The tumor microenvironment presents a significant obstacle to the efficacy of clinical cancer therapy. Recently we demonstrated that the lymphatic endothelium plays an active and dynamic role in regulating anti-tumor immunity. Lymphatic growth in the context of tumor formation alters local interstitial flows, cell trafficking and antigen delivery to the sentinel node; all of which may alter local immune responses. Our group explores the hypothesis that tumor-associated lymphatic vessels regulate the activation, local function, and retention of cytotoxic T lymphocytes in tumor microenvironments. We specifically explore these mechanisms in the context of the skin using mouse models of cutaneous acute viral infection and melanoma as well as patient samples. Understanding these mechanisms of regulation will provide novel therapeutic targets that synergize with existing immunotherapies.