Eric Barklis, Ph.D.
- Professor of Molecular Microbiology and Immunology, School of Medicine
- Molecular Microbiology and Immunology Graduate Program, School of Medicine
- Cancer Biology Graduate Program, School of Medicine
- Program in Molecular and Cellular Biosciences, School of Medicine
Biography
Experience
2001-present - Professor, Vollum Institute and MMI, OHSU
1999-present - Director, Electron Microscope Core Facility, OHSU
1994-01 - Associate Professor, Vollum Institute and MMI, OHSU
1987-94 - Assistant Professor, Vollum Institute and MMI, OHSU
1984-87 - Postdoctoral Fellow, Massachusetts Institute of Technology
Education and training
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Degrees
- B.S., 1973, Massachusetts Institute of Technology
- Ph.D., 1984, Massachusetts Institute of Technology
Publications
Publications
A nanobody interaction with SARS-COV-2 Spike allows the versatile targeting of lentivirus vectors
Journal of virologyESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages
eLifeSecond site reversion of HIV-1 envelope protein baseplate mutations maps to the matrix protein
Journal of virologyAnalysis of HIV-1 envelope cytoplasmic tail effects on viral replication
VirologyA potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants
iScienceCapsid-specific nanobody effects on HIV-1 assembly and infectivity
VirologyCeramide synthase 2 deletion decreases the infectivity of HIV-1
Journal of Biological ChemistryA global lipid map defines a network essential for Zika virus replication
Nature communicationsHIV-1 matrix trimerization-impaired mutants are rescued by matrix substitutions that enhance envelope glycoprotein incorporation
Journal of virologyAnalysis of HIV-1 matrix-envelope cytoplasmic tail interactions
Journal of virologyOrganization of Farnesylated, Carboxymethylated KRAS4B on Membranes
Journal of molecular biologyReplication of HIV-1 envelope protein cytoplasmic domain variants in permissive and restrictive cells
VirologyLipid biosensor interactions with wild type and matrix deletion HIV-1 Gag proteins
VirologyAnalysis of K-Ras interactions by biotin ligase tagging
Cancer Genomics and ProteomicsAnalysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties
Bioorganic and Medicinal ChemistryTrimer enhancement mutation effects on HIV-1 matrix protein binding activities
Journal of virologyAnalysis of HIV-1 gag protein interactions via biotin ligase tagging
Journal of virologyRRE-dependent HIV-1 Env RNA effects on Gag protein expression, assembly and release
VirologyAnalysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding site
Journal of Biological ChemistrySecond site reversion of a mutation near the amino terminus of the HIV-1 capsid protein
VirologySultam thioureas
SynlettAnalysis of the N-terminal region of the murine leukemia virus nucleocapsid protein
Virus ResearchDeterminants of the HIV-1 core assembly pathway
VirologyHIV-1 matrix protein binding to RNA
Journal of molecular biologySecond-site compensatory mutations of HIV-1 capsid mutations
Journal of virologySmall molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action
Molecular biology of the cellStructure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis
Molecular and cellular biologyAnalysis of human immunodeficiency virus type 1 matrix binding to membranes and nucleic acids
Journal of virology