Kim A. Neve, Ph.D.
- Professor of Behavioral Neuroscience, School of Medicine
- Research Pharmacologist, VAMC
- Behavioral Neuroscience Graduate Program, School of Medicine
- Neuroscience Graduate Program, School of Medicine
Biography
Background
Kim Neve received his B.A. in 1979 from Dana College, in Blair, Nebraska, and entered the Psychobiology graduate program at the University of California, Irvine. He received his Ph.D. in Biological Sciences from UCI in 1984, then spent 3 years as a postdoctoral fellow in the laboratory of Perry Molinoff in the Department of Pharmacology at the University of Pennsylvania. In 1987 he was hired as a research pharmacologist at the Portland VA Medical Center, with appointments as assistant professor in the Departments of Psychiatry and Pharmacology. Neve joined the Department of Behavioral Neuroscience in 1995, and rose to the rank of professor in 1998.
Summary of Current Research
Research in the Neve lab is broadly concerned with the function of the brain dopamine system. We use genetically modified dopamine receptors expressed in cells in culture and in mouse brain to explore the effects of dopamine, therapeutic drugs, and abused substances on the receptors and the role of the receptors in dopamine-dependent behaviors. An example of this work is our utilization of in vitro mutagenesis to investigate the interactions of dopamine D2 receptors with agonists and signaling pathway, another is our use of virus-mediated expression of dopamine receptors in vivo to normalize behavior in dopamine receptor knock-out mice. The techniques that we use in these investigations include co-expression and biochemical analysis of a variety of signal transduction molecules (wildtype and mutant receptors, G proteins, effector enzymes), metabolic labeling and immunoprecipitation, confocal fluorescence microscopy, and mouse behavioral assays for the rewarding and aversive properties of abused drugs.
Non-Academic Interests
Family, snowboarding, cycling, reading
Education and training
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Degrees
- B.A., 1979, Dana College
- Ph.D., 1984, University of California at Irvine
Areas of interest
- Dopamine receptors
- Signal transduction
- Cellular and molecular biology of g protein-coupled receptors
- Structure-function analysis of dopamine receptors
- Behavior
Publications
Publications
Comparison of the function of two novel human dopamine D2 receptor variants identifies a likely mechanism for their pathogenicity
Biochemical PharmacologyGait Abnormalities and Aberrant D2 Receptor Expression and Signaling in Mice Carrying the Human Pathogenic Mutation DRD2I212F
Molecular pharmacologyTyrphostin A9 protects axons in experimental autoimmune encephalomyelitis through activation of ERKs
Life SciencesA Gain-of-Function Variant in Dopamine D2 Receptor and Progressive Chorea and Dystonia Phenotype
Movement DisordersSignaling-Biased and Constitutively Active Dopamine D2 Receptor Variant
ACS Chemical NeuroscienceArrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation
Molecular PsychiatryTaar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1
eLifeCorrelated gene expression and anatomical communication support synchronized brain activity in the mouse functional connectome
Journal of NeuroscienceCocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors
eLifeDesensitized D2 autoreceptors are resistant to trafficking
Scientific ReportsActivation of D1/5 Dopamine Receptors
NeuropsychopharmacologyEffects of D1 receptor knockout on fear and reward learning
Neurobiology of Learning and MemoryGenetic polymorphisms affect mouse and human trace amine-associated receptor 1 function
PloS oneDepression of serotonin synaptic transmission by the dopamine Precursor L-DOPA
Cell ReportsDistinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium
eLifeRole for Rab10 in methamphetamine-induced behavior
PloS oneUse of radiolabeled antagonist assays for assessing agonism at D2 and D3 dopamine receptors
Journal of Neuroscience MethodsCharacterization of [3H]LS-3-134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand
Journal of neurochemistryMutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor
Journal of Biological ChemistryNormalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration
NeuroscienceLoss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway
Journal of NeuroscienceA dopam/ine D 2 receptor mutant capable of G protein- mediated signaling but deficient in arrestin binding
Molecular pharmacologyAn intracellular loop 2 amino acid residue determines differential binding of arrestin to the dopamine D 2 and D 3 receptors
Molecular pharmacologyNovel interaction of the dopamine D2 receptor and the Ca 2+ binding protein S100B
Molecular pharmacology