Bruce Jeffrey Schnapp, Ph.D.

  • Professor of Cell, Developmental and Cancer Biology, School of Medicine
  • Cell and Developmental Biology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Bruce Schnapp is a Professor in the Department of Cell, Developmental and Cancer Biology. He earned his B.S. (Biology) in 1972 and his Ph.D. (Neuroscience) in 1976 at the University of Connecticut. After postdoctoral work in the Department of Neurobiology at Harvard Medical School, Dr. Schnapp joined the intramural program at NIH in 1983, and maintained his lab off campus at the Marine Biological Laboratory in Woods Hole, MA until 1989. Dr. Schnapp was Associate Professor in the Department of Physiology at Boston University Medical School (1989-1990) before moving his lab to Department of Cell Biology at Harvard Medical School (1991-2001), and then to OHSU in 2001.

Areas of interest

  • cell biology; transport; kinesin; dynein; myosin; zebrafish; melanocytes

Publications

Publications

  • Zebrafish Melanophilin Facilitates Melanosome Dispersion by Regulating Dynein

    Current Biology
    1. Lavinia Sheets
    2. David G. Ransom
    3. Eve M. Mellgren
    4. Stephen L. Johnson
    5. Bruce J. Schnapp
  • A change in the selective translocation of the kinesin-1 motor domain marks the initial specification of the axon

    Neuron
    1. Catherine Jacobson
    2. Bruce Schnapp
    3. Gary A. Banker
  • A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP

    Journal of Cell Biology
    1. Trent P. Munro
    2. Sunjong Kwon
    3. Bruce J. Schnapp
    4. Daniel St Johnston
  • UUCAC- and Vera-dependent localization of VegT RNA in Xenopus oocytes

    Current Biology
    1. Sunjong Kwon
    2. Tatiana Abramson
    3. Trent P. Munro
    4. Corinne M. John
    5. Martin Köhrmann
    6. Bruce J. Schnapp
  • Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

    Journal of Cell Biology
    1. Kristen J. Verhey
    2. Debra Meyer
    3. Reneé Deehan
    4. John Blenis
    5. Bruce J. Schnapp
    6. Tom A. Rapoport
    7. Ben Margolis
  • Dynactin-dependent, dynein-driven vesicle transport in the absence of membrane proteins

    Molecular Cell
    1. Virgil Muresan
    2. Michael C. Stankewich
    3. Walter Steffen
    4. Jon S. Morrow
    5. Erika L.F. Holzbaur
    6. Bruce J. Schnapp
  • The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors

    Journal of Neuroscience
    1. Virgil Muresan
    2. Asya Lyass
    3. Bruce J. Schnapp
  • A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates

    Current Biology
    1. James O. Deshler
    2. Martin I. Highett
    3. Tatiana Abramson
    4. Bruce J. Schnapp
  • KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles

    Molecular biology of the cell
    1. Virgil Muresan
    2. Tatiana Abramson
    3. Asya Lyass
    4. Dirk Winter
    5. Elena Porro
    6. Filbert Hong
    7. Nancy L. Chamberlin
    8. Bruce J. Schnapp
  • Light chain-dependent regulation of kinesin's interaction with microtubules

    Journal of Cell Biology
    1. Kristen J. Verhey
    2. Donna L. Lizotte
    3. Tatiana Abramson
    4. Linda Barenboim
    5. Bruce J. Schnapp
    6. Tom A. Rapoport
  • Improved nm displacement detector for microscopic beads at frequencies below 10 Hz

    Review of Scientific Instruments
    1. Daqun Li
    2. Bruce J. Schnapp
  • Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum

    Science
    1. James O. Deshler
    2. Martin I. Highett
    3. Bruce J. Schnapp
  • Projecting two-axis nanometer scale displacement of microscopic beads onto a quadrant photodetector with a laser beam

    Review of Scientific Instruments
    1. Daqun Li
    2. Bruce J. Schnapp
  • RNA localization in Xenopus oocytes

    Seminars in Cell and Developmental Biology
    1. Bruce J. Schnapp
    2. Eric A. Arn
    3. James O. Deshler
    4. Martin I. Highett
  • Optimized filter set and viewing conditions for the S65T mutant of GFP in living cells

    BioTechniques
    1. Mark J. Zylka
    2. Bruce J. Schnapp
  • Plus-end motors override minus-end motors during transport of squid axon vesicles on microtubules

    Journal of Cell Biology
    1. Virgil Muresan
    2. Chris P. Godek
    3. Thomas S. Reese
    4. Bruce J. Schnapp
  • Kinetics of spindle pole body separation in budding yeast

    Proceedings of the National Academy of Sciences of the United States of America
    1. Jason A. Kahana
    2. Bruce J. Schnapp
    3. Pamela A. Silver
  • Two heads are better than one

    Nature
    1. Bruce J. Schnapp
  • Direct observation of kinesin stepping by optical trapping interferometry

    Nature
    1. Karel Svoboda
    2. Christoph F. Schmidt
    3. Bruce J. Schnapp
    4. Steven M. Block
  • Single kinesin molecules crossbridge microtubules in vitro

    Proceedings of the National Academy of Sciences of the United States of America
    1. S. B. Andrews
    2. P. E. Gallant
    3. R. D. Leapman
    4. B. J. Schnapp
    5. T. S. Reese
  • Kinesin is bound with high affinity to squid axon organelles that move to the plus-end of microtubules

    Journal of Cell Biology
    1. Bruce J. Schnapp
    2. Thomas S. Reese
    3. Ruth Bechtold
  • Bead movement by single kinesin molecules studied with optical tweezers

    Nature
    1. Steven M. Block
    2. Lawrence S.B. Goldstein
    3. Bruce J. Schnapp
  • Delayed start-up of kinesin-driven microtubule gliding following inhibition by adenosine 5′-[β,γ-imido]triphosphate

    Proceedings of the National Academy of Sciences of the United States of America
    1. Bruch J. Schnapp
    2. Bruce Crise
    3. Michael P. Sheetz
    4. Thomas S. Reese
    5. Shahid Khan
  • The primary structure and analysis of the squid kinesin heavy chain

    Journal of Biological Chemistry
    1. Kenneth S. Kosik
    2. Lisa D. Orecchio
    3. Bruce Schnapp
    4. Hideyo Inouye
    5. Rachael L. Neve
  • Dynein is the motor for retrograde axonal transport of organelles

    Proceedings of the National Academy of Sciences of the United States of America
    1. B. J. Schnapp
    2. T. S. Reese