Eric Barklis, Ph.D.

  • Professor of Molecular Microbiology and Immunology, School of Medicine
  • Molecular Microbiology and Immunology Graduate Program, School of Medicine
  • Cancer Biology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Experience

2001-present - Professor, Vollum Institute and MMI, OHSU
1999-present - Director, Electron Microscope Core Facility, OHSU
1994-01 - Associate Professor, Vollum Institute and MMI, OHSU
1987-94 - Assistant Professor, Vollum Institute and MMI, OHSU
1984-87 - Postdoctoral Fellow, Massachusetts Institute of Technology

Education and training

  • Degrees

    • B.S., 1973, Massachusetts Institute of Technology
    • Ph.D., 1984, Massachusetts Institute of Technology

Publications

Publications

  • A nanobody interaction with SARS-COV-2 Spike allows the versatile targeting of lentivirus vectors

    Journal of virology
    1. Ayna Alfadhli
    2. Timothy A. Bates
    3. Robin Lid Barklis
    4. Ce Ann Romanaggi
    5. Fikadu G. Tafesse
    6. Eric Barklis
  • ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

    eLife
    1. Timothy A. Bates
    2. Mila Trank-Greene
    3. Xammy Nguyenla
    4. Aidan Anastas
    5. Sintayehu K. Gurmessa
    6. Ilaria R. Merutka
    7. Shandee Dixon
    8. Anthony Shumate
    9. Abigail R. Groncki
    10. Matthew A.H. Parson
    11. Jessica R. Ingram
    12. Eric Barklis
    13. John E. Burke
    14. Ujwal Shinde
    15. Hidde L. Ploegh
    16. Fikadu G. Tafesse
  • Second site reversion of HIV-1 envelope protein baseplate mutations maps to the matrix protein

    Journal of virology
    1. Ayna Alfadhli
    2. Ce Ann Romanaggi
    3. Robin Lid Barklis
    4. Eric Barklis
  • Analysis of HIV-1 envelope cytoplasmic tail effects on viral replication

    Virology
    1. Ayna Alfadhli
    2. Ce Ann Romanaggi
    3. Robin Lid Barklis
    4. Eric Barklis
  • A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants

    iScience
    1. Jules B. Weinstein
    2. Timothy A. Bates
    3. Hans C. Leier
    4. Savannah K. McBride
    5. Eric Barklis
    6. Fikadu G. Tafesse
  • Capsid-specific nanobody effects on HIV-1 assembly and infectivity

    Virology
    1. Ayna Alfadhli
    2. Ce Ann Romanaggi
    3. Robin Lid Barklis
    4. Ilaria Merutka
    5. Timothy A. Bates
    6. Fikadu G. Tafesse
    7. Eric Barklis
  • Ceramide synthase 2 deletion decreases the infectivity of HIV-1

    Journal of Biological Chemistry
    1. Eric Barklis
    2. Ayna Alfadhli
    3. Jennifer E. Kyle
    4. Lisa M. Bramer
    5. Kent J. Bloodsworth
    6. Robin Lid Barklis
    7. Hans C. Leier
    8. R. Max Petty
    9. Iris D. Zelnik
    10. Thomas O. Metz
    11. Anthony H. Futerman
    12. Fikadu G. Tafesse
  • A global lipid map defines a network essential for Zika virus replication

    Nature communications
    1. Hans C. Leier
    2. Jules B. Weinstein
    3. Jennifer E. Kyle
    4. Joon Yong Lee
    5. Lisa M. Bramer
    6. Kelly G. Stratton
    7. Douglas Kempthorne
    8. Aaron R. Navratil
    9. Endale G. Tafesse
    10. Thorsten Hornemann
    11. William B. Messer
    12. Edward A. Dennis
    13. Thomas O. Metz
    14. Eric Barklis
    15. Fikadu G. Tafesse
  • HIV-1 matrix trimerization-impaired mutants are rescued by matrix substitutions that enhance envelope glycoprotein incorporation

    Journal of virology
    1. Philip R. Tedbury
    2. Mariia Novikova
    3. Ayna Alfadhli
    4. Yuta Hikichi
    5. Ioannis Kagiampakis
    6. Vineet N. KewalRamani
    7. Eric Barklis
    8. Eric O. Freed
  • Analysis of HIV-1 matrix-envelope cytoplasmic tail interactions

    Journal of virology
    1. Ayna Alfadhli
    2. August O. Staubus
    3. Philip R. Tedbury
    4. Mariia Novikova
    5. Eric O. Freed
    6. Eric Barklis
  • Organization of Farnesylated, Carboxymethylated KRAS4B on Membranes

    Journal of molecular biology
    1. Eric Barklis
    2. Andrew G. Stephen
    3. August O. Staubus
    4. Robin Lid Barklis
    5. Ayna Alfadhli
  • Replication of HIV-1 envelope protein cytoplasmic domain variants in permissive and restrictive cells

    Virology
    1. August O. Staubus
    2. Ayna Alfadhli
    3. Robin Lid Barklis
    4. Eric Barklis
  • Lipid biosensor interactions with wild type and matrix deletion HIV-1 Gag proteins

    Virology
    1. Eric Barklis
    2. August O. Staubus
    3. Andrew Mack
    4. Logan Harper
    5. Robin Lid Barklis
    6. Ayna Alfadhli
  • Analysis of K-Ras interactions by biotin ligase tagging

    Cancer Genomics and Proteomics
    1. Christopher Ritchie
    2. Andrew Mack
    3. Logan Harper
    4. Ayna Alfadhli
    5. Philip J.S. Stork
    6. Xiaolin Nan
    7. Eric Barklis
  • Analysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties

    Bioorganic and Medicinal Chemistry
    1. Ayna Alfadhli
    2. Andrew Mack
    3. Logan Harper
    4. Sam Berk
    5. Christopher Ritchie
    6. Eric Barklis
  • Trimer enhancement mutation effects on HIV-1 matrix protein binding activities

    Journal of virology
    1. Ayna Alfadhli
    2. Andrew Mack
    3. Christopher Ritchie
    4. Isabel Cylinder
    5. Logan Harper
    6. Philip R. Tedbury
    7. Eric O. Freed
    8. Eric Barklis
  • Analysis of HIV-1 gag protein interactions via biotin ligase tagging

    Journal of virology
    1. Christopher Ritchie
    2. Isabel Cylinder
    3. Emily J. Platt
    4. Eric Barklis
  • RRE-dependent HIV-1 Env RNA effects on Gag protein expression, assembly and release

    Virology
    1. Claudia S. López
    2. Rachel Sloan
    3. Isabel Cylinder
    4. Susan L. Kozak
    5. David Kabat
    6. Eric Barklis
  • Analysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding site

    Journal of Biological Chemistry
    1. Ayna Alfadhli
    2. Henry McNett
    3. Jacob Eccles
    4. Seyram Tsagli
    5. Colleen Noviello
    6. Rachel Sloan
    7. Claudia S. López
    8. David H. Peyton
    9. Eric Barklis
  • Second site reversion of a mutation near the amino terminus of the HIV-1 capsid protein

    Virology
    1. Claudia S. López
    2. Seyram M. Tsagli
    3. Rachel Sloan
    4. Jacob Eccles
    5. Eric Barklis
  • Sultam thioureas

    Synlett
    1. Rachel M. Feeny
    2. Diane N. Le
    3. Joseph W. Parks
    4. Mark G. Epstein
    5. Joseph V. Pagano
    6. Albert C. Abbene
    7. Elaina B. Graham
    8. Joanna R. Farrell
    9. Jason R. McGuire
    10. Robert W. Zoellner
    11. Edward J. Valente
    12. Eric Barklis
    13. Warren J.L. Wood
  • Analysis of the N-terminal region of the murine leukemia virus nucleocapsid protein

    Virus Research
    1. Amelia Still
    2. Douglas Huseby
    3. Eric Barklis
  • Determinants of the HIV-1 core assembly pathway

    Virology
    1. Claudia S. López
    2. Jacob D. Eccles
    3. Amelia Still
    4. Rachel E. Sloan
    5. Robin Lid Barklis
    6. Seyram M. Tsagli
    7. Eric Barklis
  • HIV-1 matrix protein binding to RNA

    Journal of molecular biology
    1. Ayna Alfadhli
    2. Henry McNett
    3. Seyram Tsagli
    4. Hans Peter Bächinger
    5. David H. Peyton
    6. Eric Barklis
  • Second-site compensatory mutations of HIV-1 capsid mutations

    Journal of virology
    1. Colleen M. Noviello
    2. Claudia S. López
    3. Ben Kukull
    4. Henry McNett
    5. Amelia Still
    6. Jacob Eccles
    7. Rachel Sloan
    8. Eric Barklis
  • Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action

    Molecular biology of the cell
    1. Jimmy D. Dikeakos
    2. Katelyn M. Atkins
    3. Laurel Thomas
    4. Lori Emert-Sedlak
    5. In Ja L. Byeon
    6. Jinwon Jung
    7. Jinwoo Ahn
    8. Matthew D. Wortman
    9. Ben Kukull
    10. Masumichi Saito
    11. Hirokazu Koizumi
    12. Danielle M. Williamson
    13. Masateru Hiyoshi
    14. Eric Barklis
    15. Masafumi Takiguchi
    16. Shinya Suzu
    17. Angela M. Gronenborn
    18. Thomas E. Smithgall
    19. Gary Thomas
  • Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis

    Molecular and cellular biology
    1. Shelya X. Zeng
    2. Yanping Li
    3. Yetao Jin
    4. Qi Zhang
    5. David M. Keller
    6. Carolyn M. McQuaw
    7. Eric Barklis
    8. Stacie Stone
    9. Maureen Hoatlin
    10. Yingming Zhao
    11. Hua Lu
  • Analysis of human immunodeficiency virus type 1 matrix binding to membranes and nucleic acids

    Journal of virology
    1. Ayna Alfadhli
    2. Amelia Still
    3. Eric Barklis