David B. Jacoby, M.D.
- Professor of Medicine, School of Medicine
- Neuroscience Graduate Program, School of Medicine
- Program in Molecular and Cellular Biosciences, School of Medicine
Biography
Dr. David Jacoby is a professor in the Department of Medicine, Division of Pulmonary and Critical Care Medicine. His secondary appointment is professor in the Department of Chemical Physiology and Biochemistry, OHSU School of Medicine.
He was born in New York, and is a graduate of Princeton University and New York Medical College. He was a resident and chief resident in internal medicine at Temple University Hospital and did his fellowship at the Cardiovascular Research Institute at the University of California, San Francisco.
He was a member of the Division of Pulmonary and Critical Care Medicine at Johns Hopkins for 13 years, where he was research director for the division. As part of the Oregon Opportunity Act, Dr. Jacoby was recruited to OHSU as chief of pulmonary and critical care in 2003. He led the expansion of that division in patient care, research and education. He became interim chair of the Department of Medicine in 2017 and permanent chair in 2018. He was named interim dean of the School of Medicine in 2021 and dean in 2022. He stepped down as dean in 2024, returning to his tenured faculty role.
Education and training
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Degrees
- B.A., 1976, Princeton
- M.D., 1980, New York Medical College
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Residency
- Internal medicine, Temple University Hospital, Philadelphia, Pennsylvania, 1981-1983
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Fellowship
- Clinical pulmonary, University of California, San Francisco, 1984-1985
- Pulmonary Research, Cardiovascular Research Institute, UCSF 1985 - 1987
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Certifications
- Board Certified in Internal Medicine
- Board Certified in Pulmonary Medicine
- Board Certified in Critical Care Medicine
Publications
Elsevier pure profilePublications
Maternal high-fat diet programs offspring airway hyperinnervation and hyperresponsiveness
JCI InsightEosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet
American Journal of Physiology - Lung Cellular and Molecular PhysiologyGrandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring
American Journal of Physiology - Lung Cellular and Molecular PhysiologyMaternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring
American Journal of Physiology - Lung Cellular and Molecular PhysiologyEosinophils and airway nerves in asthma
ERS MonographInsulin increases sensory nerve density and reflex bronchoconstriction in obese mice
JCI InsightMulticolor labeling of airway neurons and analysis of parasympathetic heterogeneity
Scientific ReportsUnique Allergic Asthma Phenotypes in Offspring of House Dust Mite-exposed Mice
American journal of respiratory cell and molecular biologyAirway sensory nerve density is increased in chronic cough
American journal of respiratory and critical care medicineMetformin prevents airway hyperreactivity in rats with dietary obesity
American Journal of Physiology - Lung Cellular and Molecular PhysiologyMini review
Neuroscience LettersPioglitazone prevents obesity-related airway hyperreactivity and neuronal M2 receptor dysfunction
American Journal of Physiology - Lung Cellular and Molecular PhysiologyTLR7 is expressed by support cells, but not sensory neurons, in ganglia
Journal of NeuroinflammationIL-5 exposure in utero increases lung nerve density and airway reactivity in adult offspring
American journal of respiratory cell and molecular biologyLung eosinophils increase vagus nerve-mediated airway reflex bronchoconstriction in mice
American journal of physiology. Lung cellular and molecular physiologyOptogenetic control of airway cholinergic neurons in vivo
American journal of respiratory cell and molecular biologyTransient receptor potential ankyrin-1 causes rapid bronchodilation via nonepithelial PGE
American Journal of Physiology - Lung Cellular and Molecular PhysiologyOrganophosphorus pesticides induce cytokine release from differentiated human THP1 cells
American journal of respiratory cell and molecular biologyEosinophils increase airway sensory nerve density in mice and in human asthma
Science translational medicineNewly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs
American Journal of Physiology - Lung Cellular and Molecular PhysiologyOzone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-α blockade
Physiological reportsHuman and mouse eosinophils have antiviral activity against parainfluenza virus
American journal of respiratory cell and molecular biology