Ariana Sattler

  • Current Student, 2020 Cohort
  • Ece Eksi lab, Teresa Zimmers Lab
  • Graduate Program in Biomedical Sciences Students, School of Medicine

Biography

Research Interests: Emerging field of cancer-neuroscience. She studies sympathetic nerves and how they impact pancreatic ductal adenocarcinoma (PDAC) growth, progression and metastasis, as well as how neuro-modulatory crosstalk between nerves, cancer cells, and cancer associated fibroblasts (CAFs) could be tumor-supportive.

PBMS Hub: Integrated Cancer Biology (ICB)

Education and training

  • Degrees

    • B.S., 2018, Southern Oregon University

Additional information

Honors and awards

  • CEDAR Exploratory Grant: Defining crosstalk in the TME (2025)
  • CEDAR Exploratory Grant: Optimizing 3D tumor staining and clearing methods (2025)
  • Brendon Colson Travel Award (2024)
  • CEDAR Exploratory Grant: Evaluating spatial proteomic shifts in the PDAC TME (2024)
  • FLAME Award, Presidential Honor (2024)
  • Cancer Early Detection Advanced Research Center OHSU Exploratory Grant (2024)
  • OHSU School of Medicine Nicholas L. Tartar Trust Fellowship (2023)
  • OHSU Knight Cancer Institute SciOps Collaborative Grant (2023)
  • Women in Science PDX Science Talk ‘23 Conference Scholarship (2023)
  • Program in Biomedical Sciences Scholar Award (2022)
  • Professional Development Scholarship, Women in Science Portland (2021)

Publications

Selected publications

  • Sattler, A., et al. Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity”. Cancer Metastasis Rev 44, 25 (2025). https://doi.org/10.1007/s10555-025-10241-x
  • Grigoriev, V., Korzun, T., Moses, A. S., Jozic, A., Zhu, X., Kim, J., Newton, S., Eygeris, Y., Diba, P., Sattler, A. L., et al. (2024). Targeting Metastasis in Head and Neck Squamous Cell Carcinoma Using Follistatin mRNA Lipid Nanoparticles. ACS Nano. https://doi.org/10.1021/acsnano.4c06930
  • Korzun, T., Moses, A. S., Jozic, A., Grigoriev, V., Newton, S., Kim, J., Diba, P., Sattler, A., et al. (2024). Lipid Nanoparticles Elicit Reactogenicity and Sickness Behavior in Mice Via Toll-Like Receptor 4 and Myeloid Differentiation Protein 88 Axis. ACS Nano, 18(36), 24842–24859. https://doi.org/10.1021/acsnano.4c05088
  • Zhu X, Olson B, Keith D, Norgard MA, Levasseur PR, Diba P, Protzek S, Li J, Li X, Korzun T, Sattler AL, et al. GDF15 and LCN2 for early detection and prognosis of pancreatic cancer. Transl Oncol. 2024 Sep 30;50:102129. doi: 10.1016/j.tranon.2024.102129. Epub ahead of print. PMID: 39353236.
  • Diba P, Sattler AL, et al. Unraveling the lost balance: Adrenergic dysfunction in cancer cachexia. Auton Neurosci. 2024 Feb;251:103136. doi: 10.1016/j.autneu.2023.103136. Epub 2023 Dec 6. PMID: 38071925; PMCID: PMC10883135.
  • Korzun T, Moses AS, Diba P, Sattler AL, et al. From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics. Pharmaceuticals (Basel). 2023 Jul 31;16(8):1088. doi: 10.3390/ph16081088. PMID: 37631003; PMCID: PMC10459564.
  • Korzun T, Moses AS, Diba P, Sattler AL, et al. Development and Perspectives: Multifunctional Nucleic Acid Nanomedicines for Treatment of Gynecological Cancers. Small. 2023 Jul 30:e2301776. doi: 10.1002/smll.202301776. Epub ahead of print. PMID: 37518857; PMCID: PMC10827528.
  • Helms, E.J., Berry, M.W., Chaw, R.C., DuFort, C.C., Sun, D., Onate, M.K., Oon, C., Bhattacharyya, S., Sanford-Crane, H., Horton, W., Finan, J.M., Sattler, A., et al. (2022). Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer-Associated Fibroblasts. Cancer Discovery, 12(2), 484-501. doi: 10.1158/2159-8290.CD-21-0601.
  • Dietz, M. S., Sutton, T. L., Walker, B. S., Gast, C. E., Zarour, L., Sengupta, S. K., Swain, J. R., Eng, J., Parappilly, M., Limbach, K., Sattler, A., et al. Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors. Sci Rep 11, 13630 (2021). https://doi.org/10.1038/s41598-021-93053-7

Publications