Carsten Schultz, Ph.D.

  • Professor of Chemical Physiology and Biochemistry, School of Medicine
  • Chair, Chemical Physiology and Biochemistry, School of Medicine
  • Helen Jo Whitsell Dean's Leadership Professor
  • Graduate Program in Biomedical Sciences, School of Medicine

Biography

My laboratory has been developing tools to help understanding the cell biology of signaling networks. Our techniques permit the visualization as well as the non-invasive manipulation of intact cells. We have a long-standing interest in cell-based assays to study the impact of mutations in cystic fibrosis. Our expertise in lipid and especially phosphoinositide synthesis and cell biology connected us to growth factor and cannabinoid receptor signaling and receptor internalization. The use of photo-activatable (“caged”) lipid derivatives led to several discoveries including the finding that sphingosine releases calcium from lysosomes. Since our move to OHSU, we increased our efforts for better understanding pancreatic islet biology and especially the extracellular factors that govern insulin and glucagon secretion. 

Our newest toolset comprises of multifunctional lipid derivatives that are photo-crosslinkable, can perform click chemistry for labeling, and feature a “caged” group to control probe metabolism inside cells. These tools became especially useful during the COVID pandemic when it became important to study the lipid interactomes in healthy and virus-infected cells. This topic is part of an extensive collaboration with the Pacific Northwest National Laboratory (PNNL) and Dr. Fikadu Tafesse, a virologist from the OHSU Department of Microbiology and Molecular Immunology.   In addition, using our lipid tools, we identified essential proteins that regulate lipid transport in cells. We are currently learning to perform cryo-electron microscopy for performing structural analysis of lipid binding proteins.        

Education and training

  • Degrees

    • Ph.D., 1989, Chemistry, Bremen University, Germany
  • Fellowship

    • 1990-93 Postdoctoral, Pharmacology, University of California San Diego

Areas of interest

  • Chemical Biology of Signaling Networks
  • Islets of Langerhans biology
  • Cystic fibrosis
  • Growth factor receptors and GPCRs
  • Multifunctional lipid tools
  • Lipids in health and disease
  • Light-sensitive tools
  • Unnatural amino acids for click chemistry
  • Fluorescent reporters and sensors

Publications

Selected publications

  • Mueller, R., Kojic, A., Citir, M., Schultz, C. Synthesis and cellular labeling of multifunctional phosphatidylinositol bis- and trisphosphate derivatives. Angew. Chem. Int. Engl., (2021). Accepted
  • Farley, S., Laguerre, A., Schultz, C. Caged lipids for subcellular manipulation. Curr. Op. Chem. Biol. (2021), Accepted

Publications

  • A Genetically Encoded Sensor for Real-Time Monitoring of Poly-ADP-Ribosylation Dynamics In Vitro and in Cells

    ACS Sensors
    1. Alix Thomas
    2. Kapil Upadhyaya
    3. Daniel Bejan
    4. Hayden Adoff
    5. Michael Cohen
    6. Carsten Schultz
  • Trifunctional fatty acid derivatives

    Chemical Communications
    1. Scotland E. Farley
    2. Ryu Hashimoto
    3. Judah Evangelista
    4. Frank Stein
    5. Per Haberkant
    6. Kazuya Kikuchi
    7. Fikadu G. Tafesse
    8. Carsten Schultz
  • Trifunctional lipid derivatives

    Chemical Communications
    1. Alix Thomas
    2. Rainer Müller
    3. Scotland Farley
    4. Ana Kojic
    5. Frank Stein
    6. Per Haberkant
    7. Carsten Schultz
  • Trifunctional Sphinganine

    ACS chemical biology
    1. Scotland Farley
    2. Frank Stein
    3. Per Haberkant
    4. Fikadu G. Tafesse
    5. Carsten Schultz
  • Where chemical biology meets physiology

    Nature Chemical Biology
    1. Kimberly E. Beatty
    2. Carsten Schultz
  • Chemical Tools for Lipid Cell Biology

    Accounts of Chemical Research
    1. Carsten Schultz
  • Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling

    Cell Chemical Biology
    1. Daniel J. Sanderson
    2. Kelsie M. Rodriguez
    3. Daniel S. Bejan
    4. Ninni E. Olafsen
    5. Inga D. Bohn
    6. Ana Kojic
    7. Sunil Sundalam
    8. Ivan R. Siordia
    9. Anna K. Duell
    10. Nancy Deng
    11. Carsten Schultz
    12. Denis M. Grant
    13. Jason Matthews
    14. Michael S. Cohen
  • Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis

    Neuron
    1. Svenja Bolz
    2. Natalie Kaempf
    3. Dmytro Puchkov
    4. Michael Krauss
    5. Giulia Russo
    6. Tolga Soykan
    7. Christopher Schmied
    8. Martin Lehmann
    9. Rainer Müller
    10. Carsten Schultz
    11. David Perrais
    12. Tanja Maritzen
    13. Volker Haucke
  • A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants

    Nature communications
    1. Scotland E. Farley
    2. Jennifer E. Kyle
    3. Hans C. Leier
    4. Lisa M. Bramer
    5. Jules B. Weinstein
    6. Timothy A. Bates
    7. Joon Yong Lee
    8. Thomas O. Metz
    9. Carsten Schultz
    10. Fikadu G. Tafesse
  • ATP is an essential autocrine factor for pancreatic β-cell signaling and insulin secretion

    Physiological reports
    1. Sebastian Hauke
    2. Jona Rada
    3. Gergely Tihanyi
    4. Danny Schilling
    5. Carsten Schultz
  • Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis

    Frontiers in Microbiology
    1. Dario L. Frey
    2. Calum Bridson
    3. Susanne Dittrich
    4. Simon Y. Graeber
    5. Mirjam Stahl
    6. Sabine Wege
    7. Felix Herth
    8. Olaf Sommerburg
    9. Carsten Schultz
    10. Alexander Dalpke
    11. Marcus A. Mall
    12. Sébastien Boutin
  • Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

    EMBO Journal
    1. Guan Ting Liu
    2. Gaga Kochlamazashvili
    3. Dmytro Puchkov
    4. Rainer Müller
    5. Carsten Schultz
    6. Albert I. Mackintosh
    7. Dennis Vollweiter
    8. Volker Haucke
    9. Tolga Soykan
  • ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response

    Journal of lipid research
    1. Asli D. Yildirim
    2. Mevlut Citir
    3. Asli E. Dogan
    4. Zehra Veli
    5. Zehra Yildirim
    6. Ozlem Tufanli
    7. Alexis Traynor-Kaplan
    8. Carsten Schultz
    9. Ebru Erbay
  • Genetic Deletion of Mmp9 Does Not Reduce Airway Inflammation and Structural Lung Damage in Mice with Cystic Fibrosis-like Lung Disease

    International journal of molecular sciences
    1. Claudius Wagner
    2. Anita Balázs
    3. Jolanthe Schatterny
    4. Zhe Zhou-Suckow
    5. Julia Duerr
    6. Carsten Schultz
    7. Marcus A. Mall
  • Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease

    Journal of Cystic Fibrosis
    1. Camilla Margaroli
    2. Hamed Horati
    3. Luke W. Garratt
    4. Vincent D. Giacalone
    5. Craig Schofield
    6. A. Susanne Dittrich
    7. Tim Rosenow
    8. Brian S. Dobosh
    9. Hong S. Lim
    10. Dario L. Frey
    11. Mieke Veltman
    12. George L. Silva
    13. Milton R. Brown
    14. Carsten Schultz
    15. Harm A.W.M. Tiddens
    16. Sarath Ranganathan
    17. Joshua D. Chandler
    18. Peng Qiu
    19. Limin Peng
    20. Bob J. Scholte
    21. Marcus A. Mall
    22. Anthony Kicic
    23. Lokesh Guglani
    24. Stephen M. Stick
    25. Hettie M. Janssens
    26. Rabindra Tirouvanziam
  • Membrane-Permeant, Bioactivatable Coumarin Derivatives for In-Cell Labelling

    ChemBioChem
    1. Madeleine Schultz
    2. Rainer Müller
    3. Yulia Ermakova
    4. Jan Erik Hoffmann
    5. Carsten Schultz
  • Recruitment of a splicing factor to the nuclear lamina for its inactivation

    Communications Biology
    1. Karen Vester
    2. Marco Preußner
    3. Nicole Holton
    4. Suihan Feng
    5. Carsten Schultz
    6. Florian Heyd
    7. Markus C. Wahl
  • amTCO, a newtrans-cyclooctene derivative to study drug-target interactions in cells

    Chemical Communications
    1. Cécile Echalier
    2. Anna Rutkowska
    3. Ana Kojic
    4. Douglas W. Thomson
    5. Lee J. Edwards
    6. Blandine S.J. McKay
    7. Marcel Mülbaier
    8. Carsten Schultz
    9. Giovanna Bergamini
  • Bioaccumulation of therapeutic drugs by human gut bacteria

    Nature
    1. Martina Klünemann
    2. Sergej Andrejev
    3. Sonja Blasche
    4. Andre Mateus
    5. Prasad Phapale
    6. Saravanan Devendran
    7. Johanna Vappiani
    8. Bernd Simon
    9. Timothy A. Scott
    10. Eleni Kafkia
    11. Dimitrios Konstantinidis
    12. Katharina Zirngibl
    13. Eleonora Mastrorilli
    14. Manuel Banzhaf
    15. Marie Therese Mackmull
    16. Felix Hövelmann
    17. Leo Nesme
    18. Ana Rita Brochado
    19. Lisa Maier
    20. Thomas Bock
    21. Vinita Periwal
    22. Manjeet Kumar
    23. Yongkyu Kim
    24. Melanie Tramontano
    25. Carsten Schultz
    26. Martin Beck
    27. Janosch Hennig
    28. Michael Zimmermann
    29. Daniel C. Sévin
    30. Filipe Cabreiro
    31. Mikhail M. Savitski
    32. Peer Bork
    33. Athanasios Typas
    34. Kiran R. Patil
  • IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease

    European Respiratory Journal
    1. Matthias Hagner
    2. Melanie Albrecht
    3. Matteo Guerra
    4. Peter Braubach
    5. Olga Halle
    6. Zhe Zhou-Suckow
    7. Simone Butz
    8. Danny Jonigk
    9. Gesine Hansen
    10. Carsten Schultz
    11. Anna Maria Dittrich
    12. Marcus A. Mall
  • Maturation of the matrix and viral membrane of HIV-1

    Science
    1. Kun Qu
    2. Zunlong Ke
    3. Vojtech Zila
    4. Maria Anders-Össwein
    5. Bärbel Glass
    6. Frauke Mücksch
    7. Rainer Müller
    8. Carsten Schultz
    9. Barbara Müller
    10. Hans Georg Kräusslich
    11. John A.G. Briggs
  • Monitoring neutrophil elastase and cathepsin g activity in human sputum samples

    Journal of Visualized Experiments
    1. Dario L. Frey
    2. Matteo Guerra
    3. Marcus A. Mall
    4. Carsten Schultz
  • Monitoring the cellular metabolism of a membrane-permeant photo-caged phosphatidylinositol 3,4,5-trisphosphate derivative

    Chemistry and Physics of Lipids
    1. Mevlut Citir
    2. Rainer Müller
    3. Sebastian Hauke
    4. Alexis Traynor-Kaplan
    5. Carsten Schultz
  • Regulation of Calcium Oscillations in β-Cells by Co-activated Cannabinoid Receptors

    Cell Chemical Biology
    1. Aurélien Laguerre
    2. Kaya Keutler
    3. Sebastian Hauke
    4. Carsten Schultz
  • Relationship between airway dysbiosis, inflammation and lung function in adults with cystic fibrosis

    Journal of Cystic Fibrosis
    1. Dario L. Frey
    2. Sébastien Boutin
    3. Susanne A. Dittrich
    4. Simon Y. Graeber
    5. Mirjam Stahl
    6. Sabine Wege
    7. Felix J.F. Herth
    8. Olaf Sommerburg
    9. Carsten Schultz
    10. Marcus A. Mall
    11. Alexander H. Dalpke