Eric Schnell, M.D., Ph.D.

  • Associate Professor of Anesthesiology and Perioperative Medicine, School of Medicine
  • Neuroscience Graduate Program, School of Medicine

Biography

My research focuses on the synaptic integration of newborn neurons into the adult brain. Specifically, I am studying the process of synapse formation by these neurons at a molecular level using a combination of molecular biology, imaging, and single cell electrophysiology techniques. More recently, my lab has been studying the synaptic integration of newborn neurons in epileptic brains and after traumatic brain injury, with the goal of improving medical care for brain-injured patients.

Education and training

  • Degrees

    • B.A., 1993, Harvard University
    • M.A., 1995, University of Cambridge
    • Ph.D., 2002, University of California
    • M.D., 2004, University of California

  • Residency

    • Internship, Internal Medicine, University of California, San Francisco, 2004-2005Residency, Anesthesiology, University of California, San Francisco, 2005-2008Chief Resident, 2007-2008

  • Certifications

    • American Board of Anesthesiology, 2009

Memberships and associations:

  • Society for Neuroscience American Society of Anesthesiologists Oregon Society of Anesthesiologists Society for Neuroscience in Anesthesia and Critical Care

Publications

Publications

  • Altered Hippocampal Activation in Seizure-Prone CACNA2D2 Knock-out Mice

    eNeuro
    1. Alyssa B. Danis
    2. Ashlynn A. Gallagher
    3. Ashley N. Anderson
    4. Arielle Isakharov
    5. Kathleen A. Beeson
    6. Eric Schnell

  • Inhibitory CCK+ basket synapse defects in mouse models of dystroglycanopathy

    eLife
    1. Jennifer N. Jahncke
    2. Daniel S. Miller
    3. Milana Krush
    4. Eric Schnell
    5. Kevin M. Wright

  • Adaptive Mossy Cell Circuit Plasticity after Status Epilepticus

    Journal of Neuroscience
    1. Corwin R. Butler
    2. Gary L. Westbrook
    3. Eric Schnell

  • α2δ-2 is required for depolarization-induced suppression of excitation in Purkinje cells

    Journal of Physiology
    1. Kathleen A. Beeson
    2. Gary L. Westbrook
    3. Eric Schnell

  • Construction and validation of an ultraviolet germicidal irradiation system using locally available components

    PloS one
    1. Eric Schnell
    2. Elham Karamooz
    3. Melanie J. Harriff
    4. Jane E. Yates
    5. Christopher Pfeiffer
    6. Stephen M. Smith

  • Roadmap for Conducting Neuroscience Research in the COVID-19 Era and Beyond

    Journal of Neurosurgical Anesthesiology
    1. Phillip E. Vlisides
    2. Keith M. Vogt
    3. Dinesh Pal
    4. Eric Schnell
    5. William M. Armstead
    6. Ansgar M. Brambrink
    7. Philip Kuo
    8. Priscilla Nelson
    9. Susana Vacas
    10. Nicolai Goettel
    11. Linda S. Aglio
    12. Ehab Farag
    13. Reza Gorji
    14. Paul S. García
    15. Ines P. Koerner

  • Diazepam inhibits post-traumatic neurogenesis and blocks aberrant dendritic development

    Journal of neurotrauma
    1. Laura Villasana
    2. Austin Peters
    3. Raluca McCallum
    4. Chang Liu
    5. Eric Schnell

  • Early detonation by sprouted mossy fibers enables aberrant dentate network activity

    Proceedings of the National Academy of Sciences of the United States of America
    1. William D. Hendricks
    2. Gary L. Westbrook
    3. Eric Schnell

  • Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L

    eLife
    1. Christina Chatzi
    2. Yingyu Zhang
    3. Wiiliam D. Hendricks
    4. Yang Chen
    5. Eric Schnell
    6. Richard H. Goodman
    7. Gary L. Westbrook

  • Neuronal network remodeling and Wnt pathway dysregulation in the intrahippocampal kainate mouse model of temporal lobe epilepsy

    PloS one
    1. Kunal Gupta
    2. Eric Schnell

  • Ketamine Alters Hippocampal Cell Proliferation and Improves Learning in Mice after Traumatic Brain Injury

    Anesthesiology
    1. Austin J. Peters
    2. Laura E. Villasana
    3. Eric Schnell

  • Short-term depression of sprouted mossy fiber synapses from adult-born granule cells

    Journal of Neuroscience
    1. William D. Hendricks
    2. Yang Chen
    3. Aesoon L. Bensen
    4. Gary L. Westbrook
    5. Eric Schnell

  • Functional integration of adult-born hippocampal neurons after traumatic brain injury

    eNeuro
    1. Laura E. Villasana
    2. Kristine N. Kim
    3. Gary L. Westbrook
    4. Eric Schnell

  • Localized hypoxia within the subgranular zone determines the early survival of newborn hippocampal granule cells

    eLife
    1. Christina Chatzi
    2. Eric Schnell
    3. Gary L. Westbrook

  • Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons

    Frontiers in Neuroscience
    1. Eric Schnell
    2. Thomas H. Long
    3. Ae Soon L. Bensen
    4. Eric K. Washburn
    5. Gary L. Westbrook

  • Neurologic impairment following closed head injury predicts post-traumatic neurogenesis

    Experimental Neurology
    1. L. E. Villasana
    2. G. L. Westbrook
    3. E. Schnell

  • Neural injury alters proliferation and integration of adult-generated neurons in the dentate gyrus

    Journal of Neuroscience
    1. Julia V. Perederiy
    2. Bryan W. Luikart
    3. Eric K. Washburn
    4. Eric Schnell
    5. Gary L. Westbrook

  • Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions

    Journal of Neuroscience
    1. Jennifer L. Hoy
    2. Paola A. Haeger
    3. John R.L. Constable
    4. Renee J. Arias
    5. Raluca McCallum
    6. Michael Kyweriga
    7. Lawrence Davis
    8. Eric Schnell
    9. Michael Wehr
    10. Pablo E. Castillo
    11. Philip Washbourne

  • Neuroligin-1 Overexpression in Newborn Granule Cells In Vivo

    PloS one
    1. Eric Schnell
    2. Ae Soon L. Bensen
    3. Eric K. Washburn
    4. Gary L. Westbrook

  • Functional dependence of neuroligin on a new non-PDZ intracellular domain

    Nature Neuroscience
    1. Seth L. Shipman
    2. Eric Schnell
    3. Takaaki Hirai
    4. Bo Shiun Chen
    5. Katherine W. Roche
    6. Roger A. Nicoll

  • Pten knockdown in vivo increases excitatory drive onto dentate granule cells

    Journal of Neuroscience
    1. Bryan W. Luikart
    2. Eric Schnell
    3. Eric K. Washburn
    4. Ae Soon L. Bensen
    5. Kenneth R. Tovar
    6. Gary L. Westbrook

  • Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

    Proceedings of the National Academy of Sciences of the United States of America
    1. Eric Schnell
    2. Max Sizemore
    3. Siavash Karimzadegan
    4. Lu Chen
    5. David S. Bredt
    6. Roger A. Nicoll

  • Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97

    European Journal of Neuroscience
    1. Nikolaj Klöcker
    2. Robert C. Bunn
    3. Eric Schnell
    4. Georgina Caruana
    5. Alan Bernstein
    6. Roger A. Nicoll
    7. David S. Bredt

  • Synaptic strength regulated by palmitate cycling on PSD-95

    Cell
    1. Alaa El Din El-Husseini
    2. Eric Schnell
    3. Srikanth Dakoji
    4. Neal Sweeney
    5. Qiang Zhou
    6. Oliver Prange
    7. Catherine Gauthier-Campbell
    8. Andrea Aguilera-Moreno
    9. Roger A. Nicoll
    10. David S. Bredt

  • Hippocampal synaptic transmission and plasticity are preserved in myosin Va mutant mice

    Journal of neurophysiology
    1. Eric Schnell
    2. Roger A. Nicoll

  • Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering

    Journal of Cell Biology
    1. Alaa E. El-Husseini
    2. Sarah E. Craven
    3. Dane M. Chetkovich
    4. Bonnie L. Firestein
    5. Eric Schnell
    6. Chiye Aoki
    7. David S. Bredt

  • PSD-95 involvement in maturation of excitatory synapses

    Science
    1. A. E.D. El-Husseini
    2. E. Schnell
    3. D. M. Chetkovich
    4. R. A. Nicoll
    5. D. S. Bredt