Carsten Schultz, Ph.D.
- Professor of Chemical Physiology and Biochemistry, School of Medicine
- Chair, Chemical Physiology and Biochemistry, School of Medicine
- Helen Jo Whitsell Dean's Leadership Professor
- Graduate Program in Biomedical Sciences, School of Medicine
Biography
My laboratory has been developing tools to help understanding the cell biology of signaling networks. Our techniques permit the visualization as well as the non-invasive manipulation of intact cells. We have a long-standing interest in cell-based assays to study the impact of mutations in cystic fibrosis. Our expertise in lipid and especially phosphoinositide synthesis and cell biology connected us to growth factor and cannabinoid receptor signaling and receptor internalization. The use of photo-activatable (“caged”) lipid derivatives led to several discoveries including the finding that sphingosine releases calcium from lysosomes. Since our move to OHSU, we increased our efforts for better understanding pancreatic islet biology and especially the extracellular factors that govern insulin and glucagon secretion.
Our newest toolset comprises of multifunctional lipid derivatives that are photo-crosslinkable, can perform click chemistry for labeling, and feature a “caged” group to control probe metabolism inside cells. These tools became especially useful during the COVID pandemic when it became important to study the lipid interactomes in healthy and virus-infected cells. This topic is part of an extensive collaboration with the Pacific Northwest National Laboratory (PNNL) and Dr. Fikadu Tafesse, a virologist from the OHSU Department of Microbiology and Molecular Immunology. In addition, using our lipid tools, we identified essential proteins that regulate lipid transport in cells. We are currently learning to perform cryo-electron microscopy for performing structural analysis of lipid binding proteins.
Education and training
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Degrees
- Ph.D., 1989, Chemistry, Bremen University, Germany
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Fellowship
- 1990-93 Postdoctoral, Pharmacology, University of California San Diego
Areas of interest
- Chemical Biology of Signaling Networks
- Islets of Langerhans biology
- Cystic fibrosis
- Growth factor receptors and GPCRs
- Multifunctional lipid tools
- Lipids in health and disease
- Light-sensitive tools
- Unnatural amino acids for click chemistry
- Fluorescent reporters and sensors
Additional information
Publications
Selected publications
- Mueller, R., Kojic, A., Citir, M., Schultz, C. Synthesis and cellular labeling of multifunctional phosphatidylinositol bis- and trisphosphate derivatives. Angew. Chem. Int. Engl., (2021). Accepted
- Farley, S., Laguerre, A., Schultz, C. Caged lipids for subcellular manipulation. Curr. Op. Chem. Biol. (2021), Accepted
Publications
A Genetically Encoded Sensor for Real-Time Monitoring of Poly-ADP-Ribosylation Dynamics In Vitro and in Cells
ACS SensorsTrifunctional fatty acid derivatives
Chemical CommunicationsTrifunctional lipid derivatives
Chemical CommunicationsTrifunctional Sphinganine
ACS chemical biologyWhere chemical biology meets physiology
Nature Chemical BiologyChemical Tools for Lipid Cell Biology
Accounts of Chemical ResearchStructurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
Cell Chemical BiologySynaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis
NeuronA global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants
Nature communicationsATP is an essential autocrine factor for pancreatic β-cell signaling and insulin secretion
Physiological reportsChanges in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis
Frontiers in MicrobiologyEndosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission
EMBO JournalER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response
Journal of lipid researchGenetic Deletion of Mmp9 Does Not Reduce Airway Inflammation and Structural Lung Damage in Mice with Cystic Fibrosis-like Lung Disease
International journal of molecular sciencesMacrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease
Journal of Cystic FibrosisMembrane-Permeant, Bioactivatable Coumarin Derivatives for In-Cell Labelling
ChemBioChemRecruitment of a splicing factor to the nuclear lamina for its inactivation
Communications BiologyamTCO, a newtrans-cyclooctene derivative to study drug-target interactions in cells
Chemical CommunicationsBioaccumulation of therapeutic drugs by human gut bacteria
NatureIL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease
European Respiratory JournalMaturation of the matrix and viral membrane of HIV-1
ScienceMonitoring neutrophil elastase and cathepsin g activity in human sputum samples
Journal of Visualized ExperimentsMonitoring the cellular metabolism of a membrane-permeant photo-caged phosphatidylinositol 3,4,5-trisphosphate derivative
Chemistry and Physics of LipidsRegulation of Calcium Oscillations in β-Cells by Co-activated Cannabinoid Receptors
Cell Chemical BiologyRelationship between airway dysbiosis, inflammation and lung function in adults with cystic fibrosis
Journal of Cystic Fibrosis