Baotong Xie, Ph.D.

  • Research Assistant Professor of Integrative Biosciences, School of Dentistry

Biography

Dr. Xie received his Ph.D. in biochemistry and cellular biology from Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences. He then, as a postdoctoral researcher, started to use Drosophila as a model organism to investigate neuronal cell fate determination at Cincinnati Children’s Hospital Medical Center. As a research assistant professor, Dr. Xie’s current research interests focus on: 1) using Drosophila to understand the host-microbiome interactions and the role of human oral bacteria in health; 2) understanding the molecular mechanisms of the Hippo signaling pathway in neuronal cell fate determination and in tissue growth control.

Areas of interest

  • The formation of a functional nerve system requires the generation of a great diversity of neuronal subtypes. Our research interests focus on the elucidation of the molecular mechanisms underlying neuronal diversification.

Publications

Selected publications

  • Baotong Xie*, David Morton and Tiffany Cook*. Opposing transcriptional and post-transcriptional roles for Scalloped in binary Hippo-dependent neural fate decisions. Developmental Biology, In Press, available online at: https://doi.org/10.1016/j.ydbio.2019.06.022. * Corresponding author.
  • Jukam D**, Xie B**, Rister J**, Terrell D, Charlton-Perkins M, Pistillo D, Gebelein B, Desplan C, & Cook T. Opposite network-level feedback in the Hippo pathway for growth regulation and post-mitotic neural fate. Science, 2013 Oct 11, 342 (6155): 1238016. (**equal contribution).
  • Terrell DA, Xie B, Workman M, Mahato S, Zelhof A, Gebelein B and Cook T. OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. Developmental Dynamics, 2012 Jan, 241(1): 215-228.
  • Johnston R, Otake Y, Sood P, Vogt N, Behnia R, Vasiliauskas D, McDonald E, Xie B, Koenig S, Cook T, Gebelein B, Kussell E, Nagakoshi H, Desplan C. Interlocked feedforward loops ensure robust Rhodopsin expression in the Drosophila eye. Cell, 2011 Jun, 145(6): 956-68.
  • Charlton-Perkins M, Whitaker L, Fei Y, Xie B, Li-Kroeger D, Gebelein B, Cook T. Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. Neural Development, 2011 May; 6:20.
  • McDonald EC**, Xie B**, Workman M, Charlton-Perkins M, Terrell DA, Reischl J, Wimmer EA, Gebelein BA, Cook TA. Seperable transcriptional regulatory domains with Otd control photoreceptor terminal differentiation events. Developmental Biology. 2010 Nov; 347(1): 122-32. (**equal contribution).
  • Xie B, Charlton-Perkins M, McDonald E, Gebelein B, Cook T. Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila. Development. 2007 Dec; 134(23): 4243-53.
  • Fu ZY, Xie BT, Ma YT, Gong ZX. Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies. Acta Biochim Biophys Sin (Shanghai). 2006 Sep; 38(9):625-32.
  • Xie B, Huang R, Huang L, Zhou G, Gong Z. The functional domains of human ventricular myosin light chain 1. Biophys Chem. 2003 Oct 1; 106(1):57-66.
  • Xie BT, Ye YJ, Gong ZX. The phosphorylation of NS protein of wheat rosette stunt virus. Acta Biochim Biophys Sin (Shanghai). 2003 Jun;35(6):518-21.

Publications

  • Intraspecies interactions of Streptococcus mutans impact biofilm architecture and virulence determinants in childhood dental caries

    mSphere
    1. Stephanie S. Momeni
    2. Xixi Cao
    3. Baotong Xie
    4. Katherine Rainey
    5. Noel K. Childers
    6. Hui Wu

  • Plasmalogen, a glycerophospholipid crucial for Streptococcus mutans acid tolerance and colonization

    Applied and Environmental Microbiology
    1. Rong Mu
    2. Stephanie Momeni
    3. Madeline Krieger
    4. Baotong Xie
    5. Xixi Cao
    6. Justin Merritt
    7. Hui Wu

  • The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila

    PLoS genetics
    1. Qingliang Sang
    2. Gang Wang
    3. David B. Morton
    4. Hui Wu
    5. Baotong Xie

  • Opposing transcriptional and post-transcriptional roles for Scalloped in binary Hippo-dependent neural fate decisions

    Developmental Biology
    1. Baotong Xie
    2. David B. Morton
    3. Tiffany A. Cook

  • Opposite feedbacks in the Hippo pathway for growth control and neural fate

    Science
    1. David Jukam
    2. Baotong Xie
    3. Jens Rister
    4. David Terrell
    5. Mark Charlton-Perkins
    6. Daniela Pistillo
    7. Brian Gebelein
    8. Claude Desplan
    9. Tiffany Cook

  • OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye

    Developmental Dynamics
    1. David Terrell
    2. Baotong Xie
    3. Michael Workman
    4. Simpla Mahato
    5. Andrew Zelhof
    6. Brian Gebelein
    7. Tiffany Cook

  • Interlocked feedforward loops control cell-type-specific rhodopsin expression in the drosophila eye

    Cell
    1. Robert J. Johnston
    2. Yoshiaki Otake
    3. Pranidhi Sood
    4. Nina Vogt
    5. Rudy Behnia
    6. Daniel Vasiliauskas
    7. Elizabeth McDonald
    8. Baotong Xie
    9. Sebastian Koenig
    10. Reinhard Wolf
    11. Tiffany Cook
    12. Brian Gebelein
    13. Edo Kussell
    14. Hideki Nakagoshi
    15. Claude Desplan

  • Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling

    Neural Development
    1. Mark Charlton-Perkins
    2. S. Leigh Whitaker
    3. Yueyang Fei
    4. Baotong Xie
    5. David Li-Kroeger
    6. Brian Gebelein
    7. Tiffany Cook

  • Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events

    Developmental Biology
    1. Elizabeth C. McDonald
    2. Baotong Xie
    3. Michael Workman
    4. Mark Charlton-Perkins
    5. David A. Terrell
    6. Joachim Reischl
    7. Ernst A. Wimmer
    8. Brian A. Gebelein
    9. Tiffany A. Cook

  • Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila

    Development
    1. Baotong Xie
    2. Mark Charlton-Perkins
    3. Elizabeth McDonald
    4. Brian Gebelein
    5. Tiffany Cook