Charles T. Roberts, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Professor of Pediatrics, School of Medicine
  • Professor of Cell, Developmental and Cancer Biology, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Charles Roberts, Ph.D., is Senior Advisor and Professor in the Divisions of Metabolic Health & Disease and Reproductive and Developmental Sciences at the Oregon National Primate Research Center (ONPRC) and Professor of Pediatrics and Cell, Developmental, and Cancer Biology at Oregon Health & Science University (OHSU). He received his Ph.D. in biochemistry and molecular biology at the University of California, Santa Barbara (UCSB), in 1975. Following an American Cancer Society-supported postdoctoral fellowship, he was an Assistant Professor of Biological Sciences at UCSB from 1978-1984. He was then recruited to the Diabetes Branch at the National Institutes of Health in 1984 as a Special Expert, was appointed Associate Chief of the Section of Molecular Physiology in 1989 with tenure and was promoted to Senior Investigator in 1992. In 1994, Dr. Roberts was recruited to OHSU as Professor of Pediatrics and Associate Chair for Research. He was subsequently recruited to ONPRC in 2007. Dr. Roberts has been continuously funded by the NIH for >45 years, has served on >50 NIH, VA, and DOD grant review panels, and has co-founded four biotechnology companies and holds six issued patents in the clinical therapeutics and diagnostics space. Dr. Roberts’ current research is focused on metabolic comorbidities associated with antiretroviral therapy for HIV and long COVID using nonhuman primate models.

Education and training

  • Degrees

    • B.A., 1971, University of California, Santa Barbara
    • Ph.D., 1975, University of California, Santa Barbara

  • Fellowship

    • 1977 Postdoctoral fellowship, University of California, Santa Barbara, Gene Regulation

Memberships and associations:

  • UC Irvine Institute for Clinical and Translational Science (CTSA) External Advisory Committee, 2010-present
  • Endocrine Society Annual Meeting Steering Committee, 2011-2014
  • NIDDK Cellular Aspects of Diabetes and Obesity (CADO) IRG, 2011, 2012; standing member 2013-2017
  • Grant reviewer, Diabetes Fonds (Netherlands), 2014
  • External project reviewer, Science Foundation Ireland, 2014
  • National Association for Biomedical Research Board of Directors, 2016-2019
  • Preclinical Gut Health Consortium, Bill & Melinda Gates Foundation, 2016-2019
  • NIDDK Topics in Endocrinology, Metabolism, and Reproductive Biology SEP, 2020
  • NIDDK Cell Signaling and Molecular Endocrinology (CSME) IRG, 2021
  • FASEB Science Policy Committee Animals in Research and Education Subcommittee, 2021-present; vice-chair 2023-2024
  • ZRG1 IIDB-X M Topics on HIV Molecular Virology, Therapies and Comorbidities member conflict panel, 2023

Honors and awards

  • Cystic Fibrosis Foundation Fellowship Award, 10/74
  • American Cancer Society Postdoctoral Fellowship, 1975-1977

Publications

Selected publications

  • Impaired placental hemodynamics and function in a non-human primate model of gestational protein restriction. Scientific Reports January 2023 Jamie O. Lo, Matthias C. Schabel, Jessica Gaffney, Katherine S. Lewandowski, Christopher D. Kroenke, Charles T. Roberts Jr., Brian P. Scottoline, Antonio E. Frias, Elinor L. Sullivan, Victoria H. J. Roberts

Publications

  • Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue

    Obesity
    1. Jacob J. Robino
    2. Alexander P. Plekhanov
    3. Qingzhang Zhu
    4. Michael D. Jensen
    5. Philipp E. Scherer
    6. Charles T. Roberts
    7. Oleg Varlamov

  • Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates

    JCI Insight
    1. Gabriela Webb
    2. Kristin A. Sauter
    3. Diana Takahashi
    4. Melissa Kirigiti
    5. Lindsay Bader
    6. Sarah R. Lindsley
    7. Hannah Blomenkamp
    8. Cicely Zaro
    9. Molly Shallman
    10. Casey McGuire
    11. Heather Hofmeister
    12. Uriel Avila
    13. Cleiton Pessoa
    14. Joseph M. Hwang
    15. Allyson McCullen
    16. Matthew Humkey
    17. Jason Reed
    18. Lina Gao
    19. Lee Winchester
    20. Courtney V. Fletcher
    21. Oleg Varlamov
    22. Todd T. Brown
    23. Jonah B. Sacha
    24. Paul Kievit
    25. Charles T. Roberts

  • Gestational and early postnatal protein malnutrition disrupts neurodevelopment in rhesus macaques

    Cerebral Cortex
    1. Joshua A. Karpf
    2. Elinor Sullivan
    3. Victoria Roberts
    4. Colin Studholme
    5. Charles Roberts
    6. Christopher D. Kroenke

  • Western-style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy without proinflammatory responses in rhesus macaques

    American Journal of Reproductive Immunology
    1. Benjamin J. Burwitz
    2. Sofiya Yusova
    3. Jacob J. Robino
    4. Diana Takahashi
    5. Addie Luo
    6. Ov D. Slayden
    7. Cecily V. Bishop
    8. Jon D. Hennebold
    9. Charles T. Roberts
    10. Oleg Varlamov

  • Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques

    Stem Cell Reports
    1. Suhas Sureshchandra
    2. Chi N. Chan
    3. Jacob J. Robino
    4. Lindsay K. Parmelee
    5. Michael J. Nash
    6. Stephanie R. Wesolowski
    7. Eric M. Pietras
    8. Jacob E. Friedman
    9. Diana Takahashi
    10. Weining Shen
    11. Xiwen Jiang
    12. Jon D. Hennebold
    13. Devorah Goldman
    14. William Packwood
    15. Jonathan R. Lindner
    16. Charles T. Roberts
    17. Benjamin J. Burwitz
    18. Ilhem Messaoudi
    19. Oleg Varlamov

  • Rapid Point-of-Care Test for Determination of C-Peptide Levels

    Journal of Diabetes Science and Technology
    1. Paturi V. Rao
    2. Eric Bean
    3. Dhanalakshmi Nair-Schaef
    4. Siting Chen
    5. Steven C. Kazmierczak
    6. Charles T. Roberts
    7. Srinivasa R. Nagalla

  • Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine

    Nature communications
    1. Sara M. Hendrickson
    2. Archana Thomas
    3. Kamm Prongay
    4. Andrew J. Haertel
    5. Laura M. Garzel
    6. Leanne Gill
    7. Tasha Barr
    8. Nicholas S. Rhoades
    9. Rachel Reader
    10. Mark Galan
    11. Julie M. Carroll
    12. Charles T. Roberts
    13. Lina Gao
    14. Ian J. Amanna
    15. Ilhem Messaoudi
    16. Mark K. Slifka

  • Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques

    Human Reproduction
    1. Cecily V. Bishop
    2. Diana Takahashi
    3. Emily Mishler
    4. Ov D. Slayden
    5. Charles T. Roberts
    6. Jon Hennebold
    7. Cadence True

  • Effects of pre- And postnatal protein restriction on maternal and offspring metabolism in the nonhuman primate

    American Journal of Physiology - Regulatory Integrative and Comparative Physiology
    1. Melissa A. Kirigiti
    2. Tim Frazee
    3. Baylin Bennett
    4. Anam Arik
    5. Peter Blundell
    6. Lindsay Bader
    7. Jennifer Bagley
    8. Antonio E. Frias
    9. Elinor L. Sullivan
    10. Charles T. Roberts
    11. Paul Kievit

  • Glycosylated fibronectin point-of-care test for diagnosis of pre-eclampsia in a low-resource setting

    BJOG: An International Journal of Obstetrics and Gynaecology
    1. S. R. Nagalla
    2. V. Janaki
    3. A. R. Vijayalakshmi
    4. K. Chayadevi
    5. D. Pratibha
    6. P. V. Rao
    7. K. M. Sage
    8. D. Nair-Schaef
    9. E. Bean
    10. C. T. Roberts
    11. M. G. Gravett

  • Maternal serum glycosylated fibronectin as a short-Term predictor of preeclampsia

    BMC Pregnancy and Childbirth
    1. Evelyn A. Huhn
    2. Ina Hoffmann
    3. Begoña Martinez De Tejada
    4. Soeren Lange
    5. Kylie M. Sage
    6. Charles T. Roberts
    7. Michael G. Gravett
    8. Srinivasa R. Nagalla
    9. Olav Lapaire

  • Estradiol replacement timing and obesogenic diet effects on body composition and metabolism in postmenopausal macaques

    Endocrinology
    1. Jonathan Q. Purnell
    2. Henryk F. Urbanski
    3. Paul Kievit
    4. Charles T. Roberts
    5. Cynthia L. Bethea

  • Genetic Architecture of Human Obesity Traits in the Rhesus Macaque

    Obesity
    1. Michael J. Raboin
    2. John Letaw
    3. Asia D. Mitchell
    4. David Toffey
    5. Jessica McKelvey
    6. Charles T. Roberts
    7. Joanne E. Curran
    8. Amanda Vinson

  • Meeting Report

    Pediatric endocrinology reviews : PER
    1. Charles T. Roberts
    2. Kevin Cj Yuen

  • Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons

    Molecular Metabolism
    1. Brandon L. Roberts
    2. Baylin J. Bennett
    3. Camdin M. Bennett
    4. Julie M. Carroll
    5. Louise S. Dalbøge
    6. C. Hall
    7. Wafa Hassouneh
    8. Kristy M. Heppner
    9. Melissa A. Kirigiti
    10. Sarah R. Lindsley
    11. Katherine G. Tennant
    12. Cadence A. True
    13. Andrew Whittle
    14. Anitra C. Wolf
    15. Charles T. Roberts
    16. Mads Tang-Christensen
    17. Mark W. Sleeman
    18. Michael A. Cowley
    19. Kevin L. Grove
    20. Paul Kievit

  • Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates

    Scientific Reports
    1. Lucia Carbone
    2. Brett A. Davis
    3. Suzanne S. Fei
    4. Ashley White
    5. Kimberly A. Nevonen
    6. Diana Takahashi
    7. Amanda Vinson
    8. Cadence True
    9. Charles T. Roberts
    10. Oleg Varlamov

  • Adverse Placental Perfusion and Pregnancy Outcomes in a New Nonhuman Primate Model of Gestational Protein Restriction

    Reproductive Sciences
    1. Victoria H.J. Roberts
    2. Jamie O. Lo
    3. Katherine S. Lewandowski
    4. Peter Blundell
    5. Kevin L. Grove
    6. Christopher D. Kroenke
    7. Elinor L. Sullivan
    8. Charles T. Roberts
    9. Antonio E. Frias

  • Combined androgen excess and Western-style diet accelerates adipose tissue dysfunction in young adult, female nonhuman primates

    Human Reproduction
    1. Oleg Varlamov
    2. Cecily V. Bishop
    3. Mithila Handu
    4. Diana Takahashi
    5. Sathya Srinivasan
    6. Ashley White
    7. Charles T. Roberts

  • A novel, stable, aqueous Glucagon formulation using Ferulic acid as an Excipient

    Journal of Diabetes Science and Technology
    1. Parkash A. Bakhtiani
    2. Nicholas Caputo
    3. Jessica R. Castle
    4. Joseph El Youssef
    5. Julie M. Carroll
    6. Larry L. David
    7. Charles T. Roberts
    8. Ward Kenneth

  • Cell-Autonomous heterogeneity of nutrient uptake in white adipose tissue of rhesus macaques

    Endocrinology
    1. Oleg Varlamov
    2. Michael Chu
    3. Anda Cornea
    4. Harini Sampath
    5. Charles T. Roberts

  • Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

    Leukemia
    1. J. Huan
    2. N. I. Hornick
    3. N. A. Goloviznina
    4. A. N. Kamimae-Lanning
    5. L. L. David
    6. P. A. Wilmarth
    7. T. Mori
    8. J. R. Chevillet
    9. A. Narla
    10. C. T. Roberts
    11. M. M. Loriaux
    12. B. H. Chang
    13. P. Kurre

  • Maternal serum biomarkers for risk assessment in gestational diabetes. A potential universal screening test to predict GDM status

    Indian Journal of Endocrinology and Metabolism
    1. Srinivasa R. Nagalla
    2. Caryn K. Snyder
    3. John E. Michaels
    4. Mary J. Laughlin
    5. Charles T. Roberts
    6. Madhuri Balaji
    7. V. Balaji
    8. V. Seshiah
    9. Paturi V. Rao

  • Maternal serum glycosylated fibronectin as a point-of-care biomarker for assessment of preeclampsia

    American journal of obstetrics and gynecology
    1. Juha Rasanen
    2. Matthew J. Quinn
    3. Amber Laurie
    4. Eric Bean
    5. Charles T. Roberts
    6. Srinivasa R. Nagalla
    7. Michael G. Gravett

  • Salivary protein glycosylation as a noninvasive biomarker for assessment of glycemia

    Journal of Diabetes Science and Technology
    1. Paturi V. Rao
    2. Amber Laurie
    3. Eric S. Bean
    4. Charles T. Roberts
    5. Srinivasa R. Nagalla