Bill B. Messer, M.D., Ph.D.

  • Associate Professor of Molecular Microbiology and Immunology, School of Medicine
  • Associate Professor of Medicine, Division of Infectious Diseases, School of Medicine
  • Molecular Microbiology and Immunology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Dr. Messer completed his Ph.D. in ecology in 2003 under the mentorship of Dr. Tom Whitmore in the Department of Geography and in the lab of Dr. Aravinda de Silva in the Department of Microbiology and Immunology at UNC Chapel Hill. His dissertation focused on the evolution of dengue virus serotype 3 and the emergence of dengue hemorrhagic fever in Sri Lanka. After completing his M.D. and residency and his residency in internal medicine at UNC in 2008, he joined the lab of Dr. Ralph Baric where he took primary responsibility for the dengue virus research program, supported by the Southeast Regional Center for Excellence in Biodefense. In May, 2012, following completion of his fellowship in infectious diseases, Dr. Messer was appointed clinical assistant professor in the Department of Medicine in the UNC School of Medicine. In November, 2012, Dr. Messer joined the faculty in the departments of medicine and molecular microbiology and immunology at Oregon Health & Sciences University as an assistant professor where he continues to study dengue virus genetics.

Education and training

  • Degrees

    • M.D., 2006, University of North Carolina at Chapel Hill School of Medicine
    • Ph.D., 2003, University of North Carolina at Chapel Hill
  • Residency

    • Internal medicine, University of North Carolina Hospitals, Chapel Hill, NC, 2009
  • Fellowship

    • Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, 2012
  • Certifications

    • American Board of Internal Medicine, Internal Medicine, 2010
    • American Board of Internal Medicine, Infectious Diseases, 2011

Memberships and associations:

  • American College of Physicians

Publications

Elsevier pure profile

Publications

  • Contralateral second dose improves antibody responses to a 2-dose mRNA vaccination regimen

    Journal of Clinical Investigation
    1. Sedigheh Fazli
    2. Archana Thomas
    3. Abram E. Estrada
    4. Hiro A.P. Ross
    5. David Xthona Lee
    6. Steven Kazmierczak
    7. Mark K. Slifka
    8. David Montefiori
    9. William B. Messer
    10. Marcel E. Curlin
  • Extreme γ′ fibrinogen levels in COVID-19 patients

    Blood Cells, Molecules, and Diseases
    1. Matthew Hudkins
    2. Heather Hamilton
    3. Samantha J. Underwood
    4. Diana E. Kazmierczak
    5. Elizabeth N. Dewey
    6. Steven C. Kazmierczak
    7. William B. Messer
    8. Akram Khan
    9. Martin A. Schreiber
    10. David H. Farrell
  • Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes

    Nature communications
    1. Al Ozonoff
    2. Naresh Doni Jayavelu
    3. Shanshan Liu
    4. Esther Melamed
    5. Carly E. Milliren
    6. Jingjing Qi
    7. Linda N. Geng
    8. Grace A. McComsey
    9. Charles B. Cairns
    10. Lindsey R. Baden
    11. Joanna Schaenman
    12. Albert C. Shaw
    13. Hady Samaha
    14. Vicki Seyfert-Margolis
    15. Florian Krammer
    16. Lindsey B. Rosen
    17. Hanno Steen
    18. Caitlin Syphurs
    19. Ravi Dandekar
    20. Casey P. Shannon
    21. Rafick P. Sekaly
    22. Lauren I.R. Ehrlich
    23. David B. Corry
    24. Farrah Kheradmand
    25. Mark A. Atkinson
    26. Scott C. Brakenridge
    27. Nelson I. Agudelo Higuita
    28. Jordan P. Metcalf
    29. Catherine L. Hough
    30. William B. Messer
    31. Bali Pulendran
    32. Kari C. Nadeau
    33. Mark M. Davis
    34. Ana Fernandez Sesma
    35. Viviana Simon
    36. Harm van Bakel
    37. Seunghee Kim-Schulze
    38. David A. Hafler
    39. Ofer Levy
    40. Monica Kraft
    41. Chris Bime
    42. Elias K. Haddad
    43. Carolyn S. Calfee
    44. David J. Erle
    45. Charles R. Langelier
    46. Walter Eckalbar
    47. Steven E. Bosinger
    48. Bjoern Peters
    49. Steven H. Kleinstein
    50. Elaine F. Reed
  • IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition

    Nature communications
    1. Benjamin S. Haslund-Gourley
    2. Kyra Woloszczuk
    3. Jintong Hou
    4. Jennifer Connors
    5. Gina Cusimano
    6. Mathew Bell
    7. Bhavani Taramangalam
    8. Slim Fourati
    9. Nathan Mege
    10. Mariana Bernui
    11. Matthew C. Altman
    12. Florian Krammer
    13. Harm van Bakel
    14. Holden T. Maecker
    15. Nadine Rouphael
    16. Joann Diray-Arce
    17. Brian Wigdah
    18. Michele A. Kutzler
    19. Charles B. Cairns
    20. Elias K. Haddad
    21. Mary Ann Comunale
    22. Al Ozonoff
    23. Lauren I.R. Ehrlich
    24. Esther Melamed
    25. Ana Fernandez Sesma
    26. Viviana Simon
    27. Bali Pulendran
    28. Kari C. Nadeau
    29. Mark M. Davis
    30. Grace A. McCoey
    31. Rafick Sekaly
    32. Lindsey R. Baden
    33. Ofer Levy
    34. Joanna Schaenman
    35. Elaine F. Reed
    36. Albert C. Shaw
    37. David A. Hafler
    38. Ruth R. Montgomery
    39. Steven H. Kleinstein
    40. Patrice M. Becker
    41. Alison D. Augustine
    42. Carolyn S. Calfee
    43. David J. Erle
    44. Michael E. Debakey
    45. David B. Corry
    46. Farrah Kheradmand
    47. Mark A. Atkinson
    48. Scott C. Brakenridge
    49. Catherine L. Hough
    50. William B. Messer
  • Preventing unnecessary urine cultures at a Veteran's affairs healthcare system

    Infection control and hospital epidemiology
    1. Chad D. Nix
    2. William B. Messer
    3. Amy Boda
    4. Kimberly T. MaCkay
    5. Jennifer Holmquist
    6. La'Tonzia L. Adams
    7. Eric Gladwin
    8. Christopher D. Pfeiffer
  • The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

    Vaccines
    1. Whitney C. Weber
    2. Zachary J. Streblow
    3. Craig N. Kreklywich
    4. Michael Denton
    5. Gauthami Sulgey
    6. Magdalene M. Streblow
    7. Dorca Marcano
    8. Paola N. Flores
    9. Rachel M. Rodriguez-Santiago
    10. Luisa I. Alvarado
    11. Vanessa Rivera-Amill
    12. William B. Messer
    13. Romana Hochreiter
    14. Karin Kosulin
    15. Katrin Dubischar
    16. Vera Buerger
    17. Daniel N. Streblow
  • A Maximum Entropy Model of the Distribution of Dengue Serotype in Mexico

    Transboundary and Emerging Diseases
    1. Esther Annan
    2. Jailos Lubinda
    3. Jesús Treviño
    4. William Messer
    5. Dina Fonseca
    6. Penghua Wang
    7. Jurgen Pilz
    8. Benjamin Lintner
    9. Aracely Angulo-Molina
    10. Ana L. Gallego-Hernández
    11. Ubydul Haque
  • An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants

    JCI Insight
    1. Timothy A. Bates
    2. Hans C. Leier
    3. Savannah K. McBride
    4. Devin Schoen
    5. Zoe L. Lyski
    6. David X. Lee
    7. William Messer
    8. Marcel Curlin
    9. Fikadu G. Tafesse
  • Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein

    PLoS neglected tropical diseases
    1. John M. Powers
    2. Zoe L. Lyski
    3. Whitney C. Weber
    4. Michael Denton
    5. Magdalene M. Streblow
    6. Adam T. Mayo
    7. Nicole N. Haese
    8. Chad D. Nix
    9. Rachel Rodríguez-Santiago
    10. Luisa I. Alvarado
    11. Vanessa Rivera-Amill
    12. William B. Messer
    13. Daniel N. Streblow
  • Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients

    Cell Reports Medicine
    1. Joann Diray-Arce
    2. Slim Fourati
    3. Naresh Doni Jayavelu
    4. Ravi Patel
    5. Cole Maguire
    6. Ana C. Chang
    7. Ravi Dandekar
    8. Jingjing Qi
    9. Brian H. Lee
    10. Patrick van Zalm
    11. Andrew Schroeder
    12. Ernie Chen
    13. Anna Konstorum
    14. Anderson Brito
    15. Jeremy P. Gygi
    16. Alvin Kho
    17. Jing Chen
    18. Shrikant Pawar
    19. Ana Silvia Gonzalez-Reiche
    20. Annmarie Hoch
    21. Carly E. Milliren
    22. James A. Overton
    23. Kerstin Westendorf
    24. James Abraham
    25. Michael Adkisson
    26. Marisa Albert
    27. Luz Altamirano Torres
    28. Bonny Alvarenga
    29. Matthew L. Anderson
    30. Evan J. Anderson
    31. Azlann Arnett
    32. Hiromitsu Asashima
    33. Mark A. Atkinson
    34. Lindsey R. Baden
    35. Brenda Barton
    36. Katherine Beach
    37. Elizabeth Beagle
    38. Patrice M. Becker
    39. Matthew R. Bell
    40. Mariana Bernui
    41. Chris Bime
    42. Arun Boddapati Kumar
    43. Leland J. Booth
    44. Brittney Borresen
    45. Scott C. Brakenridge
    46. Laurel Bristow
    47. Robert Bryant
    48. Carolyn S. Calfee
    49. Catherine L. Hough
    50. William B. Messer
  • Relationship of Heterologous Virus Responses and Outcomes in Hospitalized COVID-19 Patients

    Journal of Immunology
    1. Yael Rosenberg-Hasson
    2. Tyson H. Holmes
    3. Joann Diray-Arce
    4. Jing Chen
    5. Ryan Kellogg
    6. Michael Snyder
    7. Patrice M. Becker
    8. Al Ozonoff
    9. Nadine Rouphael
    10. Elaine F. Reed
    11. Holden T. Maecker
    12. Ozonoff Al Ozonoff
    13. Joann Diray-Arce
    14. Carly E. Milliren
    15. Kerry McEnaney
    16. Brenda Barton
    17. Claudia Lentucci
    18. Mehmet Saluvan
    19. Ana C. Chang
    20. Annmarie Hoch
    21. Marisa Albert
    22. Tanzia Shaheen
    23. Alvin T. Kho
    24. Shanshan Liu
    25. Sanya Thomas
    26. Jing Chen
    27. Maimouna D. Murphy
    28. Mitchell Cooney
    29. Caitlin Syphurs
    30. Arash Nemati Hayati
    31. Robert Bryant
    32. James Abraham
    33. Joanna Schaenman
    34. Elaine F. Reed
    35. Ramin Salehi-Rad
    36. David Elashoff
    37. Jenny Brook
    38. Estefania Ramires-Sanchez
    39. Megan Llamas
    40. Adreanne Rivera
    41. Claudia Perdomo
    42. Dawn C. Ward
    43. Clara E. Magyar
    44. Jennifer Fulcher
    45. Harry C. Pickering
    46. Subha Sen
    47. Naresh Doni Jayavelu
    48. Matthew C. Altman
    49. Catherine L. Hough
    50. William B. Messer
  • A lyophilized colorimetric RT-LAMP test kit for rapid, low-cost, at-home molecular testing of SARS-CoV-2 and other pathogens

    Scientific Reports
    1. Xin Song
    2. Felicity J. Coulter
    3. Ming Yang
    4. Jessica L. Smith
    5. Fikadu G. Tafesse
    6. William B. Messer
    7. John H. Reif
  • Bimodal distribution pattern associated with the PCR cycle threshold (Ct) and implications in COVID-19 infections

    Scientific Reports
    1. Doris Yang
    2. Donna E. Hansel
    3. Marcel E. Curlin
    4. John M. Townes
    5. William B. Messer
    6. Guang Fan
    7. Xuan Qin
  • BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age

    Cell Reports
    1. Timothy A. Bates
    2. Pei Lu
    3. Ye Jin Kang
    4. Devin Schoen
    5. Micah Thornton
    6. Savannah K. McBride
    7. Chanhee Park
    8. Daehwan Kim
    9. William B. Messer
    10. Marcel E. Curlin
    11. Fikadu G. Tafesse
    12. Lenette L. Lu
  • Case Report

    Infectious Diseases in Clinical Practice
    1. Hiromichi Park
    2. Hita Bhagat
    3. William Messer
    4. Marissa Maier
  • Case Report

    Frontiers in Neurology
    1. Michelle Cohen
    2. Madeline Nguyen
    3. Chad D. Nix
    4. Brendan Case
    5. Joshua P. Nickerson
    6. Jacqueline Bernard
    7. Julia Durrant
    8. Delaram Safarpour
    9. Tarvez Tucker
    10. Kamila Vagnerova
    11. William B. Messer
  • Development and Validation of an Enzyme Immunoassay for Detection and Quantification of SARS-CoV-2 Salivary IgA and IgG

    Journal of Immunology
    1. Veronica P. Costantini
    2. Kenny Nguyen
    3. Zoe Lyski
    4. Shannon Novosad
    5. Ana C. Bardossy
    6. Amanda K. Lyons
    7. Paige Gable
    8. Preeta K. Kutty
    9. Joseph D. Lutgring
    10. Amanda Brunton
    11. Natalie J. Thornburg
    12. Allison C. Brown
    13. L. Clifford McDonald
    14. William Messer
    15. Jan Vinjé
  • Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients

    EBioMedicine
    1. Al Ozonoff
    2. Joanna Schaenman
    3. Naresh Doni Jayavelu
    4. Carly E. Milliren
    5. Carolyn S. Calfee
    6. Charles B. Cairns
    7. Monica Kraft
    8. Lindsey R. Baden
    9. Albert C. Shaw
    10. Florian Krammer
    11. Harm van Bakel
    12. Denise A. Esserman
    13. Shanshan Liu
    14. Ana Fernandez Sesma
    15. Viviana Simon
    16. David A. Hafler
    17. Ruth R. Montgomery
    18. Steven H. Kleinstein
    19. Ofer Levy
    20. Christian Bime
    21. Elias K. Haddad
    22. David J. Erle
    23. Bali Pulendran
    24. Kari C. Nadeau
    25. Mark M. Davis
    26. Catherine L. Hough
    27. William B. Messer
    28. Nelson I.Agudelo Higuita
    29. Jordan P. Metcalf
    30. Mark A. Atkinson
    31. Scott C. Brakenridge
    32. David Corry
    33. Farrah Kheradmand
    34. Lauren I.R. Ehrlich
    35. Esther Melamed
    36. Grace A. McComsey
    37. Rafick Sekaly
    38. Joann Diray-Arce
    39. Bjoern Peters
    40. Alison D. Augustine
    41. Elaine F. Reed
    42. Matthew C. Altman
    43. Patrice M. Becker
    44. Nadine Rouphael
    45. Chris Bime
    46. Mark M. Davis
    47. Kerry McEnaney
    48. Brenda Barton
    49. Claudia Lentucci
    50. Mehmet Saluvan
  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific Memory B Cells from Individuals with Diverse Disease Severities Recognize SARS-CoV-2 Variants of Concern

    Journal of Infectious Diseases
    1. Zoe L. Lyski
    2. Amanda E. Brunton
    3. Matt I. Strnad
    4. Peter E. Sullivan
    5. Sarah A.R. Siegel
    6. Fikadu G. Tafesse
    7. Mark K. Slifka
    8. William B. Messer
  • Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants

    Science Immunology
    1. Timothy A. Bates
    2. Savannah K. McBride
    3. Hans C. Leier
    4. Gaelen Guzman
    5. Zoe L. Lyski
    6. Devin Schoen
    7. Bradie Winders
    8. Joon Yong Lee
    9. David Xthona Lee
    10. William B. Messer
    11. Marcel E. Curlin
    12. Fikadu G. Tafesse
  • Adapting Rapid Diagnostic Tests to Detect Historical Dengue Virus Infections

    Frontiers in immunology
    1. Fernando Echegaray
    2. Peter Laing
    3. Samantha Hernandez
    4. Sully Marquez
    5. Amanda Harris
    6. Ian Laing
    7. Adam Chambers
    8. Neil McLennan
    9. Victor A. Sugiharto
    10. Hua Wei Chen
    11. Sandra Vivero Villagran
    12. Abigail Collingwood
    13. Magelda Montoya
    14. Fausto Bustos Carrillo
    15. Mark P. Simons
    16. Philip J. Cooper
    17. Andrea Lopez
    18. Gabriel Trueba
    19. Joseph Eisenberg
    20. Shuenn Jue Wu
    21. William Messer
    22. Eva Harris
    23. Josefina Coloma
    24. Leah C. Katzelnick
  • Cellular and humoral immune responses in mice immunized with vaccinia virus expressing the sars-cov-2 spike protein

    Journal of Immunology
    1. Jake C. Harbour
    2. Zoe L. Lyski
    3. John B. Schell
    4. Archana Thomas
    5. William B. Messer
    6. Mark K. Slifka
    7. Jeffrey C. Nolz
  • Clinical symptoms of dengue infection among patients from a non-endemic area and potential for a predictive model

    American Journal of Tropical Medicine and Hygiene
    1. Ruchira R. Khosavanna
    2. Bettie W. Kareko
    3. Adam C. Brady
    4. Brian L. Booty
    5. Chad D. Nix
    6. Zoe L. Lyski
    7. Marcel D. Curlin
    8. William B. Messer
  • Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2

    Cell Reports
    1. Timothy A. Bates
    2. Jules B. Weinstein
    3. Scotland Farley
    4. Hans C. Leier
    5. William B. Messer
    6. Fikadu G. Tafesse
  • Establishment of Monoclonal Antibody Standards for Quantitative Serological Diagnosis of SARS-CoV-2 in Low-Incidence Settings

    Open Forum Infectious Diseases
    1. Archana Thomas
    2. William B. Messer
    3. Donna E. Hansel
    4. Daniel N. Streblow
    5. Steven C. Kazmierczak
    6. Zoe L. Lyski
    7. Zhengchun Lu
    8. Mark K. Slifka
  • Identification of SARS-CoV-2 RNA in healthcare heating, ventilation, and air conditioning units

    Indoor Air
    1. Patrick F. Horve
    2. Leslie G. Dietz
    3. Mark Fretz
    4. David A. Constant
    5. Andrew Wilkes
    6. John M. Townes
    7. Robert G. Martindale
    8. William B. Messer
    9. Kevin G. Van Den Wymelenberg