David B. Jacoby, M.D.

  • Professor of Medicine, School of Medicine
  • Neuroscience Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Dr. David Jacoby is a professor in the Department of Medicine, Division of Pulmonary and Critical Care Medicine. His secondary appointment is professor in the Department of Chemical Physiology and Biochemistry, OHSU School of Medicine.

He was born in New York, and is a graduate of Princeton University and New York Medical College. He was a resident and chief resident in internal medicine at Temple University Hospital and did his fellowship at the Cardiovascular Research Institute at the University of California, San Francisco.

He was a member of the Division of Pulmonary and Critical Care Medicine at Johns Hopkins for 13 years, where he was research director for the division. As part of the Oregon Opportunity Act, Dr. Jacoby was recruited to OHSU as chief of pulmonary and critical care in 2003. He led the expansion of that division in patient care, research and education. He became interim chair of the Department of Medicine in 2017 and permanent chair in 2018. He was named interim dean of the School of Medicine in 2021 and dean in 2022. He stepped down as dean in 2024, returning to his tenured faculty role.

Education and training

  • Degrees

    • B.A., 1976, Princeton
    • M.D., 1980, New York Medical College
  • Residency

    • Internal medicine, Temple University Hospital, Philadelphia, Pennsylvania, 1981-1983
  • Fellowship

    • Clinical pulmonary, University of California, San Francisco, 1984-1985
    • Pulmonary Research, Cardiovascular Research Institute, UCSF 1985 - 1987
  • Certifications

    • Board Certified in Internal Medicine
    • Board Certified in Pulmonary Medicine
    • Board Certified in Critical Care Medicine

Publications

Elsevier pure profile

Publications

  • Maternal high-fat diet programs offspring airway hyperinnervation and hyperresponsiveness

    JCI Insight
    1. Kayla R. Williams
    2. Hoyt A.T.K. Bright
    3. Allison Fryer
    4. David B. Jacoby
    5. Zhenying Nie
  • Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet

    American Journal of Physiology - Lung Cellular and Molecular Physiology
    1. Becky Proskocil-Chen
    2. Gina N. Bash
    3. David B. Jacoby
    4. Allison D. Fryer
    5. Zhenying Nie
  • Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring

    American Journal of Physiology - Lung Cellular and Molecular Physiology
    1. Katie M. Lebold
    2. Madeline Cook
    3. Alexandra B. Pincus
    4. Kimberly A. Nevonen
    5. Brett A. Davis
    6. Lucia Carbone
    7. Gina N. Calco
    8. Aubrey B. Pierce
    9. Becky J. Proskocil
    10. Allison D. Fryer
    11. David B. Jacoby
    12. Matthew G. Drake
  • Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring

    American Journal of Physiology - Lung Cellular and Molecular Physiology
    1. Gina N. Calco
    2. Yem J. Alharithi
    3. Kayla R. Williams
    4. David B. Jacoby
    5. Allison D. Fryer
    6. Alina Maloyan
    7. Zhenying Nie
  • Eosinophils and airway nerves in asthma

    ERS Monograph
    1. Ubaldo De La Torre
    2. Allison D. Fryer
    3. David B. Jacoby
    4. Matthew G. Drake
  • Insulin increases sensory nerve density and reflex bronchoconstriction in obese mice

    JCI Insight
    1. Gina N. Calco
    2. Jessica N. Maung
    3. David B. Jacoby
    4. Allison D. Fryer
    5. Zhenying Nie
  • Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity

    Scientific Reports
    1. Alexandra B. Pincus
    2. Samuel J. Huang
    3. Katie M. Lebold
    4. Ubaldo De La Torre
    5. Becky J. Proskocil
    6. Matthew G. Drake
    7. Hiroyuki Nakai
    8. Allison D. Fryer
    9. David B. Jacoby
  • Unique Allergic Asthma Phenotypes in Offspring of House Dust Mite-exposed Mice

    American journal of respiratory cell and molecular biology
    1. Katie M. Lebold
    2. Matthew G. Drake
    3. Alexandra B. Pincus
    4. Aubrey B. Pierce
    5. Allison D. Fryer
    6. David B. Jacoby
  • Airway sensory nerve density is increased in chronic cough

    American journal of respiratory and critical care medicine
    1. Clare O. Shapiro
    2. Becky J. Proskocil
    3. Laura J. Oppegard
    4. Emily D. Blum
    5. Nicole L. Kappel
    6. Christopher H. Chang
    7. Allison D. Fryer
    8. David B. Jacoby
    9. Richard W. Costello
    10. Matthew G. Drake
  • Metformin prevents airway hyperreactivity in rats with dietary obesity

    American Journal of Physiology - Lung Cellular and Molecular Physiology
    1. Gina N. Calco
    2. Becky J. Proskocil
    3. David B. Jacoby
    4. Allison D. Fryer
    5. Zhenying Nie
  • Mini review

    Neuroscience Letters
    1. Alexandra B. Pincus
    2. Allison D. Fryer
    3. David B. Jacoby
  • Pioglitazone prevents obesity-related airway hyperreactivity and neuronal M2 receptor dysfunction

    American Journal of Physiology - Lung Cellular and Molecular Physiology
    1. Becky J. Proskocil
    2. Allison D. Fryer
    3. David B. Jacoby
    4. Zhenying Nie
  • TLR7 is expressed by support cells, but not sensory neurons, in ganglia

    Journal of Neuroinflammation
    1. Becky J. Proskocil
    2. Karol Wai
    3. Katherine M. Lebold
    4. Mason A. Norgard
    5. Katherine A. Michaelis
    6. Ubaldo De La Torre
    7. Madeline Cook
    8. Daniel L. Marks
    9. Allison D. Fryer
    10. David B. Jacoby
    11. Matthew G. Drake
  • IL-5 exposure in utero increases lung nerve density and airway reactivity in adult offspring

    American journal of respiratory cell and molecular biology
    1. Katie M. Lebold
    2. Matthew G. Drake
    3. Lauren B. Hales-Beck
    4. Allison D. Fryer
    5. David B. Jacoby
  • Lung eosinophils increase vagus nerve-mediated airway reflex bronchoconstriction in mice

    American journal of physiology. Lung cellular and molecular physiology
    1. Zhenying Nie
    2. Jessica N. Maung
    3. David B. Jacoby
    4. Allison D. Fryer
  • Optogenetic control of airway cholinergic neurons in vivo

    American journal of respiratory cell and molecular biology
    1. Alexandra B. Pincus
    2. Sweta Adhikary
    3. Katherine M. Lebold
    4. Allison D. Fryer
    5. David B. Jacoby
  • Transient receptor potential ankyrin-1 causes rapid bronchodilation via nonepithelial PGE

    American Journal of Physiology - Lung Cellular and Molecular Physiology
    1. Brenda J. Marsh
    2. Allison D. Fryer
    3. David B. Jacoby
    4. Matthew G. Drake
  • Organophosphorus pesticides induce cytokine release from differentiated human THP1 cells

    American journal of respiratory cell and molecular biology
    1. Becky J. Proskocil
    2. Ana Cristina G. Grodzki
    3. David B. Jacoby
    4. Pamela J. Lein
    5. Allison D. Fryer
  • Eosinophils increase airway sensory nerve density in mice and in human asthma

    Science translational medicine
    1. Matthew G. Drake
    2. Gregory D. Scott
    3. Emily D. Blum
    4. Katherine M. Lebold
    5. Zhenying Nie
    6. James J. Lee
    7. Allison D. Fryer
    8. Richard W. Costello
    9. David B. Jacoby
  • Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs

    American Journal of Physiology - Lung Cellular and Molecular Physiology
    1. Sarah A. Wicher
    2. David B. Jacoby
    3. Allison D. Fryer
  • Ozone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-α blockade

    Physiological reports
    1. Sarah A. Wicher
    2. Katy L. Lawson
    3. David B. Jacoby
    4. Allison D. Fryer
    5. Matthew G. Drake
  • Human and mouse eosinophils have antiviral activity against parainfluenza virus

    American journal of respiratory cell and molecular biology
    1. Matthew G. Drake
    2. Elizabeth R. Bivins-Smith
    3. Becky J. Proskocil
    4. Zhenying Nie
    5. Gregory D. Scott
    6. James J. Lee
    7. Nancy A. Lee
    8. Allison D. Fryer
    9. David B. Jacoby