Ines P. Koerner, M.D., Ph.D., FNCS

  • Professor of Anesthesiology and Perioperative Medicine, School of Medicine
  • Professor of Neurological Surgery, School of Medicine
  • Vice Chair for Critical Care, Anesthesiology and Perioperative Medicine, School of Medicine
  • Medical Director of the Neurosciences ICU, Anesthesiology and Perioperative Medicine, School of Medicine

Biography

Dr. Koerner is anesthesiologists and neurointensivist, whose research focuses on ways to employ the inflammatory response after brain injury to simultaneously limit damage and enhance recovery. Dr. Koerner completed her anesthesiology residency in Germany and obtained a doctorate degree from Johannes Gutenberg-University in Mainz. After completing post-doctoral and clinical fellowships at OHSU, she joined OHSU faculty as a clinician-scientist. She is Vice Chair for Critical Care in the Department of Anesthesiology & Perioperative Medicine and serves as Medical Director of the Neurosciences Intensive Care Unit at OHSU. Her research on the role of microglia after stroke and cardiac arrest has received funding from the NIH and AHA.

Education and training

  • Residency

    • Anesthesiology and Critical Care Medicine, Johannes Gutenberg University, Mainz, Germany, 2003

  • Fellowship

    • Postdoctoral Fellowship Neuroscience, OHSU, 2006
    • Critical Care Medicine, OHSU, 2006

  • Certifications

    • German Board of Anesthesiology and Critical Care Medicine, 2007
    • American Board of Anesthesiology, 2012
    • United Council for Neurological Subspecialties, Neurocritical Care, 2013

Memberships and associations:

  • Society for Neuroscience in Anesthesiology and Critical Care, Secretary/Treasurer
  • Association of University Anesthesiologists (elected)
  • American Heart Association
  • International Anesthesia Research Society
  • Fellow, Neurocritical Care Society

Areas of interest

  • Neurocritical Care, Cerebral Ischemia, Neuroinflammation

Honors and awards

  • John D. Michenfelder New Investigator Award, Society for Neuroscience in Anesthesiology and Critical Care, 2006
  • Junior Faculty Award, Association of University Anesthesiologists, 2012
  • Professional Board Award, OHSU, 2018
  • Presidential Citation, Neurocritical Care Society, 2018, 2019

Publications

Elsevier pure profile

Selected publications

  • Vlisides PE, Vogt KM, Pal D, Schnell E, Armstead WM, Brambrink AM, Kuo P, Nelson P, Vacas S, Goettel N, Aglio LS, Farag E, Gorji R, Garcia PS, Koerner IP; for the SNACC Research Committee: Roadmap for Cunducting Neuroscience Research in the COVID-19 Era and Beyond: Recommendations From the SNACC Research Committee. Journal of Neurosurgical Anesthesiology, 2021 Apr:33(2):100-106
  • Treister AK, Koerner IP: Pharmacological Treatment of Meningitis and Encephalitis in Adult Patients. Review. Journal of Neuroanaesthesiology and Critical Care, 2019;6:145-152
  • Lele AV, Hoefnagel AL, Schloemerkemper N, Wyler DA, Chaikittisilpa N, Vavilala MS, Naik BI, Williams JH, Raghavan LV, Koerner IP; for the SNACC Task Force for Developing Guidelines for Perioperative Management of External Ventricular and Lumbar Drains: Perioperative Management of Adult Patients with External Ventricular and Lumbar Drains: Guidelines from the Society for Neuroscience in Anesthesiology and Critical Care. Journal of Neurosurgical Anesthesiology, 2017 Jul;29(3):191-210
  • Nelson JW, Zhang W, Alkayed NJ, Koerner IP: Peroxisomal translocation of soluble epoxide hydrolase protects against ischemic stroke injury. Journal of Cerebral Blood Flow and Metabolism, 2015 Sep;35(9):1416-20, PMCID: PMC4640333
  • Hutchens MP, Fujiyoshi T, Koerner IP, Herson PS: Extracranial hypothermia during cardiac arrest and cardiopulmonary resuscitation is neuroprotective in vivo. Therapeutic Hypothermia and Temperature Management, 2014 Jun;4(2):79-87, PMCID: PMC4046354
  • Wang JM, Fujiyoshi T, Kosaka Y, Raybuck JD, Lattal KM, Ikeda M, Herson PS, Koerner IP: Inhibition of Soluble Epoxide Hydrolase after Cardiac Arrest/Cardiopulmonary Resuscitation Induces a Neuroprotective Phenotype in Activated Microglia and Improves Neuronal Survival. Journal of Cerebral Blood Flow and Metabolism 33:1574-81, 2013, PMCID: PMC3790926
  • Fairbanks SL, Young JM, Nelson JW, Davis C, Koerner IP, Alkayed NJ: Mechanism of the Sex Difference in Neuronal Ischemic Cell Death. Neuroscience 219:183-191; 2012, PMCID: PMC3402645
  • Weinstein JR, Koerner IP, Möller T. Microglia in ischemic brain injury. Review. Future Neurology, 5:227-246, 2010, PMCID: PMC2853969
  • Koerner IP, Zhang W, Cheng J, Parker S, Hurn PD, Alkayed NJ: Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Frontiers in Bioscience 13:2833-2841; 2008, PMC2593891
  • Koerner IP, Jacks R, Grant DF, DeBarber AE, Koop D, Alkayed NJ: Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. Journal of Neuroscience 27:4642-4649; 2007, PMID: 17460077

Publications

  • Rationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage)

    Neurocritical Care
    1. Katharina M. Busl
    2. Cameron R. Smith
    3. Andrea B. Troxel
    4. Maurizio Fava
    5. Nicholas Illenberger
    6. Ralisa Pop
    7. Wenqing Yang
    8. Luciola Martins Frota
    9. Hanzhi Gao
    10. Guogen Shan
    11. Brian L. Hoh
    12. Carolina B. Maciel
    13. Alan Boulos
    14. Andras Laufer
    15. Charles E. Argoff
    16. Christopher Figueroa
    17. Erin Barnes
    18. James Lee
    19. Mahtab Sheikh
    20. Nibras Bughrara
    21. Panayiotis Varelas
    22. Toni Schaeffer
    23. Christine Spainhour
    24. Ofer Sadan
    25. Owen Samuels
    26. Tommy T. Thomas
    27. Yawar Qadri
    28. Eusebia Calvillo
    29. Jose Ignacio Suarez
    30. Kate Rosenblatt
    31. Tina Tuong Vi Le Doshi
    32. Amber Patchell
    33. Candace Hendricks
    34. Christopher Kramer
    35. Elird Bojaxhi
    36. Ewa Szymkiewicz
    37. Ferenc Rabai
    38. Jeffrey Peel
    39. Lauren Ng
    40. Megan Gauthier
    41. Miriam Anacker
    42. Sindhuja Nimma
    43. W. Christopher Fox
    44. William David Freeman
    45. Alejandro Rabinstein
    46. Amy Headlee
    47. Bridget Neja
    48. Carey Huebert
    49. Ines P. Koerner
    50. Kimberly M. Mauer

  • Roadmap for Conducting Neuroscience Research in the COVID-19 Era and Beyond

    Journal of Neurosurgical Anesthesiology
    1. Phillip E. Vlisides
    2. Keith M. Vogt
    3. Dinesh Pal
    4. Eric Schnell
    5. William M. Armstead
    6. Ansgar M. Brambrink
    7. Philip Kuo
    8. Priscilla Nelson
    9. Susana Vacas
    10. Nicolai Goettel
    11. Linda S. Aglio
    12. Ehab Farag
    13. Reza Gorji
    14. Paul S. García
    15. Ines P. Koerner

  • Peroxisomal translocation of soluble epoxide hydrolase protects against ischemic stroke injury

    Journal of Cerebral Blood Flow and Metabolism
    1. Jonathan W. Nelson
    2. Wenri Zhang
    3. Nabil J. Alkayed
    4. Ines P. Koerner

  • Extracranial hypothermia during cardiac arrest and cardiopulmonary resuscitation is neuroprotective in vivo

    Therapeutic Hypothermia and Temperature Management
    1. Michael P. Hutchens
    2. Tetsuhiro Fujiyoshi
    3. Ines P. Koerner
    4. Paco S. Herson

  • Inhibition of soluble epoxide hydrolase after cardiac arrest/ cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival

    Journal of Cerebral Blood Flow and Metabolism
    1. Jianming Wang
    2. Tetsuhiro Fujiyoshi
    3. Yasuharu Kosaka
    4. Jonathan D. Raybuck
    5. K. Matthew Lattal
    6. Mizuko Ikeda
    7. Paco S. Herson
    8. Ines P. Koerner

  • Mechanism of the sex difference in neuronal ischemic cell death

    Neuroscience
    1. S. L. Fairbanks
    2. J. M. Young
    3. J. W. Nelson
    4. C. M. Davis
    5. I. P. Koerner
    6. N. J. Alkayed

  • Estrogen induces rapid translocation of estrogen receptor β, but not estrogen receptor α, to the neuronal plasma membrane

    Neuroscience
    1. L. C. Sheldahl
    2. R. A. Shapiro
    3. D. N. Bryant
    4. I. P. Koerner
    5. D. M. Dorsa

  • Induction of cerebral ischemic tolerance by erythromycin preconditioning reprograms the transcriptional response to ischemia and suppresses inflammation

    Anesthesiology
    1. Ines P. Koerner
    2. Matthias Gatting
    3. Ruediger Noppens
    4. Oliver Kempski
    5. Ansgar M. Brambrink

  • Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury

    Journal of Neuroscience
    1. Ines P. Koerner
    2. Rachel Jacks
    3. Andrea E. DeBarber
    4. Dennis Koop
    5. Peizhong Mao
    6. David F. Grant
    7. Nabil J. Alkayed

  • Soluble epoxide hydrolase

    Journal of Cerebral Blood Flow and Metabolism
    1. Wenri Zhang
    2. Ines P. Koerner
    3. Ruediger Noppens
    4. Marjorie Grafe
    5. Hsing Ju Tsai
    6. Christophe Morisseau
    7. Ayala Luria
    8. Bruce D. Hammock
    9. John R. Falck
    10. Nabil J. Alkayed

  • Soluble epoxide hydrolase

    Journal of Cerebral Blood Flow and Metabolism
    1. Wenri Zhang
    2. Jeffrey J. Iliff
    3. Yazan K. Alhadid
    4. Ardi Ardeshiri
    5. Ines P. Koerner
    6. Patricia D. Hurn
    7. Nabil J. Alkayed

  • An early bolus of hypertonic saline hydroxyethyl starch improves long-term outcome after global cerebral ischemia

    Critical care medicine
    1. Ruediger R. Noppens
    2. Michael Christ
    3. Ansgar M. Brambrink
    4. Ines P. Koerner
    5. Axel Heimann
    6. Oliver Kempski

  • Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen-glucose deprivation

    European Journal of Neuroscience
    1. A. Ardeshiri
    2. M. H. Kelley
    3. I. P. Korner
    4. P. D. Hurn
    5. P. S. Herson

  • Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection

    Proceedings of the National Academy of Sciences of the United States of America
    1. Yun Xu
    2. Wenri Zhang
    3. Judith Klaus
    4. Jennifer Young
    5. Ines Koerner
    6. Laird C. Sheldahl
    7. Patricia D. Hurn
    8. Francisco Martínez-Murillo
    9. Nabil J. Alkayed

  • The antibiotic erythromycin induces tolerance against transient global cerebral ischemia in rats (pharmacologic preconditioning)

    Anesthesiology
    1. Ansgar M. Brambrink
    2. Ines P. Koerner
    3. Kathrin Diehl
    4. Georg Strobel
    5. Ruediger Noppens
    6. Oliver Kempski