Charles S. Springer, Jr., Ph.D.

  • Professor, Advanced Imaging Research Center
  • Physiology and Pharmacology Graduate Program, School of Medicine
  • Biomedical Engineering Graduate Program, School of Medicine

Biography

Over the years, Charles Springer, Ph.D., and co-workers have: introduced frequency shift reagents for the tissue 23Na magnetic resonance (MR), systematized tissue 23Na quadrupolar effects, systematized in vivoMR effects of bulk magnetic susceptibility (the bases of: fMRI, myocellular -1H2C- frequency splitting, most tissue 1H2O phase shifts, etc.), introduced relaxographic imaging (natural, unsupervised segmentation), and introduced the MR shutter-speed concept. The latter is a correction and generalization of the colloquially used "NMR time-scale" term. The shutter-speed has proven to be important in improving the mathematical modeling of MRI pharmacokinetics – especially of (Dynamic-Contrast-Enhanced) DCE-MRI data. An early success of shutter-speed DCE-MRI pharmacokinetic modeling has been the realization of breast cancer screening with essentially perfect specificity. This solves the very serious high false positive rate problem of mammographic screening. Also, shutter-speed corrections are usually necessary in order for DCE-MRI data to be used for accurate molecular imaging of water. 

Dr. Springer received his B.S. and Ph.D. in chemistry from St. Louis University and the Ohio State University, respectively. He was a postdoctoral associate in the Aerospace Research Laboratory at the Wright‑Patterson Air Force Base in Ohio. He was a member of the Stony Brook Chemistry faculty for 35 years, and the Brookhaven National Laboratory Chemistry faculty for the last ten of those. 

Dr. Springer served as director of the Advanced Imaging Research Center for six years, and is a member of the OHSU Physiology and Pharmacology and Biomedical Engineering faculties. Springer has held visiting faculty appointments at CalTech and Harvard Medical School. He has received the U.S. Air Force Research and Development Award, the Brookhaven National Laboratory Science and Technology Award, is a Fellow of the International Society for Magnetic Resonance in Medicine (ISMRM), and chaired the In VivoMagnetic Resonance Gordon Research Conference. Dr. Springer has served on the ISMRM Board of Trustees and serves on the Editorial Boards of NMR in Biomedicine and Contrast Media and Molecular Imaging.

Education and training

  • Degrees

    • Ph.D., 1972, The Ohio State University

  • Fellowship

    • Postdoctoral associate at the Aerospace Research Laboratory, Wright-Patterson Air Force Base, Ohio

Areas of interest

  • Magnetic resonance spectroscopy
  • MR shutter-speed
  • DCE-MRI
  • Neuroscience
  • Pharmacokinetics
  • In vivo magnetic resonance

Publications

Publications

  • Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient

    Journal of Membrane Biology
    1. Charles S. Springer
    2. Martin Pike
    3. Thomas M. Barbara

  • Metabolic activity diffusion imaging (MADI)

    NMR in biomedicine
    1. Charles S. Springer
    2. Eric M. Baker
    3. Xin Li
    4. Brendan Moloney
    5. Martin M. Pike
    6. Gregory J. Wilson
    7. Valerie C. Anderson
    8. Manoj K. Sammi
    9. Mark G. Garzotto
    10. Ryan P. Kopp
    11. Fergus V. Coakley
    12. William D. Rooney
    13. Jeffrey H. Maki

  • Metabolic activity diffusion imaging (MADI)

    NMR in biomedicine
    1. Charles S. Springer
    2. Eric M. Baker
    3. Xin Li
    4. Brendan Moloney
    5. Gregory J. Wilson
    6. Martin M. Pike
    7. Thomas M. Barbara
    8. William D. Rooney
    9. Jeffrey H. Maki

  • DCE-MRI of Brain Fluid Barriers

    Tissue Barriers
    1. Valerie C. Anderson
    2. Ian J. Tagge
    3. Aaron Doud
    4. Xin Li
    5. Charles S. Springer
    6. Joseph F. Quinn
    7. Jeffrey A. Kaye
    8. Katherine V. Wild
    9. William D. Rooney

  • Gray matter blood-brain barrier water exchange dynamics are reduced in progressive multiple sclerosis

    Journal of Neuroimaging
    1. Ian J. Tagge
    2. Valerie C. Anderson
    3. Charles S. Springer
    4. Manoj K. Sammi
    5. Dennis N. Bourdette
    6. Rebecca I. Spain
    7. William D. Rooney

  • Observation of Reduced Homeostatic Metabolic Activity and/or Coupling in White Matter Aging

    Journal of Neuroimaging
    1. Valerie C. Anderson
    2. Ian J. Tagge
    3. Xin Li
    4. Joseph F. Quinn
    5. Jeffrey A. Kaye
    6. Dennis N. Bourdette
    7. Rebecca I. Spain
    8. Louis P. Riccelli
    9. Manoj K. Sammi
    10. Charles S. Springer
    11. William D. Rooney

  • Shutter-Speed DCE-MRI Analyses of Human Glioblastoma Multiforme (GBM) Data

    Journal of Magnetic Resonance Imaging
    1. Ruiliang Bai
    2. Bao Wang
    3. Yinhang Jia
    4. Zejun Wang
    5. Charles S. Springer
    6. Zhaoqing Li
    7. Chuanjin Lan
    8. Yi Zhang
    9. Peng Zhao
    10. Yingchao Liu

  • Brain active transmembrane water cycling measured by MR is associated with neuronal activity

    Magnetic Resonance in Medicine
    1. Ruiliang Bai
    2. Charles S. Springer
    3. Dietmar Plenz
    4. Peter J. Basser

  • NMR shutter-speed elucidates apparent population inversion of 1H2O signals due to active transmembrane water cycling

    Magnetic Resonance in Medicine
    1. Xin Li
    2. Silvia Mangia
    3. Jing Huei Lee
    4. Ruiliang Bai
    5. Charles S. Springer

  • Fast, Na+/K+ pump driven, steady-state transcytolemmal water exchange in neuronal tissue

    Magnetic Resonance in Medicine
    1. Ruiliang Bai
    2. Charles S. Springer
    3. Dietmar Plenz
    4. Peter J. Basser

  • Using 1H2O MR to measure and map sodium pump activity in vivo

    Journal of Magnetic Resonance
    1. Charles S. Springer

  • Human whole blood 1H2O transverse relaxation with gadolinium-based contrast reagents

    Magnetic Resonance in Medicine
    1. Gregory J. Wilson
    2. Charles S. Springer
    3. Sarah Bastawrous
    4. Jeffrey H. Maki

  • Early prediction and evaluation of breast cancer response to neoadjuvant chemotherapy using quantitative DCE-MRI

    Translational Oncology
    1. Alina Tudorica
    2. Karen Y. Oh
    3. Stephen Y.C. Chui
    4. Nicole Roy
    5. Megan L. Troxell
    6. Arpana Naik
    7. Kathleen A. Kemmer
    8. Yiyi Chen
    9. Megan L. Holtorf
    10. Aneela Afzal
    11. Charles S. Springer
    12. Xin Li
    13. Wei Huang

  • Relative sensitivities of DCE-MRI pharmacokinetic parameters to arterial input function (AIF) scaling

    Journal of Magnetic Resonance
    1. Xin Li
    2. Yu Cai
    3. Brendan Moloney
    4. Yiyi Chen
    5. Wei Huang
    6. Mark Woods
    7. Fergus V. Coakley
    8. William D. Rooney
    9. Mark G. Garzotto
    10. Charles S. Springer

  • Mapping human brain capillary water lifetime

    NMR in biomedicine
    1. William D. Rooney
    2. Xin Li
    3. Manoj K. Sammi
    4. Dennis N. Bourdette
    5. Edward A. Neuwelt
    6. Charles S. Springer

  • Synergistic antivascular and antitumor efficacy with combined cediranib and SC6889 in intracranial mouse glioma

    PloS one
    1. Merryl R. Lobo
    2. Ayaka Kukino
    3. Huong Tran
    4. Matthias C. Schabel
    5. Charles S. Springer
    6. G. Yancey Gillespie
    7. Marjorie R. Grafe
    8. Randall L. Woltjer
    9. Martin M. Pike

  • Human whole-blood 1H2O longitudinal relaxation with normal and high-relaxivity contrast reagents

    Magnetic Resonance in Medicine
    1. Gregory J. Wilson
    2. Mark Woods
    3. Charles S. Springer
    4. Sarah Bastawrous
    5. Puneet Bhargava
    6. Jeffrey H. Maki

  • Intratumor mapping of intracellular water lifetime

    NMR in biomedicine
    1. Charles S. Springer
    2. Xin Li
    3. Luminita A. Tudorica
    4. Karen Y. Oh
    5. Nicole Roy
    6. Stephen Y.C. Chui
    7. Arpana M. Naik
    8. Megan L. Holtorf
    9. Aneela Afzal
    10. William D. Rooney
    11. Wei Huang

  • Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields

    Magnetic Resonance in Medicine
    1. Christian Labadie
    2. Jing Huei Lee
    3. William D. Rooney
    4. Silvia Jarchow
    5. Monique Aubert-Frécon
    6. Charles S. Springer
    7. Harald E. Möller

  • Taui, A high-resolution metabolic imaging biomarker for myocardium

    Journal of Cardiovascular Magnetic Resonance
    1. Charles S. Springer
    2. Craig S. Broberg
    3. William D. Rooney

  • Feasibility of shutter-speed DCE-MRI for improved prostate cancer detection

    Magnetic Resonance in Medicine
    1. Xin Li
    2. Ryan A. Priest
    3. William J. Woodward
    4. Ian J. Tagge
    5. Faisal Siddiqui
    6. Wei Huang
    7. William D. Rooney
    8. Tomasz M. Beer
    9. Mark G. Garzotto
    10. Charles S. Springer

  • Cell membrane water exchange effects in prostate DCE-MRI

    Journal of Magnetic Resonance
    1. Xin Li
    2. Ryan A. Priest
    3. William J. Woodward
    4. Faisal Siddiqui
    5. Tomasz M. Beer
    6. Mark G. Garzotto
    7. William D. Rooney
    8. Charles S. Springer

  • Active trans-plasma membrane water cycling in yeast is revealed by NMR

    Biophysical Journal
    1. Yajie Zhang
    2. Marie Poirier-Quinot
    3. Charles S. Springer
    4. James A. Balschi

  • Discrimination of benign and malignant breast lesions by using shutter-speed dynamic contrast-enhanced MR imaging 1

    RADIOLOGY
    1. Wei Huang
    2. Luminita A. Tudorica
    3. Xin Li
    4. Sunitha B. Thakur
    5. Yiyi Chen
    6. Elizabeth A. Morris
    7. Ian J. Tagge
    8. Maayan E. Korenblit
    9. William D. Rooney
    10. Jason A. Koutcher
    11. Charles S. Springer

  • Discrimination of intra- and extracellular 23Na+ signals in yeast cell suspensions using longitudinal magnetic resonance relaxography

    Journal of Magnetic Resonance
    1. Yajie Zhang
    2. Marie Poirer-Quinot
    3. Charles S. Springer
    4. James A. Balschi

  • Dynamic-contrast-enhanced-MRI with extravasating contrast reagent

    Journal of Magnetic Resonance
    1. Xin Li
    2. William D. Rooney
    3. Csanád G. Várallyay
    4. Seymur Gahramanov
    5. Leslie L. Muldoon
    6. James A. Goodman
    7. Ian J. Tagge
    8. Audrey H. Selzer
    9. Martin M. Pike
    10. Edward A. Neuwelt
    11. Charles S. Springer

  • Springer Jr, Charles S.

    eMagRes
    1. Charles S. Springer