Holly E. Hinson, M.D., M.C.R.

  • Associate Professor of Neurology, School of Medicine

Biography

As a  clinician in the Neurosciences Intensive Care Unit, I strive to provide cutting-edge care for severely brain-injured patients. In my relatively young field of neurocritical care, many of our treatment paradigms lack the mature evidence base of other fields. As a clinician-scientist it is my goal to conduct clinical trials to enhance understanding of underlying pathophysiology, and to test novel mechanism-based treatments to aid the maturation of our subspecialty.

Through clinical encounters with challenging patients during my fellowship, I developed a strong interest in autonomic dysfunction after acute  brain injury. I became dissatisfied with mere symptom management, and desired to understand the pathophysiology underlying the clinical manifestations we observed in the ICU. Since joining the faculty at OHSU, my interests have broadened to include other types of autonomic dysfunction, specifically hyperthermia or fever, after severe brain injury. To address this clinically relevant issue, I designed an observational study to test the hypothesis that early fever after severe TBI was associated with neurologic deterioration, and/or promoted the production of pro-inflammatory cytokines. I was awarded the Oregon Multidisciplinary Training Program for Emergency Medicine Clinical Research K12 for my projected, entitled "Fever and Inflammation in Neurotrauma (FAINT)."

Honors:

2010—Abstract Dual Catheters in Severe Intraventricular Hemorrhage selected  for presentation in Critical Care and Emergency Neurology Section Highlights in the Field at the 62nd American Academy of Neurology Annual Meeting, Toronto,  Canada.

2010—Awarded a fellowship to attend NINDS sponsored Clinical Trial Methods Course in  August 2010 for Dysautonomia in Traumatic Brain Injury protocol.

2011—Abstract Anatomical basis of paroxsysmal sympathetic hyperactivity chosen to be featured as a daily highlight among the best abstracts accepted  for presentation at the 24th Annual Congress of the European Society  of Intensive Care Medicine.

2012—Winner of the American Academy of Neurology Practice Research Training  Fellowship Grant 2012 for Quantifying Paroxysmal Sympathetic Hyperactivity  in Traumatic Brain Injury.

2013—Session entitled "Weathering the Storm: Brain Injury & the Autonomic  Nervous System" selected as the members submitted session for the 11th  annual NCS meeting.

2014—American Heart Association Young Investigator Award for abstract, "Differences  in Inflammatory Dysregulation in TBI versus Major Trauma" submitted to the 2014  Resuscitation Science Symposium, Chicago, IL.

Education and training

  • Degrees

    • B.A., 2001, Rice University
    • M.D., 2005, University of Texas Health Science
    • M.C.R., 2016, Oregon Health & Science University

  • Residency

    • Intern, Department of Internal Medicine, University of Maryland School of Medicine, Baltimore, 2006

  • Fellowship

    • Fellow, neurologic critical care, Department of Neurology, anesthesiology and critical care medicine and neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland, 2011

  • Certifications

    • American Board of Psychiatry and Neurology, 2009

Memberships and associations:

  • 2004–present  American Academy of Neurology, member

Publications

Elsevier pure profile

Publications

  • Diagnostic Performance of GFAP, UCH-L1, and MAP-2 Within 30 and 60 Minutes of Traumatic Brain Injury

    JAMA Network Open
    1. Linda Papa
    2. W. Ian McKinley
    3. Alex B. Valadka
    4. Zachary C. Newman
    5. Rachel K. Nordgren
    6. Pierce E. Pramuka
    7. Claire E. Barbosa
    8. Alexandra M.P. Brito
    9. Lindsey J. Loss
    10. Luis Tinoco-Garcia
    11. H. E. Hinson
    12. Martin A. Schreiber
    13. Susan E. Rowell

  • Evaluating and Updating the IMPACT Model to Predict Outcomes in Two Contemporary North American Traumatic Brain Injury Cohorts

    Journal of neurotrauma
    1. Naoki Takegami
    2. Abel Torres-Espi
    3. Yoshihito Imagawa
    4. Itsunori Watanabe
    5. Susan Rowell
    6. Martin Schreiber
    7. Adam R. Ferguson
    8. H. E. Hinson

  • Predicting Progression of Intracranial Hemorrhage in the Prehospital TXA for TBI Trial

    Journal of neurotrauma
    1. H. E. Hinson
    2. Hannah L. Radabaugh
    3. Nincheng Li
    4. Toshinori Fukuda
    5. Jeffrey Pollock
    6. Martin Schreiber
    7. Susan Rowell
    8. Adam R. Ferguson

  • Delayed cerebral ischemia associated with surgery for pituitary macroadenomas that express elevated levels of PACAP

    Brain Hemorrhages
    1. Dominic A. Siler
    2. Kate U. Rosen
    3. Stephen G. Bowden
    4. Andrew Y. Powers
    5. Jesse J. Liu
    6. Aclan Dogan
    7. Holly E. Hinson
    8. Maria Fleseriu
    9. Randy L. Woltjer
    10. Justin S. Cetas

  • Physiological Responses and Training Satisfaction During National Rollout of a Neurosurgical Intraoperative Catastrophe Simulator for Resident Training

    Operative Neurosurgery
    1. Dominic A. Siler
    2. Daniel R. Cleary
    3. Karen J. Tonsfeldt
    4. Arvin R. Wali
    5. Holly E. Hinson
    6. Alexander A. Khalessi
    7. Nathan R. Selden

  • Eicosanoid ratios are associated with hemorrhage severity and predict development of delayed cerebral ischemia following subarachnoid hemorrhage

    Brain Hemorrhages
    1. Dominic A. Siler
    2. Alexa M. Semonche
    3. Ravi Samatham
    4. Jesse J. Liu
    5. Ross P. Martini
    6. Nabil J. Alkayed
    7. Holly E. Hinson
    8. Justin S. Cetas

  • Extracellular Vesicle Levels of Nervous System Injury Biomarkers in Critically Ill Trauma Patients with and without Traumatic Brain Injury

    Neurotrauma Reports
    1. Vivian A. Guedes
    2. Sara Mithani
    3. Cydni Williams
    4. Dilorom Sass
    5. Ethan G. Smith
    6. Rany Vorn
    7. Chelsea Wagner
    8. Chen Lai
    9. Jessica Gill
    10. Holly E. Hinson

  • Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide

    Cell Reports Medicine
    1. Hannah J. Irvine
    2. Animesh Acharjee
    3. Zoe Wolcott
    4. Zsuzsanna Ament
    5. H. E. Hinson
    6. Bradley J. Molyneaux
    7. J. Marc Simard
    8. Kevin N. Sheth
    9. W. Taylor Kimberly

  • Antibody-Free Mass Spectrometry Identification of Vascular Integrity Markers in Major Trauma

    Neurotrauma Reports
    1. H. E. Hinson
    2. Jon Jacobs
    3. Shannon McWeeney
    4. Ann Wachana
    5. Tujin Shi
    6. Kendall Martin
    7. Karin Rodland

  • Assistance from Automated ASPECTS Software Improves Reader Performance

    Journal of Stroke and Cerebrovascular Diseases
    1. Philip R. Delio
    2. Matthew L. Wong
    3. Jenny P. Tsai
    4. H. E. Hinson
    5. John McMenamy
    6. Thang Q. Le
    7. Divya Prabhu
    8. Barry S. Mann
    9. Karen Copeland
    10. Keith Kwok
    11. Hafez Haerian
    12. Maarten J. Lansberg
    13. Jeremy J. Heit

  • Fibrinolytic Activation in Patients with Progressive Intracranial Hemorrhage after Traumatic Brain Injury

    Journal of neurotrauma
    1. Kelly A. Fair
    2. David H. Farrell
    3. Belinda H. McCully
    4. Elizabeth A. Rick
    5. Elizabeth N. Dewey
    6. Cole Hilliard
    7. Rondi Dean
    8. Amber Lin
    9. Holly Hinson
    10. Ronald Barbosa
    11. Martin A. Schreiber
    12. Susan E. Rowell

  • Incorporating immunoproteins in the development of classification models of progression of intracranial hemorrhage after traumatic brain injury

    Journal of Head Trauma Rehabilitation
    1. H. E. Hinson
    2. Peter Li
    3. Loren Myers
    4. Chinar Agarwal
    5. Jeffrey Pollock
    6. Shannon McWeeney

  • Proceedings of the First Curing Coma Campaign NIH Symposium

    Neurocritical Care
    1. Jan Claassen
    2. Yama Akbari
    3. Sheila Alexander
    4. Mary Kay Bader
    5. Kathleen Bell
    6. Thomas P. Bleck
    7. Melanie Boly
    8. Jeremy Brown
    9. Sherry H.Y. Chou
    10. Michael N. Diringer
    11. Brian L. Edlow
    12. Brandon Foreman
    13. Joseph T. Giacino
    14. Olivia Gosseries
    15. Theresa Green
    16. David M. Greer
    17. Daniel F. Hanley
    18. Jed A. Hartings
    19. Raimund Helbok
    20. J. Claude Hemphill
    21. H. E. Hinson
    22. Karen Hirsch
    23. Theresa Human
    24. Michael L. James
    25. Nerissa Ko
    26. Daniel Kondziella
    27. Sarah Livesay
    28. Lori K. Madden
    29. Shraddha Mainali
    30. Stephan A. Mayer
    31. Victoria McCredie
    32. Molly M. McNett
    33. Geert Meyfroidt
    34. Martin M. Monti
    35. Susanne Muehlschlegel
    36. Santosh Murthy
    37. Paul Nyquist
    38. Dai Wai M. Olson
    39. J. Javier Provencio
    40. Eric Rosenthal
    41. Gisele Sampaio Silva
    42. Simone Sarasso
    43. Nicholas D. Schiff
    44. Tarek Sharshar
    45. Lori Shutter
    46. Robert D. Stevens
    47. Paul Vespa
    48. Walter Videtta
    49. Amy Wagner
    50. Wendy Ziai

  • Registered Nurses' Perceptions after a Patient with Ebola Virus Disease Is Admitted to Their Hospital

    Health security
    1. Nanci Nagel
    2. Helen Salisbury
    3. Holly Hinson

  • Blood-based biomarkers for prediction of intracranial hemorrhage and outcome in patients with moderate or severe traumatic brain injury

    Journal of Trauma and Acute Care Surgery
    1. Taylor N. Anderson
    2. Jun Hwang
    3. Myrna Munar
    4. Linda Papa
    5. Holly E. Hinson
    6. Allison Vaughan
    7. Susan E. Rowell

  • Early Tranexamic Acid Administration after Traumatic Brain Injury Is Associated with Reduced Syndecan-1 and Angiopoietin-2 in Patients with Traumatic Intracranial Hemorrhage

    Journal of Head Trauma Rehabilitation
    1. Taylor N. Anderson
    2. Holly E. Hinson
    3. Elizabeth N. Dewey
    4. Elizabeth A. Rick
    5. Martin A. Schreiber
    6. Susan E. Rowell

  • Osmotherapy for malignant cerebral edema in a phase 2 prospective, double blind, randomized, placebo-controlled study of IV glibenclamide

    Journal of Stroke and Cerebrovascular Diseases
    1. H. E. Hinson
    2. Elizabeth Sun
    3. Bradley J. Molyneaux
    4. Rüdiger von Kummer
    5. Andrew Demchuk
    6. Javier Romero
    7. W. Taylor Kimberly
    8. Kevin N. Sheth

  • American Academy of Neurology members' preparedness to treat sexual and gender minorities

    Neurology
    1. Nicole Rosendale
    2. Tasha Ostendorf
    3. David A. Evans
    4. Allison Weathers
    5. Jason J. Sico
    6. Julie Randall
    7. Holly E. Hinson

  • Automated Calculation of Alberta Stroke Program Early CT Score

    Stroke
    1. Gregory W. Albers
    2. Michael J. Wald
    3. Michael Mlynash
    4. Juergen Endres
    5. Roland Bammer
    6. Matus Straka
    7. Andreas Maier
    8. Holly E. Hinson
    9. Kevin N. Sheth
    10. W. Taylor Kimberly
    11. Bradley J. Molyneaux