Ian Martin, Ph.D.
- Associate Professor of Neurology, School of Medicine
- Biochemistry and Molecular Biology Graduate Program, School of Medicine
- Neuroscience Graduate Program, School of Medicine
- Program in Molecular and Cellular Biosciences, School of Medicine
- Jungers Center for Neurosciences Research
Biography
Dr. Martin entered graduate school at Virginia Commonwealth University where he worked with Mike Grotewiel on the biology of aging using Drosophila melanogaster. He then joined Ted and Valina Dawson’s laboratory at Johns Hopkins University as a postdoctoral fellow to investigate the role of LRRK2 (leucine-rich repeat kinase 2) in Parkinson’s disease pathogenesis. His work has identified a role for LRRK2 kinase activity in disease pathogenesis through ribosomal protein phosphorylation and altered mRNA translation.
Dr. Martin joined the OHSU department of Neurology as Assistant Professor with memberships in the Jungers Center for Neurosciences and OHSU Parkinson and Movement Disorder Program. He will continue to use Drosophila genetics to examine how dopamine neuron degeneration occurs following mutations linked to Parkinson’s disease.
Education and training
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Degrees
- B.S., 2003, King’s College
- Ph.D., 2008, Virginia Commonwealth University
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Fellowship
- Post-doctoral fellow, Johns Hopkins University, 2009–2015
Publications
Publications
Natural variation in age-related dopamine neuron degeneration is glutathione dependent and linked to life span
Proceedings of the National Academy of Sciences of the United States of AmericaVisualizing and profiling de novo protein synthesis in Drosophila with cell-type specificity
Methods in cell biologyRapid cell type-specific nascent proteome labeling in Drosophila
eLifeDopamine neuron-specific LRRK2 G2019S effects on gene expression revealed by translatome profiling
Neurobiology of DiseaseDysregulated mRNA translation in the G2019S LRRK2 and LRRK2 knock-out mouse brains
eNeuroDefects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis
Cell Stem CellDietary amino acids impact LRRK2-induced neurodegeneration in Parkinson's disease models
Journal of NeuroscienceGenetic modifiers of neurodegeneration in a drosophila model of parkinson’s disease
GeneticsLRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity
Journal of Chemical NeuroanatomyA novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans
GeneticsAbberant protein synthesis in G2019S LRRK2 drosophila parkinson disease-related phenotypes
FlyParaquat exposure and Sod2 knockdown have dissimilar impacts on the Drosophila melanogaster carbonylated protein proteome
ProteomicsRibosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in parkinson's disease
CellChloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice
Genes, Brain and BehaviorRecent advances in the genetics of parkinson's disease
Annual Review of Genomics and Human GeneticsThe New York Stem Cell Foundation
Annals of the New York Academy of SciencesA forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment
Experimental Gerontology