Kathleen A. Grant, Ph.D.

  • Professor, Oregon National Primate Research Center
  • Professor of Behavioral Neuroscience, School of Medicine
  • Chief, Division of Neuroscience, Oregon National Primate Research Center
  • Behavioral Neuroscience Graduate Program, School of Medicine

Biography

Kathleen (Kathy) Grant, Ph.D. is Chief and Professor, Division of Neuroscience at the Oregon National Primate Research Center. Her scientific interests are in animal models of addiction, particularly alcoholism.

Her studies in non human primates are aimed at understanding the co-morbidity of stress and excessive alcohol drinking examining risk factors such genetics, in utero exposure, adolescent vulnerability, sex differences and menstrual cycle effects, brain adaptations and cognitive impairments.

Education and training

  • Degrees

    • B.S., 1979, University of Santa Clara
    • M.S., 1982, University of Washington
    • Ph.D., 1984, University of Washington

  • Fellowship

    • National Research Service Award, University of Chicago, 1984-1987

Memberships and associations:

  • 1992- Alcoholism: Clinical and Experimental Research; 2001-present: Reviewing Editor
  • 1995- Behavioral Pharmacology
  • 2013- Alcohol
  • RSA, ASPET, SFN, APA, ISBRA

Areas of interest

  • Animal models of alcohol and drug addiction
  • Stress response to chronic alcohol drinking
  • MRI imaging of brain circuitry
  • Advances in cognitive assessment of primate behavior
  • Behavioral pharmacology

Additional information

Honors and awards

  • 2009 - 2013 National Advisory Council, NIAAA
  • 2013 Henri Begleiter Excellence in Research Award, Research Society on Alcoholism
  • 2015 Master Lecture, 2015 American Psychological Association Convention
  • 2016-2018 President, Behavioral Pharmacology Society (BPS)
  • 2017 Plenary Lecture, Collaborative Perspectives on Addiction, APA

Publications

Selected publications

  •       Grant, K. A., Newman, N. N., Gonzales, S. W., & Cuzon Carlson, V. C. (2022). Impact of putamen inhibition by DREADDs on schedule-induced drinking in rhesus monkeys. Journal Experimental Analysis of Behavior, 117(3), 493–504. https://doi.org/10.1002/jeab.761
  •      Grant KA, Newman N, Lynn C, Davenport C, Gonzales S, Cuzon Carlson VC, Kroenke CD. (2022) Brain Functional Connectivity Mapping of Behavioral Flexibility in Rhesus Monkeys. J Neurosci. 2022 Jun 15;42(24):4867-4878. doi: 10.1523/JNEUROSCI.0816-21.2022. Epub 2022 May 12. PMID: 35552233; PMCID: PMC9188385.
  •      Moore S, Radunskaya A, Zollinger E, Grant KA, Gonzales S, Walter NAR, Baker EJ. (2022) Pairing food and drink: A physiological model of blood ethanol levels for a variety of drinking behaviors. Math Biosci. 2022 Mar;345:108778. doi: 10.1016/j.mbs.2022.108778. Epub 2022 Jan 13. PMID: 35033503; PMCID: PMC8918017.
  •      Patel RR, Varodayan FP, Herman MA, Jimenez V, Agnore R, Gao L, Bajo M, Cuzon Carlson VC, Walter NA, Fei SS, Grant KA, Roberto M. (2022) Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques. Neuropsychopharmacology. 2022
  •      Baker EJ, Moore S, Gonzales SW, Grant KA. (2023) Long-term drinking stability in the open-access self-administration monkey model. Alcohol. 2023 Dec;113:41-48. doi: 10.1016/j.alcohol.2023.07.002. Epub 2023 Jul 27. PMID: 37516372.
  •      Mulholland, P. J., Padula, A. E., Wilhelm, L. J., Park, B., Grant, K. A., Ferguson, B. M., & Cervera-Juanes, R. (2023). Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking. Translational psychiatry, 13(1), 364. https://doi.org/10.1038/s41398-023-02676-z
  •      Ford, M. M., George, B. E., Van Laar, V. S., Holleran, K. M., Naidoo, J., Hadaczek, P., Vanderhooft, L. E., Peck, E. G., Dawes, M. H., Ohno, K., Bringas, J., McBride, J. L., Samaranch, L., Forsayeth, J. R., Jones, S. R., Grant, K. A., & Bankiewicz, K. S. (2023). GDNF gene therapy for alcohol use disorder in male non-human primates. Nature medicine, 29(8), 2030–2040. https://doi.org/10.1038/s41591-023-02463-9
  •      Baker, E. J., Moore, S., Gonzales, S. W., & Grant, K. A. (2023). Long-term drinking stability in the open-access self-administration monkey model. Alcohol (Fayetteville, N.Y.), 113, 41–48. doi.org/10.1016/j.alcohol.2023.07.002
  •      Juanes, R. C., Mulholland, P., Padula, A., Wilhelm, L., Park, B., Grant, K., & Ferguson, B. (2023). Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking. Research square, rs.3.rs-3315122. https://doi.org/10.21203/rs.3.rs-3315122/v1
  •      Lewis SA, Cinco IR, Doratt BM, Blanton MB, Hoagland C, Newman N, Davies M, Grant KA, Messaoudi I. (2023) Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung. EBioMedicine. 2023 Nov;97:104812. doi: 10.1016/j.ebiom.2023.104812. Epub 2023 Oct 2. PMID: 37793211; PMCID: PMC10562860.