Leslie Myatt, Ph.D., FRCOG

  • Professor of Obstetrics and Gynecology, School of Medicine
  • Bob and Charlee Moore Professor for Nutrition and Wellness
  • Director of Perinatal Research, Obstetrics and Gynecology, School of Medicine
  • Director, Center for Developmental Health
  • Director, Moore Institute for Nutrition and Wellness

Biography

Dr. Myatt was born and raised in Yorkshire, England and received both his BSc and PhD from the University of London, UK. He moved to Oregon in 2015 having previously been a faculty member at the University of Texas Health Science Center San Antonio, and at the University of Cincinnati, where he was Director of the NIH-funded Physician Scientist Training Program (MD/PhD) and the Women’s Reproductive Health Research Scholars Program. Dr. Myatt served as Editor of the journal Placenta (1997 to 2004), President of the Perinatal Research Society (1997), President of the International Federation of Placenta Associations (2002 to 2004) and President of the Society for Gynecologic Investigation (2009 to 2010).

He is internationally known for his research which applies basic science approaches to clinical problems in perinatology, including preeclampsia, preterm birth and gestational diabetes. His research interests include prediction of adverse pregnancy outcomes, the role of obesity, gestational diabetes and sexual dimorphism in placental metabolism and function and fetal programming, the use of nanotechnology to locate and treat ectopic pregnancy and the regulation of prostaglandin synthesis and action in intrauterine tissues at parturition. He has published over 300 papers and 400 abstracts and has served on many review panels and study sections for NIH, CIHR and other international grant giving bodies. Dr Myatt is also Principal Investigator of the Global Pregnancy Collaboration (CoLab), which works with maternal and fetal medicine researchers around the globe to facilitate research addressing adverse pregnancy outcomes. In addition he is very active as a mentor currently being Principal Investigator of the Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Program at OHSU and serving on the national NIH-funded Reproductive Scientist Development Program (RSDP) Selection Committee and the SMFM/AAOGF Scholarly Activities Committee.

He was elected as a Fellow (ad eundem) of the Royal College of Obstetricians and Gynaecologists in 2013 for his contributions to women’s health research and has been honored with the Naftolin Award for Mentorship, the Distinguished Scientist Award and the DeCherney Society Lifetime Distinguished Service Award of the Society for Reproductive Investigation and the Senior Award in Placentology by the International Federation of Placenta Associations.

His passions in life are his family, mentorship and soccer. Memorable moments include meeting his wife, helicopter skiing and being embraced by Stevie Wonder!

Education and training

  • Degrees

    • B.Sc., 1972, University of London
    • Ph.D., 1979, University of London

Memberships and associations:

  • Society for Reproductive Investigation
  • Perinatal Research Society
  • International Federation of Placenta Associations
  • Global Pregnancy Collaboration (CoLab)

Areas of interest

  • Perinatology
  • Placental function and adverse pregnancy outcomes
  • Prediction of adverse pregnancy outcomes
  • DOHaD (Developmental Origins of Health and Disease)

Honors and awards

  • DeCherney Society Lifetime Distinguished Service Award, Society for Reproductive Investigation 2024
  • Senior Award in Placentology, International Federation of Placenta Associations 2019
  • Distinguished Scientist Award, Society for Reproductive Investigation 2017
  • Naftolin Award for Mentorship, Society for Gynecologic Investigation 2014

Publications

Publications

  • Advanced multi-modal mass spectrometry imaging reveals functional differences of placental villous compartments at microscale resolution

    Nature communications
    1. Marija Veličković
    2. Leena Kadam
    3. Joonhoon Kim
    4. Kevin J. Zemaitis
    5. Dušan Veličković
    6. Yuqian Gao
    7. Ruonan Wu
    8. Thomas L. Fillmore
    9. Daniel Orton
    10. Sarah M. Williams
    11. Matthew E. Monroe
    12. Ronald J. Moore
    13. Paul D. Piehowski
    14. Lisa M. Bramer
    15. Leslie Myatt
    16. Kristin E. Burnum-Johnson

  • Associations between maternal plasma concentrations of corticotrophin releasing hormone and the placental transcriptome

    Placenta
    1. Alison Paquette
    2. Mariana Parenti
    3. Samantha Lapehn
    4. Chaini Konwar
    5. Leena Kadam
    6. Evan J. Firsick
    7. Emily S. Barrett
    8. Julie MacIsaac
    9. James MacDonald
    10. Theo Bammler
    11. Kecia Carroll
    12. Daniel Enquobahrie
    13. Michael Kobor
    14. Kaja Z. LeWinn
    15. Ruby Nguyen
    16. Roger Smith
    17. Adam Spirzo
    18. Qi Zhao
    19. Leslie Myatt
    20. Nicole R. Bush
    21. Louis Muglia
    22. Sheela Sathyanarayana

  • A transcriptomic comparison of in vitro models of the human placenta

    Placenta
    1. Samantha Lapehn
    2. Sidharth Nair
    3. Evan J. Firsick
    4. James MacDonald
    5. Ciara Thoreson
    6. James A. Litch
    7. Nicole R. Bush
    8. Leena Kadam
    9. Sylvie Girard
    10. Leslie Myatt
    11. Bhagwat Prasad
    12. Sheela Sathyanarayana
    13. Alison G. Paquette

  • More than the passage of time

    American journal of obstetrics and gynecology
    1. Ellen L. Tilden
    2. Katherine Kissler
    3. Leslie Myatt
    4. Louise Lundborg
    5. Michelle Turney
    6. Marit L. Bovbjerg
    7. Elise Erickson

  • Sexual dimorphism in lipidomic changes in maternal blood and placenta associated with obesity and gestational diabetes

    Placenta
    1. Leena Kadam
    2. Marija Veličković
    3. Kelly Stratton
    4. Carrie D. Nicora
    5. Jennifer E. Kyle
    6. Eric Wang
    7. Matthew E. Monroe
    8. Lisa M. Bramer
    9. Leslie Myatt
    10. Kristin E. Burnum-Johnson

  • A Common OXTR Risk Variant Alters Regulation of Gene Expression by DNA Hydroxymethylation in Pregnant Human Myometrium

    Reproductive Sciences
    1. Joshua S. Danoff
    2. Travis S. Lillard
    3. Leslie Myatt
    4. Jessica J. Connelly
    5. Elise N. Erickson

  • ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition

    Communications Biology
    1. Meng Die Li
    2. Jiang Wen Lu
    3. Fan Zhang
    4. Wen Jia Lei
    5. Fan Pan
    6. Yi Kai Lin
    7. Li Jun Ling
    8. Leslie Myatt
    9. Wang Sheng Wang
    10. Kang Sun

  • A genome scale transcriptional regulatory model of the human placenta

    Science Advances
    1. Alison Paquette
    2. Kylia Ahuna
    3. Yeon Mi Hwang
    4. Jocelynn Pearl
    5. Hanna Liao
    6. Paul Shannon
    7. Leena Kadam
    8. Samantha Lapehn
    9. Matthew Bucher
    10. Ryan Roper
    11. Cory Funk
    12. James MacDonald
    13. Theo Bammler
    14. Priyanka Baloni
    15. Heather Brockway
    16. W. Alex Mason
    17. Nicole Bush
    18. Kaja Z. Lewinn
    19. Catherine J. Karr
    20. John Stamatoyannopoulos
    21. Louis J. Muglia
    22. Helen Jones
    23. Yoel Sadovsky
    24. Leslie Myatt
    25. Sheela Sathyanarayana
    26. Nathan D. Price

  • C/EBPδ deficiency delays infection-induced preterm birth

    BMC Medicine
    1. Wen Jia Lei
    2. Fan Zhang
    3. Meng Die Li
    4. Fan Pan
    5. Li Jun Ling
    6. Jiang Wen Lu
    7. Leslie Myatt
    8. Kang Sun
    9. Wang Sheng Wang

  • Global inequities in adverse pregnancy outcomes

    AJOG Global Reports
    1. James M. Roberts
    2. Seye Abimbola
    3. Tracy L. Bale
    4. Aluisio Barros
    5. Zulfiqar A. Bhutta
    6. Joyce L. Browne
    7. Ann C. Celi
    8. Polite Dube
    9. Cornelia R. Graves
    10. Marieke J. Hollestelle
    11. Scarlett Hopkins
    12. Ali Khashan
    13. Koiwah Koi-Larbi
    14. Eve Lackritz
    15. Leslie Myatt
    16. Christopher W.G. Redman
    17. Özge Tunçalp
    18. Sten H. Vermund
    19. Michael G. Gravett

  • Glutathione-Responsive Methotrexate Polymersomes for Potential Management of Ectopic Pregnancy

    Small
    1. Babak Mamnoon
    2. Abraham S. Moses
    3. Subisha Sundaram
    4. Constanze J. Raitmayr
    5. Terry Morgan
    6. Maureen K. Baldwin
    7. Leslie Myatt
    8. Oleh Taratula
    9. Olena R. Taratula

  • Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy

    npj Vaccines
    1. Lin Li
    2. Yusuke Matsui
    3. Mary K. Prahl
    4. Arianna G. Cassidy
    5. Yarden Golan
    6. Unurzul Jigmeddagva
    7. Nida Ozarslan
    8. Christine Y. Lin
    9. Sirirak Buarpung
    10. Veronica J. Gonzalez
    11. Megan A. Chidboy
    12. Emilia Basilio
    13. Kara L. Lynch
    14. Dongli Song
    15. Priya Jegatheesan
    16. Daljeet S. Rai
    17. Balaji Govindaswami
    18. Jordan Needens
    19. Monica Rincon
    20. Leslie Myatt
    21. Taha Y. Taha
    22. Mauricio Montano
    23. Melanie Ott
    24. Warner C. Greene
    25. Stephanie L. Gaw

  • Care plan for individuals at risk for preeclampsia

    American journal of obstetrics and gynecology
    1. James M. Roberts
    2. Tekoa L. King
    3. John R. Barton
    4. Stacy Beck
    5. Ira M. Bernstein
    6. Tiffani E. Buck
    7. Michele A. Forgues-Lackie
    8. Francesca L. Facco
    9. Alison D. Gernand
    10. Cornelia R. Graves
    11. Arundhati Jeyabalan
    12. Alisse Hauspurg
    13. Tracy A. Manuck
    14. Jenny E. Myers
    15. Trashaun M. Powell
    16. Elizabeth F. Sutton
    17. Elizabeth Tinker
    18. Eleni Tsigas
    19. Leslie Myatt

  • Metformin Impacts Human Syncytiotrophoblast Mitochondrial Function from Pregnancies Complicated by Obesity and Gestational Diabetes Mellitus in a Sexually Dimorphic Manner

    Antioxidants
    1. Jessica F. Hebert
    2. Leslie Myatt

  • Mono(2-ethylhexyl) phthalate induces transcriptomic changes in placental cells based on concentration, fetal sex, and trophoblast cell type

    Archives of Toxicology
    1. Samantha Lapehn
    2. Scott Houghtaling
    3. Kylia Ahuna
    4. Leena Kadam
    5. James W. MacDonald
    6. Theo K. Bammler
    7. Kaja Z. LeWinn
    8. Leslie Myatt
    9. Sheela Sathyanarayana
    10. Alison G. Paquette

  • Nano-Theranostic Modality for Visualization of the Placenta and Photo-Hyperthermia for Potential Management of Ectopic Pregnancy

    Small
    1. Abraham S. Moses
    2. Leena Kadam
    3. Anna St Lorenz
    4. Maureen K. Baldwin
    5. Terry Morgan
    6. Jessica Hebert
    7. Youngrong Park
    8. Hyelim Lee
    9. Ananiya A. Demessie
    10. Tetiana Korzun
    11. Babak Mamnoon
    12. Adam W.G. Alani
    13. Oleh Taratula
    14. Leslie Myatt
    15. Olena R. Taratula

  • Oxytocin receptor DNA methylation is associated with exogenous oxytocin needs during parturition and postpartum hemorrhage

    Communications Medicine
    1. Elise N. Erickson
    2. Leslie Myatt
    3. Joshua S. Danoff
    4. Kathleen M. Krol
    5. Jessica J. Connelly

  • Predicting labor onset relative to the estimated date of delivery using smart ring physiological data

    npj Digital Medicine
    1. Elise N. Erickson
    2. Neta Gotlieb
    3. Leonardo M. Pereira
    4. Leslie Myatt
    5. Clara Mosquera-Lopez
    6. Peter G. Jacobs

  • Characterization of placental and decidual cell development in early pregnancy loss by single-cell RNA sequencing

    Cell and Bioscience
    1. Yuhua Zheng
    2. Jing Pan
    3. Chenglai Xia
    4. Haiying Chen
    5. Huadong Zhou
    6. Weina Ju
    7. Jerzy Wegiel
    8. Leslie Myatt
    9. James M. Roberts
    10. Xiaoling Guo
    11. Nanbert Zhong

  • Human leukocyte antigen HLA-C, HLA-G, HLA-F, and HLA-E placental profiles are altered in early severe preeclampsia and preterm birth with chorioamnionitis

    American journal of obstetrics and gynecology
    1. Caroline E. Dunk
    2. Matthew Bucher
    3. Jianhong Zhang
    4. Heyam Hayder
    5. Daniel E. Geraghty
    6. Stephen J. Lye
    7. Leslie Myatt
    8. Rinat Hackmon

  • Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination

    JCI Insight
    1. Yusuke Matsui
    2. Lin Li
    3. Mary Prahl
    4. Arianna G. Cassidy
    5. Nida Ozarslan
    6. Yarden Golan
    7. Veronica J. Gonzalez
    8. Christine Y. Lin
    9. Unurzul Jigmeddagva
    10. Megan A. Chidboy
    11. Mauricio Montano
    12. Taha Y. Taha
    13. Mir M. Khalid
    14. Bharath Sreekumar
    15. Jennifer M. Hayashi
    16. Pei Yi Chen
    17. G. Renuka Kumar
    18. Lakshmi Warrier
    19. Alan H.B. Wu
    20. Dongli Song
    21. Priya Jegatheesan
    22. Daljeet S. Rai
    23. Balaji Govindaswami
    24. Jordan Needens
    25. Monica Rincon
    26. Leslie Myatt
    27. Ifeyinwa V. Asiodu
    28. Valerie J. Flaherman
    29. Yalda Afshar
    30. Vanessa L. Jacoby
    31. Amy P. Murtha
    32. Joshua F. Robinson
    33. Melanie Ott
    34. Warner C. Greene
    35. Stephanie L. Gaw

  • Oxytocin receptor single nucleotide polymorphism predicts atony-related postpartum hemorrhage

    BMC Pregnancy and Childbirth
    1. Elise N. Erickson
    2. Kathleen M. Krol
    3. Allison M. Perkeybile
    4. Jessica J. Connelly
    5. Leslie Myatt

  • Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression

    BMC Medicine
    1. Ya nan Zhu
    2. Xiao wen Gan
    3. Fan Pan
    4. Xiao tian Ni
    5. Leslie Myatt
    6. Wang sheng Wang
    7. Kang Sun

  • Differences in glycolysis and mitochondrial respiration between cytotrophoblast and syncytiotrophoblast in-vitro

    International journal of molecular sciences
    1. Matthew Bucher
    2. Leena Kadam
    3. Kylia Ahuna
    4. Leslie Myatt

  • Dyslipidemia, insulin resistance, and impairment of placental metabolism in the offspring of obese mothers

    Journal of Developmental Origins of Health and Disease
    1. Matthew Bucher
    2. Kim Ramil C. Montaniel
    3. Leslie Myatt
    4. Susan Weintraub
    5. Hagai Tavori
    6. Alina Maloyan