Dr. Seghete's research takes a translational approach to perinatal mental health and substance use, with a particular emphasis on moving neurobiological research on perinatal mental health and substance use towards the development and implementation of preventive interventions. Her research reflects investigation of the continuum of translational research, from basic clinical science to evaluation of intervention mechanisms of action in pregnant and postpartum people with variable risk factors for perinatal mental health difficulties, substance use, parenting stress, and their intersections. Childhood adversity and trauma are a core theme running through her research, with a focus on its impact across the lifespan (adolescence through adulthood) and as a moderator of treatment outcome.  She emphasize neurobiological methods to identify cognitive and emotional brain processes that can then be targeted in behavioral interventions. Her research also takes clinical science to the next level, with recent efforts expanding to include using our knowledge of mechanisms of action to refine interventions so they are potable and sustainable within primary prenatal care settings that can be provided to a larger catchment of at-risk individuals (e.g., childhood adversity, substance use).  Dr. Seghete is the Director of the Pediatric Neuropsychology Clinic in the Child and Adolescent Psychiatry Clinic at Doernbecher Children's Hospital and also has extensive clinical expertise working in women’s mental health.