Laurence Trussell, Ph.D.
- Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
- Professor, Oregon Hearing Research Center, School of Medicine
- Neuroscience Graduate Program, School of Medicine
- Physiology and Pharmacology Graduate Program, School of Medicine
- Program in Molecular and Cellular Biosciences, School of Medicine
Biography
Laurence Trussell received his Ph.D. in Biology from the University of California, Los Angeles in 1983. After initial postdoctoral work at UCLA, he obtained further training at Washington University, St. Louis. In 1990, he received a faculty appointment at the University of Wisconsin, Madison. In 1999, he was appointed as professor in the Oregon Hearing Research Center with an appointment as scientist at the Vollum Institute.
These are a few of Dr. Trussell's major milestones and significant discoveries:
- Neurons that encode timing of acoustic signals are molecularly and biophysically specialized for that function
- Cellular/synaptic learning mechanisms occur even at the earliest levels of sensory processing
- Co-release of multiple transmitters from neurons act together on the same receptor
- Ca2+ channels are expressed in axons and control the triggering of complex spike activity
Dr. Trussel is also the Interim Director of the Oregon Hearing Research Center (OHRC).
Education and training
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Degrees
- Ph.D., 1983, University of California, Los Angeles
Areas of interest
- Brainstem circuits that process acoustic signals
- Synaptic physiology: How do cells and synapses preserve information provided by the ear?
Additional information
Publications
Publications
Molecular logic for cellular specializations that initiate the auditory parallel processing pathways
Nature communicationsCalcium-Sensitive Subthreshold Oscillations and Electrical Coupling in Principal Cells of Mouse Dorsal Cochlear Nucleus
Journal of NeuroscienceThe Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons
eLifeDescending Axonal Projections from the Inferior Colliculus Target Nearly All Excitatory and Inhibitory Cell Types of the Dorsal Cochlear Nucleus
Journal of NeuroscienceElectrical signaling in cochlear efferents is driven by an intrinsic neuronal oscillator
Proceedings of the National Academy of Sciences of the United States of AmericaKCNQ Channels Enable Reliable Presynaptic Spiking and Synaptic Transmission at High Frequency
Journal of NeuroscienceVestibular Organ Dissection and Whole-Mount Immunolabeling in Mouse
Bio-protocolDistinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons
eLifeIncomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse
eLifeTrigeminal Contributions to the Dorsal Cochlear Nucleus in Mouse
Frontiers in NeuroscienceIdentification of an inhibitory neuron subtype, the l-stellate cell of the cochlear nucleus
eLifeSelective targeting of unipolar brush cell subtypes by cerebellar mossy fibers
eLifeRapid Rebalancing of Excitation and Inhibition by Cortical Circuitry
NeuronCorelease of inhibitory neurotransmitters in the mouse auditory midbrain
Journal of NeuroscienceDouble-Nanodomain Coupling of Calcium Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing
NeuronSerotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific
Cell ReportsSlow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters
NeuronAuditory Golgi cells are interconnected predominantly by electrical synapses
Journal of neurophysiologySpontaneous activity defines effective convergence ratios in an inhibitory circuit
Journal of NeuroscienceON and OFF unipolar brush cells transform multisensory inputs to the auditory system
NeuronSingle granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus
Journal of NeuroscienceChemical synaptic transmission onto superficial stellate cells of the mouse dorsal cochlear nucleus
Journal of neurophysiologyControl of interneuron firing by subthreshold synaptic potentials in principal cells of the dorsal cochlear nucleus
NeuronPresynaptic HCN Channels Regulate Vesicular Glutamate Transport
Neuron