseaseDementia in the oldest old
PLoS MedicineRare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Nature genetics