Bill D. Rooney, Ph.D.

  • Associate Professor of Behavioral Neuroscience, School of Medicine
  • Director, Professor, Advanced Imaging Research Center
  • Behavioral Neuroscience Graduate Program, School of Medicine

Biography

Bill Rooney, Ph.D., is the director of the Advanced Imaging Research Center, a professor in behavioral neurosciences at the OHSU School of Medicine, and a scientist-inventor focused on the development and application of quantitative magnetic resonance techniques to characterize tissue structure and function.    In the lab, he’s working to phenotype brain blood vessels using dynamic MRI acquisitions combined with pharmacokinetic modeling—and to apply these techniques to learn how brain blood vessels change in disease processes such as multiple sclerosis, Alzheimer's disease, and brain tumors. Dr. Rooney also investigates cellular metabolism and its relationship to tissue degeneration. Using 31P and 1H magnetic resonance spectroscopic techniques, he investigates the relationship between defects in energy metabolism and tissue loss.    Dr. Rooney joined OHSU in 2005 after working as a scientist and scholar at the University of California San Francisco and Brookhaven National Laboratory.

Education and training

  • Degrees

    • Ph.D., 1990, Department of Chemistry at the State University of New York at Stony Brook

  • Fellowship

    • NIH, NRSA fellowship in neuroimaging, Department of Radiology, University of California, San Francisco

Areas of interest

  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • MRI
  • Pharmacokinetics
  • Brain

Publications

Publications

  • MRI patterns of thigh muscle involvement in immune-mediated necrotizing myopathy and dermatomyositis

    BMC Rheumatology
    1. Anson W. Wilks
    2. Kiana M. Vakil-Gilani
    3. William D. Rooney
    4. Dongseok Choi
    5. Daniela Ghetie
    6. Nizar Chahin

  • A model-informed clinical trial simulation tool with a graphical user interface for Duchenne muscular dystrophy

    CPT: Pharmacometrics and Systems Pharmacology
    1. Jongjin Kim
    2. Juan Francisco Morales
    3. Sanghoon Kang
    4. Marian Klose
    5. Rebecca J. Willcocks
    6. Michael J. Daniels
    7. Ramona Belfiore-Oshan
    8. Glenn A. Walter
    9. William D. Rooney
    10. Krista Vandenborne
    11. Sarah Kim

  • Clinical importance of changes in magnetic resonance biomarkers for Duchenne muscular dystrophy

    Annals of Clinical and Translational Neurology
    1. Rebecca J. Willcocks
    2. Alison M. Barnard
    3. Michael J. Daniels
    4. Sean C. Forbes
    5. William T. Triplett
    6. John F. Brandsema
    7. Erika L. Finanger
    8. William D. Rooney
    9. Sarah Kim
    10. Dah Jyuu Wang
    11. Donovan J. Lott
    12. Claudia R. Senesac
    13. Glenn A. Walter
    14. H. Lee Sweeney
    15. Krista Vandenborne

  • Comparison of dynamic susceptibility contrast (DSC) using gadolinium and iron-based contrast agents in high-grade glioma at high-field MRI

    Neuroradiology Journal
    1. Doonyaporn Wongsawaeng
    2. Daniel Schwartz
    3. Xin Li
    4. Leslie L. Muldoon
    5. Jared Stoller
    6. Cooper Stateler
    7. Samantha Holland
    8. Laszlo Szidonya
    9. William D. Rooney
    10. Cory Wyatt
    11. Prakash Ambady
    12. Rongwei Fu
    13. Edward A. Neuwelt
    14. Ramon F. Barajas

  • Five multivariate Duchenne muscular dystrophy progression models bridging six-minute walk distance and MRI relaxometry of leg muscles

    Journal of Pharmacokinetics and Pharmacodynamics
    1. Deok Yong Yoon
    2. Michael J. Daniels
    3. Rebecca J. Willcocks
    4. William T. Triplett
    5. Juan Francisco Morales
    6. Glenn A. Walter
    7. William D. Rooney
    8. Krista Vandenborne
    9. Sarah Kim

  • Impact of stalling events on microcirculatory hemodynamics in the aged brain

    Microcirculation
    1. Mohammad Jamshidi
    2. Thomas Ventimiglia
    3. Patrice Sudres
    4. Cong Zhang
    5. Frédéric Lesage
    6. William Rooney
    7. Daniel Schwartz
    8. Andreas A. Linninger

  • Prototype Description and Ex Vivo Evaluation of a System for Combined Endorectal Magnetic Resonance Imaging and In-Bore Biopsy of the Prostate

    Journal of Computer Assisted Tomography
    1. Fergus V. Coakley
    2. Bryan R. Foster
    3. David W. Schroeder
    4. William D. Rooney
    5. Randall W. Jones
    6. Christopher L. Amling

  • Vascular synthesis based on hemodynamic efficiency principle recapitulates measured cerebral circulation properties in the human brain

    Journal of Cerebral Blood Flow and Metabolism
    1. Andreas A. Linninger
    2. Thomas Ventimiglia
    3. Mohammad Jamshidi
    4. Mathieu Pascal Suisse
    5. Ali Alaraj
    6. Frédéric Lesage
    7. Xin Li
    8. Daniel L. Schwartz
    9. William D. Rooney

  • ω-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults

    JAMA Network Open
    1. Lynne H. Shinto
    2. Charles F. Murchison
    3. Lisa C. Silbert
    4. Hiroko H. Dodge
    5. David Lahna
    6. William Rooney
    7. Jeffrey Kaye
    8. Joseph F. Quinn
    9. Gene Bowman

  • Brain volumetrics across the lifespan of the rhesus macaque

    Neurobiology of Aging
    1. Steven Dash
    2. Byung Park
    3. Christopher D. Kroenke
    4. William D. Rooney
    5. Henryk F. Urbanski
    6. Steven G. Kohama

  • Metabolic activity diffusion imaging (MADI)

    NMR in biomedicine
    1. Charles S. Springer
    2. Eric M. Baker
    3. Xin Li
    4. Brendan Moloney
    5. Martin M. Pike
    6. Gregory J. Wilson
    7. Valerie C. Anderson
    8. Manoj K. Sammi
    9. Mark G. Garzotto
    10. Ryan P. Kopp
    11. Fergus V. Coakley
    12. William D. Rooney
    13. Jeffrey H. Maki

  • Metabolic activity diffusion imaging (MADI)

    NMR in biomedicine
    1. Charles S. Springer
    2. Eric M. Baker
    3. Xin Li
    4. Brendan Moloney
    5. Gregory J. Wilson
    6. Martin M. Pike
    7. Thomas M. Barbara
    8. William D. Rooney
    9. Jeffrey H. Maki

  • Multivariate modeling of magnetic resonance biomarkers and clinical outcome measures for Duchenne muscular dystrophy clinical trials

    CPT: Pharmacometrics and Systems Pharmacology
    1. Sarah Kim
    2. Rebecca J. Willcocks
    3. Michael J. Daniels
    4. Juan Francisco Morales
    5. Deok Yong Yoon
    6. William T. Triplett
    7. Alison M. Barnard
    8. Daniela J. Conrado
    9. Varun Aggarwal
    10. Ramona Belfiore-Oshan
    11. Terina N. Martinez
    12. Glenn A. Walter
    13. William D. Rooney
    14. Krista Vandenborne

  • Postmortem 7T MRI for guided histopathology and evaluation of cerebrovascular disease

    Journal of Neuropathology and Experimental Neurology
    1. David Lahna
    2. Natalie Roese
    3. Randy Woltjer
    4. Erin L. Boespflug
    5. Daniel Schwartz
    6. John Grinstead
    7. Hiroko H. Dodge
    8. Rachel Wall
    9. Jeffrey A. Kaye
    10. William D. Rooney
    11. Lisa C. Silbert

  • Processing speed and memory test performance are associated with different brain region volumes in Veterans and others with progressive multiple sclerosis

    Frontiers in Neurology
    1. Rebecca I. Spain
    2. Andrea Hildebrand
    3. Carin S. Waslo
    4. William D. Rooney
    5. Joshua Emmons
    6. Daniel L. Schwartz
    7. Mark S. Freedman
    8. M. Mateo Paz Soldan
    9. Pavle Repovic
    10. Andrew J. Solomon
    11. John Rinker
    12. Mitchell Wallin
    13. Jodie K. Haselkorn
    14. Olaf Stuve
    15. Robert H. Gross
    16. Aaron P. Turner

  • Protocol for an exploratory, randomised, single-blind clinical trial of aerobic exercise to promote remyelination in multiple sclerosis

    BMJ open
    1. Lindsey Wooliscroft
    2. Sharon McCoy
    3. Andrea Hildebrand
    4. William Rooney
    5. Barry S. Oken
    6. Rebecca Irene Spain
    7. Kerry S. Kuehl
    8. Dennis Bourdette
    9. Michelle Cameron

  • Vascular disease risk factors in multiple sclerosis

    Multiple sclerosis and related disorders
    1. Manoj K. Sammi
    2. Allison Fryman
    3. Eric Baker
    4. Brendan Moloney
    5. Katherine Powers
    6. Randy West
    7. Frank Bittner
    8. Michael Lane
    9. Kayla Martin
    10. Yuliya Pepelyayeva
    11. Valerie C. Anderson
    12. William D. Rooney
    13. Vijayshree Yadav

  • Changes in Visceral and Ectopic Adipose Tissue Stores Across Pregnancy and Their Relationship to Gestational Weight Gain

    Journal of Nutrition
    1. Kimberly K. Vesco
    2. Nicole E. Marshall
    3. Eric Baetscher
    4. Michael C. Leo
    5. William Rooney
    6. Melanie Francisco
    7. Eric Baker
    8. Janet C. King
    9. Patrick Catalano
    10. Antonio E. Frias
    11. Jonathan Q. Purnell

  • Characterizing Expiratory Respiratory Muscle Degeneration in Duchenne Muscular Dystrophy Using MRI

    CHEST
    1. Alison M. Barnard
    2. Donovan J. Lott
    3. Abhinandan Batra
    4. William T. Triplett
    5. Rebecca J. Willcocks
    6. Sean C. Forbes
    7. William D. Rooney
    8. Michael J. Daniels
    9. Barbara K. Smith
    10. Krista Vandenborne
    11. Glenn A. Walter

  • DCE-MRI of Brain Fluid Barriers

    Tissue Barriers
    1. Valerie C. Anderson
    2. Ian J. Tagge
    3. Aaron Doud
    4. Xin Li
    5. Charles S. Springer
    6. Joseph F. Quinn
    7. Jeffrey A. Kaye
    8. Katherine V. Wild
    9. William D. Rooney

  • Development of Contractures in DMD in Relation to MRI-Determined Muscle Quality and Ambulatory Function

    Journal of Neuromuscular Diseases
    1. Rebecca J. Willcocks
    2. Alison M. Barnard
    3. Ryan J. Wortman
    4. Claudia R. Senesac
    5. Donovan J. Lott
    6. Ann T. Harrington
    7. Kirsten L. Zilke
    8. Sean C. Forbes
    9. William D. Rooney
    10. Dah Jyuu Wang
    11. Erika L. Finanger
    12. Gihan I. Tennekoon
    13. Michael J. Daniels
    14. William T. Triplett
    15. Glenn A. Walter
    16. Krista Vandenborne

  • Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI

    Neurology
    1. Alison M. Barnard
    2. David W. Hammers
    3. William T. Triplett
    4. Sarah Kim
    5. Sean C. Forbes
    6. Rebecca J. Willcocks
    7. Michael J. Daniels
    8. Claudia R. Senesac
    9. Donovan J. Lott
    10. Ishu Arpan
    11. William D. Rooney
    12. Richard T. Wang
    13. Stanley F. Nelson
    14. H. Lee Sweeney
    15. Krista Vandenborne
    16. Glenn A. Walter

  • Immediate impact of yogic breathing on pulsatile cerebrospinal fluid dynamics

    Scientific Reports
    1. Selda Yildiz
    2. John Grinstead
    3. Andrea Hildebrand
    4. John Oshinski
    5. William D. Rooney
    6. Miranda M. Lim
    7. Barry Oken

  • Step Activity Monitoring in Boys with Duchenne Muscular Dystrophy and its Correlation with Magnetic Resonance Measures and Functional Performance

    Journal of Neuromuscular Diseases
    1. Kavya S. Nair
    2. Donovan J. Lott
    3. Sean C. Forbes
    4. Alison M. Barnard
    5. Rebecca J. Willcocks
    6. Claudia R. Senesac
    7. Michael J. Daniels
    8. Ann T. Harrington
    9. Gihan I. Tennekoon
    10. Kirsten Zilke
    11. Erika L. Finanger
    12. Richard S. Finkel
    13. William D. Rooney
    14. Glenn A. Walter
    15. Krista Vandenborne

  • Deep grey matter injury in multiple sclerosis

    Brain
    1. Daniel Ontaneda
    2. Praneeta C. Raza
    3. Kedar R. Mahajan
    4. Douglas L. Arnold
    5. Michael G. Dwyer
    6. Susan A. Gauthier
    7. Douglas N. Greve
    8. Daniel M. Harrison
    9. Roland G. Henry
    10. David K.B. Li
    11. Caterina Mainero
    12. Wayne Moore
    13. Sridar Narayanan
    14. Jiwon Oh
    15. Raihaan Patel
    16. Daniel Pelletier
    17. Alexander Rauscher
    18. William D. Rooney
    19. Nancy L. Sicotte
    20. Roger Tam
    21. Daniel S. Reich
    22. Christina J. Azevedo

  • Disease-modifying effects of edasalonexent, an NF-κB inhibitor, in young boys with Duchenne muscular dystrophy

    Neuromuscular Disorders
    1. Richard S. Finkel
    2. Erika Finanger
    3. Krista Vandenborne
    4. H. Lee Sweeney
    5. Gihan Tennekoon
    6. Perry B. Shieh
    7. Rebecca Willcocks
    8. Glenn Walter
    9. William D. Rooney
    10. Sean C. Forbes
    11. William T. Triplett
    12. Sabrina W. Yum
    13. Maria Mancini
    14. James MacDougall
    15. Angelika Fretzen
    16. Pradeep Bista
    17. Andrew Nichols
    18. Joanne M. Donovan

  • Gray matter blood-brain barrier water exchange dynamics are reduced in progressive multiple sclerosis

    Journal of Neuroimaging
    1. Ian J. Tagge
    2. Valerie C. Anderson
    3. Charles S. Springer
    4. Manoj K. Sammi
    5. Dennis N. Bourdette
    6. Rebecca I. Spain
    7. William D. Rooney

  • MRI characteristics of Japanese macaque encephalomyelitis

    Journal of Neuroimaging
    1. Ian J. Tagge
    2. Steven G. Kohama
    3. Larry S. Sherman
    4. Dennis N. Bourdette
    5. Randall Woltjer
    6. Paul Wang
    7. Scott W. Wong
    8. William D. Rooney

  • Myelin-specific T cells in animals with Japanese macaque encephalomyelitis

    Annals of Clinical and Translational Neurology
    1. Aparna N. Govindan
    2. Kristin S. Fitzpatrick
    3. Minsha Manoharan
    4. Ian Tagge
    5. Steven G. Kohama
    6. Betsy Ferguson
    7. Samuel M. Peterson
    8. Grayson S. Wong
    9. William D. Rooney
    10. Byung Park
    11. Michael K. Axthelm
    12. Dennis N. Bourdette
    13. Larry S. Sherman
    14. Scott W. Wong