Joshua Moreau, Ph.D. (he/him)

  • Assistant Professor of Division of Oncological Sciences, School of Medicine
  • Assistant Professor of Dermatology, School of Medicine
  • Assistant Professor of Cell, Developmental and Cancer Biology, School of Medicine
  • Assistant Professor, CEDAR, OHSU Knight Cancer Institute, School of Medicine

Biography

Joshua Moreau is an Assistant Professor in the Division of Oncological Sciences, Department of Dermatology, Department of Cell, Developmental & Cancer Biology, and a member of CEDAR. His laboratory seeks to explore the intersection between adaptive immune function and tissue biology. A major research focus is to understand how tissue resident lymphocytes in barrier organs, especially the skin, integrate microenvironmental signals during inflammatory disease and cancer. Combining multiomic approaches with functional immunology, this work investigates the basic biology of tissue resident lymphocytes and the role of these cells during disease pathogenesis. A long-term goal is to leverage these insights to develop new strategies for tissue specific immunotherapy. Prior to starting his lab at OHSU, Josh completed an Ph.D. in Immunology at the Princess Margaret Cancer Centre and University of Toronto before moving to the University of California, San Francisco for a postdoc in tissue specific immunity with Dr. Michael Rosenblum. 

Education and training

  • Degrees

    • Ph.D., University of Toronto

  • Fellowship

    • Postdoctoral Fellowship, UCSF

Areas of interest

  • tissue specific immunity
  • adaptive immunity
  • cutaneous immunology
  • cancer immunotherapy
  • melanoma
  • B cells
  • hidradenitis suppurativa

Honors and awards

  • Melanoma Research Alliance Young Investigator, 2024-2027
  • Human Frontier Science Program Fellow, 2018-2021
  • Cancer Research Society SNGS Award, 2021

Publications

Publications

  • IL-12/IL-23 Blockade Reveals Patterns of Asynchronous Inflammation in Pyoderma Gangrenosum

    Journal of Investigative Dermatology
    1. Rashi Yadav
    2. Morgan Vague
    3. Malia Rettig
    4. Christopher P. Loo
    5. Kasidy Brown
    6. Abrar Samiea
    7. Joshua M. Moreau
    8. Alex G. Ortega-Loayza

  • Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche

    Science Immunology
    1. Jarish N. Cohen
    2. Victoire Gouirand
    3. Courtney E. Macon
    4. Margaret M. Lowe
    5. Ian C. Boothby
    6. Joshua M. Moreau
    7. Iris K. Gratz
    8. Angelika Stoecklinger
    9. Casey T. Weaver
    10. Arlene H. Sharpe
    11. Roberto R. Ricardo-Gonzalez
    12. Michael D. Rosenblum

  • Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa

    JCI Insight
    1. Margaret M. Lowe
    2. Jarish N. Cohen
    3. Madison I. Moss
    4. Sean Clancy
    5. James P. Adler
    6. Ashley E. Yates
    7. Haley B. Naik
    8. Rashi Yadav
    9. Mariela Pauli
    10. Ian Taylor
    11. Austin McKay
    12. Hobart Harris
    13. Esther Kim
    14. Scott L. Hansen
    15. Michael D. Rosenblum
    16. Joshua M. Moreau

  • Identifying and antagonizing the interactions between layilin and glycosylated collagens

    Cell Chemical Biology
    1. Jeff E. Glasgow
    2. James R. Byrnes
    3. Susannah D. Barbee
    4. Joshua M. Moreau
    5. Michael D. Rosenblum
    6. James A. Wells

  • Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

    Journal of Visualized Experiments
    1. Madison I. Moss
    2. Mariela Pauli
    3. Joshua M. Moreau
    4. Jarish N. Cohen
    5. Michael D. Rosenblum
    6. Margaret M. Lowe

  • Layilin anchors regulatory t cells in skin

    Journal of Immunology
    1. Pooja Mehta
    2. Victoire Gouirand
    3. Devi P. Boda
    4. Jingxian Zhang
    5. Sofia V. Gearty
    6. Bahar Zirak
    7. Margaret M. Lowe
    8. Sean Clancy
    9. Ian Boothby
    10. Kelly M. Mahuron
    11. Adam Fries
    12. Matthew F. Krummel
    13. Parminder Mankoo
    14. Hsin Wen Chang
    15. Jared Liu
    16. Joshua M. Moreau
    17. Tiffany C. Scharschmidt
    18. Adil Daud
    19. Esther Kim
    20. Isaac M. Neuhaus
    21. Hobart W. Harris
    22. Wilson Liao
    23. Michael D. Rosenblum

  • Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation

    Science Immunology
    1. Joshua M. Moreau
    2. Miqdad O. Dhariwala
    3. Victoire Gouirand
    4. Devi P. Boda
    5. Ian C. Boothby
    6. Margaret M. Lowe
    7. Jarish N. Cohen
    8. Courtney E. Macon
    9. John M. Leech
    10. Lokesh A. Kalekar
    11. Tiffany C. Scharschmidt
    12. Michael D. Rosenblum

  • A Blueprint for Identifying Phenotypes and Drug Targets in Complex Disorders with Empirical Dynamics

    Patterns
    1. Madison S. Krieger
    2. Joshua M. Moreau
    3. Haiyu Zhang
    4. May Chien
    5. James L. Zehnder
    6. Morgan Craig

  • Layilin augments integrin activation to promote antitumor immunity

    Journal of Experimental Medicine
    1. Kelly M. Mahuron
    2. Joshua M. Moreau
    3. Jeff E. Glasgow
    4. Devi P. Boda
    5. Mariela L. Pauli
    6. Victoire Gouirand
    7. Luv Panjabi
    8. Robby Grewal
    9. Jacob M. Luber
    10. Anubhav N. Mathur
    11. Renny M. Feldman
    12. Eric Shifrut
    13. Pooja Mehta
    14. Margaret M. Lowe
    15. Michael D. Alvarado
    16. Alexander Marson
    17. Meromit Singer
    18. Jim Wells
    19. Ray Jupp
    20. Adil I. Daud
    21. Michael D. Rosenblum

  • c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells

    Cell Reports
    1. Eric A. Shikatani
    2. Rickvinder Besla
    3. Sherine Ensan
    4. Aditi Upadhye
    5. Nadiya Khyzha
    6. Angela Li
    7. Takuo Emoto
    8. Felix Chiu
    9. Norbert Degousee
    10. Joshua M. Moreau
    11. Heather M. Perry
    12. Danya Thayaparan
    13. Henry S. Cheng
    14. Shaun Pacheco
    15. David Smyth
    16. Hossein Noyan
    17. Caleb C.J. Zavitz
    18. Carla M.T. Bauer
    19. Ingo Hilgendorf
    20. Peter Libby
    21. Filip K. Swirski
    22. Jennifer L. Gommerman
    23. Jason E. Fish
    24. Martin R. Stampfli
    25. Myron I. Cybulsky
    26. Barry B. Rubin
    27. Christopher J. Paige
    28. Timothy P. Bender
    29. Coleen A. McNamara
    30. Mansoor Husain
    31. Clinton S. Robbins

  • Differential regulation of IgA + B cells in vitro by stromal cells from distinctive anatomical compartments

    Journal of Leukocyte Biology
    1. Selena Y. Cen
    2. Joshua M. Moreau
    3. Caren Furlonger
    4. Alexandra Berger
    5. Christopher J. Paige

  • Inflammatory T cells maintain a healing disposition

    Science Immunology
    1. Joshua M. Moreau
    2. Michael D. Rosenblum

  • Interleukin-15 in cancer immunotherapy

    Journal for immunotherapy of cancer
    1. Alexandra Berger
    2. Sarah J. Colpitts
    3. Melanie S.S. Seabrook
    4. Caren L. Furlonger
    5. Maura B. Bendix
    6. Joshua M. Moreau
    7. William M. McKillop
    8. Jeffrey A. Medin
    9. Christopher J. Paige

  • Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses

    Science Immunology
    1. Lokesh A. Kalekar
    2. Jarish N. Cohen
    3. Nicolas Prevel
    4. Priscila Muñoz Sandoval
    5. Anubhav N. Mathur
    6. Joshua M. Moreau
    7. Margaret M. Lowe
    8. Audrey Nosbaum
    9. Paul J. Wolters
    10. Anna Haemel
    11. Francesco Boin
    12. Michael D. Rosenblum

  • Bone marrow basophils provide survival signals to immature B cells in vitro but are dispensable in vivo

    PloS one
    1. Joshua M. Moreau
    2. Selena Cen
    3. Alexandra Berger
    4. Caren Furlonger
    5. Christopher J. Paige

  • Tumor-secreted products repress B-cell lymphopoiesis in a murine model of breast cancer

    European Journal of Immunology
    1. Joshua M. Moreau
    2. Michael Mielnik
    3. Alexandra Berger
    4. Caren Furlonger
    5. Christopher J. Paige

  • Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses

    Blood
    1. Joshua M. Moreau
    2. Alexandra Berger
    3. Megan E. Nelles
    4. Michael Mielnik
    5. Caren Furlonger
    6. Selena Y. Cen
    7. Rickvinder Besla
    8. Clinton S. Robbins
    9. Christopher J. Paige

  • Murine splenic CD4⁺ T cells, induced by innate immune cell interactions and secreted factors, develop antileukemia cytotoxicity

    Cancer Immunology Research
    1. Megan E. Nelles
    2. Joshua M. Moreau
    3. Caren L. Furlonger
    4. Alexandra Berger
    5. Jeffrey A. Medin
    6. Christopher J. Paige