Beth A. Habecker, Ph.D.
- Professor of Chemical Physiology and Biochemistry, School of Medicine
- Professor of Anesthesiology and Perioperative Medicine, School of Medicine
- Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
- Graduate Program in Biomedical Sciences, School of Medicine
- Neuroscience Graduate Program, School of Medicine
- M.D./Ph.D. Program Committee, School of Medicine
Biography
Dr. Habecker received her PhD in Pharmacology from the University of Washington in Seattle, and carried out postdoctoral training in Neuroscience with Dr. Story Landis at Case Western Reserve University and the National Institute for Neurological Disorders and Stroke. The current focus of her laboratory is on sympathetic neuron-target interactions after injury, with a particular focus myocardial infarction and the changes that occur in sympathetic nerves within the heart after MI. Her lab has identified mechanisms involved in axon degeneration, axon sprouting/ regeneration, and alterations in neurotransmitter and peptide production. They have also connected changes in cardiac nerves to altered arrhythmia susceptibility and cardiac function.
Education and training
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Degrees
- B.A., 1987, Spring Arbor University
- Ph.D., 1992, University of Washington
Areas of interest
- Autonomic neuron plasticity
- Neurotransmitter/receptor expression
Additional information
Publications
Publications
Characteristics of Patients Hospitalized With Methamphetamine-Associated Heart Failure A Comparative Study of Enrolled vs Nonenrolled Patients
Journal of Cardiovascular NursingChronic nicotine exposure is associated with electrophysiological and sympathetic remodeling in the intact rabbit heart
American Journal of Physiology - Heart and Circulatory PhysiologyHypertension increases sympathetic neuron activity by enhancing intraganglionic cholinergic collateral connections
Journal of PhysiologyHypertension-induced heart failure disrupts cardiac sympathetic innervation
American Journal of Physiology - Heart and Circulatory PhysiologyIschemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons
American Journal of Physiology - Heart and Circulatory PhysiologyMolecular and cellular neurocardiology in heart disease
Journal of PhysiologySympathetic dysfunction is associated with worse fatigue and early and subtle symptoms in heart failure
European Journal of Cardiovascular NursingSympathetic structural and electrophysiological remodeling in a rabbit model of reperfused myocardial infarction
American Journal of Physiology - Heart and Circulatory PhysiologyCandidate biomarkers of physical frailty in heart failure
European Journal of Cardiovascular NursingCholinergic collaterals arising from noradrenergic sympathetic neurons in mice
Journal of PhysiologyLoss of chondroitin sulfate proteoglycan sulfation allows delayed sympathetic reinnervation after cardiac ischemia–reperfusion
Physiological reportsA primer on incorporating sex as a biological variable into the conduct and reporting of basic and clinical research studies
American Journal of Physiology - Heart and Circulatory PhysiologyBackground and Design of the Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF) Study
Journal of Cardiac FailureChondroitin Sulfate Proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction
eLifeDistinct morphology of cardiac- and brown adipose tissue-projecting neurons in the stellate ganglia of mice
Physiological reportsSmall Molecules Targeting PTPσ-Trk Interactions Promote Sympathetic Nerve Regeneration
ACS Chemical NeuroscienceTherapeutics That Promote Sympathetic Reinnervation Modulate the Inflammatory Response After Myocardial Infarction
JACC: Basic to Translational ScienceUntangling Peripheral Sympathetic Neurocircuits
Frontiers in Cardiovascular MedicineCharacterizing Sex Differences in Physical Frailty Phenotypes in Heart Failure
Circulation: Heart FailureDevelopmental exposure to DDT or DDE alters sympathetic innervation of brown adipose in adult female mice
Environmental Health: A Global Access Science SourceExploring gender differences in trajectories of clinical markers and symptoms after left ventricular assist device implantation
European Journal of Cardiovascular NursingPhosphorylation of Lamin A/C at serine 22 modulates Nav1.5 function
Physiological reportsAdrenergic supersensitivity and impaired neural control of cardiac electrophysiology following regional cardiac sympathetic nerve loss
Scientific Reports