Our goal is to unravel the mechanisms underlying neuronal dysfunction in the retina in response to axon injury and diseases such as glaucoma. The retina, a complex tissue at the back of the eye, plays an essential role in processing visual information, extending from photoreceptors to retinal ganglion cells, and then to the brain through the optic nerve. Our research focuses on visualizing and recording from neurons to understand how eye diseases like glaucoma disturb normal retinal circuits.

We take an integrative approach, fostering collaborative science to address complex questions at the forefront of ophthalmological research. This involves utilizing large datasets from multielectrode array systems, patch-clamp recordings, high-resolution confocal microscopy, behavior, and transcriptomic analyses. Through these methods, we aim to uncover the principles of visual processing in both health and disease.

Funding

NIH NEI 1R01EY034973       – 2023-28
NIH NEI 1R01EY032564        – 2022-27
NIH NEI 2R01 EY027202      – 2022-26
NIH NEI U24EY033269         – 2021-26
NIH NEI R01 EY030429        – 2020-25