Laurence Trussell, Ph.D.

  • Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
  • Professor, Oregon Hearing Research Center, School of Medicine
  • Neuroscience Graduate Program, School of Medicine
  • Physiology and Pharmacology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Laurence Trussell received his Ph.D. in Biology from the University of California, Los Angeles in 1983. After initial postdoctoral work at UCLA, he obtained further training at Washington University, St. Louis. In 1990, he received a faculty appointment at the University of Wisconsin, Madison. In 1999, he was appointed as professor in the Oregon Hearing Research Center with an appointment as scientist at the Vollum Institute.

These are a few of Dr. Trussell's major milestones and significant discoveries:
- Neurons that encode timing of acoustic signals are molecularly and biophysically specialized for that function
- Cellular/synaptic learning mechanisms occur even at the earliest levels of sensory processing
- Co-release of multiple transmitters from neurons act together on the same receptor
- Ca2+ channels are expressed in axons and control the triggering of complex spike activity

Dr. Trussel is also the Interim Director of the Oregon Hearing Research Center (OHRC).

Education and training

  • Degrees

    • Ph.D., 1983, University of California, Los Angeles

Areas of interest

  • Brainstem circuits that process acoustic signals
  • Synaptic physiology: How do cells and synapses preserve information provided by the ear?

Publications

Publications

  • Molecular logic for cellular specializations that initiate the auditory parallel processing pathways

    Nature communications
    1. Junzhan Jing
    2. Ming Hu
    3. Tenzin Ngodup
    4. Qianqian Ma
    5. Shu Ning Natalie Lau
    6. M. Cecilia Ljungberg
    7. Matthew J. McGinley
    8. Laurence O. Trussell
    9. Xiaolong Jiang
  • Calcium-Sensitive Subthreshold Oscillations and Electrical Coupling in Principal Cells of Mouse Dorsal Cochlear Nucleus

    Journal of Neuroscience
    1. Hui Hong
    2. Lucille A. Moore
    3. Pierre F. Apostolides
    4. Laurence O. Trussell
  • The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons

    eLife
    1. Tenzin Ngodup
    2. Tomohiko Irie
    3. Seán P. Elkins
    4. Laurence O. Trussell
  • Descending Axonal Projections from the Inferior Colliculus Target Nearly All Excitatory and Inhibitory Cell Types of the Dorsal Cochlear Nucleus

    Journal of Neuroscience
    1. Timothy S. Balmer
    2. Laurence O. Trussell
  • Electrical signaling in cochlear efferents is driven by an intrinsic neuronal oscillator

    Proceedings of the National Academy of Sciences of the United States of America
    1. Hui Hong
    2. Douglas Zeppenfeld
    3. Laurence O. Trussell
  • KCNQ Channels Enable Reliable Presynaptic Spiking and Synaptic Transmission at High Frequency

    Journal of Neuroscience
    1. Yihui Zhang
    2. Dainan Li
    3. Youad Darwish
    4. Xin Fu
    5. Laurence O. Trussell
    6. Hai Huang
  • Vestibular Organ Dissection and Whole-Mount Immunolabeling in Mouse

    Bio-protocol
    1. Timothy S. Balmer
    2. Laurence O. Trussell
  • Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons

    eLife
    1. Gabriel E. Romero
    2. Laurence O. Trussell
  • Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse

    eLife
    1. Timothy S. Balmer
    2. Carolina Borges-Merjane
    3. Laurence O. Trussell
  • Trigeminal Contributions to the Dorsal Cochlear Nucleus in Mouse

    Frontiers in Neuroscience
    1. Timothy S. Balmer
    2. Laurence O. Trussell
  • Identification of an inhibitory neuron subtype, the l-stellate cell of the cochlear nucleus

    eLife
    1. Tenzin Ngodup
    2. Gabriel E. Romero
    3. Laurence O. Trussell
  • Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers

    eLife
    1. Timothy S. Balmer
    2. Laurence O. Trussell
  • Rapid Rebalancing of Excitation and Inhibition by Cortical Circuitry

    Neuron
    1. Alexandra K. Moore
    2. Aldis P. Weible
    3. Timothy S. Balmer
    4. Laurence O. Trussell
    5. Michael Wehr
  • Corelease of inhibitory neurotransmitters in the mouse auditory midbrain

    Journal of Neuroscience
    1. Lucille A. Moore
    2. Laurence O. Trussell
  • Double-Nanodomain Coupling of Calcium Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing

    Neuron
    1. Tomohiko Irie
    2. Laurence O. Trussell
  • Serotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific

    Cell Reports
    1. Zheng Quan Tang
    2. Laurence O. Trussell
  • Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters

    Neuron
    1. Hsin Wei Lu
    2. Timothy S. Balmer
    3. Gabriel E. Romero
    4. Laurence O. Trussell
  • Auditory Golgi cells are interconnected predominantly by electrical synapses

    Journal of neurophysiology
    1. Daniel B. Yaeger
    2. Laurence O. Trussell
  • Spontaneous activity defines effective convergence ratios in an inhibitory circuit

    Journal of Neuroscience
    1. Hsin Wei Lu
    2. Laurence O. Trussell
  • ON and OFF unipolar brush cells transform multisensory inputs to the auditory system

    Neuron
    1. Carolina Borges-Merjane
    2. Laurence O. Trussell
  • Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus

    Journal of Neuroscience
    1. Daniel B. Yaeger
    2. Laurence O. Trussell
  • Chemical synaptic transmission onto superficial stellate cells of the mouse dorsal cochlear nucleus

    Journal of neurophysiology
    1. Pierre F. Apostolides
    2. Laurence O. Trussell
  • Control of interneuron firing by subthreshold synaptic potentials in principal cells of the dorsal cochlear nucleus

    Neuron
    1. Pierre F. Apostolides
    2. Laurence O. Trussell
  • Presynaptic HCN Channels Regulate Vesicular Glutamate Transport

    Neuron
    1. Hai Huang
    2. Laurence O. Trussell