Benjamin J. Burwitz

  • Associate Professor, Oregon National Primate Research Center

Biography

Dr. Burwitz received his PhD from the Cellular & Molecular Pathology Graduate Program at the University of Wisconsin-Madison in 2010. He is currently an Associate Professor and core scientist in the divisions of Pathobiology & Immunology and Metabolic Health & Disease at the Oregon National Primate Research Center. He has 20 years of experience in infectious disease immunology, with a focus on non-human primate models. His lab studies viral infections with liver involvement, including Hepatitis B, Yellow Fever, and HIV, and strives to understand pathogen:host interactions for the design of novel prophylactic and therapeutic drugs.

In addition to his active viral immunology program, Dr. Burwitz also researches genome editing technologies in non-human primate embryos for the creation of new models of human disease. In 2022, the Burwitz Lab welcomed two transgenic rhesus macaques expressing the Hepatitis B entry receptor in their livers, making them artificially susceptible to this virus. This massive team effort brought together immunologists, virologists, and reproductive scientists, and this group is continuing forward with additional models of human disease.

Overall, Dr. Burwitz’s lab is a diverse group of researchers converging on the immunology and pathogenesis of infectious diseases and emerging genome editing technologies.

Education and training

  • Degrees

    • B.S., 2004, University of Wisconsin
    • Ph.D., 2010, University of Wisconsin

Areas of interest

  • Hepatitis B virus/HIV co-infections
  • Hematopoietic stem cell transplantation

Publications

Selected publications

  • Ericsen AJ, Lauck M, Mohns MS, DiNapoli SR, Mutschler JP, Greene JM, Weinfurter JT, Lehrer-Brey G, Prall TM, Gieger SM, Buechler CR, Crosno KA, Peterson EJ, Reynolds MR, Wiseman RW, Burwitz BJ, Estes JD, Sacha JB, Friedrich TC, Brenchley JM, O'Connor DH. Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication. PLoS Pathog. 2016 Dec 7;12(12):e1006048. doi: 10.1371/journal.ppat.1006048. 
  • Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB, Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A, Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ, Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi: 10.1371/journal.ppat.1006014. eCollection 2016 Nov. PMID: 27829026, PMCID: PMC5102353
  • Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS, Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G, Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC, Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, Picker LJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB. MR1-restricted mucosal-associated invariant T cells respond to mycobacterial vaccination and infection in nonhuman primates.
  • Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S, Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM, Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K. Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. PLoS Pathog. 2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868. eCollection 2016 Aug. PMID: 27580123, PMCID: PMC5006984

Publications