Jeffrey W. Tyner, Ph.D.

  • Professor of Medicine, School of Medicine
  • Co-leader, Translational Oncology Program, OHSU Knight Cancer Institute, School of Medicine
  • Cell and Developmental Biology Graduate Program, School of Medicine
  • Cancer Biology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

My research can be characterized by two primary interests: 1) identification of the genetic lesions underlying cancer pathogenesis for each cancer patient, and 2) identification of specific, gene-targeted therapies that can be individually tailored to cancer patients on the basis of their causative oncogenic lesions. Towards this end, I have developed two functional screening strategies making use of siRNA and small-molecule kinase inhibitor libraries to interrogate the genes and signaling pathways required for growth and viability of malignant cells. I have applied these techniques directly to primary cells from cancer patients to identify new oncogenes. It has also become clear that functional screening can only reveal part of the answer when used as a stand-alone technique. As such, I am integrating analysis of these same patient samples with a series of genomic techniques for the identification of point mutations, translocations, mis-splicing, or gene over-expression events. Simultaneous application of both functional and genomic screens will accelerate our understanding of the genes and pathways that contribute to neoplasia, such that cancer therapy can be individually tailored for each patient.

Areas of interest

  • Hematology/Oncology Kinase Signaling Genetics of Kinase Dysregulation Targeted Therapies
  • Personalized Medicine

Publications

Publications

  • Knowledge graphs facilitate prediction of drug response for acute myeloid leukemia

    iScience
    1. Guangrong Qin
    2. Yue Zhang
    3. Jeffrey W. Tyner
    4. Christopher J. Kemp
    5. Ilya Shmulevich

  • Mapping the proteogenomic landscape enables prediction of drug response in acute myeloid leukemia

    Cell Reports Medicine
    1. James C. Pino
    2. Camilo Posso
    3. Sunil K. Joshi
    4. Michael Nestor
    5. Jamie Moon
    6. Joshua R. Hansen
    7. Chelsea Hutchinson-Bunch
    8. Marina A. Gritsenko
    9. Karl K. Weitz
    10. Kevin Watanabe-Smith
    11. Nicola Long
    12. Jason E. McDermott
    13. Brian J. Druker
    14. Tao Liu
    15. Jeffrey W. Tyner
    16. Anupriya Agarwal
    17. Elie Traer
    18. Paul D. Piehowski
    19. Cristina E. Tognon
    20. Karin D. Rodland
    21. Sara J.C. Gosline

  • Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia

    Nature genetics
    1. Andrew Stiff
    2. Maarten Fornerod
    3. Bailee N. Kain
    4. Deedra Nicolet
    5. Benjamin J. Kelly
    6. Katherine E. Miller
    7. Krzysztof Mrózek
    8. Isaiah Boateng
    9. Audrey Bollas
    10. Elizabeth A.R. Garfinkle
    11. Omolegho Momoh
    12. Foluke A. Fasola
    13. Hannah O. Olawumi
    14. Nuria Mencia-Trinchant
    15. Jean F. Kloppers
    16. Anne Cecilia van Marle
    17. Eileen Hu
    18. Saranga Wijeratne
    19. Gregory Wheeler
    20. Christopher J. Walker
    21. Jill Buss
    22. Adrienne Heyrosa
    23. Helee Desai
    24. Andrea Laganson
    25. Ethan Hamp
    26. Yazan Abu-Shihab
    27. Hasan Abaza
    28. Parker Kronen
    29. Sidharth Sen
    30. Megan E. Johnstone
    31. Kate Quinn
    32. Ben Wronowski
    33. Erin Hertlein
    34. Linde A. Miles
    35. Alice S. Mims
    36. Christopher C. Oakes
    37. James S. Blachly
    38. Karilyn T. Larkin
    39. Bethany Mundy-Bosse
    40. Andrew J. Carroll
    41. Bayard L. Powell
    42. Jonathan E. Kolitz
    43. Richard M. Stone
    44. Cassandra Duarte
    45. Diana Abbott
    46. Maria L. Amaya
    47. Craig T. Jordan
    48. Geoffrey L. Uy
    49. Wendy Stock
    50. Kellie J. Archer
    51. Electra D. Paskett
    52. Monica L. Guzman
    53. Ross L. Levine
    54. Kamal Menghrajani
    55. Debyani Chakravarty
    56. Michael F. Berger
    57. Daniel Bottomly
    58. Shannon K. McWeeney
    59. Jeffrey W. Tyner
    60. John C. Byrd
    61. Nathan Salomonis
    62. H. Leighton Grimes
    63. Elaine R. Mardis
    64. Ann Kathrin Eisfeld

  • Refined ELN 2024 risk stratification improves survival prognostication following venetoclax-based therapy in AML

    Blood
    1. Curtis A. Lachowiez
    2. Vishvaas I. Ravikumar
    3. Jad Othman
    4. Jenny O'Nions
    5. Daniel T. Peters
    6. Christine McMahon
    7. Ronan Swords
    8. Rachel Cook
    9. Jennifer N. Saultz
    10. Jeffrey W. Tyner
    11. Richard Dillon
    12. Joshua F. Zeidner
    13. Daniel A. Pollyea

  • Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia

    Clinical Cancer Research
    1. Rucha V. Modak
    2. Katia G. de Oliveira Rebola
    3. John McClatchy
    4. Mona Mohammadhosseini
    5. Alisa Damnernsawad
    6. Stephen E. Kurtz
    7. Christopher A. Eide
    8. Guanming Wu
    9. Ted Laderas
    10. Tamilla Nechiporuk
    11. Marina A. Gritsenko
    12. Joshua R. Hansen
    13. Chelsea Hutchinson
    14. Sara J.C. Gosline
    15. Paul Piehowski
    16. Daniel Bottomly
    17. Nicholas Short
    18. Karin Rodland
    19. Shannon K. McWeeney
    20. Jeffrey W. Tyner
    21. Anupriya Agarwal

  • Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity

    iScience
    1. Alan S. Futran
    2. Tao Lu
    3. Katherine Amberg-Johnson
    4. Jiayi Xu
    5. Xiaoxiao Yang
    6. Saidi He
    7. Sarah Boyce
    8. Jeffrey A. Bell
    9. Robert Pelletier
    10. Takao Suzuki
    11. Xianhai Huang
    12. Heng Qian
    13. Liping Fang
    14. Li Xing
    15. Zhaowu Xu
    16. Stephen E. Kurtz
    17. Jeffrey W. Tyner
    18. Wayne Tang
    19. Tao Guo
    20. Karen Akinsanya
    21. David Madge
    22. Kristian K. Jensen

  • Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy

    Blood cancer discovery
    1. Christopher A. Eide
    2. Stephen E. Kurtz
    3. Andy Kaempf
    4. Nicola Long
    5. Sunil Kumar Joshi
    6. Tamilla Nechiporuk
    7. Ariane Huang
    8. Charles A. Dibb
    9. Akosha Taylor
    10. Daniel Bottomly
    11. Shannon K. McWeeney
    12. Jessica Minnier
    13. Curtis A. Lachowiez
    14. Jennifer N. Saultz
    15. Ronan T. Swords
    16. Anupriya Agarwal
    17. Bill H. Chang
    18. Brian J. Druker
    19. Jeffrey W. Tyner

  • Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia

    Blood Advances
    1. Curtis A. Lachowiez
    2. Nicola Long
    3. Jennifer Saultz
    4. Arpita Gandhi
    5. Laura F. Newell
    6. Brandon Hayes-Lattin
    7. Richard T. Maziarz
    8. Jessica Leonard
    9. Daniel Bottomly
    10. Shannon McWeeney
    11. Jennifer Dunlap
    12. Richard Press
    13. Gabrielle Meyers
    14. Ronan Swords
    15. Rachel J. Cook
    16. Jeffrey W. Tyner
    17. Brian J. Druker
    18. Elie Traer

  • Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

    Molecular Cancer Research
    1. William M. Yashar
    2. Brittany M. Curtiss
    3. Daniel J. Coleman
    4. Jake VanCampen
    5. Garth Kong
    6. Jommel Macaraeg
    7. Joseph Estabrook
    8. Emek Demir
    9. Nicola Long
    10. Daniel Bottomly
    11. Shannon K. McWeeney
    12. Jeffrey W. Tyner
    13. Brian J. Druker
    14. Julia E. Maxson
    15. Theodore P. Braun

  • Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

    Blood
    1. Daria Frank
    2. Pradeep Kumar Patnana
    3. Jan Vorwerk
    4. Lianghao Mao
    5. Lavanya Mokada Gopal
    6. Noelle Jung
    7. Thorben Hennig
    8. Leo Ruhnke
    9. Joris Maximillian Frenz
    10. Maithreyan Kuppusamy
    11. Robert Autry
    12. Lanying Wei
    13. Kaiyan Sun
    14. Helal Mohammed Mohammed Ahmed
    15. Axel Künstner
    16. Hauke Busch
    17. Heiko Müller
    18. Stephan Hutter
    19. Gregor Hoermann
    20. Longlong Liu
    21. Xiaoqing Xie
    22. Yahya Al-Matary
    23. Subbaiah Chary Nimmagadda
    24. Fiorella Charles Cano
    25. Michael Heuser
    26. Felicitas Thol
    27. Gudrun Göhring
    28. Doris Steinemann
    29. Jürgen Thomale
    30. Theo Leitner
    31. Anja Fischer
    32. Roland Rad
    33. Christoph Röllig
    34. Heidi Altmann
    35. Desiree Kunadt
    36. Wolfgang E. Berdel
    37. Jana Hüve
    38. Felix Neumann
    39. Jürgen Klingauf
    40. Virginie Calderon
    41. Bertram Opalka
    42. Ulrich Dührsen
    43. Frank Rosenbauer
    44. Martin Dugas
    45. Julian Varghese
    46. Hans Christian Reinhardt
    47. Nikolas von Bubnoff
    48. Tarik Möröy
    49. Georg Lenz
    50. Aarif M.N. Batcha
    51. Marianna Giorgi
    52. Murugan Selvam
    53. Eunice Wang
    54. Shannon K. McWeeney
    55. Jeffrey W. Tyner
    56. Friedrich Stölzel
    57. Matthias Mann
    58. Ashok Kumar Jayavelu
    59. Cyrus Khandanpour

  • Immune cell proportions correlate with clinicogenomic features and ex vivo drug responses in acute myeloid leukemia

    Frontiers in Oncology
    1. Kyle A. Romine
    2. Daniel Bottomly
    3. William Yashar
    4. Nicola Long
    5. Matthew Viehdorfer
    6. Shannon K. McWeeney
    7. Jeffrey W. Tyner

  • Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures

    Blood
    1. Benjamin Diamond
    2. Bachisio Ziccheddu
    3. Kylee Maclachlan
    4. Justin Taylor
    5. Eileen Boyle
    6. Juan Arango Ossa
    7. Jacob Jahn
    8. Maurizio Affer
    9. Tulasigeri M. Totiger
    10. David Coffey
    11. Namrata Chandhok
    12. Justin Watts
    13. Luisa Cimmino
    14. Sydney X. Lu
    15. Niccolò Bolli
    16. Kelly Bolton
    17. Heather Landau
    18. Jae H. Park
    19. Karuna Ganesh
    20. Andrew McPherson
    21. Mikkael A. Sekeres
    22. Alexander Lesokhin
    23. David J. Chung
    24. Yanming Zhang
    25. Caleb Ho
    26. Mikhail Roshal
    27. Jeffrey Tyner
    28. Stephen Nimer
    29. Elli Papaemmanuil
    30. Saad Usmani
    31. Gareth Morgan
    32. Ola Landgren
    33. Francesco Maura

  • Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR

    Journal of Ovarian Research
    1. Wenwen Chien
    2. Jeffrey W. Tyner
    3. Sigal Gery
    4. Yueyuan Zheng
    5. Li Yan Li
    6. Mohan Shankar Gopinatha Pillai
    7. Chehyun Nam
    8. Neil A. Bhowmick
    9. De Chen Lin
    10. H. Phillip Koeffler

  • Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

    Signal Transduction and Targeted Therapy
    1. Qi Zhang
    2. Bridget Riley-Gillis
    3. Lina Han
    4. Yanan Jia
    5. Alessia Lodi
    6. Haijiao Zhang
    7. Saravanan Ganesan
    8. Rongqing Pan
    9. Sergej N. Konoplev
    10. Shannon R. Sweeney
    11. Jeremy A. Ryan
    12. Yulia Jitkova
    13. Kenneth Dunner
    14. Shaun E. Grosskurth
    15. Priyanka Vijay
    16. Sujana Ghosh
    17. Charles Lu
    18. Wencai Ma
    19. Stephen Kurtz
    20. Vivian R. Ruvolo
    21. Helen Ma
    22. Connie C. Weng
    23. Cassandra L. Ramage
    24. Natalia Baran
    25. Ce Shi
    26. Tianyu Cai
    27. Richard Eric Davis
    28. Venkata L. Battula
    29. Yingchang Mi
    30. Jing Wang
    31. Courtney D. DiNardo
    32. Michael Andreeff
    33. Jeffery W. Tyner
    34. Aaron Schimmer
    35. Anthony Letai
    36. Rose Ann Padua
    37. Carlos E. Bueso-Ramos
    38. Stefano Tiziani
    39. Joel Leverson
    40. Relja Popovic
    41. Marina Konopleva

  • A genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways that mediate resistance to sorafenib in acute myeloid leukemia

    Haematologica
    1. Alisa Damnernsawad
    2. Daniel Bottomly
    3. Stephen E. Kurtz
    4. Christopher A. Eide
    5. Shannon K. McWeeney
    6. Jeffrey W. Tyner
    7. Tamilla Nechiporuk

  • Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia

    Blood Advances
    1. Stephen E. Kurtz
    2. Christopher A. Eide
    3. Andy Kaempf
    4. Nicola Long
    5. Daniel Bottomly
    6. Olga Nikolova
    7. Brian J. Druker
    8. Shannon K. McWeeney
    9. Bill H. Chang
    10. Jeffrey W. Tyner
    11. Anupriya Agarwal

  • Comprehensive molecular characterization of a rare case of Philadelphia chromosome-positive acute myeloid leukemia

    Cold Spring Harbor Molecular Case Studies
    1. Mara W. Rosenberg
    2. Samantha L. Savage
    3. Christopher A. Eide
    4. Anna Reister Schultz
    5. Rachel Cook
    6. Richard Press
    7. Carole Rempfer
    8. Garrett Eickelberg
    9. Beth Wilmot
    10. Shannon K. McWeeney
    11. Jeffrey W. Tyner
    12. Brian J. Druker
    13. Cristina E. Tognon

  • Dual BTK/SYK inhibition with CG-806 (luxeptinib) disrupts B-cell receptor and Bcl-2 signaling networks in mantle cell lymphoma

    Cell Death and Disease
    1. Elana Thieme
    2. Tingting Liu
    3. Nur Bruss
    4. Carly Roleder
    5. Vi Lam
    6. Xiaoguang Wang
    7. Tamilla Nechiporuk
    8. Geoffrey Shouse
    9. Olga V. Danilova
    10. Daniel Bottomly
    11. Shannon K. McWeeney
    12. Jeffrey W. Tyner
    13. Stephen E. Kurtz
    14. Alexey V. Danilov

  • Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib

    Cancer Biology and Therapy
    1. Myles Vigoda
    2. Chase Mathieson
    3. Nathaniel Evans
    4. Carolyn Hale
    5. Jennifer Jennings
    6. Olivia Lucero
    7. Sophia Jeng
    8. Daniel Bottomly
    9. Daniel Clayburgh
    10. Peter Andersen
    11. Ryan Li
    12. Daniel Petrisor
    13. Jeffrey W. Tyner
    14. Shannon McWeeney
    15. Molly Kulesz-Martin

  • Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML

    Blood
    1. Fei Yang
    2. Nicola Long
    3. Tauangtham Anekpuritanang
    4. Daniel Bottomly
    5. Jonathan C. Savage
    6. Tiffany Lee
    7. Jose Solis-Ruiz
    8. Uma Borate
    9. Beth Wilmot
    10. Cristina Tognon
    11. Allison M. Bock
    12. Daniel A. Pollyea
    13. Saikripa Radhakrishnan
    14. Srinidhi Radhakrishnan
    15. Prapti Patel
    16. Robert H. Collins
    17. Srinivas Tantravahi
    18. Michael W. Deininger
    19. Guang Fan
    20. Brian Druker
    21. Ujwal Shinde
    22. Jeffrey W. Tyner
    23. Richard Press
    24. Shannon McWeeney
    25. Anupriya Agarwal

  • Integrative analysis of drug response and clinical outcome in acute myeloid leukemia

    Cancer Cell
    1. Daniel Bottomly
    2. Nicola Long
    3. Anna Reister Schultz
    4. Stephen E. Kurtz
    5. Cristina E. Tognon
    6. Kara Johnson
    7. Melissa Abel
    8. Anupriya Agarwal
    9. Sammantha Avaylon
    10. Erik Benton
    11. Aurora Blucher
    12. Uma Borate
    13. Theodore P. Braun
    14. Jordana Brown
    15. Jade Bryant
    16. Russell Burke
    17. Amy Carlos
    18. Bill H. Chang
    19. Hyun Jun Cho
    20. Stephen Christy
    21. Cody Coblentz
    22. Aaron M. Cohen
    23. Amanda d'Almeida
    24. Rachel Cook
    25. Alexey Danilov
    26. Kim Hien T. Dao
    27. Michie Degnin
    28. James Dibb
    29. Christopher A. Eide
    30. Isabel English
    31. Stuart Hagler
    32. Heath Harrelson
    33. Rachel Henson
    34. Hibery Ho
    35. Sunil K. Joshi
    36. Brian Junio
    37. Andy Kaempf
    38. Yoko Kosaka
    39. Ted Laderas
    40. Matt Lawhead
    41. Hyunjung Lee
    42. Jessica T. Leonard
    43. Chenwei Lin
    44. Evan F. Lind
    45. Selina Qiuying Liu
    46. Pierrette Lo
    47. Marc M. Loriaux
    48. Samuel Luty
    49. Julia E. Maxson
    50. Tara Macey
    51. Jacqueline Martinez
    52. Jessica Minnier
    53. Andrea Monteblanco
    54. Motomi Mori
    55. Quinlan Morrow
    56. Dylan Nelson
    57. Justin Ramsdill
    58. Angela Rofelty
    59. Alexandra Rogers
    60. Kyle A. Romine
    61. Peter Ryabinin
    62. Jennifer N. Saultz
    63. David A. Sampson
    64. Samantha L. Savage
    65. Robert Schuff
    66. Robert Searles
    67. Rebecca L. Smith
    68. Stephen E. Spurgeon
    69. Tyler Sweeney
    70. Ronan T. Swords
    71. Aashis Thapa
    72. Karina Thiel-Klare
    73. Elie Traer
    74. Jake Wagner
    75. Beth Wilmot
    76. Joelle Wolf
    77. Guanming Wu
    78. Amy Yates
    79. Haijiao Zhang
    80. Christopher R. Cogle
    81. Robert H. Collins
    82. Michael W. Deininger
    83. Christopher S. Hourigan
    84. Craig T. Jordan
    85. Tara L. Lin
    86. Micaela E. Martinez
    87. Rachel R. Pallapati
    88. Daniel A. Pollyea
    89. Anthony D. Pomicter
    90. Justin M. Watts
    91. Scott J. Weir
    92. Brian J. Druker
    93. Shannon K. McWeeney
    94. Jeffrey W. Tyner

  • Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia

    Molecular cancer therapeutics
    1. William G. Rice
    2. Stephen B. Howell
    3. Hongying Zhang
    4. Nasrin Rastgoo
    5. Andrea Local
    6. Stephen E. Kurtz
    7. Pierrette Lo
    8. Daniel Bottomly
    9. Beth Wilmot
    10. Shannon K. McWeeney
    11. Brian J. Druker
    12. Jeffrey W. Tyner