Bruce Jeffrey Schnapp, Ph.D.
- Professor of Cell, Developmental and Cancer Biology, School of Medicine
- Cell and Developmental Biology Graduate Program, School of Medicine
- Program in Molecular and Cellular Biosciences, School of Medicine
Biography
Bruce Schnapp is a Professor in the Department of Cell, Developmental and Cancer Biology. He earned his B.S. (Biology) in 1972 and his Ph.D. (Neuroscience) in 1976 at the University of Connecticut. After postdoctoral work in the Department of Neurobiology at Harvard Medical School, Dr. Schnapp joined the intramural program at NIH in 1983, and maintained his lab off campus at the Marine Biological Laboratory in Woods Hole, MA until 1989. Dr. Schnapp was Associate Professor in the Department of Physiology at Boston University Medical School (1989-1990) before moving his lab to Department of Cell Biology at Harvard Medical School (1991-2001), and then to OHSU in 2001.
Areas of interest
- cell biology; transport; kinesin; dynein; myosin; zebrafish; melanocytes
Publications
Publications
Zebrafish Melanophilin Facilitates Melanosome Dispersion by Regulating Dynein
Current BiologyA change in the selective translocation of the kinesin-1 motor domain marks the initial specification of the axon
NeuronA repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP
Journal of Cell BiologyUUCAC- and Vera-dependent localization of VegT RNA in Xenopus oocytes
Current BiologyCargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
Journal of Cell BiologyDynactin-dependent, dynein-driven vesicle transport in the absence of membrane proteins
Molecular CellThe kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors
Journal of NeuroscienceA highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates
Current BiologyKIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles
Molecular biology of the cellLight chain-dependent regulation of kinesin's interaction with microtubules
Journal of Cell BiologyImproved nm displacement detector for microscopic beads at frequencies below 10 Hz
Review of Scientific InstrumentsLocalization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum
ScienceProjecting two-axis nanometer scale displacement of microscopic beads onto a quadrant photodetector with a laser beam
Review of Scientific InstrumentsRNA localization in Xenopus oocytes
Seminars in Cell and Developmental BiologyOptimized filter set and viewing conditions for the S65T mutant of GFP in living cells
BioTechniquesPlus-end motors override minus-end motors during transport of squid axon vesicles on microtubules
Journal of Cell BiologyKinetics of spindle pole body separation in budding yeast
Proceedings of the National Academy of Sciences of the United States of AmericaTwo heads are better than one
NatureDirect observation of kinesin stepping by optical trapping interferometry
NatureSingle kinesin molecules crossbridge microtubules in vitro
Proceedings of the National Academy of Sciences of the United States of AmericaKinesin is bound with high affinity to squid axon organelles that move to the plus-end of microtubules
Journal of Cell BiologyBead movement by single kinesin molecules studied with optical tweezers
NatureDelayed start-up of kinesin-driven microtubule gliding following inhibition by adenosine 5′-[β,γ-imido]triphosphate
Proceedings of the National Academy of Sciences of the United States of AmericaThe primary structure and analysis of the squid kinesin heavy chain
Journal of Biological ChemistryDynein is the motor for retrograde axonal transport of organelles
Proceedings of the National Academy of Sciences of the United States of America