Leo L. Han, M.D., M.P.H.

  • Associate Professor of Obstetrics and Gynecology, School of Medicine
  • Affiliate Associate Professor, Oregon National Primate Research Center

Biography

Leo Han, M.D., M.P.H. is an Associate Professor of Obstetrics and Gynecology. He completed medical school at Northwestern (2010), residency at the University of Colorado (2014), and fellowship here at OHSU (2017) with a Master’s in Public Health.  He currently is also a former Reproductive Science Development Program (RSDP) K12 scholar.

Dr. Han provides full spectrum obstetric and gynecologic care at the Center for Women’s Health, with a focus on family planning.

Dr. Han’s research spans a diverse range in reproductive health and family planning.  His primary research involves non-hormonal contraceptive discovery and understanding fertility regulation in the lower reproductive tract. In particular, he is interested in the cervix as a target for new contraceptive methods and has clinical, translational and basic science projects focused on studying the effects of progestogens and non-steroid modulators of mucus on the endocervix. He is also interested in the intersection of family planning and the internet, and understanding how digital information platforms influence the public perception of contraception and abortion care.  Dr. Han is the co-director of the resident research program at OHSU. 

Dr Han’s major research focus is in developing new, non-hormonal contraceptives.  His projects in contraception have led to collaborations with research scientists at the Oregon National Primate Research Center (ONPRC), the Population Council, University of North Carolina, and the World Health Organization (WHO). His current research is on regulation cervical mucus, specifically, defining the endocervix as a target for fertility regulation.

Education and training

  • Degrees

    • M.D., 2010, Northwestern Center Feinberg School of Medicine
    • M.P.H., 2016, Oregon Health & Science University

  • Residency

    • University of Colorado in Denver

  • Fellowship

    • Family Planning 2017, Oregon Health & Science University

Memberships and associations:

  • American College of Obstetricians and Gynecologists
  • Reproductive Scientist Development Program
  • Society of Family Planning
  • Society for Reproductive Investigation
  • Society for the Study of Reproduction
  • American Society for Reproductive Medicine

Areas of interest

  • Reproductive Medicine
  • Family Planning
  • Contraception
  • Public Health

Additional information

Publications

Elsevier pure profile

Selected publications

  • Han L, Andrews W, Wong K, Jensen JT. Conditionally reprogrammed macaque endocervical cells retain steroid receptor expression and produce mucus. Biol Reprod. 2020 May 26;102(6):1191-1202. doi: 10.1093/biolre/ioaa039. PMID: 32232331; PMCID: PMC7253786.
  • Han L, Padua E, Hart KD, Edelman A, Jensen JT. Comparing cervical mucus changes in response to an oral progestin or oestrogen withdrawal in ovarian-suppressed women: a clinical pilot. Eur J Contracept Reprod Health Care. 2019 Jun;24(3):209-215. doi: 10.1080/13625187.2019.1605503. Epub 2019 May 8. PMID: 31066303; PMCID: PMC6638556.
  • Han L, Padua E, Edelman A, Jensen JT. Appraising cervical mucus: a new approach to evaluating contraceptives. Eur J Contracept Reprod Health Care. 2018 Feb;23(1):78-83. doi: 10.1080/13625187.2018.1437134. Epub 2018 Feb 19. PMID: 29457758.
  • Han L, Saavedra-Avendano B, Lambert W, Fu R, Rodriguez MI, Edelman A, Darney B. Emergency Contraception in Mexico: Trends in Knowledge and Ever-Use 2006-2014. Matern Child Health J. 2017 Nov;21(11):2132-2139. doi: 10.1007/s10995-017-2328-6. PMID: 28699094.
  • Han L, Teal SB, Sheeder J, Tocce K. Preventing repeat pregnancy in adolescents: is immediate postpartum insertion of the contraceptive implant cost effective? Am J Obstet Gynecol. 2014 Jul;211(1):24.e1-7. doi: 10.1016/j.ajog.2014.03.015. Epub 2014 Mar 11. PMID: 24631431.

Publications

  • Association of body mass index on time to fetal expulsion for individuals undergoing medication abortion over 13 weeks gestational duration

    Contraception
    1. Megan Fuerst
    2. Kristin C. Prewitt
    3. Bharti Garg
    4. Shaalini Ramanadhan
    5. Leo Han

  • Association of willingness to use hormonal contraception with knowledge

    Contraception
    1. Kathleen M. Beardsworth
    2. Bharti Garg
    3. Blair G. Darney
    4. Leo Han

  • Common misperceptions and public knowledge about intrauterine devices among US-based online respondents

    Contraception
    1. Rachel J. Shin
    2. Nina Nguyen
    3. Bharti Garg
    4. Blair Darney
    5. Leo Han

  • Copper levels in cervical mucus of copper intrauterine device users versus non-users

    International Journal of Gynecology and Obstetrics
    1. Leo L. Han
    2. Alison B. Edelman
    3. Oluwadamilola Sosanya
    4. Bharti Garg
    5. Vivia Chi
    6. Martina Ralle

  • Timing of Coronavirus Disease 2019 (COVID-19) Vaccination and Effects on Menstrual Cycle Changes

    Obstetrics and gynecology
    1. Alison Edelman
    2. Emily R. Boniface
    3. Victoria Male
    4. Sharon Cameron
    5. Eleonora Benhar
    6. Leo Han
    7. Kristen A. Matteson
    8. Agathe Van Lamsweerde
    9. Jack T. Pearson
    10. Blair G. Darney

  • Transcriptional profiling of mucus production in rhesus macaque endocervical cells under hormonal regulation

    Biology of reproduction
    1. Katrina Rapp
    2. Shuhao Wei
    3. Mackenzie Roberts
    4. Shan Yao
    5. Suzanne S. Fei
    6. Lina Gao
    7. Karina Ray
    8. Alexander Wang
    9. Rachelle Godiah
    10. Leo Han

  • Hormonal regulation of non-cystic fibrosis transmembrane conductance regulator ion channels in the endocervix

    F and S Science
    1. Mackenzie Roberts
    2. Shan Yao
    3. Shuhao Wei
    4. Jeffrey T. Jensen
    5. Leo Han

  • Public perceptions of abortion complications

    American journal of obstetrics and gynecology
    1. Sarina R. Chaiken
    2. Blair G. Darney
    3. Marta Schenck
    4. Leo Han

  • The effect of deliberate non-adherence to a norgestrel progestin-only pill

    Contraception
    1. Anna Glasier
    2. Alison Edelman
    3. Mitchell D. Creinin
    4. Vivian Brache
    5. Carolyn L. Westhoff
    6. Leo Han
    7. Melissa J. Chen
    8. Agnes Hemon

  • Treatment of unfavorable bleeding patterns in contraceptive implant users

    American journal of obstetrics and gynecology
    1. Alison Edelman
    2. Emily Boniface
    3. Kaitlin Schrote
    4. Marci Messerle-Forbes
    5. Andrea O'Donnell
    6. Jeffrey T. Jensen
    7. Leo Han

  • Functional evaluation of the cystic fibrosis transmembrane conductance regulator in the endocervix

    Biology of reproduction
    1. Leo Han
    2. MacKenzie Roberts
    3. Addie Luo
    4. Shuhao Wei
    5. Ov D. Slayden
    6. Kelvin D. MacDonald

  • Mechanism of action of a 0.075 mg norgestrel progestogen-only pill 2. Effect on cervical mucus and theoretical risk of conception

    Contraception
    1. Leo Han
    2. Mitchell D. Creinin
    3. Agnes Hemon
    4. Anna Glasier
    5. Melissa J. Chen
    6. Alison Edelman

  • Mechanism of action of norgestrel 0.075 mg a progestogen-only pill. I. Effect on ovarian activity

    Contraception
    1. Anna Glasier
    2. Alison Edelman
    3. Mitchell D. Creinin
    4. Leo Han
    5. Melissa C. Matulich
    6. Vivian Brache
    7. Carolyn L. Westhoff
    8. Agnes Hemon

  • Mucus secretions from a conditionally reprogrammed primary endocervical cell culture

    F and S Science
    1. Daye Park
    2. Ashok Reddy
    3. Phillip A. Wilmarth
    4. Jeffrey Jensen
    5. Leo Han

  • Comparing endocervical mucus proteome of humans and rhesus macaques

    Proteomics - Clinical Applications
    1. Leo Han
    2. Daye Park
    3. Ashok Reddy
    4. Phillip A. Wilmarth
    5. Jeffrey T. Jensen

  • How do women interpret abortion information they find online?

    Contraception
    1. Marissa Forbes
    2. Blair G. Darney
    3. Shaalini Ramanadhan
    4. Mary Earp
    5. Lauren Waldner-James
    6. Leo Han

  • Willingness to use cannabis for gynecological conditions

    Journal of Women's Health
    1. Leo Han
    2. Katie Alton
    3. Alyssa Covelli Colwill
    4. Jeffrey T. Jensen
    5. Sara McCrimmon
    6. Blair G. Darney

  • Conditionally reprogrammed macaque endocervical cells retain steroid receptor expression and produce mucus

    Biology of reproduction
    1. Leo Han
    2. Walker Andrews
    3. Karsten Wong
    4. Jeffrey T. Jensen

  • The Abortion Web Ecosystem

    Journal of medical Internet research
    1. Leo Han
    2. Emily R. Boniface
    3. Lisa Yin Han
    4. Jonathan Albright
    5. Nora Doty
    6. Blair G. Darney

  • Comparing cervical mucus changes in response to an oral progestin or oestrogen withdrawal in ovarian-suppressed women

    European Journal of Contraception and Reproductive Health Care
    1. Leo Han
    2. Emily Padua
    3. Kyle D. Hart
    4. Alison Edelman
    5. Jeffrey T. Jensen

  • Do menstrual cups increase risk of IUD expulsion? A survey of self-reported IUD and menstrual hygiene product use in the United States

    European Journal of Contraception and Reproductive Health Care
    1. Ariela N. Schnyer
    2. Jeffrey T. Jensen
    3. Alison Edelman
    4. Leo Han

  • Appraising cervical mucus

    European Journal of Contraception and Reproductive Health Care
    1. Leo Han
    2. Emily Padua
    3. Alison Edelman
    4. Jeffrey T. Jensen

  • Effects of concurrent vaginal miconazole treatment on the absorption and exposure of Nestorone® (segesterone acetate) and ethinyl estradiol delivered from a contraceptive vaginal ring

    Contraception
    1. Katharine B. Simmons
    2. Narender Kumar
    3. Marlena Plagianos
    4. Kevin Roberts
    5. Elena Hoskin
    6. Leo Han
    7. Mohcine Alami
    8. George Creasy
    9. Bruce Variano
    10. Ruth Merkatz

  • Emergency Contraception in Mexico

    Maternal and child health journal
    1. Leo Han
    2. Biani Saavedra-Avendano
    3. William Lambert
    4. Rongwei Fu
    5. Maria I. Rodriguez
    6. Alison Edelman
    7. Blair Darney