Ian Martin, Ph.D.

  • Associate Professor of Neurology, School of Medicine
  • Biochemistry and Molecular Biology Graduate Program, School of Medicine
  • Neuroscience Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine
  • Jungers Center for Neurosciences Research

Biography

Dr. Martin entered graduate school at Virginia Commonwealth University where he worked with Mike Grotewiel on the biology of aging using Drosophila melanogaster. He then joined Ted and Valina Dawson’s laboratory at Johns Hopkins University as a postdoctoral fellow to investigate the role of LRRK2 (leucine-rich repeat kinase 2) in Parkinson’s disease pathogenesis. His work has identified a role for LRRK2 kinase activity in disease pathogenesis through ribosomal protein phosphorylation and altered mRNA translation.

Dr. Martin joined the OHSU department of Neurology as Assistant Professor with memberships in the Jungers Center for Neurosciences and OHSU Parkinson and Movement Disorder Program. He will continue to use Drosophila genetics to examine how dopamine neuron degeneration occurs following mutations linked to Parkinson’s disease.

Education and training

  • Degrees

    • B.S., 2003, King’s College
    • Ph.D., 2008, Virginia Commonwealth University
  • Fellowship

    • Post-doctoral fellow, Johns Hopkins University, 2009–2015

Publications

Publications

  • Natural variation in age-related dopamine neuron degeneration is glutathione dependent and linked to life span

    Proceedings of the National Academy of Sciences of the United States of America
    1. Colin R. Coleman
    2. Judit Pallos
    3. Alicia Arreola-Bustos
    4. Lu Wang
    5. Daniel Raftery
    6. Daniel E.L. Promislow
    7. Ian Martin
  • Visualizing and profiling de novo protein synthesis in Drosophila with cell-type specificity

    Methods in cell biology
    1. Stefanny Villalobos-Cantor
    2. Ruth M. Barrett
    3. Alec F. Condon
    4. Alicia Arreola-Bustos
    5. Kelsie M. Rodriguez
    6. Michael S. Cohen
    7. Ian Martin
  • Rapid cell type-specific nascent proteome labeling in Drosophila

    eLife
    1. Stefanny Villalobos-Cantor
    2. Ruth M. Barrett
    3. Alec F. Condon
    4. Alicia Arreola-Bustos
    5. Kelsie M. Rodriguez
    6. Michael S. Cohen
    7. Ian Martin
  • Dopamine neuron-specific LRRK2 G2019S effects on gene expression revealed by translatome profiling

    Neurobiology of Disease
    1. Judit Pallos
    2. Sophia Jeng
    3. Shannon McWeeney
    4. Ian Martin
  • Dysregulated mRNA translation in the G2019S LRRK2 and LRRK2 knock-out mouse brains

    eNeuro
    1. Jungwoo Wren Kim
    2. Xiling Yin
    3. Ian Martin
    4. Yulan Xiong
    5. Stephen M. Eacker
    6. Nicholas T. Ingolia
    7. Ted M. Dawson
    8. Valina L. Dawson
  • Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis

    Cell Stem Cell
    1. Jungwoo Wren Kim
    2. Xiling Yin
    3. Aanishaa Jhaldiyal
    4. Mohammed Repon Khan
    5. Ian Martin
    6. Zhong Xie
    7. Tamara Perez-Rosello
    8. Manoj Kumar
    9. Leire Abalde-Atristain
    10. Jinchong Xu
    11. Li Chen
    12. Stephen M. Eacker
    13. D. James Surmeier
    14. Nicholas T. Ingolia
    15. Ted M. Dawson
    16. Valina L. Dawson
  • Dietary amino acids impact LRRK2-induced neurodegeneration in Parkinson's disease models

    Journal of Neuroscience
    1. Vinita G. Chittoor-Vinod
    2. Steffany Villalobos-Cantor
    3. Hanna Roshak
    4. Kelsey Shea
    5. Leire Abalde-Atristain
    6. Ian Martin
  • Genetic modifiers of neurodegeneration in a drosophila model of parkinson’s disease

    Genetics
    1. Sierra Lavoy
    2. Vinita G. Chittoor-Vinod
    3. Clement Y. Chow
    4. Ian Martin
  • LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

    Journal of Chemical Neuroanatomy
    1. Senthilkumar S. Karuppagounder
    2. Yulan Xiong
    3. Yunjong Lee
    4. Maeve C. Lawless
    5. Donghyun Kim
    6. Emily Nordquist
    7. Ian Martin
    8. Preston Ge
    9. Saurav Brahmachari
    10. Aanishaa Jhaldiyal
    11. Manoj Kumar
    12. Shaida A. Andrabi
    13. Ted M. Dawson
    14. Valina L. Dawson
  • A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans

    Genetics
    1. Edward G. Hawkins
    2. Ian Martin
    3. Lindsay M. Kondo
    4. Meredith E. Judy
    5. Victoria E. Brings
    6. Chung Lung Chan
    7. Ginamari G. Blackwell
    8. Jill C. Bettinger
    9. Andrew G. Davies
  • Abberant protein synthesis in G2019S LRRK2 drosophila parkinson disease-related phenotypes

    Fly
    1. Ian Martin
    2. Leire Abalde-Atristain
    3. Jungwoo Wren Kim
    4. Ted M. Dawson
    5. Valina L. Dawson
  • Paraquat exposure and Sod2 knockdown have dissimilar impacts on the Drosophila melanogaster carbonylated protein proteome

    Proteomics
    1. Suresh K. Narayanasamy
    2. David C. Simpson
    3. Ian Martin
    4. Mike Grotewiel
    5. Scott Gronert
  • Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in parkinson's disease

    Cell
    1. Ian Martin
    2. Jungwoo Wren Kim
    3. Byoung Dae Lee
    4. Ho Chul Kang
    5. Jin Chong Xu
    6. Hao Jia
    7. Jeannette Stankowski
    8. Min Sik Kim
    9. Jun Zhong
    10. Manoj Kumar
    11. Shaida A. Andrabi
    12. Yulan Xiong
    13. Dennis W. Dickson
    14. Zbigniew K. Wszolek
    15. Akhilesh Pandey
    16. Ted M. Dawson
    17. Valina L. Dawson
  • Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice

    Genes, Brain and Behavior
    1. P. Bhandari
    2. J. S. Hill
    3. S. P. Farris
    4. B. Costin
    5. I. Martin
    6. C. L. Chan
    7. J. T. Alaimo
    8. J. C. Bettinger
    9. A. G. Davies
    10. M. F. Miles
    11. M. Grotewiel
  • Recent advances in the genetics of parkinson's disease

    Annual Review of Genomics and Human Genetics
    1. Ian Martin
    2. Valina L. Dawson
    3. Ted M. Dawson
  • The New York Stem Cell Foundation

    Annals of the New York Academy of Sciences
    1. Caroline Marshall
    2. George Kai Wang
    3. Elisa Cimetta
    4. Chutima Talchai
    5. Dieter Egli
    6. Jae won Shim
    7. Ian Martin
    8. Faizzan Ahmad
    9. Andrew Sproul
    10. Ting Chen
    11. Valentina Fossati
    12. David Mckeon
    13. Kristin Smith
    14. Susan L. Solomon
  • A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment

    Experimental Gerontology
    1. Melanie A. Jones
    2. Julia Warner Gargano
    3. Devin Rhodenizer
    4. Ian Martin
    5. Poonam Bhandari
    6. Mike Grotewiel