Jared Fischer, Ph.D.

  • Assistant Professor of Molecular and Medical Genetics, School of Medicine
  • Scientist, CEDAR, OHSU Knight Cancer Institute, School of Medicine

Biography

Jared Fischer studies tissues from unique mouse models to elucidate the phenotypic progression involved in tumor formation. He received his Ph.D. in molecular genetics from the University of Cincinnati.

Publications

Publications

  • Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay

    Science translational medicine
    1. Jose L. Montoya Mira
    2. Arnaud Quentel
    3. Ranish K. Patel
    4. Dove Keith
    5. Megan Sousa
    6. Jessica Minnier
    7. Benjamin R. Kingston
    8. Larry David
    9. Sadik C. Esener
    10. Rosalie C. Sears
    11. Charles Lopez
    12. Brett C. Sheppard
    13. Utkan Demirci
    14. Melissa Wong
    15. Jared Fischer

  • Tumor-immune hybrid cells evade the immune response and potentiate colorectal cancer metastasis through CTLA4

    Clinical and Experimental Medicine
    1. Pariyada Tanjak
    2. Amphun Chaiboonchoe
    3. Thanawat Suwatthanarak
    4. Kullanist Thanormjit
    5. Onchira Acharayothin
    6. Jantappapa Chanthercrob
    7. Thammawat Parakonthun
    8. Asada Methasate
    9. Jared M. Fischer
    10. Melissa H. Wong
    11. Vitoon Chinswangwatanakul

  • Profiling protease cleavage patterns in plasma for pancreatic cancer detection

    Scientific Reports
    1. Morgan R. Stewart
    2. Arnaud Quentel
    3. Elise Manalo
    4. Jose Montoya Mira
    5. Srivathsan Ranganathan
    6. Bruce P. Branchaud
    7. Jared M. Fischer
    8. Eugene Tu
    9. Fehmi Civitci
    10. Yu Jui Chiu
    11. Adem Yildirim

  • Hybrid Silica-Coated PLGA Nanoparticles for Enhanced Enzyme-Based Therapeutics

    Pharmaceutics
    1. Kyle T. Gustafson
    2. Negin Mokhtari
    3. Elise C. Manalo
    4. Jose Montoya Mira
    5. Austin Gower
    6. Ya San Yeh
    7. Mukanth Vaidyanathan
    8. Sadik C. Esener
    9. Jared M. Fischer

  • Protein-Coated Biodegradable Gas-Stabilizing Nanoparticles for Cancer Therapy and Diagnosis Using Focused Ultrasound

    Advanced Materials Interfaces
    1. Sinan Sabuncu
    2. Jose Montoya Mira
    3. Arnaud Quentel
    4. Michelle M. Gomes
    5. Fehmi Civitci
    6. Jared M. Fischer
    7. Adem Yildirim

  • Ultrafast Background-Free Ultrasound Imaging Using Blinking Nanoparticles

    Nano Letters
    1. Sinan Sabuncu
    2. Ruth Javier Ramirez
    3. Jared M. Fischer
    4. Fehmi Civitci
    5. Adem Yildirim

  • Computational Modeling of TP63–TP53 Interaction and Rational Design of Inhibitors

    Molecular cancer therapeutics
    1. E. Sila Ozdemir
    2. Michelle M. Gomes
    3. Jared M. Fischer

  • Label-free enrichment of rare unconventional circulating neoplastic cells using a microfluidic dielectrophoretic sorting device

    Communications Biology
    1. Jose Montoya Mira
    2. Ajay A. Sapre
    3. Brett S. Walker
    4. Jesus Bueno Alvarez
    5. Kyle T. Gustafson
    6. Eugene Tu
    7. Jared M. Fischer
    8. Melissa H. Wong
    9. Sadik Esener
    10. Yu Jui Chiu

  • Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

    EBioMedicine
    1. Hillary H. Le
    2. Suleyman S. Cinaroglu
    3. Elise C. Manalo
    4. Aysegul Ors
    5. Michelle M. Gomes
    6. Burcin Duan Sahbaz
    7. Karla Bonic
    8. Carlos A. Origel Marmolejo
    9. Arnaud Quentel
    10. Justin S. Plaut
    11. Taryn E. Kawashima
    12. E. Sila Ozdemir
    13. Sanjay V. Malhotra
    14. Yavuz Ahiska
    15. Ugur Sezerman
    16. Gunseli Bayram Akcapinar
    17. Joshua C. Saldivar
    18. Emel Timucin
    19. Jared M. Fischer

  • Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors

    Scientific Reports
    1. Matthew S. Dietz
    2. Thomas L. Sutton
    3. Brett S. Walker
    4. Charles E. Gast
    5. Luai Zarour
    6. Sidharth K. Sengupta
    7. John R. Swain
    8. Jennifer Eng
    9. Michael Parappilly
    10. Kristen Limbach
    11. Ariana Sattler
    12. Erik Burlingame
    13. Yuki Chin
    14. Austin Gower
    15. Jose L.Montoya Mira
    16. Ajay Sapre
    17. Yu Jui Chiu
    18. Daniel R. Clayburgh
    19. Su Ellen J. Pommier
    20. Jeremy P. Cetnar
    21. Jared M. Fischer
    22. Jerry J. Jaboin
    23. Rodney F. Pommier
    24. Brett C. Sheppard
    25. V. Liana Tsikitis
    26. Alison H. Skalet
    27. Skye C. Mayo
    28. Charles D. Lopez
    29. Joe W. Gray
    30. Gordon B. Mills
    31. Zahi Mitri
    32. Young Hwan Chang
    33. Koei Chin
    34. Melissa H. Wong

  • Association between weight loss and serum biomarkers with risk of incident cancer in the Longitudinal Assessment of Bariatric Surgery cohort

    Surgery for Obesity and Related Diseases
    1. Andrea M. Stroud
    2. Elizabeth N. Dewey
    3. Farah A. Husain
    4. Jared M. Fischer
    5. Anita P. Courcoulas
    6. David R. Flum
    7. James E. Mitchell
    8. Walter J. Pories
    9. Jonathan Q. Purnell
    10. Bruce Wolfe

  • Silica cloaking of adenovirus enhances gene delivery while reducing immunogenicity

    Journal of Controlled Release
    1. Ajay A. Sapre
    2. Gen Yong
    3. Ya san Yeh
    4. Laura E. Ruff
    5. Justin S. Plaut
    6. Zeynep Sayar
    7. Anupriya Agarwal
    8. Jacqueline Martinez
    9. Theresa N. Nguyen
    10. Yu Tsueng Liu
    11. Bradley T. Messmer
    12. Sadik C. Esener
    13. Jared M. Fischer

  • Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

    Science Advances
    1. Charles E. Gast
    2. Alain D. Silk
    3. Luai Zarour
    4. Lara Riegler
    5. Joshua G. Burkhart
    6. Kyle T. Gustafson
    7. Michael S. Parappilly
    8. Minna Roh-Johnson
    9. James R. Goodman
    10. Brennan Olson
    11. Mark Schmidt
    12. John R. Swain
    13. Paige S. Davies
    14. Vidya Shasthri
    15. Shinji Iizuka
    16. Patrick Flynn
    17. Spencer Watson
    18. James Korkola
    19. Sara A. Courtneidge
    20. Jared M. Fischer
    21. Jerry Jaboin
    22. Kevin G. Billingsley
    23. Charles D. Lopez
    24. Julja Burchard
    25. Joe Gray
    26. Lisa M. Coussens
    27. Brett C. Sheppard
    28. Melissa H. Wong

  • Between-region genetic divergence reflects the mode and tempo of tumor evolution

    Nature genetics
    1. Ruping Sun
    2. Zheng Hu
    3. Andrea Sottoriva
    4. Trevor A. Graham
    5. Arbel Harpak
    6. Zhicheng Ma
    7. Jared M. Fischer
    8. Darryl Shibata
    9. Christina Curtis

  • An intact Pms2 ATPase domain is not essential for male fertility

    DNA Repair
    1. Jared M. Fischer
    2. Sandra Dudley
    3. Ashleigh J. Miller
    4. Robert (Mike) Liskay

  • Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation

    Proceedings of the National Academy of Sciences of the United States of America
    1. Jared M. Fischer
    2. Peter P. Calabrese
    3. Ashleigh J. Miller
    4. Nina M. Munoz
    5. William M. Grady
    6. Darryl Shibata
    7. R. Michael Liskay

  • Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention

    Carcinogenesis
    1. Jared M. Fischer
    2. Arnout G. Schepers
    3. Hans Clevers
    4. Darryl Shibata
    5. R. Michael Liskay

  • Different phenotypic consequences of simultaneous versus stepwise Apc loss

    Oncogene
    1. J. M. Fischer
    2. A. J. Miller
    3. D. Shibata
    4. R. M. Liskay

  • Mutation in aging mice occurs in diverse cell types that proliferate postmutation

    Aging Cell
    1. Jared M. Fischer
    2. James R. Stringer

  • Visualizing loss of heterozygosity in living mouse cells and tissues

    Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
    1. Jared M. Fischer
    2. James R. Stringer

  • Evolutionary rate of ribosomal DNA in Pneumocystis species is normal despite the extraordinarily low copy-number of rDNA genes

    Journal of Eukaryotic Microbiology
    1. Jared M. Fischer
    2. Scott P. Keely
    3. James R. Stringer

  • Exposure of mice to arsenic and/or benzo[a]pyrene does not increase the frequency of Aprt-deficient cells recovered from explanted skin of Aprt heterozygous mice

    Environmental and Molecular Mutagenesis
    1. Jared M. Fischer
    2. Susan B. Robbins
    3. Sasi S. Kannamkumarath
    4. Mustafa Al-Zoughool
    5. Saundra L. Stringer
    6. Glenn Talaska
    7. Joseph A. Caruso
    8. Peter J. Stambrook
    9. James R. Stringer

  • Expression and loss of alleles in cultured mouse embryonic fibroblasts and stem cells carrying allelic fluorescent protein genes

    BMC Molecular Biology
    1. Jon S. Larson
    2. Moying Yin
    3. Jared M. Fischer
    4. Saundra L. Stringer
    5. James R. Stringer

  • Co-mutagenic activity of arsenic and benzo[a]pyrene in mouse skin

    Mutation Research - Genetic Toxicology and Environmental Mutagenesis
    1. Jared M. Fischer
    2. Susan B. Robbins
    3. Mustafa Al-Zoughool
    4. Sasi S. Kannamkumarath
    5. Saundra L. Stringer
    6. Jon Scott Larson
    7. Joseph A. Caruso
    8. Glenn Talaska
    9. Peter J. Stambrook
    10. James R. Stringer

  • Modeling variation in tumors in vivo

    Proceedings of the National Academy of Sciences of the United States of America
    1. James R. Stringer
    2. Jon S. Larson
    3. Jared M. Fischer
    4. Marlo Medvedovic
    5. Megan N. Hersh
    6. Gregory P. Boivin
    7. Saundra L. Stringer

  • Increased mutation in mice genetically predisposed to oxidative damage in the brain

    Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
    1. James R. Stringer
    2. Jon S. Larson
    3. Jared M. Fischer
    4. Saundra L. Stringer

  • Phylogenetic identification of Pneumocystic murina sp. nov., a new species in laboratory mice

    Microbiology
    1. Scoot P. Keely
    2. Jared M. Fischer
    3. Melanie T. Cushion
    4. James R. Stringer

  • Evolution and Speciation of Pneumocystis

    Journal of Eukaryotic Microbiology
    1. Scott P. Keely
    2. Jared M. Fischer
    3. James R. Stringer