We are using Drosophila to study basic mechanisms of neurodegeneration. Currently, we are focusing on two proteins that play key roles in Alzheimer’s disease; the Amyloid Precursor Protein and Tau. We are investigating what effects disease-associated changes in these proteins have on their functions and how this effects the genetic pathways these proteins are involved in. To address this, we use behavioral assays, histology and confocal imaging, as well as various molecular and sequencing techniques. Using genetic manipulations, we study whether other proteins can ameliorate disease-associated phenotypes or contribute to the pathogenicity. In a second project, we are investigating effects of aging on behavior and the function of the nervous system. In addition, my group is part of a research center that tests effects of botanical dietary supplements on enhancing resilience during aging and in neurodegenerative diseases.