Andrei Sdrulla, M.D., Ph.D.

  • Associate Professor of Anesthesiology and Perioperative Medicine, School of Medicine
  • Associate Program Director Pain Medicine Fellowship, Anesthesiology and Perioperative Medicine, School of Medicine
  • M.D./Ph.D. Program Committee, School of Medicine

Biography

Dr. Sdrulla’s research is focused on the synaptic mechanisms of spinal cord stimulation (SCS), in an effort to optimize the efficacy of SCS devices and address safety concerns. Dr. Sdrulla and colleagues at Johns Hopkins University identified a novel form of synaptic depression in the spinal cord in mice, induced by conditioning protocols similar to those used clinically in SCS systems. Dr. Sdrulla’s research combines electrophysiological recordings and in vivo multiphoton imaging. As a dedicated clinician scientist, Dr. Sdrulla hopes his research will help advance non-pharmacological therapeutic modalities for refractory pain.

Education and training

  • Degrees

    • B.A., 1999, Stanford University
    • Ph.D., 2008, Johns Hopkins University School of Medicine
    • M.D., 2008, Johns Hopkins University School of Medicine

  • Residency

    • Anesthesiology, Johns Hopkins University School of Medicine, 2013

  • Fellowship

    • Pain medicine, Oregon Health & Science University, 2014

  • Certifications

    • American Board of Anesthesiology, 2014.

Memberships and associations:

  • American Society of Anesthesiologists

Publications

Elsevier pure profile

Publications

  • Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations

    Molecular Pain
    1. Wei Fan
    2. Steve J. Sullivan
    3. Andrei D. Sdrulla

  • Excitatory and Inhibitory Neurons of the Spinal Cord Superficial Dorsal Horn Diverge in Their Somatosensory Responses and Plasticity in Vivo

    Journal of Neuroscience
    1. Steve J. Sullivan
    2. Andrei D. Sdrulla

  • Success with dorsal root entry zone lesioning after a failed trial of spinal cord stimulation in a patient with pain due to brachial plexus avulsion

    Pain Reports
    1. Lucia Lopez
    2. Andrei D. Sdrulla

  • Differential modulation of excitatory and inhibitory populations of superficial dorsal horn neurons in lumbar spinal cord by Aß-fiber electrical stimulation

    Pain
    1. Wei Fan
    2. Andrei D. Sdrulla

  • Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

    eLife
    1. Zhigang Shi
    2. Nicole E. Pelletier
    3. Jennifer Wong
    4. Baoxin Li
    5. Andrei D. Sdrulla
    6. Christopher J. Madden
    7. Daniel L. Marks
    8. Virginia L. Brooks

  • Minimally invasive procedures for neuropathic pain

    Pain management
    1. Andrei Sdrulla
    2. Grace Chen

  • Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice

    Pain
    1. Andrei D. Sdrulla
    2. Qian Xu
    3. Shao Qiu He
    4. Vinod Tiwari
    5. Fei Yang
    6. Chen Zhang
    7. Bin Shu
    8. Ronen Shechter
    9. Srinivasa N. Raja
    10. Yun Wang
    11. Xinzhong Dong
    12. Yun Guan

  • Comparison of intensity-dependent inhibition of spinal wide-dynamic range neurons by dorsal column and peripheral nerve stimulation in a rat model of neuropathic pain

    European Journal of Pain (United Kingdom)
    1. F. Yang
    2. Q. Xu
    3. Y. K. Cheong
    4. R. Shechter
    5. A. Sdrulla
    6. S. Q. He
    7. V. Tiwari
    8. X. Dong
    9. P. W. Wacnik
    10. R. Meyer
    11. Srinivasa N. Raja
    12. Yun Guan

  • Conventional and kilohertz-frequency spinal cord stimulation produces intensity-and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain

    Anesthesiology
    1. Ronen Shechter
    2. Fei Yang
    3. Qian Xu
    4. Yong Kwan Cheong
    5. Shao Qiu He
    6. Andrei Sdrulla
    7. Alene F. Carteret
    8. Paul W. Wacnik
    9. Xinzhong Dong
    10. Richard A. Meyer
    11. Srinivasa N. Raja
    12. Yun Guan

  • Double dissociation between long-term depression and dendritic spine morphology in cerebellar Purkinje cells

    Nature Neuroscience
    1. Andrei D. Sdrulla
    2. David J. Linden

  • Dynamic imaging of cerebellar Purkinje cells reveals a population of filopodia which cross-link dendrites during early postnatal development

    Cerebellum
    1. Andrei Sdrulla
    2. David Linden

  • A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development

    Neuron
    1. Songli Wang
    2. Andrei Sdrulla
    3. Jane E. Johnson
    4. Yoshifumi Yokota
    5. Ben A. Barres

  • Notch receptor activation inhibits oligodendrocyte differentiation

    Neuron
    1. Songli Wang
    2. Andrei D. Sdrulla
    3. Guy DiSibio
    4. Gay Bush
    5. Donna Nofziger
    6. Carol Hicks
    7. Gerry Weinmaster
    8. Ben A. Barres