Lisa C. Silbert, M.D., M.C.R.

  • Professor of Neurology, School of Medicine
  • Gibbs Family Professor

Biography

Lisa C. Silbert, MD, MCR, FAAN, is a Professor in the Department of Neurology at Oregon Health & Science University School of Medicine, Director of the Neuroimaging Core at the Oregon Aging and Alzheimer's Disease Center, Director of the Dementia Clinic at the VA Portland Health Care System, and a Clinical Research Concentration Lead for the OHSU SOM Scholarly Projects course. She completed her neurology residency at UCLA and fellowship training in both Geriatric Neurology and Clinical Neurophysiology at OHSU. Dr. Silbert's clinical practice consists primarily of patients with neurodegenerative disease affecting cognitive function, and intraoperative neurophysiological monitoring.

Dr. Silbert's research focuses on the effects of cerebral white matter ischemic change on cognitive and motor function in the elderly. Her studies include investigations of how differing rates of white matter damage affect cognition, how changes in cerebral blood flow and microstructural white matter integrity impact expansion of white matter hyperintensity lesions, and the utilization of post-mortem high field MRI for targeted histopathological characterization of small vessel cerebrovascular disease. She has received funding for this work from the Alzheimer's Association, the American Academy of Neurology Foundation, and the NIH/NIA, including a K23/Paul B. Beeson career development award in aging research and an R01.

Education and training

  • Residency

    • University of California, Los Angeles - Neurology Residency

  • Fellowship

    • Oregon Health & Science University - Clinical Neurophysiology and Geriatric Neurology

  • Certifications

    • ABPN

Publications

Elsevier pure profile

Publications

  • Emotional characteristics and intrinsic brain network functional connectivity among adults aged 75+

    Social cognitive and affective neuroscience
    1. Patrick J. Pruitt
    2. Kexin Yu
    3. David Lahna
    4. Daniel Schwartz
    5. Scott Peltier
    6. Lisa Silbert
    7. Hiroko Dodge

  • Life-Space Mobility Is Related to Loneliness Among Living-Alone Older Adults

    Journal of the American Geriatrics Society
    1. Kexin Yu
    2. Chao Yi Wu
    3. Lisa L. Barnes
    4. Lisa C. Silbert
    5. Zachary Beattie
    6. Raina Croff
    7. Lyndsey Miller
    8. Hiroko H. Dodge
    9. Jeffrey A. Kaye

  • Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest

    npj Microgravity
    1. Sutton B. Richmond
    2. Rachael D. Seidler
    3. Jeffrey J. Iliff
    4. Daniel L. Schwartz
    5. Madison Luther
    6. Lisa C. Silbert
    7. Scott J. Wood
    8. Jacob J. Bloomberg
    9. Edwin Mulder
    10. Jessica K. Lee
    11. Alberto De Luca
    12. Juan Piantino

  • Enlarged perivascular spaces are associated with white matter injury, cognition and inflammation in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

    Brain Communications
    1. Nikolaos Karvelas
    2. Bradley Oh
    3. Earnest Wang
    4. Yann Cobigo
    5. Torie Tsuei
    6. Stephen Fitzsimons
    7. Kyan Younes
    8. Alexander Ehrenberg
    9. Michael D. Geschwind
    10. Daniel Schwartz
    11. Joel H. Kramer
    12. Adam R. Ferguson
    13. Bruce L. Miller
    14. Lisa C. Silbert
    15. Howard J. Rosen
    16. Fanny M. Elahi

  • I-CONECT intervention effects on weekly time spent outside of home and social contacts among socially isolated older adults

    Frontiers in Public Health
    1. Kexin Yu
    2. Chao Yi Wu
    3. Lisa C. Silbert
    4. Jeffrey A. Kaye
    5. Hiroko H. Dodge

  • Internet-Based Conversational Engagement Randomized Controlled Clinical Trial (I-CONECT) Among Socially Isolated Adults 75+ Years Old With Normal Cognition or Mild Cognitive Impairment

    Gerontologist
    1. Hiroko H. Dodge
    2. Kexin Yu
    3. Chao Yi Wu
    4. Patrick J. Pruitt
    5. Meysam Asgari
    6. Jeffrey A. Kaye
    7. Benjamin M. Hampstead
    8. Laura Struble
    9. Kathleen Potempa
    10. Peter Lichtenberg
    11. Raina Croff
    12. Roger L. Albin
    13. Lisa C. Silbert
    14. Elena Alfaro
    15. Mattie McDonald
    16. Jacob Lindsey
    17. Colton Scavone
    18. Nita Sheridan
    19. Khoa Nguyen
    20. Alexis Ellis
    21. Louis Weisberg
    22. Deborah Moore
    23. Brandy Peacock
    24. Brennan Heller
    25. Carissa Thornall
    26. Sandy Ruhf
    27. Mary Ziemer-Mcginn
    28. Farah Custodio
    29. Diane Farrell
    30. Aimee Lynch
    31. Dillon Banker
    32. Gracia Reyes
    33. Kathryn Rabe
    34. Laura Seeton
    35. Jessica Pedroza
    36. David Forystek
    37. Nicolas May
    38. Jonathan Reader
    39. Arijit K. Bhaumik

  • White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old

    Alzheimer's and Dementia
    1. Lisa C. Silbert
    2. Natalie E. Roese
    3. Victoria Krajbich
    4. Justin Hurworth
    5. David Lahna
    6. Daniel L. Schwartz
    7. Hiroko H. Dodge
    8. Randall L. Woltjer

  • ω-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults

    JAMA Network Open
    1. Lynne H. Shinto
    2. Charles F. Murchison
    3. Lisa C. Silbert
    4. Hiroko H. Dodge
    5. David Lahna
    6. William Rooney
    7. Jeffrey Kaye
    8. Joseph F. Quinn
    9. Gene Bowman

  • Associations of Enlarged Perivascular Spaces With Brain Lesions, Brain Age, and Clinical Outcomes in Chronic Traumatic Brain Injury

    Neurology
    1. Amelia J. Hicks
    2. Benjamin Sinclair
    3. Sandy R. Shultz
    4. William Pham
    5. Lisa C. Silbert
    6. Daniel L. Schwartz
    7. Christopher C. Rowe
    8. Jennie L. Ponsford
    9. Meng Law
    10. Gershon Spitz

  • Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease

    EBioMedicine
    1. Taeho Jo
    2. Junpyo Kim
    3. Paula Bice
    4. Kevin Huynh
    5. Tingting Wang
    6. Matthias Arnold
    7. Peter J. Meikle
    8. Corey Giles
    9. Rima Kaddurah-Daouk
    10. Andrew J. Saykin
    11. Kwangsik Nho
    12. Alexandra Kueider-Paisley
    13. P. Murali Doraiswamy
    14. Colette Blach
    15. Arthur Moseley
    16. Will Thompson
    17. Lisa St John-Williams
    18. Siamak Mahmoudiandehkhordi
    19. Jessica Tenenbaum
    20. Kathleen Welsh-Balmer
    21. Brenda Plassman
    22. Shannon L. Risacher
    23. Gabi Kastenmüller
    24. Xianlin Han
    25. Rebecca Baillie
    26. Rob Knight
    27. Pieter Dorrestein
    28. James Brewer
    29. Emeran Mayer
    30. Jennifer Labus
    31. Pierre Baldi
    32. Arpana Gupta
    33. Oliver Fiehn
    34. Dinesh Barupal
    35. Peter Meikle
    36. Sarkis Mazmanian
    37. Dan Rader
    38. Mitchel Kling
    39. Leslie Shaw
    40. John Trojanowski
    41. Cornelia van Duijin
    42. Alejo Nevado-Holgado
    43. David Bennett
    44. Ranga Krishnan
    45. Ali Keshavarzian
    46. Robin Vogt
    47. Lisa C. Silbert
    48. Jeffrey A. Kaye
    49. Joseph Quinn
    50. Aimee Pierce

  • Differences in Life Space Activity Patterns Between Older Adults With Mild Cognitive Impairment Living Alone or as a Couple

    JMIR Aging
    1. Marijn Muurling
    2. Wan Tai M. Au-Yeung
    3. Zachary Beattie
    4. Chao Yi Wu
    5. Hiroko Dodge
    6. Nathaniel K. Rodrigues
    7. Sarah Gothard
    8. Lisa C. Silbert
    9. Lisa L. Barnes
    10. Joel S. Steele
    11. Jeffrey Kaye

  • Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

    Communications Medicine
    1. Tiago Azevedo
    2. Richard A.I. Bethlehem
    3. David J. Whiteside
    4. Nol Swaddiwudhipong
    5. James B. Rowe
    6. Pietro Lió
    7. Timothy Rittman
    8. Gail Li
    9. Eric C. Petrie
    10. Elaine R. Peskind
    11. Teresa Villena
    12. Walter Martinez
    13. Carl Sadowsky
    14. Athena Lee
    15. Lisa Ravdin
    16. Michael Lin
    17. Gloria Chiang
    18. Norman Relkin
    19. Robert B. Santulli
    20. Mary L. Hynes
    21. Marc Seltzer
    22. Laura A. Flashman
    23. Karen Anderson
    24. Karen Blank
    25. Godfrey D. Pearlson
    26. Smita Kittur
    27. Stephen Correia
    28. Paul Malloy
    29. Stephen Salloway
    30. Steven Potkin
    31. Paul Newhouse
    32. Angelica Garcia
    33. Jiong Shi
    34. Joseph Masdeu
    35. Arthur Wiliams
    36. Jacobo Mintzer
    37. Abigail O’Connelll
    38. Akiva Mintz
    39. Donna Munic
    40. Charles Bernick
    41. Aaron Ritter
    42. Jonathan D. Drake
    43. Lori A. Daiello
    44. Geoffrey Tremont
    45. Jonathan Drake
    46. Brian R. Ott
    47. Kaycee M. Sink
    48. Joseph Quinn
    49. Jeffrey A. Kaye
    50. Lisa C. Silbert

  • Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults

    JAMA Network Open
    1. Samantha A. Keil
    2. Abigail G. Schindler
    3. Marie X. Wang
    4. Juan Piantino
    5. Lisa C. Silbert
    6. Jonathan E. Elliott
    7. Madeleine L. Werhane
    8. Ronald G. Thomas
    9. Sherry Willis
    10. Miranda M. Lim
    11. Jeffrey J. Iliff

  • Mood and activity changes during the COVID-19 pandemic in rural and urban Veterans and their cohabitants

    Clinical Gerontologist
    1. Jack C. Lennon
    2. Nathan Hantke
    3. Nora Mattek
    4. Chao Yi Wu
    5. Hiroko Dodge
    6. Rachel Wall
    7. Zachary Beattie
    8. Jeffrey Kaye
    9. Lisa C. Silbert

  • Postmortem 7T MRI for guided histopathology and evaluation of cerebrovascular disease

    Journal of Neuropathology and Experimental Neurology
    1. David Lahna
    2. Natalie Roese
    3. Randy Woltjer
    4. Erin L. Boespflug
    5. Daniel Schwartz
    6. John Grinstead
    7. Hiroko H. Dodge
    8. Rachel Wall
    9. Jeffrey A. Kaye
    10. William D. Rooney
    11. Lisa C. Silbert

  • Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment

    BMC Geriatrics
    1. Cosimo Tuena
    2. Sara Maestri
    3. Silvia Serino
    4. Elisa Pedroli
    5. Marco Stramba-Badiale
    6. Giuseppe Riva
    7. Lisa C. Silbert
    8. Betty Lind
    9. Rachel Crissey
    10. Jeffrey A. Kaye
    11. Raina Carter
    12. Sara Dolen
    13. Joseph Quinn
    14. Lon S. Schneider
    15. Sonia Pawluczyk
    16. Mauricio Becerra
    17. Liberty Teodoro
    18. Karen Dagerman
    19. Bryan M. Spann
    20. James Brewer
    21. Adam Fleisher
    22. Helen Vanderswag
    23. Jaimie Ziolkowski
    24. Judith L. Heidebrink
    25. Lisa Zbizek-Nulph
    26. Joanne L. Lord
    27. Colleen S. Albers
    28. Ronald Petersen
    29. Sara S. Mason
    30. David Knopman
    31. Kris Johnson
    32. Javier Villanueva-Meyer
    33. Valory Pavlik
    34. Nathaniel Pacini
    35. Ashley Lamb
    36. Joseph S. Kass
    37. Rachelle S. Doody
    38. Victoria Shibley
    39. Munir Chowdhury
    40. Susan Rountree
    41. Mimi Dang
    42. Yaakov Stern
    43. Lawrence S. Honig
    44. Akiva Mintz
    45. Beau Ances
    46. John C. Morris
    47. David Winkfield
    48. Maria Carroll
    49. Georgia Stobbs-Cucchi
    50. Aimee Pierce

  • Reduced total number of enlarged perivascular spaces in post-traumatic epilepsy patients with unilateral lesions – a feasibility study

    Seizure
    1. Gernot Hlauschek
    2. Morten I. Lossius
    3. Daniel L. Schwartz
    4. Lisa C. Silbert
    5. Amelia J. Hicks
    6. Jennie L. Ponsford
    7. Lucy Vivash
    8. Benjamin Sinclair
    9. Patrick Kwan
    10. Terrence J. O'Brien
    11. Sandy R. Shultz
    12. Meng Law
    13. Gershon Spitz

  • Regional Neuroanatomic Effects on Brain Age Inferred Using Magnetic Resonance Imaging and Ridge Regression

    Journals of Gerontology - Series A Biological Sciences and Medical Sciences
    1. Roy J. Massett
    2. Alexander S. Maher
    3. Phoebe E. Imms
    4. Anar Amgalan
    5. Nikhil N. Chaudhari
    6. Nahian F. Chowdhury
    7. Andrei Irimia
    8. Michael W. Weiner
    9. Paul Aisen
    10. Ronald Petersen
    11. Clifford R. Jack
    12. William Jagust
    13. John Q. Trojanowki
    14. Arthur W. Toga
    15. Laurel Beckett
    16. Robert C. Green
    17. Andrew J. Saykin
    18. John C. Morris
    19. Richard J. Perrin
    20. Leslie M. Shaw
    21. Zaven Khachaturian
    22. Maria Carrillo
    23. William Potter
    24. Lisa Barnes
    25. Marie Bernard
    26. Hector González
    27. Carole Ho
    28. John K. Hsiao
    29. Jonathan Jackson
    30. Eliezer Masliah
    31. Donna Masterman
    32. Ozioma Okonkwo
    33. Laurie Ryan
    34. Nina Silverberg
    35. Adam Fleisher
    36. Diana Truran Sacrey
    37. Juliet Fockler
    38. Cat Conti
    39. Dallas Veitch
    40. John Neuhaus
    41. Chengshi Jin
    42. Rachel Nosheny
    43. Miriam Ashford
    44. Derek Flenniken
    45. Adrienne Kormos
    46. Tom Montine
    47. Lisa C. Silbert
    48. Jeffrey A. Kaye
    49. Joseph Quinn
    50. Aimee Pierce

  • Remote Spectral Light Sensing in the Home Environment

    Sensors
    1. Christina L. Reynolds
    2. Aylmer Tan
    3. Jonathan E. Elliott
    4. Carolyn E. Tinsley
    5. Rachel Wall
    6. Jeffrey A. Kaye
    7. Lisa C. Silbert
    8. Miranda M. Lim

  • A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

    Communications Medicine
    1. Marianna Inglese
    2. Neva Patel
    3. Kristofer Linton-Reid
    4. Flavia Loreto
    5. Zarni Win
    6. Richard J. Perry
    7. Christopher Carswell
    8. Matthew Grech-Sollars
    9. William R. Crum
    10. Haonan Lu
    11. Paresh A. Malhotra
    12. Lisa C. Silbert
    13. Betty Lind
    14. Rachel Crissey
    15. Jeffrey A. Kaye
    16. Raina Carter
    17. Sara Dolen
    18. Joseph Quinn
    19. Lon S. Schneider
    20. Sonia Pawluczyk
    21. Mauricio Becerra
    22. Liberty Teodoro
    23. Karen Dagerman
    24. Bryan M. Spann
    25. James Brewer
    26. Helen Vanderswag
    27. Adam Fleisher
    28. Jaimie Ziolkowski
    29. Judith L. Heidebrink
    30. Zbizek-Nulph
    31. Joanne L. Lord
    32. Lisa Zbizek-Nulph
    33. Ronald Petersen
    34. Sara S. Mason
    35. Colleen S. Albers
    36. David Knopman
    37. Kris Johnson
    38. Javier Villanueva-Meyer
    39. Valory Pavlik
    40. Nathaniel Pacini
    41. Ashley Lamb
    42. Joseph S. Kass
    43. Rachelle S. Doody
    44. Victoria Shibley
    45. Munir Chowdhury
    46. Susan Rountree
    47. Mimi Dang
    48. Yaakov Stern
    49. Lawrence S. Honig
    50. Aimee Pierce

  • Can changes in social contact (frequency and mode) mitigate low mood before and during the COVID-19 pandemic? The I-CONECT project

    Journal of the American Geriatrics Society
    1. Chao Yi Wu
    2. Nora Mattek
    3. Katherine Wild
    4. Lyndsey M. Miller
    5. Jeffrey A. Kaye
    6. Lisa C. Silbert
    7. Hiroko H. Dodge

  • Emotional characteristics of socially isolated older adults with MCI using tablet administered NIH toolbox

    Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
    1. Kexin Yu
    2. Katherine Wild
    3. N. Maritza Dowling
    4. Jeffrey A. Kaye
    5. Lisa C. Silbert
    6. Hiroko H. Dodge