Kimberly E. Beatty, Ph.D.

  • Associate Professor of Biomedical Engineering, School of Medicine
  • Associate Professor of Physiology and Pharmacology, School of Medicine
  • Biomedical Engineering Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine
  • OHSU Center for Spatial Systems Biomedicine, School of Medicine
  • Chemical Physiology and Biochemistry, School of Medicine

Biography

The Beatty group applies novel chemical tools and technologies towards illuminating human diseases.  When Dr. Beatty started her group at OHSU in 2012, she decided that her focus would be on using innovative and creative approaches to identify and investigate the molecular basis of human diseases, including tuberculosis (TB) and breast cancer.  Research in the Beatty group is collaborative and interdisciplinary.  Her team works on the following projects: 

1.1  Chemical tools for detecting hydrolase activities in Mycobacterium tuberculosis (Mtb).

1.2  Illuminating drug susceptibility in Mtb.

1.3  A new technology for tracking and mapping proteins by light and electron microscopy.

1.4  Identifying molecular interactions that confer drug resistance in breast cancer.

1.5  Synthesis of new fluorescent and fluorogenic probes.

Before joining the faculty at OHSU, Dr. Beatty earned her PhD in chemistry with Professor David Tirrell at Caltech. She completed her postdoc training at UC Berkeley with Professor Carolyn Bertozzi. 

Education and training

  • Degrees

    • B.S., 2002, University of California, Santa Barbara
    • Ph.D., 2008, California Institute of Technology

Areas of interest

  • Developing new chemical tools for illuminating human diseases

Publications

Publications

  • Where chemical biology meets physiology

    Nature Chemical Biology
    1. Kimberly E. Beatty
    2. Carsten Schultz

  • Orthogonal Versatile Interacting Peptide Tags for Imaging Cellular Proteins

    Biochemistry
    1. Alexa Suyama
    2. Kaylyn L. Devlin
    3. Miguel Macias-Contreras
    4. Julia K. Doh
    5. Ujwal Shinde
    6. Kimberly E. Beatty

  • Investigating β-Lactam Drug Targets in Mycobacterium tuberculosis Using Chemical Probes

    ACS Infectious Diseases
    1. Samantha R. Levine
    2. Kimberly E. Beatty

  • MiniVIPER Is a Peptide Tag for Imaging and Translocating Proteins in Cells

    Biochemistry
    1. Julia K. Doh
    2. Savannah J. Tobin
    3. Kimberly E. Beatty

  • Coloring Cell Complexity

    ACS Central Science
    1. Kimberly E. Beatty

  • Generation of coilr probe peptides for viper-labeling of cellular proteins

    Bio-protocol
    1. Julia K. Doh
    2. Savannah J. Tobin
    3. Kimberly E. Beatty

  • Imaging viper-labeled cellular proteins by correlative light and electron microscopy

    Bio-protocol
    1. Julia K. Doh
    2. Young Hwan Chang
    3. Caroline A. Enns
    4. Claudia S. Lopez
    5. Kimberly E. Beatty

  • Implementing viper for imaging cellular proteins by fluorescence microscopy

    Bio-protocol
    1. Julia K. Doh
    2. Caroline A. Enns
    3. Kimberly E. Beatty

  • VIPERnano

    ACS Applied Materials and Interfaces
    1. Erin Morgan
    2. Julia Doh
    3. Kimberly Beatty
    4. Norbert Reich

  • VIPER is a genetically encoded peptide tag for fluorescence and electron microscopy

    Proceedings of the National Academy of Sciences of the United States of America
    1. Julia K. Doh
    2. Jonathan D. White
    3. Hannah K. Zane
    4. Young Hwan Chang
    5. Claudia S. López
    6. Caroline A. Enns
    7. Kimberly E. Beatty

  • Versatile Interacting Peptide (VIP) Tags for Labeling Proteins with Bright Chemical Reporters

    ChemBioChem
    1. Hannah K. Zane
    2. Julia K. Doh
    3. Caroline A. Enns
    4. Kimberly E. Beatty

  • Profiling Esterases in Mycobacterium tuberculosis Using Far-Red Fluorogenic Substrates

    ACS chemical biology
    1. Katie R. Tallman
    2. Samantha R. Levine
    3. Kimberly E. Beatty

  • Small-Molecule Probes Reveal Esterases with Persistent Activity in Dormant and Reactivating Mycobacterium tuberculosis

    ACS Infectious Diseases
    1. Katie R. Tallman
    2. Samantha R. Levine
    3. Kimberly E. Beatty

  • Synthesis of a far-red fluorophore and its use as an esterase probe in living cells

    Chemical Communications
    1. Samantha R. Levine
    2. Kimberly E. Beatty

  • Far-red fluorogenic probes for esterase and lipase detection

    ChemBioChem
    1. Katie R. Tallman
    2. Kimberly E. Beatty

  • An expanded set of fluorogenic sulfatase activity probes

    ChemBioChem
    1. Elizabeth L. Smith
    2. Carolyn R. Bertozzi
    3. Kimberly E. Beatty

  • Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains

    Proceedings of the National Academy of Sciences of the United States of America
    1. Kimberly E. Beatty
    2. Monique Williams
    3. Brian L. Carlson
    4. Benjamin M. Swarts
    5. Robin M. Warren
    6. Paul D. Van Helden
    7. Carolyn R. Bertozzi

  • A BODIPY-cyclooctyne for protein imaging in live cells

    ChemBioChem
    1. Kimberly E. Beatty
    2. Janek Szychowski
    3. John D. Fisk
    4. David A. Tirrell

  • Bioluminescent probes of sulfatase activity

    ChemBioChem
    1. Jason S. Rush
    2. Kimberly E. Beatty
    3. Carolyn R. Bertozzi

  • Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition

    ChemBioChem
    1. Kimberly E. Beatty
    2. John D. Fisk
    3. Brian P. Smart
    4. Ying Ying Lu
    5. Janek Szychowski
    6. Matthew J. Hangauer
    7. Jeremy M. Baskin
    8. Carolyn R. Bertozzi
    9. David A. Tirrell

  • Cell-selective metabolic labeling of proteins

    Nature Chemical Biology
    1. John T. Ngo
    2. Julie A. Champion
    3. Alborz Mahdavi
    4. I. Caglar Tanrikulu
    5. Kimberly E. Beatty
    6. Rebecca E. Connor
    7. Tae Hyeon Yoo
    8. Daniela C. Dieterich
    9. Erin M. Schuman
    10. David A. Tirrell

  • Two-color labeling of temporally defined protein populations in mammalian cells

    Bioorganic and Medicinal Chemistry Letters
    1. Kimberly E. Beatty
    2. David A. Tirrell

  • Fluorescence visualization of newly synthesized proteins in mammalian cells

    Angewandte Chemie - International Edition
    1. Kimberly E. Beatty
    2. Julie C. Liu
    3. Fang Xie
    4. Daniela C. Dieterich
    5. Erin M. Schuman
    6. Qian Wang
    7. David A. Tirrell

  • Selective dye-labeling of newly synthesized proteins in bacterial cells

    Journal of the American Chemical Society
    1. Kimberly E. Beatty
    2. Fang Xie
    3. Qian Wang
    4. David A. Tirrell

  • Reactivity of recombinant and mutant vanadium bromoperoxidase from the red alga Corallina officinalis

    Journal of Inorganic Biochemistry
    1. Jayme N. Carter
    2. Kimberly E. Beatty
    3. Matthew T. Simpson
    4. Alison Butler