Publications

• Nivolumab Plus 5-Azacitidine in Pediatric Relapsed/Refractory Acute Myeloid Leukemia (AML)

  Cancers Feb 2024
  1. Anupam Verma
  2. Yueh Yun Chi
  3. Jemily Malvar
  4. Adam Lamble
  5. Sonali Chaudhury
  6. Archana Agarwal
  7. Hong Tao Li
  8. Gangning Liang
  9. Roy Leong
  10. Patrick A. Brown
  11. Joel Kaplan
  12. Eric S. Schafer
  13. Tamra Slone
  14. Melinda Pauly
  15. Bill H. Chang
  16. Elliot Stieglitz
  17. Alan S. Wayne
  18. Nobuko Hijiya
  19. Deepa Bhojwani

• The genomic basis of childhood T-lineage acute lymphoblastic leukaemia

  Nature Aug 29, 2024
  1. Petri Pölönen
  2. Danika Di Giacomo
  3. Anna Eames Seffernick
  4. Abdelrahman Elsayed
  5. Shunsuke Kimura
  6. Francesca Benini
  7. Lindsey E. Montefiori
  8. Brent L. Wood
  9. Jason Xu
  10. Changya Chen
  11. Zhongshan Cheng
  12. Haley Newman
  13. Jason Myers
  14. Ilaria Iacobucci
  15. Elizabeth Li
  16. Jonathan Sussman
  17. Dale Hedges
  18. Yawei Hui
  19. Caroline Diorio
  20. Lahari Uppuluri
  21. David Frank
  22. Yiping Fan
  23. Yunchao Chang
  24. Soheil Meshinchi
  25. Rhonda Ries
  26. Rawan Shraim
  27. Alexander Li
  28. Kathrin M. Bernt
  29. Meenakshi Devidas
  30. Stuart S. Winter
  31. Kimberly P. Dunsmore
  32. Hiroto Inaba
  33. William L. Carroll
  34. Nilsa C. Ramirez
  35. Aaron H. Phillips
  36. Richard W. Kriwacki
  37. Jun J. Yang
  38. Tiffaney L. Vincent
  39. Yaqi Zhao
  40. Pankaj S. Ghate
  41. Jian Wang
  42. Colleen Reilly
  43. Xin Zhou
  44. Mathijs A. Sanders
  45. Junko Takita
  46. Motohiro Kato
  47. Nao Takasugi
  48. Bill H. Chang
  49. Richard D. Press
  50. Mignon Loh
  51. Evadnie Rampersaud
  52. Elizabeth Raetz
  53. Stephen P. Hunger
  54. Kai Tan
  55. Ti Cheng Chang
  56. Gang Wu
  57. Stanley B. Pounds
  58. Charles G. Mullighan
  59. David T. Teachey

• Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy

  Blood cancer discovery 2023
  1. Christopher A. Eide
  2. Stephen E. Kurtz
  3. Andy Kaempf
  4. Nicola Long
  5. Sunil Kumar Joshi
  6. Tamilla Nechiporuk
  7. Ariane Huang
  8. Charles A. Dibb
  9. Akosha Taylor
  10. Daniel Bottomly
  11. Shannon K. McWeeney
  12. Jessica Minnier
  13. Curtis A. Lachowiez
  14. Jennifer N. Saultz
  15. Ronan T. Swords
  16. Anupriya Agarwal
  17. Bill H. Chang
  18. Brian J. Druker
  19. Jeffrey W. Tyner

• Patient-Specific Targeting of the T-Cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases

  Clinical Cancer Research Oct 15, 2023
  1. Olivia M. Lucero
  2. Ji Ann Lee
  3. Jenna Bowman
  4. Kara Johnson
  5. Gopal Sapparapu
  6. John K. Thomas
  7. Guang Fan
  8. Bill H. Chang
  9. Karina Thiel-Klare
  10. Christopher A. Eide
  11. Craig Okada
  12. Mike Palazzolo
  13. Evan Lind
  14. Yoko Kosaka
  15. Brian J. Druker
  16. Nicholas Lydon
  17. Peter M. Bowers

• Patients with Down syndrome can be included in early phase clinical trials- a report from the T2016-003 Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) study

  Leukemia May 2023
  1. N. Gossai
  2. D. Bhojwani
  3. E. S. Schafer
  4. B. H. Chang
  5. L. Pommert
  6. A. Verma
  7. J. Malvar
  8. Y. Y. Chi
  9. J. Hitzler
  10. M. J. Burke
  11. K. R. Rabin

• Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia

  Blood Advances May 24, 2022
  1. Stephen E. Kurtz
  2. Christopher A. Eide
  3. Andy Kaempf
  4. Nicola Long
  5. Daniel Bottomly
  6. Olga Nikolova
  7. Brian J. Druker
  8. Shannon K. McWeeney
  9. Bill H. Chang
  10. Jeffrey W. Tyner
  11. Anupriya Agarwal

• Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed/refractory AML

  American Journal of Hematology May 2022
  1. Lauren Pommert
  2. Eric S. Schafer
  3. Jemily Malvar
  4. Nathan Gossai
  5. Ellynore Florendo
  6. Kirthi Pulakanti
  7. Katelyn Heimbruch
  8. Cary Stelloh
  9. Yueh Yun Chi
  10. Richard Sposto
  11. Sridhar Rao
  12. Van Thu Huynh
  13. Patrick Brown
  14. Bill H. Chang
  15. Susan I. Colace
  16. Michelle L. Hermiston
  17. Kenneth Heym
  18. Raymond J. Hutchinson
  19. Joel A. Kaplan
  20. Rajen Mody
  21. Tracey A. O'Brien
  22. Andrew E. Place
  23. Peter H. Shaw
  24. David S. Ziegler
  25. Alan Wayne
  26. Deepa Bhojwani
  27. Michael J. Burke

• Fetal Hepatomegaly

  NeoReviews Dec 1, 2022
  1. Jina Park
  2. Devlynne Sasha Ondusko
  3. Bill H. Chang
  4. Emily A. Edwards
  5. Sylvia Doan
  6. Ken Gatter
  7. Ibrahim Hajjali
  8. Amanda Kim

• Integrative analysis of drug response and clinical outcome in acute myeloid leukemia

  Cancer Cell Aug 8, 2022
  1. Daniel Bottomly
  2. Nicola Long
  3. Anna Reister Schultz
  4. Stephen E. Kurtz
  5. Cristina E. Tognon
  6. Kara Johnson
  7. Melissa Abel
  8. Anupriya Agarwal
  9. Sammantha Avaylon
  10. Erik Benton
  11. Aurora Blucher
  12. Uma Borate
  13. Theodore P. Braun
  14. Jordana Brown
  15. Jade Bryant
  16. Russell Burke
  17. Amy Carlos
  18. Bill H. Chang
  19. Hyun Jun Cho
  20. Stephen Christy
  21. Cody Coblentz
  22. Aaron M. Cohen
  23. Amanda d'Almeida
  24. Rachel Cook
  25. Alexey Danilov
  26. Kim Hien T. Dao
  27. Michie Degnin
  28. James Dibb
  29. Christopher A. Eide
  30. Isabel English
  31. Stuart Hagler
  32. Heath Harrelson
  33. Rachel Henson
  34. Hibery Ho
  35. Sunil K. Joshi
  36. Brian Junio
  37. Andy Kaempf
  38. Yoko Kosaka
  39. Ted Laderas
  40. Matt Lawhead
  41. Hyunjung Lee
  42. Jessica T. Leonard
  43. Chenwei Lin
  44. Evan F. Lind
  45. Selina Qiuying Liu
  46. Pierrette Lo
  47. Marc M. Loriaux
  48. Samuel Luty
  49. Julia E. Maxson
  50. Tara Macey
  51. Jacqueline Martinez
  52. Jessica Minnier
  53. Andrea Monteblanco
  54. Motomi Mori
  55. Quinlan Morrow
  56. Dylan Nelson
  57. Justin Ramsdill
  58. Angela Rofelty
  59. Alexandra Rogers
  60. Kyle A. Romine
  61. Peter Ryabinin
  62. Jennifer N. Saultz
  63. David A. Sampson
  64. Samantha L. Savage
  65. Robert Schuff
  66. Robert Searles
  67. Rebecca L. Smith
  68. Stephen E. Spurgeon
  69. Tyler Sweeney
  70. Ronan T. Swords
  71. Aashis Thapa
  72. Karina Thiel-Klare
  73. Elie Traer
  74. Jake Wagner
  75. Beth Wilmot
  76. Joelle Wolf
  77. Guanming Wu
  78. Amy Yates
  79. Haijiao Zhang
  80. Christopher R. Cogle
  81. Robert H. Collins
  82. Michael W. Deininger
  83. Christopher S. Hourigan
  84. Craig T. Jordan
  85. Tara L. Lin
  86. Micaela E. Martinez
  87. Rachel R. Pallapati
  88. Daniel A. Pollyea
  89. Anthony D. Pomicter
  90. Justin M. Watts
  91. Scott J. Weir
  92. Brian J. Druker
  93. Shannon K. McWeeney
  94. Jeffrey W. Tyner

• A phase 1 study of entinostat in children and adolescents with recurrent or refractory solid tumors, including CNS tumors

  Pediatric Blood and Cancer 2021
  1. Andrew Bukowinski
  2. Bill Chang
  3. Joel M. Reid
  4. Xiaowei Liu
  5. Charles G. Minard
  6. Jane B. Trepel
  7. Min Jung Lee
  8. Elizabeth Fox
  9. Brenda J. Weigel

• Concomitant use of a dual Src/ABL kinase inhibitor eliminates the in vitro efficacy of blinatumomab against Ph⁺ ALL

  Blood Feb 18, 2021
  1. Jessica T. Leonard
  2. Yoko Kosaka
  3. Pavani Malla
  4. Dorian LaTocha
  5. Adam Lamble
  6. Brandon Hayes-Lattin
  7. Kaelan Byrd
  8. Brian J. Druker
  9. Jeffrey W. Tyner
  10. Bill H. Chang
  11. Evan Lind

• Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia

  Clinical Cancer Research May 15, 2020
  1. Michael J. Burke
  2. Rumen Kostadinov
  3. Richard Sposto
  4. Lia Gore
  5. Shannon M. Kelley
  6. Cara Rabik
  7. Jane B. Trepel
  8. Min Jung Lee
  9. Akira Yuno
  10. Sunmin Lee
  11. Deepa Bhojwani
  12. Sima Jeha
  13. Bill H. Chang
  14. Maria Luisa Sulis
  15. Michelle L. Hermiston
  16. Paul Gaynon
  17. Van Huynh
  18. Anupam Verma
  19. Rebecca Gardner
  20. Kenneth M. Heym
  21. Robyn M. Dennis
  22. David S. Ziegler
  23. Theodore W. Laetsch
  24. Javier E. Oesterheld
  25. Steven G. Dubois
  26. Jessica A. Pollard
  27. Julia Glade-Bender
  28. Todd M. Cooper
  29. Joel A. Kaplan
  30. Midhat S. Farooqi
  31. Byunggil Yoo
  32. Erin Guest
  33. Alan S. Wayne
  34. Patrick A. Brown

• Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia

  Leukemia Jan 1, 2020
  1. Christopher A. Eide
  2. Stephen E. Kurtz
  3. Andy Kaempf
  4. Nicola Long
  5. Anupriya Agarwal
  6. Cristina E. Tognon
  7. Motomi Mori
  8. Brian J. Druker
  9. Bill H. Chang
  10. Alexey V. Danilov
  11. Jeffrey W. Tyner

• Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

  EMBO Reports Jul 2019
  1. Sherif Abdelhamed
  2. John T. Butler
  3. Ben Doron
  4. Amber Halse
  5. Eneida Nemecek
  6. Phillip A. Wilmarth
  7. Daniel L. Marks
  8. Bill H. Chang
  9. Terzah Horton
  10. Peter Kurre

• Replication timing alterations in leukemia affect clinically relevant chromosome domains

  Blood Advances Nov 12, 2019
  1. Juan Carlos Rivera-Mulia
  2. Takayo Sasaki
  3. Claudia Trevilla-Garcia
  4. Naoto Nakamichi
  5. David J.H.F. Knapp
  6. Colin A. Hammond
  7. Bill H. Chang
  8. Jeffrey W. Tyner
  9. Meenakshi Devidas
  10. Jared Zimmerman
  11. Kyle N. Klein
  12. Vivek Somasundaram
  13. Brian J. Druker
  14. Tanja A. Gruber
  15. Amnon Koren
  16. Connie J. Eaves
  17. David M. Gilbert

• The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells

  Cancer discovery Jul 2019
  1. Tamilla Nechiporuk
  2. Stephen E. Kurtz
  3. Olga Nikolova
  4. Tingting Liu
  5. Courtney L. Jones
  6. Angelo D’alessandro
  7. Rachel Culp-Hill
  8. Amanda D’almeida
  9. Sunil K. Joshi
  10. Mara Rosenberg
  11. Cristina E. Tognon
  12. Alexey V. Danilov
  13. Brian J. Druker
  14. Bill H. Chang
  15. Shannon K. McWeeney
  16. Jeffrey W. Tyner

• Dasatinib plus intensive chemotherapy in children, adolescents, and young adults with philadelphia chromosome–positive acute lymphoblastic leukemia

  Journal of Clinical Oncology Aug 1, 2018
  1. William B. Slayton
  2. Kirk R. Schultz
  3. John A. Kairalla
  4. Meenakshi Devidas
  5. Xinlei Mi
  6. Michael A. Pulsipher
  7. Bill H. Chang
  8. Charles Mullighan
  9. Ilaria Iacobucci
  10. Lewis B. Silverman
  11. Michael J. Borowitz
  12. Andrew J. Carroll
  13. Nyla A. Heerema
  14. Julie M. Gastier-Foster
  15. Brent L. Wood
  16. Sherri L. Mizrahy
  17. Thomas Merchant
  18. Valerie I. Brown
  19. Lance Sieger
  20. Marilyn J. Siegel
  21. Elizabeth A. Raetz
  22. Naomi J. Winick
  23. Mignon L. Loh
  24. William L. Carroll
  25. Stephen P. Hunger

• Functional genomic landscape of acute myeloid leukaemia

  Nature Oct 25, 2018
  1. Jeffrey W. Tyner
  2. Cristina E. Tognon
  3. Daniel Bottomly
  4. Beth Wilmot
  5. Stephen E. Kurtz
  6. Samantha L. Savage
  7. Nicola Long
  8. Anna Reister Schultz
  9. Elie Traer
  10. Melissa Abel
  11. Anupriya Agarwal
  12. Aurora Blucher
  13. Uma Borate
  14. Jade Bryant
  15. Russell Burke
  16. Amy Carlos
  17. Richie Carpenter
  18. Joseph Carroll
  19. Bill H. Chang
  20. Cody Coblentz
  21. Amanda d’Almeida
  22. Rachel Cook
  23. Alexey Danilov
  24. Kim Hien T. Dao
  25. Michie Degnin
  26. Deirdre Devine
  27. James Dibb
  28. David K. Edwards
  29. Christopher A. Eide
  30. Isabel English
  31. Jason Glover
  32. Rachel Henson
  33. Hibery Ho
  34. Abdusebur Jemal
  35. Kara Johnson
  36. Ryan Johnson
  37. Brian Junio
  38. Andy Kaempf
  39. Jessica Leonard
  40. Chenwei Lin
  41. Selina Qiuying Liu
  42. Pierrette Lo
  43. Marc M. Loriaux
  44. Samuel Luty
  45. Tara Macey
  46. Jason MacManiman
  47. Jacqueline Martinez
  48. Motomi Mori
  49. Dylan Nelson
  50. Ceilidh Nichols
  51. Jill Peters
  52. Justin Ramsdill
  53. Angela Rofelty
  54. Robert Schuff
  55. Robert Searles
  56. Erik Segerdell
  57. Rebecca L. Smith
  58. Stephen E. Spurgeon
  59. Tyler Sweeney
  60. Aashis Thapa
  61. Corinne Visser
  62. Jake Wagner
  63. Kevin Watanabe-Smith
  64. Kristen Werth
  65. Joelle Wolf
  66. Libbey White
  67. Amy Yates
  68. Haijiao Zhang
  69. Christopher R. Cogle
  70. Robert H. Collins
  71. Denise C. Connolly
  72. Michael W. Deininger
  73. Leylah Drusbosky
  74. Christopher S. Hourigan
  75. Craig T. Jordan
  76. Patricia Kropf
  77. Tara L. Lin
  78. Micaela E. Martinez
  79. Bruno C. Medeiros
  80. Rachel R. Pallapati
  81. Daniel A. Pollyea
  82. Ronan T. Swords
  83. Justin M. Watts
  84. Scott J. Weir
  85. David L. Wiest
  86. Ryan M. Winters
  87. Shannon K. McWeeney
  88. Brian J. Druker

• Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL

  Oncogene May 30, 2018
  1. Marilynn Chow
  2. Lina Gao
  3. Jason D. MacManiman
  4. Vincent T. Bicocca
  5. Bill H. Chang
  6. Joshi J. Alumkal
  7. Jeffrey W. Tyner

• Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia

  Leukemia Nov 1, 2018
  1. Weili Sun
  2. Jemily Malvar
  3. Richard Sposto
  4. Anupam Verma
  5. Jennifer J. Wilkes
  6. Robyn Dennis
  7. Kenneth Heym
  8. Theodore W. Laetsch
  9. Melissa Widener
  10. Susan R. Rheingold
  11. Javier Oesterheld
  12. Nobuko Hijiya
  13. Maria Luisa Sulis
  14. Van Huynh
  15. Andrew E. Place
  16. Henrique Bittencourt
  17. Raymond Hutchinson
  18. Yoav Messinger
  19. Bill Chang
  20. Yousif Matloub
  21. David S. Ziegler
  22. Rebecca Gardner
  23. Todd Cooper
  24. Francesco Ceppi
  25. Michelle Hermiston
  26. Luciano Dalla-Pozza
  27. Kirk R. Schultz
  28. Paul Gaynon
  29. Alan S. Wayne
  30. James A. Whitlock

• Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

  Science signaling Jul 17, 2018
  1. Chelsea Jenkins
  2. Samuel B. Luty
  3. Julia E. Maxson
  4. Christopher A. Eide
  5. Melissa L. Abel
  6. Corinne Togiai
  7. Eneida R. Nemecek
  8. Daniel Bottomly
  9. Shannon K. McWeeney
  10. Beth Wilmot
  11. Marc Loriaux
  12. Bill H. Chang
  13. Jeffrey W. Tyner

• Clinical and immunological responses after CD30-specific chimeric antigen receptor-redirected lymphocytes

  Journal of Clinical Investigation Sep 1, 2017
  1. Carlos A. Ramos
  2. Brandon Ballard
  3. Huimin Zhang
  4. Olga Dakhova
  5. Adrian P. Gee
  6. Zhuyong Mei
  7. Mrinalini Bilgi
  8. Meng Fen Wu
  9. Hao Liu
  10. Bambi Grilley
  11. Catherine M. Bollard
  12. Bill H. Chang
  13. Cliona M. Rooney
  14. Malcolm K. Brenner
  15. Helen E. Heslop
  16. Gianpietro Dotti
  17. Barbara Savoldo

• Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

  Blood Mar 16, 2017
  1. Viktoras Frismantas
  2. Maria Pamela Dobay
  3. Anna Rinaldi
  4. Joelle Tchinda
  5. Samuel H. Dunn
  6. Joachim Kunz
  7. Paulina Richter-Pechanska
  8. Blerim Marovca
  9. Orrin Pail
  10. Silvia Jenni
  11. Ernesto Diaz-Flores
  12. Bill H. Chang
  13. Timothy J. Brown
  14. Robert H. Collins
  15. Sebastian Uhrig
  16. Gnana P. Balasubramanian
  17. Obul R. Bandapalli
  18. Salome Higi
  19. Sabrina Eugster
  20. Pamela Voegeli
  21. Mauro Delorenzi
  22. Gunnar Cario
  23. Mignon L. Loh
  24. Martin Schrappe
  25. Martin Stanulla
  26. Andreas E. Kulozik
  27. Martina U. Muckenthaler
  28. Vaskar Saha
  29. Julie A. Irving
  30. Roland Meisel
  31. Thomas Radimerski
  32. Arend Von Stackelberg
  33. Cornelia Eckert
  34. Jeffrey W. Tyner
  35. Peter Horvath
  36. Beat C. Bornhauser
  37. Jean Pierre Bourquin

• Investigating the biology of relapsed acute leukemia

  Pediatric Hematology and Oncology Oct 3, 2017
  1. Deepa Bhojwani
  2. Michael J. Burke
  3. Terzah Horton
  4. David S. Ziegler
  5. Maria Luisa Sulis
  6. Kirk R. Schultz
  7. Alan Wayne
  8. Shai Izraeli
  9. Bill H. Chang